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The map label for this gene is hbd [H]

Identifier: 15922419

GI number: 15922419

Start: 2101863

End: 2103035

Strand: Direct

Name: hbd [H]

Synonym: ST2094

Alternate gene names: 15922419

Gene position: 2101863-2103035 (Clockwise)

Preceding gene: 15922416

Following gene: 15922420

Centisome position: 78.0

GC content: 32.82

Gene sequence:

>1173_bases
ATGATAAAAAAGATTGTAGTTGTAGGAGCCGGAACTATGGGACATGGTATAGCAGAAGTTGCAGCACTCAGCGGTTTTAA
AGTAGGTTTAATAGATATATCATGGGATTTTCTTAATAGAGCTAAAGATAGAATAACAGAATCAGTAACGAGATTATATG
AAAAAGGACAAATTAAAGAAAAAGTAGAAGATATACTAGGAAGAATGGAGTTTAATACTTCTTATGATATTGCAAAAGAC
GCAGATTTTGCAATTGAAGCAGTACCAGAAAATTTAGAATTAAAGAAAAACGTATTTAAATCATTAGATGATATCACACC
TTCTCATACTATATTAGCTACGAATACTTCTTCTATACCAATATCAGACATTGCTGAGGCAACTAAAAGGAAAGATAAAG
TAATAGGAATGCACTTCTTCAACCCTCCAGTTATAATGAAACTAGTTGAAGTCATACCAAGTAAATATACATCTGACGAA
GTAACTAATCTTACTATAGAACTAGCAAAAAAGATGAATAAAATACCAGTTAAGCTAAAGTATGAAATACCAGGGTTTGT
AAGCAATAGAATATTCATTAGACTCCTCCAAGAAGCATGTAGAGAGGTAGAAAATGGAGAAGGAAGTATTGAGGAGATAG
ATAGTGCGGCAAGGAATAAATTAAAATTACCTATGGGATTGTTTGAATTAGCTGACTACGTAGGTTTAGATGTAATAGTA
GACATTTGGGACGTCTTAGTTACTAGAGGAACCCCAGACGTAAAATGTAGTTTATATAAGAATAAAGTATTAGAAAAAAG
TTTAGGAGTAAAAAGCGGTAAAGGATTTTACACTTATCCAGCACCAGGTAAGTATATGAAAGTGCAATTACCTAACGAAA
GCAAGGTAGACCCTGCAAAACTAATTTCCTTAGCAGTTAATGAAGCTAGCTGGATGATAGAAAATGAAATAGTTAGTGCC
AAGGATATAGATACTGTAATGATCTATGGATTCAATTTCCCTAAAGGACTTCTTGAAATGGCTGACGAACTTGGGTTAGA
TAACGTGTACACATATCTAAAAGATATTTATGCTAAAGGATATGATACGTATAGACCAACAAATCTTTTAGAAAAAATGA
TCAAAGAAGGTAAACTAGGAAAGAAGTCTGGAGAAGGGTTCTACAAGTATTAA

Upstream 100 bases:

>100_bases
TATTTATATCTTACAAAACTAGTTTAAAAACATTTACTACTATTTAATTACTAGCAAACAAACCGTGATATTTAATAATC
AATAGGTTATTTTACTCTTG

Downstream 100 bases:

>100_bases
TATTTTTTAAACTGTTTATACAATTTAAGCATATGTCTAGTGTTTTAGCTGAATATGAGGCAATCCATAAAGAATTGAGA
GAACAAGGTTTTATTAGACC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MIKKIVVVGAGTMGHGIAEVAALSGFKVGLIDISWDFLNRAKDRITESVTRLYEKGQIKEKVEDILGRMEFNTSYDIAKD
ADFAIEAVPENLELKKNVFKSLDDITPSHTILATNTSSIPISDIAEATKRKDKVIGMHFFNPPVIMKLVEVIPSKYTSDE
VTNLTIELAKKMNKIPVKLKYEIPGFVSNRIFIRLLQEACREVENGEGSIEEIDSAARNKLKLPMGLFELADYVGLDVIV
DIWDVLVTRGTPDVKCSLYKNKVLEKSLGVKSGKGFYTYPAPGKYMKVQLPNESKVDPAKLISLAVNEASWMIENEIVSA
KDIDTVMIYGFNFPKGLLEMADELGLDNVYTYLKDIYAKGYDTYRPTNLLEKMIKEGKLGKKSGEGFYKY

Sequences:

>Translated_390_residues
MIKKIVVVGAGTMGHGIAEVAALSGFKVGLIDISWDFLNRAKDRITESVTRLYEKGQIKEKVEDILGRMEFNTSYDIAKD
ADFAIEAVPENLELKKNVFKSLDDITPSHTILATNTSSIPISDIAEATKRKDKVIGMHFFNPPVIMKLVEVIPSKYTSDE
VTNLTIELAKKMNKIPVKLKYEIPGFVSNRIFIRLLQEACREVENGEGSIEEIDSAARNKLKLPMGLFELADYVGLDVIV
DIWDVLVTRGTPDVKCSLYKNKVLEKSLGVKSGKGFYTYPAPGKYMKVQLPNESKVDPAKLISLAVNEASWMIENEIVSA
KDIDTVMIYGFNFPKGLLEMADELGLDNVYTYLKDIYAKGYDTYRPTNLLEKMIKEGKLGKKSGEGFYKY
>Mature_390_residues
MIKKIVVVGAGTMGHGIAEVAALSGFKVGLIDISWDFLNRAKDRITESVTRLYEKGQIKEKVEDILGRMEFNTSYDIAKD
ADFAIEAVPENLELKKNVFKSLDDITPSHTILATNTSSIPISDIAEATKRKDKVIGMHFFNPPVIMKLVEVIPSKYTSDE
VTNLTIELAKKMNKIPVKLKYEIPGFVSNRIFIRLLQEACREVENGEGSIEEIDSAARNKLKLPMGLFELADYVGLDVIV
DIWDVLVTRGTPDVKCSLYKNKVLEKSLGVKSGKGFYTYPAPGKYMKVQLPNESKVDPAKLISLAVNEASWMIENEIVSA
KDIDTVMIYGFNFPKGLLEMADELGLDNVYTYLKDIYAKGYDTYRPTNLLEKMIKEGKLGKKSGEGFYKY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=41.0344827586207, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=38.7622149837134, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI20127408, Length=397, Percent_Identity=30.2267002518892, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI261878539, Length=424, Percent_Identity=28.5377358490566, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI68989263, Length=424, Percent_Identity=28.5377358490566, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI115430219, Length=213, Percent_Identity=32.8638497652582, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1787661, Length=287, Percent_Identity=38.3275261324042, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788682, Length=399, Percent_Identity=31.328320802005, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1790281, Length=369, Percent_Identity=27.10027100271, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=40.4844290657439, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=36.1111111111111, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=36.1111111111111, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=412, Percent_Identity=32.2815533980583, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=412, Percent_Identity=32.2815533980583, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17558304, Length=403, Percent_Identity=31.7617866004963, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25144276, Length=290, Percent_Identity=34.8275862068965, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71985923, Length=359, Percent_Identity=28.4122562674095, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71985930, Length=380, Percent_Identity=24.4736842105263, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115533614, Length=189, Percent_Identity=30.6878306878307, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193203623, Length=189, Percent_Identity=30.6878306878307, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19921000, Length=402, Percent_Identity=29.1044776119403, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24583077, Length=402, Percent_Identity=29.1044776119403, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24583079, Length=402, Percent_Identity=29.1044776119403, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI20129993, Length=234, Percent_Identity=29.9145299145299, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45549573, Length=225, Percent_Identity=32.4444444444444, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 43669; Mature: 43669

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKIVVVGAGTMGHGIAEVAALSGFKVGLIDISWDFLNRAKDRITESVTRLYEKGQIKE
CCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHH
KVEDILGRMEFNTSYDIAKDADFAIEAVPENLELKKNVFKSLDDITPSHTILATNTSSIP
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
ISDIAEATKRKDKVIGMHFFNPPVIMKLVEVIPSKYTSDEVTNLTIELAKKMNKIPVKLK
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEE
YEIPGFVSNRIFIRLLQEACREVENGEGSIEEIDSAARNKLKLPMGLFELADYVGLDVIV
EECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DIWDVLVTRGTPDVKCSLYKNKVLEKSLGVKSGKGFYTYPAPGKYMKVQLPNESKVDPAK
HHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECCCCCCCCHHH
LISLAVNEASWMIENEIVSAKDIDTVMIYGFNFPKGLLEMADELGLDNVYTYLKDIYAKG
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCC
YDTYRPTNLLEKMIKEGKLGKKSGEGFYKY
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKKIVVVGAGTMGHGIAEVAALSGFKVGLIDISWDFLNRAKDRITESVTRLYEKGQIKE
CCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHH
KVEDILGRMEFNTSYDIAKDADFAIEAVPENLELKKNVFKSLDDITPSHTILATNTSSIP
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
ISDIAEATKRKDKVIGMHFFNPPVIMKLVEVIPSKYTSDEVTNLTIELAKKMNKIPVKLK
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEE
YEIPGFVSNRIFIRLLQEACREVENGEGSIEEIDSAARNKLKLPMGLFELADYVGLDVIV
EECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DIWDVLVTRGTPDVKCSLYKNKVLEKSLGVKSGKGFYTYPAPGKYMKVQLPNESKVDPAK
HHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECCCCCCCCHHH
LISLAVNEASWMIENEIVSAKDIDTVMIYGFNFPKGLLEMADELGLDNVYTYLKDIYAKG
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCC
YDTYRPTNLLEKMIKEGKLGKKSGEGFYKY
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]