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The map label for this gene is yfcY [C]

Identifier: 15922750

GI number: 15922750

Start: 2422505

End: 2423668

Strand: Direct

Name: yfcY [C]

Synonym: ST2418

Alternate gene names: 15922750

Gene position: 2422505-2423668 (Clockwise)

Preceding gene: 15922741

Following gene: 15922751

Centisome position: 89.9

GC content: 37.2

Gene sequence:

>1164_bases
GTGAATAGGAAAGTAGCCGTTATTGGGGTAGGGAATTCCAAGTTTGGAAAAAGGGACGATGTAACTATAAAGGAATTAGC
TTGGGAATCGGTCAAAGAGGCTTTGGAGGACGCTAATTTAGCTCAAAAAGATATTGATATAACAGTAATTGGGAGCACAG
CATACAGAGGGACAGAAATCTATCCCGCTCCTCCAGTTTCTGAATATTGTGGGTTAATTGGCAAAAGTCCAATAAGAGTT
GAAGCAGCTTGTGCTACCGGAAGTTCTGCAGCTTTTACTGCAATTAATTTGATTGCATCCGGTTTAGCTGATATAGTAAT
GGCTATTGGAGTAGATAAAATGACAGAAGTCGATACTTCAACCTCATTAGCAATTGGAGGACGAGGAGGAAATTATTATT
GGGAATTTCATATGTATGGTACTACATTTCCCACATATTATGCTTTATATGCAACTAGGCATATGGCTTTATTTGGAACT
ACAGAAGAAGATATGGCATTAGCATCAGTAAAAGCCCATAAATATGCTTCGTTAAATGAGAAAGCACATTTCAGAAATAA
AATTACAGTAGAAGATGTATTAAAATCTAGAGTTATATCTTGGCCAATAAAATTGTTAGATTCTTCTCCAATTAGTGATG
GTTCCGCTACAGTTATCTTTGCGTCAGAGGAAAAGGTAAGAGAACTAAAAATTGATACTCCCATATGGGTAAAAGGAATT
GGTTATAGTAGTGATACTTCATATATTGCTGCTAGAGGCGAATGGGTAGGTTTAGAAGCTGCAAGAGATGCTGCAGCTAA
AGCTTATAAAATGGCTAAGATCTCTCCGTTAGATATTGAATATGCAACTGTTCATGATTGTTTCTCAATTGCTGAGATTA
TGGCTTATGAGGATTTGGGTTTTGTTGAAAAGGGTAAGGGAGCTGAATTGTTAAGGGAAGGACAAACTGAAAAAGACGGT
AAAGTAGCTGTAAATCTATTCGGTGGTTTAAAAGCTAAAGGCCATCCTTTAGGTGCAACTGGTTTATCCATGATTTATGA
AGTTACAAAACAATTGAGGGAGGAAGCTGGACCGGTACAACATTCTTTCAAAAGATATGTTGCTTTAACTCATAATGTTG
GTGGTACGGGTCATTACGCTTACGTCATGATATTTAATAGGTGA

Upstream 100 bases:

>100_bases
ATATTCTTTGTTTAAGCAATATTGGACAAATGATAACATTTAATTCAATATCATTATATTAGAGTAAGATATATAAGTCT
TTTAAACAATTTATATTGAT

Downstream 100 bases:

>100_bases
TATAAATGGATGGAATACCCCTCCTCTTCAAATACTCTGTTCCAGACAAACTGTATGAAAAATTCTGGGAAGGACTAAAG
AAAGGTGAAATTTATACTAC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNRKVAVIGVGNSKFGKRDDVTIKELAWESVKEALEDANLAQKDIDITVIGSTAYRGTEIYPAPPVSEYCGLIGKSPIRV
EAACATGSSAAFTAINLIASGLADIVMAIGVDKMTEVDTSTSLAIGGRGGNYYWEFHMYGTTFPTYYALYATRHMALFGT
TEEDMALASVKAHKYASLNEKAHFRNKITVEDVLKSRVISWPIKLLDSSPISDGSATVIFASEEKVRELKIDTPIWVKGI
GYSSDTSYIAARGEWVGLEAARDAAAKAYKMAKISPLDIEYATVHDCFSIAEIMAYEDLGFVEKGKGAELLREGQTEKDG
KVAVNLFGGLKAKGHPLGATGLSMIYEVTKQLREEAGPVQHSFKRYVALTHNVGGTGHYAYVMIFNR

Sequences:

>Translated_387_residues
MNRKVAVIGVGNSKFGKRDDVTIKELAWESVKEALEDANLAQKDIDITVIGSTAYRGTEIYPAPPVSEYCGLIGKSPIRV
EAACATGSSAAFTAINLIASGLADIVMAIGVDKMTEVDTSTSLAIGGRGGNYYWEFHMYGTTFPTYYALYATRHMALFGT
TEEDMALASVKAHKYASLNEKAHFRNKITVEDVLKSRVISWPIKLLDSSPISDGSATVIFASEEKVRELKIDTPIWVKGI
GYSSDTSYIAARGEWVGLEAARDAAAKAYKMAKISPLDIEYATVHDCFSIAEIMAYEDLGFVEKGKGAELLREGQTEKDG
KVAVNLFGGLKAKGHPLGATGLSMIYEVTKQLREEAGPVQHSFKRYVALTHNVGGTGHYAYVMIFNR
>Mature_387_residues
MNRKVAVIGVGNSKFGKRDDVTIKELAWESVKEALEDANLAQKDIDITVIGSTAYRGTEIYPAPPVSEYCGLIGKSPIRV
EAACATGSSAAFTAINLIASGLADIVMAIGVDKMTEVDTSTSLAIGGRGGNYYWEFHMYGTTFPTYYALYATRHMALFGT
TEEDMALASVKAHKYASLNEKAHFRNKITVEDVLKSRVISWPIKLLDSSPISDGSATVIFASEEKVRELKIDTPIWVKGI
GYSSDTSYIAARGEWVGLEAARDAAAKAYKMAKISPLDIEYATVHDCFSIAEIMAYEDLGFVEKGKGAELLREGQTEKDG
KVAVNLFGGLKAKGHPLGATGLSMIYEVTKQLREEAGPVQHSFKRYVALTHNVGGTGHYAYVMIFNR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=390, Percent_Identity=33.0769230769231, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI302344760, Length=387, Percent_Identity=31.5245478036176, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI302344767, Length=312, Percent_Identity=34.2948717948718, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI302344762, Length=390, Percent_Identity=29.2307692307692, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI55956775, Length=357, Percent_Identity=27.7310924369748, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17537653, Length=391, Percent_Identity=28.6445012787724, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24585051, Length=394, Percent_Identity=30.9644670050761, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI19921506, Length=398, Percent_Identity=30.9045226130653, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42071; Mature: 42071

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKVAVIGVGNSKFGKRDDVTIKELAWESVKEALEDANLAQKDIDITVIGSTAYRGTEI
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCC
YPAPPVSEYCGLIGKSPIRVEAACATGSSAAFTAINLIASGLADIVMAIGVDKMTEVDTS
CCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
TSLAIGGRGGNYYWEFHMYGTTFPTYYALYATRHMALFGTTEEDMALASVKAHKYASLNE
CEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCCC
KAHFRNKITVEDVLKSRVISWPIKLLDSSPISDGSATVIFASEEKVRELKIDTPIWVKGI
HHHHCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEECCCCHHEEECCCCEEEEEC
GYSSDTSYIAARGEWVGLEAARDAAAKAYKMAKISPLDIEYATVHDCFSIAEIMAYEDLG
CCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCC
FVEKGKGAELLREGQTEKDGKVAVNLFGGLKAKGHPLGATGLSMIYEVTKQLREEAGPVQ
CCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHH
HSFKRYVALTHNVGGTGHYAYVMIFNR
HHHHHHEEEEECCCCCCCEEEEEEEEC
>Mature Secondary Structure
MNRKVAVIGVGNSKFGKRDDVTIKELAWESVKEALEDANLAQKDIDITVIGSTAYRGTEI
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCC
YPAPPVSEYCGLIGKSPIRVEAACATGSSAAFTAINLIASGLADIVMAIGVDKMTEVDTS
CCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
TSLAIGGRGGNYYWEFHMYGTTFPTYYALYATRHMALFGTTEEDMALASVKAHKYASLNE
CEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCCC
KAHFRNKITVEDVLKSRVISWPIKLLDSSPISDGSATVIFASEEKVRELKIDTPIWVKGI
HHHHCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEECCCCHHEEECCCCEEEEEC
GYSSDTSYIAARGEWVGLEAARDAAAKAYKMAKISPLDIEYATVHDCFSIAEIMAYEDLG
CCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCC
FVEKGKGAELLREGQTEKDGKVAVNLFGGLKAKGHPLGATGLSMIYEVTKQLREEAGPVQ
CCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHH
HSFKRYVALTHNVGGTGHYAYVMIFNR
HHHHHHEEEEECCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]