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The map label for this gene is guaAB

Identifier: 15922676

GI number: 15922676

Start: 2346456

End: 2347568

Strand: Direct

Name: guaAB

Synonym: ST2345

Alternate gene names: 15922676

Gene position: 2346456-2347568 (Clockwise)

Preceding gene: 15922675

Following gene: 15922679

Centisome position: 87.07

GC content: 32.97

Gene sequence:

>1113_bases
ATGAGTTTTGATCCACAAAAATTTGTTGATGAAATCTCTCCTCAATTAAAGGAAATTGTTGATGGTAGAGCTATAGCAGC
AGTAAGTGGTGGTGTTGATAGTACAACAGCCGCAGTTTTATCGTATAAGATTCTAGGGGATAAAGTAATTCCAGTTATGA
TAGATACGGGTTTTTTAAGAGAAAACGAAGCTGAGAATGTAAAGAATATGCTTAAAGATTTAATGCCTCTACAAGTTATT
GACGAGAGAGAAAAATTCATATCATCATTAGAGGGTATGTCAGATGCTGAAGAGAAAAGGAAAAAATTCAGGCAATTATT
TTATGATACTTTATCAAGAATCGTAAAAGAGTTCAATGCAAAATATTTAATACAAGGAACAATTGCTGCTGATTGGGTAG
AAACCCAAGGAGGTATAAAAACACAGCATAATGTTCTAGTACAGTTAGGTATAGATACTGAAAAAGAATGGGGATTTAAA
GTTGTTGAGCCTTTAGCTGATTTATATAAAGATGAGGTTAGGGCATTAGCAAAATACTTAGGTTTACCTAGGGATATATA
TAATAGGCAACCTTTTCCAGGTCCAGGACTACTTGTTAGAGTTGTAGGTAAGTTAACTAGAGAAAAGCTCGAAATCTTGA
GGAAAGTAACTACTACTGTGGAAAAGAACTTATCTGAATTAAACCTCTCTCAGTATTTTGCAGTCATTTTTGACTCTGCT
GCAGAGTATAATAAAGAGTTAAGTAATGAGGTAGGATGTGATGTTAAGGTATACAAAACATTAGCTACTGGAGTTAAAGG
TGATGTAAGGGCTTATGGTAATATAGCTGGTATTGAATGCAGGAAAGATTACGAGAGCTTAAGAGAAATTATGGAAAAAC
TTACAAGTTATAATATAACTCATGTGGTCGTTAAGATAAAGGATAAAAACCCGGAGGGTATTTATACCATAGGAATTAGA
GCTGTAAATACACAAGATTTTATGACAGCAGATTTTGCTAAGATAAATTGGAATATCCTTGAAAAAATAGCAAATGAAAT
TAATGATAAAAAAATCAAGGAAGTTGTTTATGATATAACTACAAAACCCCCAGCAACTATTGAGTATGAGTAA

Upstream 100 bases:

>100_bases
GAGATTAGCTAATATATTTAAACGTTATATTGATGTGGATTTACTTAATCAAATAAATGTATAGGTGAATTTATTAATTT
ATTTTTAGTCAGTTAAATCA

Downstream 100 bases:

>100_bases
GTTTTTCTAATAATTGTATTCTTTTTGCTGGGTGTGGATGATCGCTAAAGATGTCTGCAAATGGGCTTACCTTTATATTT
CTCCAATATTCTACTAATTC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSFDPQKFVDEISPQLKEIVDGRAIAAVSGGVDSTTAAVLSYKILGDKVIPVMIDTGFLRENEAENVKNMLKDLMPLQVI
DEREKFISSLEGMSDAEEKRKKFRQLFYDTLSRIVKEFNAKYLIQGTIAADWVETQGGIKTQHNVLVQLGIDTEKEWGFK
VVEPLADLYKDEVRALAKYLGLPRDIYNRQPFPGPGLLVRVVGKLTREKLEILRKVTTTVEKNLSELNLSQYFAVIFDSA
AEYNKELSNEVGCDVKVYKTLATGVKGDVRAYGNIAGIECRKDYESLREIMEKLTSYNITHVVVKIKDKNPEGIYTIGIR
AVNTQDFMTADFAKINWNILEKIANEINDKKIKEVVYDITTKPPATIEYE

Sequences:

>Translated_370_residues
MSFDPQKFVDEISPQLKEIVDGRAIAAVSGGVDSTTAAVLSYKILGDKVIPVMIDTGFLRENEAENVKNMLKDLMPLQVI
DEREKFISSLEGMSDAEEKRKKFRQLFYDTLSRIVKEFNAKYLIQGTIAADWVETQGGIKTQHNVLVQLGIDTEKEWGFK
VVEPLADLYKDEVRALAKYLGLPRDIYNRQPFPGPGLLVRVVGKLTREKLEILRKVTTTVEKNLSELNLSQYFAVIFDSA
AEYNKELSNEVGCDVKVYKTLATGVKGDVRAYGNIAGIECRKDYESLREIMEKLTSYNITHVVVKIKDKNPEGIYTIGIR
AVNTQDFMTADFAKINWNILEKIANEINDKKIKEVVYDITTKPPATIEYE
>Mature_369_residues
SFDPQKFVDEISPQLKEIVDGRAIAAVSGGVDSTTAAVLSYKILGDKVIPVMIDTGFLRENEAENVKNMLKDLMPLQVID
EREKFISSLEGMSDAEEKRKKFRQLFYDTLSRIVKEFNAKYLIQGTIAADWVETQGGIKTQHNVLVQLGIDTEKEWGFKV
VEPLADLYKDEVRALAKYLGLPRDIYNRQPFPGPGLLVRVVGKLTREKLEILRKVTTTVEKNLSELNLSQYFAVIFDSAA
EYNKELSNEVGCDVKVYKTLATGVKGDVRAYGNIAGIECRKDYESLREIMEKLTSYNITHVVVKIKDKNPEGIYTIGIRA
VNTQDFMTADFAKINWNILEKIANEINDKKIKEVVYDITTKPPATIEYE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=316, Percent_Identity=31.0126582278481, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1788854, Length=385, Percent_Identity=32.4675324675325, Blast_Score=177, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI71992717, Length=307, Percent_Identity=32.2475570032573, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71992710, Length=307, Percent_Identity=32.2475570032573, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI133901714, Length=303, Percent_Identity=32.6732673267327, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323873, Length=383, Percent_Identity=33.1592689295039, Blast_Score=183, Evalue=3e-47,
Organism=Drosophila melanogaster, GI281365319, Length=315, Percent_Identity=29.5238095238095, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAB_SULTO (Q96Y23)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_378345.1
- ProteinModelPortal:   Q96Y23
- SMR:   Q96Y23
- GeneID:   1460427
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST2345
- NMPDR:   fig|273063.1.peg.2513
- HOGENOM:   HBG391775
- OMA:   QGTIAPD
- ProtClustDB:   CLSK883887
- BioCyc:   STOK273063:ST2345-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00345
- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 41881; Mature: 41749

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDPQKFVDEISPQLKEIVDGRAIAAVSGGVDSTTAAVLSYKILGDKVIPVMIDTGFLR
CCCCHHHHHHHHCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCC
ENEAENVKNMLKDLMPLQVIDEREKFISSLEGMSDAEEKRKKFRQLFYDTLSRIVKEFNA
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
KYLIQGTIAADWVETQGGIKTQHNVLVQLGIDTEKEWGFKVVEPLADLYKDEVRALAKYL
CEEEEECHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GLPRDIYNRQPFPGPGLLVRVVGKLTREKLEILRKVTTTVEKNLSELNLSQYFAVIFDSA
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEYNKELSNEVGCDVKVYKTLATGVKGDVRAYGNIAGIECRKDYESLREIMEKLTSYNIT
HHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
HVVVKIKDKNPEGIYTIGIRAVNTQDFMTADFAKINWNILEKIANEINDKKIKEVVYDIT
EEEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TKPPATIEYE
CCCCCCCCCC
>Mature Secondary Structure 
SFDPQKFVDEISPQLKEIVDGRAIAAVSGGVDSTTAAVLSYKILGDKVIPVMIDTGFLR
CCCHHHHHHHHCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCC
ENEAENVKNMLKDLMPLQVIDEREKFISSLEGMSDAEEKRKKFRQLFYDTLSRIVKEFNA
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
KYLIQGTIAADWVETQGGIKTQHNVLVQLGIDTEKEWGFKVVEPLADLYKDEVRALAKYL
CEEEEECHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GLPRDIYNRQPFPGPGLLVRVVGKLTREKLEILRKVTTTVEKNLSELNLSQYFAVIFDSA
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEYNKELSNEVGCDVKVYKTLATGVKGDVRAYGNIAGIECRKDYESLREIMEKLTSYNIT
HHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
HVVVKIKDKNPEGIYTIGIRAVNTQDFMTADFAKINWNILEKIANEINDKKIKEVVYDIT
EEEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TKPPATIEYE
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479