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The map label for this gene is adh [H]

Identifier: 15922584

GI number: 15922584

Start: 2260796

End: 2261794

Strand: Direct

Name: adh [H]

Synonym: ST2252

Alternate gene names: 15922584

Gene position: 2260796-2261794 (Clockwise)

Preceding gene: 15922583

Following gene: 15922587

Centisome position: 83.9

GC content: 33.53

Gene sequence:

>999_bases
ATGATTATGATGAAAGCCTTAATTTTTGAGAAATCGGGAATTGAAAACCTAAAAATATCTGATGTAAAAGAACCAACTTT
AGGTCCGCATGATGTTCTCGTAAAAGTAAAAATGGCTGGTGTTAATCCTATTGATTATTTTGTAGTTAATTTTATACCAG
TAACTCCTATGCCTCATATCCCTGGTGCAGAGATATACGGAGAAGTCGCTAAAGTAGGGGATCACGTAAAAAGTGTAAAT
ATCGGCGATAAAGTTGTTGTCTATAATAGAGTATTTGATGGAAAGTGTGATATGTGCTTACAAGGTATGGAACAGTTATG
TAGAAATGGTGGAATAATTAGTATAATAACTAATGGAGGTTTTTCTGAATATTTTTCTGTTTCAGAACATAATCTTGTAA
AAGTTGAAGGGATTAATGATGAGATAGCTGCAAGTTTACCAGTAGCCGCATTAACCGCTTATCATGCATTAAGCACTGTG
CAAGTATTTGGTAAAACTGTAGTGGTTTTTGGTGCTAGTGGAAATACAGGACAATTTGCAGTTCAGTTTGCTAAAATGAT
GGGAGGATATGTTATTGCAGTAAGTAACAAAAACTGGGTTAAGGAATTTGGTGCTGATGAAGTAGTTAGTTATGATAAAG
TGGAGGAAAAAGTGAAAGAACTGACTAATGGAAGAATGGCAGATATAGTTATAAATTCGGTAGGCTCATCCGTTTGGGAC
AAAAGCCTATCAGTTCTAGGGTTAAATGGAAAGCTCTTGTTCTTTGGAGGTATAACGGGTAGTAATGTAAGTTTAGATTT
AGGAGCAATTTATGGAAAACATGCTAGTCTAATAGGAACTACTGGAGGTAATAGAAAAGAGTTAGTAGAATTAGCCTCTA
TGGCTAAGAAATTGAAAGTAAAAGTATGGAAAGTAAGAAAACTGGAAGATGGAAAAGAAGCTTTACAAGATTTATTTAAT
AAAAATAGAGATGGAAGAATATTAATAAAAATTGAATAA

Upstream 100 bases:

>100_bases
TTTCTAATGGTATATCTACTTTCATTAAGATTGTTATTTATAAATCAAAGAAAATTAGCTTTACTTAAGTTAAGTTAGAT
TTATACTAATATATACATAA

Downstream 100 bases:

>100_bases
AAATAAATTTTTTGTTTTTATTCTTATTATTCCCAATAACCAATAGTAGAAGAGGTAGTAGTTGATGATGAAGTTGTTGT
TGATGTTGTTGTCGAAGTAG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MIMMKALIFEKSGIENLKISDVKEPTLGPHDVLVKVKMAGVNPIDYFVVNFIPVTPMPHIPGAEIYGEVAKVGDHVKSVN
IGDKVVVYNRVFDGKCDMCLQGMEQLCRNGGIISIITNGGFSEYFSVSEHNLVKVEGINDEIAASLPVAALTAYHALSTV
QVFGKTVVVFGASGNTGQFAVQFAKMMGGYVIAVSNKNWVKEFGADEVVSYDKVEEKVKELTNGRMADIVINSVGSSVWD
KSLSVLGLNGKLLFFGGITGSNVSLDLGAIYGKHASLIGTTGGNRKELVELASMAKKLKVKVWKVRKLEDGKEALQDLFN
KNRDGRILIKIE

Sequences:

>Translated_332_residues
MIMMKALIFEKSGIENLKISDVKEPTLGPHDVLVKVKMAGVNPIDYFVVNFIPVTPMPHIPGAEIYGEVAKVGDHVKSVN
IGDKVVVYNRVFDGKCDMCLQGMEQLCRNGGIISIITNGGFSEYFSVSEHNLVKVEGINDEIAASLPVAALTAYHALSTV
QVFGKTVVVFGASGNTGQFAVQFAKMMGGYVIAVSNKNWVKEFGADEVVSYDKVEEKVKELTNGRMADIVINSVGSSVWD
KSLSVLGLNGKLLFFGGITGSNVSLDLGAIYGKHASLIGTTGGNRKELVELASMAKKLKVKVWKVRKLEDGKEALQDLFN
KNRDGRILIKIE
>Mature_332_residues
MIMMKALIFEKSGIENLKISDVKEPTLGPHDVLVKVKMAGVNPIDYFVVNFIPVTPMPHIPGAEIYGEVAKVGDHVKSVN
IGDKVVVYNRVFDGKCDMCLQGMEQLCRNGGIISIITNGGFSEYFSVSEHNLVKVEGINDEIAASLPVAALTAYHALSTV
QVFGKTVVVFGASGNTGQFAVQFAKMMGGYVIAVSNKNWVKEFGADEVVSYDKVEEKVKELTNGRMADIVINSVGSSVWD
KSLSVLGLNGKLLFFGGITGSNVSLDLGAIYGKHASLIGTTGGNRKELVELASMAKKLKVKVWKVRKLEDGKEALQDLFN
KNRDGRILIKIE

Specific function: Threonine catabolism; first step. [C]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=292, Percent_Identity=26.7123287671233, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI13236495, Length=292, Percent_Identity=26.7123287671233, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI22538446, Length=275, Percent_Identity=26.5454545454545, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI22538444, Length=275, Percent_Identity=26.5454545454545, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI194239676, Length=223, Percent_Identity=27.8026905829596, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI47519420, Length=237, Percent_Identity=29.1139240506329, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1790045, Length=200, Percent_Identity=31.5, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786518, Length=297, Percent_Identity=26.5993265993266, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790485, Length=351, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788075, Length=350, Percent_Identity=27.7142857142857, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082401, Length=332, Percent_Identity=25.3012048192771, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI226510992, Length=284, Percent_Identity=23.2394366197183, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787863, Length=187, Percent_Identity=32.0855614973262, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788073, Length=328, Percent_Identity=25.3048780487805, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=331, Percent_Identity=28.0966767371601, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=27.8592375366569, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=338, Percent_Identity=25.1479289940828, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319520, Length=349, Percent_Identity=25.214899713467, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=339, Percent_Identity=26.8436578171091, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=351, Percent_Identity=26.7806267806268, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=341, Percent_Identity=25.2199413489736, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=343, Percent_Identity=26.8221574344023, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=300, Percent_Identity=24.6666666666667, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35974; Mature: 35974

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMMKALIFEKSGIENLKISDVKEPTLGPHDVLVKVKMAGVNPIDYFVVNFIPVTPMPHI
CEEEEEEHHHCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCHHHEEEEEEEECCCCCCC
PGAEIYGEVAKVGDHVKSVNIGDKVVVYNRVFDGKCDMCLQGMEQLCRNGGIISIITNGG
CCHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCC
FSEYFSVSEHNLVKVEGINDEIAASLPVAALTAYHALSTVQVFGKTVVVFGASGNTGQFA
CHHHEECCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
VQFAKMMGGYVIAVSNKNWVKEFGADEVVSYDKVEEKVKELTNGRMADIVINSVGSSVWD
HHHHHHHCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCHHHH
KSLSVLGLNGKLLFFGGITGSNVSLDLGAIYGKHASLIGTTGGNRKELVELASMAKKLKV
CCCEEEECCCCEEEEECCCCCCCEEEEHHEECCCEEEEECCCCCHHHHHHHHHHHHHHHE
KVWKVRKLEDGKEALQDLFNKNRDGRILIKIE
EEEEEECCCCHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MIMMKALIFEKSGIENLKISDVKEPTLGPHDVLVKVKMAGVNPIDYFVVNFIPVTPMPHI
CEEEEEEHHHCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCHHHEEEEEEEECCCCCCC
PGAEIYGEVAKVGDHVKSVNIGDKVVVYNRVFDGKCDMCLQGMEQLCRNGGIISIITNGG
CCHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCC
FSEYFSVSEHNLVKVEGINDEIAASLPVAALTAYHALSTVQVFGKTVVVFGASGNTGQFA
CHHHEECCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
VQFAKMMGGYVIAVSNKNWVKEFGADEVVSYDKVEEKVKELTNGRMADIVINSVGSSVWD
HHHHHHHCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCHHHH
KSLSVLGLNGKLLFFGGITGSNVSLDLGAIYGKHASLIGTTGGNRKELVELASMAKKLKV
CCCEEEECCCCEEEEECCCCCCCEEEEHHEECCCEEEEECCCCCHHHHHHHHHHHHHHHE
KVWKVRKLEDGKEALQDLFNKNRDGRILIKIE
EEEEEECCCCHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA