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The map label for this gene is hbd [H]

Identifier: 15921801

GI number: 15921801

Start: 1505561

End: 1506517

Strand: Direct

Name: hbd [H]

Synonym: ST1507

Alternate gene names: 15921801

Gene position: 1505561-1506517 (Clockwise)

Preceding gene: 15921799

Following gene: 15921804

Centisome position: 55.87

GC content: 33.33

Gene sequence:

>957_bases
ATGAGACAAATAAAGACAGTATCCGTAATTGGTGCTGGAGTAATTGGTGCTGGTTGGAGTACTCTATTAGCTCTAAAAGG
ATATGAAAATTGGTTTTATACAGAAAAGAAAGAGACATTAGATAAAGGGCTAGCGAAAATTAAAGGATATCTCAATGTTT
TATATGAGTATAAGCTTATCGATAAGGAGCCAGATTACTATATGCAGAGAATCCATCCTACTACTAAGCTTGATGAGGCT
ATCAGTAATACAGATTTTGTATTGGAGGCTATAGTTGAAGAGTATGGAGCTAAAAAAGCGTTATTTAAACAACTTGATGA
AAAGCTTGACAAAGATGTAATATTAGCAAGTAGTACTTCTGGGTTATTAATGACAGAAATACAAAAAGCAATGACTAAAT
ATCCAGAAAGAGGAATTATTGCACATCCATGGAATCCACCACATCTTTTACCCTTAGTGGAAATTGTTCCTGGTGAAAAG
ACATCTCAAGATACAATTTATGCTACTAAAGATTTTATGGAAAACAAACTTGAAAGAGTTGTAGTAGTTTTAAAGAAAGA
AATATCGGGATTTATTGGAAATAGGTTAGCTTTTGCATTATTTAGAGAAGCAGTATATTTAGTTGATGAAGGTATTGCAA
CAGTTGAGGATATAGATAAAGTTATGACTGCTGCTATTGGCTTAAGATGGGCATTCATGGGTCCATTCCTAACCTATCAT
TTAGGAGGAGGAGAAGGAGGATTAGAGTATTTCTTCAGTAGAGGGTTTGGATACGGAGCTAATGAATGGATGCATACATT
AGCTAAGTACGATAAATTCCCATATACCGGTGTTGTAAAATCCGTGCAACAAATGAAAGAATACGAATTTGTAAAGAGCA
AAACATTTCAAGAACTATCTAGATGGAGAGACGAAAAATTAATATCTTTAATAAAATTATTAAGAGGAAAGATTTAA

Upstream 100 bases:

>100_bases
AGGATAGAATTCGAGTTAAATAATTAAAACTATTCATTGATATAGAGATTCTCATTAGCTGAAAGAAAACTACTTATACT
ACTTATACTTTTTAAATCTT

Downstream 100 bases:

>100_bases
TATTTTATTCCTCTTCTTCTTCTTTAAATTCTAAGATTCCTAAATTTTCTAATAATCCAGAATCTGTAACGTCAAATAGT
ATTGCCTCTTCTGTTTCTGA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRQIKTVSVIGAGVIGAGWSTLLALKGYENWFYTEKKETLDKGLAKIKGYLNVLYEYKLIDKEPDYYMQRIHPTTKLDEA
ISNTDFVLEAIVEEYGAKKALFKQLDEKLDKDVILASSTSGLLMTEIQKAMTKYPERGIIAHPWNPPHLLPLVEIVPGEK
TSQDTIYATKDFMENKLERVVVVLKKEISGFIGNRLAFALFREAVYLVDEGIATVEDIDKVMTAAIGLRWAFMGPFLTYH
LGGGEGGLEYFFSRGFGYGANEWMHTLAKYDKFPYTGVVKSVQQMKEYEFVKSKTFQELSRWRDEKLISLIKLLRGKI

Sequences:

>Translated_318_residues
MRQIKTVSVIGAGVIGAGWSTLLALKGYENWFYTEKKETLDKGLAKIKGYLNVLYEYKLIDKEPDYYMQRIHPTTKLDEA
ISNTDFVLEAIVEEYGAKKALFKQLDEKLDKDVILASSTSGLLMTEIQKAMTKYPERGIIAHPWNPPHLLPLVEIVPGEK
TSQDTIYATKDFMENKLERVVVVLKKEISGFIGNRLAFALFREAVYLVDEGIATVEDIDKVMTAAIGLRWAFMGPFLTYH
LGGGEGGLEYFFSRGFGYGANEWMHTLAKYDKFPYTGVVKSVQQMKEYEFVKSKTFQELSRWRDEKLISLIKLLRGKI
>Mature_318_residues
MRQIKTVSVIGAGVIGAGWSTLLALKGYENWFYTEKKETLDKGLAKIKGYLNVLYEYKLIDKEPDYYMQRIHPTTKLDEA
ISNTDFVLEAIVEEYGAKKALFKQLDEKLDKDVILASSTSGLLMTEIQKAMTKYPERGIIAHPWNPPHLLPLVEIVPGEK
TSQDTIYATKDFMENKLERVVVVLKKEISGFIGNRLAFALFREAVYLVDEGIATVEDIDKVMTAAIGLRWAFMGPFLTYH
LGGGEGGLEYFFSRGFGYGANEWMHTLAKYDKFPYTGVVKSVQQMKEYEFVKSKTFQELSRWRDEKLISLIKLLRGKI

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=321, Percent_Identity=32.0872274143302, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI296179429, Length=239, Percent_Identity=33.4728033472803, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI296179427, Length=256, Percent_Identity=31.25, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI261878539, Length=250, Percent_Identity=28.4, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI68989263, Length=250, Percent_Identity=28.4, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI20127408, Length=213, Percent_Identity=29.1079812206573, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1787661, Length=237, Percent_Identity=31.2236286919831, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790281, Length=166, Percent_Identity=37.9518072289157, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788682, Length=141, Percent_Identity=30.4964539007092, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=249, Percent_Identity=33.7349397590361, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=249, Percent_Identity=34.136546184739, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17553560, Length=241, Percent_Identity=29.4605809128631, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25144276, Length=263, Percent_Identity=29.277566539924, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17508953, Length=263, Percent_Identity=29.277566539924, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17508951, Length=263, Percent_Identity=29.277566539924, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17549919, Length=242, Percent_Identity=27.6859504132231, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71985923, Length=246, Percent_Identity=26.8292682926829, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71985930, Length=245, Percent_Identity=25.7142857142857, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=221, Percent_Identity=28.0542986425339, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17563036, Length=227, Percent_Identity=25.1101321585903, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI20129993, Length=315, Percent_Identity=33.015873015873, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45549573, Length=316, Percent_Identity=34.1772151898734, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI19921000, Length=220, Percent_Identity=28.6363636363636, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24583077, Length=220, Percent_Identity=28.6363636363636, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24583079, Length=220, Percent_Identity=28.6363636363636, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 36259; Mature: 36259

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQIKTVSVIGAGVIGAGWSTLLALKGYENWFYTEKKETLDKGLAKIKGYLNVLYEYKLI
CCCCEEEHHHHCCHHHCCHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DKEPDYYMQRIHPTTKLDEAISNTDFVLEAIVEEYGAKKALFKQLDEKLDKDVILASSTS
CCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCC
GLLMTEIQKAMTKYPERGIIAHPWNPPHLLPLVEIVPGEKTSQDTIYATKDFMENKLERV
CHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VVVLKKEISGFIGNRLAFALFREAVYLVDEGIATVEDIDKVMTAAIGLRWAFMGPFLTYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LGGGEGGLEYFFSRGFGYGANEWMHTLAKYDKFPYTGVVKSVQQMKEYEFVKSKTFQELS
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RWRDEKLISLIKLLRGKI
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRQIKTVSVIGAGVIGAGWSTLLALKGYENWFYTEKKETLDKGLAKIKGYLNVLYEYKLI
CCCCEEEHHHHCCHHHCCHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DKEPDYYMQRIHPTTKLDEAISNTDFVLEAIVEEYGAKKALFKQLDEKLDKDVILASSTS
CCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCC
GLLMTEIQKAMTKYPERGIIAHPWNPPHLLPLVEIVPGEKTSQDTIYATKDFMENKLERV
CHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VVVLKKEISGFIGNRLAFALFREAVYLVDEGIATVEDIDKVMTAAIGLRWAFMGPFLTYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LGGGEGGLEYFFSRGFGYGANEWMHTLAKYDKFPYTGVVKSVQQMKEYEFVKSKTFQELS
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RWRDEKLISLIKLLRGKI
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA