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The map label for this gene is mre11

Identifier: 15922433

GI number: 15922433

Start: 2115205

End: 2116368

Strand: Direct

Name: mre11

Synonym: ST2107

Alternate gene names: 15922433

Gene position: 2115205-2116368 (Clockwise)

Preceding gene: 15922432

Following gene: 15922434

Centisome position: 78.49

GC content: 30.24

Gene sequence:

>1164_bases
GTGAGTAAGACGCAAATTTTACATATTTCTGATACGCATTTAGGTAAGAGACAGTATAATCTTGATTTTAGGGAACAGGA
TGTATATGATACTTTTTCACAACTTATTGATATAGCTATTAAAGAGCATGTAGATGGTATAATACATACCGGTGATTTAT
TCGATATAAATGATCCACCAAATAAGGCAGAAATAGTAGCTATAAGAGAACTTAAAAGGTTAAAAGAAGCTGGAATTCCA
TTTATAGTTATTGCAGGAGATCATGATAGTCCAAAAAAGTTTACAGCTATCTATCCTCAGAAAATATTAGAAGAATTTGA
TTTAATTAAATTCTTGTCTAAACCAGATACACCGTATAAATTAGGTGAAATTACTATTTATGGTATTTCACATGTTCCAA
ATGTTGCCAAAGAGAGACTAAAAGAATTACTTTCTAGATTAAAACCGGAAAATAAGAAAAGTATACTGCTCTTACATCAA
GGTTTAAAGGAGGTATTACCCTATGAGGGAGCATGGCAGATACAAATAGACGATTTACCTAAAGCTTTTTCCTATTATGC
TTTAGGTCACTTTCATACAAGAAGGGTATTTCAGCTTGATGGTGGAAGAATTATTGAGATAGCTGGCTCACCAGATATAT
TGAGGGAAGAAGAAATAGAAGGATATGAGAAAGAGGGAAAGGGTGCAACGCTCATAGATTTCTCTGGTGATATACCTACA
ATCCAGAAAATTAACATAGATGTTCGAAAGCAATATGTAGTAACTTTAAACACTAATAATCTAAGGGAAGAGATAAGAAA
GTTAAGAGAGAAATATGATACAAATAATGAGAAAAAACCTATATTTCATATTATACTTGAAGGAAAGTCTATTCCTAAAA
ATGTCTTAATGAAAGAGCTACAAGAAATTAATAACTTTGCTCCTTATTGGAGGATATATAAAGATAATACAAAAGAGAAA
GACGAAAAAGATGTTAAGATTGATTTACCAACAGATACTACAATAGAAAATTTAATATATAATTATCTAGTTAAAATTGC
TAATTTTTCAGAGACTGAAGCCAGAATGATAGTTGATATAATTAACCGAGCTGATGAAAGAGAATATGTTAAGGAAGAAT
TAATGAAAATGATTGGTGTTGAAAATGATAATAAGAAGAATTGA

Upstream 100 bases:

>100_bases
AAGTTTGAGGGAAAACTAGCTGGAAGCGATCCAAACCTAATAGAAGAATGGAAGAAAGCTAAAGAAGAAATTGAGGAGCA
TGCAGATGTATTGAATTGGG

Downstream 100 bases:

>100_bases
CATTGAAAATTTTTTAAGTCATGATAGGTCATTAATAGAATTTAAGGGAACTGTTAACGTTATAATAGGACATAACGGTG
CAGGCAAAAGCTCGATAATC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSKTQILHISDTHLGKRQYNLDFREQDVYDTFSQLIDIAIKEHVDGIIHTGDLFDINDPPNKAEIVAIRELKRLKEAGIP
FIVIAGDHDSPKKFTAIYPQKILEEFDLIKFLSKPDTPYKLGEITIYGISHVPNVAKERLKELLSRLKPENKKSILLLHQ
GLKEVLPYEGAWQIQIDDLPKAFSYYALGHFHTRRVFQLDGGRIIEIAGSPDILREEEIEGYEKEGKGATLIDFSGDIPT
IQKINIDVRKQYVVTLNTNNLREEIRKLREKYDTNNEKKPIFHIILEGKSIPKNVLMKELQEINNFAPYWRIYKDNTKEK
DEKDVKIDLPTDTTIENLIYNYLVKIANFSETEARMIVDIINRADEREYVKEELMKMIGVENDNKKN

Sequences:

>Translated_387_residues
MSKTQILHISDTHLGKRQYNLDFREQDVYDTFSQLIDIAIKEHVDGIIHTGDLFDINDPPNKAEIVAIRELKRLKEAGIP
FIVIAGDHDSPKKFTAIYPQKILEEFDLIKFLSKPDTPYKLGEITIYGISHVPNVAKERLKELLSRLKPENKKSILLLHQ
GLKEVLPYEGAWQIQIDDLPKAFSYYALGHFHTRRVFQLDGGRIIEIAGSPDILREEEIEGYEKEGKGATLIDFSGDIPT
IQKINIDVRKQYVVTLNTNNLREEIRKLREKYDTNNEKKPIFHIILEGKSIPKNVLMKELQEINNFAPYWRIYKDNTKEK
DEKDVKIDLPTDTTIENLIYNYLVKIANFSETEARMIVDIINRADEREYVKEELMKMIGVENDNKKN
>Mature_386_residues
SKTQILHISDTHLGKRQYNLDFREQDVYDTFSQLIDIAIKEHVDGIIHTGDLFDINDPPNKAEIVAIRELKRLKEAGIPF
IVIAGDHDSPKKFTAIYPQKILEEFDLIKFLSKPDTPYKLGEITIYGISHVPNVAKERLKELLSRLKPENKKSILLLHQG
LKEVLPYEGAWQIQIDDLPKAFSYYALGHFHTRRVFQLDGGRIIEIAGSPDILREEEIEGYEKEGKGATLIDFSGDIPTI
QKINIDVRKQYVVTLNTNNLREEIRKLREKYDTNNEKKPIFHIILEGKSIPKNVLMKELQEINNFAPYWRIYKDNTKEKD
EKDVKIDLPTDTTIENLIYNYLVKIANFSETEARMIVDIINRADEREYVKEELMKMIGVENDNKKN

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRE11_SULTO (Q96YR6)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_378102.1
- ProteinModelPortal:   Q96YR6
- GeneID:   1460179
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST2107
- NMPDR:   fig|273063.1.peg.2270
- HOGENOM:   HBG553822
- OMA:   ERENDFY
- ProtClustDB:   CLSK803276
- BioCyc:   STOK273063:ST2107-MONOMER
- InterPro:   IPR004843

Pfam domain/function: PF00149 Metallophos

EC number: NA

Molecular weight: Translated: 44979; Mature: 44848

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: ACT_SITE 88-88

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTQILHISDTHLGKRQYNLDFREQDVYDTFSQLIDIAIKEHVDGIIHTGDLFDINDPP
CCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCEEECCCCC
NKAEIVAIRELKRLKEAGIPFIVIAGDHDSPKKFTAIYPQKILEEFDLIKFLSKPDTPYK
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCEE
LGEITIYGISHVPNVAKERLKELLSRLKPENKKSILLLHQGLKEVLPYEGAWQIQIDDLP
ECCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCC
KAFSYYALGHFHTRRVFQLDGGRIIEIAGSPDILREEEIEGYEKEGKGATLIDFSGDIPT
CHHHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCHHHHCCHHHCCCCCEEEEECCCCCC
IQKINIDVRKQYVVTLNTNNLREEIRKLREKYDTNNEKKPIFHIILEGKSIPKNVLMKEL
EEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHH
QEINNFAPYWRIYKDNTKEKDEKDVKIDLPTDTTIENLIYNYLVKIANFSETEARMIVDI
HHHHCCCCEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
INRADEREYVKEELMKMIGVENDNKKN
HHCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SKTQILHISDTHLGKRQYNLDFREQDVYDTFSQLIDIAIKEHVDGIIHTGDLFDINDPP
CCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCEEECCCCC
NKAEIVAIRELKRLKEAGIPFIVIAGDHDSPKKFTAIYPQKILEEFDLIKFLSKPDTPYK
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCEE
LGEITIYGISHVPNVAKERLKELLSRLKPENKKSILLLHQGLKEVLPYEGAWQIQIDDLP
ECCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCC
KAFSYYALGHFHTRRVFQLDGGRIIEIAGSPDILREEEIEGYEKEGKGATLIDFSGDIPT
CHHHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCHHHHCCHHHCCCCCEEEEECCCCCC
IQKINIDVRKQYVVTLNTNNLREEIRKLREKYDTNNEKKPIFHIILEGKSIPKNVLMKEL
EEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHH
QEINNFAPYWRIYKDNTKEKDEKDVKIDLPTDTTIENLIYNYLVKIANFSETEARMIVDI
HHHHCCCCEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
INRADEREYVKEELMKMIGVENDNKKN
HHCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479