Click here to switch to the map view.

The map label for this gene is cobQ [H]

Identifier: 15922675

GI number: 15922675

Start: 2344902

End: 2346419

Strand: Direct

Name: cobQ [H]

Synonym: ST2344

Alternate gene names: 15922675

Gene position: 2344902-2346419 (Clockwise)

Preceding gene: 15922672

Following gene: 15922676

Centisome position: 87.02

GC content: 30.96

Gene sequence:

>1518_bases
GTGATTACTCCAATAATTATTGGTGAGATAAAGGAAGCACTAGCAACCTCCTCTAAAGTTGCTTTTGTCGAGGGAATAAT
AGTAAAGAATGAGATTTGTGAGGCAATCTTTTTAAATATTTTCATCTTGTTATGCTATAATGTGGCAATTATTATAGCTT
CTACTATGAGTGATTCTGGGAAATCGACAGTAACAACGGCTATCGTTAAATTACTAGATTTAACTCCTATGAAAATACAG
AATATGTCACTAAATAGCTTTCCTACTATGGATAATGGAGAAATAGCTTTCATCCAAGCATATCAAGCGTTTGCAAAGGG
AATTGAACCAGAAAGATATATGAATCCTATTCTATTAAAGCCTGCGGGTAAAGGAATAGAAGTTATTTACTTTGGTACTC
CTATCGGAGTATATTCAGCTGAAGAGTACTATAATAAAATAGAAGAATTATGGTGGAAAATTAAGGATTATATTAGGAGA
GATGTTGTAATTGAATCAGCTGGAGGAATTGAACCGAATTTTATAGATAAAGACTTAACACTGGTAAGGTTAGTAAAAGA
GTTTAATCTTCCCGTTATATTAATTCTAGATATAGATAGAGGAGGAGCATTTACTTCAGCTTACGGTGCATATCTTACTC
TCCCAGAAAGTGTAAGAAGGAACTTGAAAGGTTTTATAATTAATAAGTTTAGAGGAGATGAAAAGTTACTTAACCCAGCT
ATAAAATGGCTTGAAGAAAAAACTGGGATGAGATATTTAGGTTATCTTCCTTATTTTGATGAACCTCCAATAATGCAAGA
AGATTCAATGAACATATTTGAATTCGGTGAAGGAGATATCGAAGTAGGTATACTAGCTTACCCTTATATGAGTAATTTTA
ACGAATTTTATGCATTTAATAAATCAAATGCACATATTAAATTTATTAAAAAGCCTTCACAATTATCTAAAGTTGACTTA
GTTATTATACCTGGTAGTAGAAATACGTTTGAAAGTCTAGTATGGTTAACGGAGAAGGGTTTTATTGAGCATATTAGAAA
GAAACCAGTCCTAGGAATATGTGGTGGTTTTCAACTTATGGGTAAAAAGCTTATAGACTCTTATGGTTATGAAAGTGGGT
CTATAAAGGAATATCAGGGTCTAGGGATATTCGACATTGAAGTTATATATGATAAAGACAAAATTATTTCTAGAAGCTGG
TCTGATATAAAAGTTAATGGTTATGAAATCAGAAGAGGAAAAATAAAATATTTGAACGAAAAGCCTATCTTAACAATTAC
TAAGCGTGGATATAAGGAAGTGAATGTTTATGATGGTGCTATAAAAGATGATAAATTAGGTTATAGTATTCATGGCTCTC
TATTTTCTGATGGAGGTAAAAAACTTCTATATGAATTATATGGTATAAAAGTTAATAGTAAAAGTCTTGAGGAGGAAATA
AAGGATCAATCTGAGAGATTAGCTAATATATTTAAACGTTATATTGATGTGGATTTACTTAATCAAATAAATGTATAG

Upstream 100 bases:

>100_bases
AAAACCTCTAATAATCTCCACAGTAGGTAATAGAAGGAGGAAGGCAAGATTGCCCAAAAACTTTGACGTTACAAATACTA
CAGAATAGTCAATTAAAGCC

Downstream 100 bases:

>100_bases
GTGAATTTATTAATTTATTTTTAGTCAGTTAAATCAATGAGTTTTGATCCACAAAAATTTGTTGATGAAATCTCTCCTCA
ATTAAAGGAAATTGTTGATG

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MITPIIIGEIKEALATSSKVAFVEGIIVKNEICEAIFLNIFILLCYNVAIIIASTMSDSGKSTVTTAIVKLLDLTPMKIQ
NMSLNSFPTMDNGEIAFIQAYQAFAKGIEPERYMNPILLKPAGKGIEVIYFGTPIGVYSAEEYYNKIEELWWKIKDYIRR
DVVIESAGGIEPNFIDKDLTLVRLVKEFNLPVILILDIDRGGAFTSAYGAYLTLPESVRRNLKGFIINKFRGDEKLLNPA
IKWLEEKTGMRYLGYLPYFDEPPIMQEDSMNIFEFGEGDIEVGILAYPYMSNFNEFYAFNKSNAHIKFIKKPSQLSKVDL
VIIPGSRNTFESLVWLTEKGFIEHIRKKPVLGICGGFQLMGKKLIDSYGYESGSIKEYQGLGIFDIEVIYDKDKIISRSW
SDIKVNGYEIRRGKIKYLNEKPILTITKRGYKEVNVYDGAIKDDKLGYSIHGSLFSDGGKKLLYELYGIKVNSKSLEEEI
KDQSERLANIFKRYIDVDLLNQINV

Sequences:

>Translated_505_residues
MITPIIIGEIKEALATSSKVAFVEGIIVKNEICEAIFLNIFILLCYNVAIIIASTMSDSGKSTVTTAIVKLLDLTPMKIQ
NMSLNSFPTMDNGEIAFIQAYQAFAKGIEPERYMNPILLKPAGKGIEVIYFGTPIGVYSAEEYYNKIEELWWKIKDYIRR
DVVIESAGGIEPNFIDKDLTLVRLVKEFNLPVILILDIDRGGAFTSAYGAYLTLPESVRRNLKGFIINKFRGDEKLLNPA
IKWLEEKTGMRYLGYLPYFDEPPIMQEDSMNIFEFGEGDIEVGILAYPYMSNFNEFYAFNKSNAHIKFIKKPSQLSKVDL
VIIPGSRNTFESLVWLTEKGFIEHIRKKPVLGICGGFQLMGKKLIDSYGYESGSIKEYQGLGIFDIEVIYDKDKIISRSW
SDIKVNGYEIRRGKIKYLNEKPILTITKRGYKEVNVYDGAIKDDKLGYSIHGSLFSDGGKKLLYELYGIKVNSKSLEEEI
KDQSERLANIFKRYIDVDLLNQINV
>Mature_505_residues
MITPIIIGEIKEALATSSKVAFVEGIIVKNEICEAIFLNIFILLCYNVAIIIASTMSDSGKSTVTTAIVKLLDLTPMKIQ
NMSLNSFPTMDNGEIAFIQAYQAFAKGIEPERYMNPILLKPAGKGIEVIYFGTPIGVYSAEEYYNKIEELWWKIKDYIRR
DVVIESAGGIEPNFIDKDLTLVRLVKEFNLPVILILDIDRGGAFTSAYGAYLTLPESVRRNLKGFIINKFRGDEKLLNPA
IKWLEEKTGMRYLGYLPYFDEPPIMQEDSMNIFEFGEGDIEVGILAYPYMSNFNEFYAFNKSNAHIKFIKKPSQLSKVDL
VIIPGSRNTFESLVWLTEKGFIEHIRKKPVLGICGGFQLMGKKLIDSYGYESGSIKEYQGLGIFDIEVIYDKDKIISRSW
SDIKVNGYEIRRGKIKYLNEKPILTITKRGYKEVNVYDGAIKDDKLGYSIHGSLFSDGGKKLLYELYGIKVNSKSLEEEI
KDQSERLANIFKRYIDVDLLNQINV

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 57395; Mature: 57395

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITPIIIGEIKEALATSSKVAFVEGIIVKNEICEAIFLNIFILLCYNVAIIIASTMSDSG
CCCCEEHHHHHHHHHCCCCEEEHHEEEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
KSTVTTAIVKLLDLTPMKIQNMSLNSFPTMDNGEIAFIQAYQAFAKGIEPERYMNPILLK
CHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEHHHHHHCCCCHHHHCCCEEEE
PAGKGIEVIYFGTPIGVYSAEEYYNKIEELWWKIKDYIRRDVVIESAGGIEPNFIDKDLT
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCHHH
LVRLVKEFNLPVILILDIDRGGAFTSAYGAYLTLPESVRRNLKGFIINKFRGDEKLLNPA
HHHHHHHCCCCEEEEEEECCCCCCHHCCCEEEECCHHHHCCCCEEEEEECCCCHHHHHHH
IKWLEEKTGMRYLGYLPYFDEPPIMQEDSMNIFEFGEGDIEVGILAYPYMSNFNEFYAFN
HHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCHHCCCHHEEEC
KSNAHIKFIKKPSQLSKVDLVIIPGSRNTFESLVWLTEKGFIEHIRKKPVLGICGGFQLM
CCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHH
GKKLIDSYGYESGSIKEYQGLGIFDIEVIYDKDKIISRSWSDIKVNGYEIRRGKIKYLNE
HHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCHHHCCCCCCEEECCEEEECCEEEEECC
KPILTITKRGYKEVNVYDGAIKDDKLGYSIHGSLFSDGGKKLLYELYGIKVNSKSLEEEI
CCEEEEECCCCEEEEEECCCCCCCCCCEEEECCHHCCCHHHHHHHHHCEEECHHHHHHHH
KDQSERLANIFKRYIDVDLLNQINV
HHHHHHHHHHHHHHHCHHHHHHCCC
>Mature Secondary Structure
MITPIIIGEIKEALATSSKVAFVEGIIVKNEICEAIFLNIFILLCYNVAIIIASTMSDSG
CCCCEEHHHHHHHHHCCCCEEEHHEEEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
KSTVTTAIVKLLDLTPMKIQNMSLNSFPTMDNGEIAFIQAYQAFAKGIEPERYMNPILLK
CHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEHHHHHHCCCCHHHHCCCEEEE
PAGKGIEVIYFGTPIGVYSAEEYYNKIEELWWKIKDYIRRDVVIESAGGIEPNFIDKDLT
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCHHH
LVRLVKEFNLPVILILDIDRGGAFTSAYGAYLTLPESVRRNLKGFIINKFRGDEKLLNPA
HHHHHHHCCCCEEEEEEECCCCCCHHCCCEEEECCHHHHCCCCEEEEEECCCCHHHHHHH
IKWLEEKTGMRYLGYLPYFDEPPIMQEDSMNIFEFGEGDIEVGILAYPYMSNFNEFYAFN
HHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCHHCCCHHEEEC
KSNAHIKFIKKPSQLSKVDLVIIPGSRNTFESLVWLTEKGFIEHIRKKPVLGICGGFQLM
CCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHH
GKKLIDSYGYESGSIKEYQGLGIFDIEVIYDKDKIISRSWSDIKVNGYEIRRGKIKYLNE
HHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCHHHCCCCCCEEECCEEEECCEEEEECC
KPILTITKRGYKEVNVYDGAIKDDKLGYSIHGSLFSDGGKKLLYELYGIKVNSKSLEEEI
CCEEEEECCCCEEEEEECCCCCCCCCCEEEECCHHCCCHHHHHHHHHCEEECHHHHHHHH
KDQSERLANIFKRYIDVDLLNQINV
HHHHHHHHHHHHHHHCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA