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The map label for this gene is lysX [H]

Identifier: 15921799

GI number: 15921799

Start: 1504037

End: 1504885

Strand: Direct

Name: lysX [H]

Synonym: ST1505

Alternate gene names: 15921799

Gene position: 1504037-1504885 (Clockwise)

Preceding gene: 15921798

Following gene: 15921801

Centisome position: 55.81

GC content: 33.69

Gene sequence:

>849_bases
ATGAGAGTGGTCTTGATAGTTGATATTGTAAGACAAGAAGAGAAATTAATAGCGAAAGCACTAGAGGAAAATAAGGTTCA
ATATGATATAATAAATGTTGCACAAGAACCTCTACCATTTAATAAAGCACTTGGTAGATACGATGTAGCGATAATAAGAC
CAGTTAGCATGTATAGAGCATTATATTCTTCAGCTGTGCTTGAAGCTGCTGGAGTTCATACCATAAACTCAAGTGATGTA
ATAAATGTGTGTGGAGATAAGATTTTAACGTACTCTAAATTGTATAGGGAGGGAATTCCAATTCCAGATTCAATAATTGC
TCTTTCTGCAGAAGCAGCATTAAAAGCTTATGAGCAAAGGGGATTTCCATTAATAGATAAACCACCAATAGGAAGCTGGG
GTAGGTTAGTCTCATTAATTAGGGATGTATTTGAAGGTAAAACAATAATTGAACACAGAGAGCTAATGGGTAATTCTGCT
TTAAAAGCTCATATAGTTCAAGAATACATTCAGTATAAAGGTAGAGATATAAGATGTATAGCAATAGGAGAAGAGCTATT
AGGTTGTTATGCTAGAAATATTCCACCAAATGAATGGAGGGCTAATGTAGCTTTAGGTGGAACTCCTTCAAACATTGAAG
TTGATGAGAAATTAAAGGAAACTGTAGTAAAAGCTGTAAGCATTGTTCACGGAGAATTTGTTTCGATAGATATACTAGAG
CATCCAAATAAAGGTTATGTAGTTAACGAATTAAATGATGTACCAGAGTTCAAGGGTTTCATGGTAGCAACTAATATAAA
TGTTGCACAAAAGCTAGTTGAATATATAAAAGAAAACTACTCTAAATGA

Upstream 100 bases:

>100_bases
TACCCATAATATTAAATGGGAGATTAGGAGCTGAAGTTACAAGAGCTTTTTCTCATCCAAATGTTACATATTACGAAATA
AGTGAATATGGTGCAGGAAT

Downstream 100 bases:

>100_bases
GCTAAGAATAAATCATGATTTGTTTCTTCTAAAAGTCTTCTGAGATTGTCAATTTTTTGTCTTAACCCTGGAACTACAGC
CTTTGGGTACTCTAAAGTCC

Product: ribosomal protein S6 modification protein

Products: NA

Alternate protein names: AAA--lysW ligase lysX [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MRVVLIVDIVRQEEKLIAKALEENKVQYDIINVAQEPLPFNKALGRYDVAIIRPVSMYRALYSSAVLEAAGVHTINSSDV
INVCGDKILTYSKLYREGIPIPDSIIALSAEAALKAYEQRGFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHRELMGNSA
LKAHIVQEYIQYKGRDIRCIAIGEELLGCYARNIPPNEWRANVALGGTPSNIEVDEKLKETVVKAVSIVHGEFVSIDILE
HPNKGYVVNELNDVPEFKGFMVATNINVAQKLVEYIKENYSK

Sequences:

>Translated_282_residues
MRVVLIVDIVRQEEKLIAKALEENKVQYDIINVAQEPLPFNKALGRYDVAIIRPVSMYRALYSSAVLEAAGVHTINSSDV
INVCGDKILTYSKLYREGIPIPDSIIALSAEAALKAYEQRGFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHRELMGNSA
LKAHIVQEYIQYKGRDIRCIAIGEELLGCYARNIPPNEWRANVALGGTPSNIEVDEKLKETVVKAVSIVHGEFVSIDILE
HPNKGYVVNELNDVPEFKGFMVATNINVAQKLVEYIKENYSK
>Mature_282_residues
MRVVLIVDIVRQEEKLIAKALEENKVQYDIINVAQEPLPFNKALGRYDVAIIRPVSMYRALYSSAVLEAAGVHTINSSDV
INVCGDKILTYSKLYREGIPIPDSIIALSAEAALKAYEQRGFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHRELMGNSA
LKAHIVQEYIQYKGRDIRCIAIGEELLGCYARNIPPNEWRANVALGGTPSNIEVDEKLKETVVKAVSIVHGEFVSIDILE
HPNKGYVVNELNDVPEFKGFMVATNINVAQKLVEYIKENYSK

Specific function: Catalyzes the ATP-dependent binding between the amino group of alpha-aminoadipate (AAA) and the gamma-carboxyl group of the C-terminal glutamate residue of lysW [H]

COG id: COG0189

COG function: function code HJ; Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI164663810, Length=213, Percent_Identity=26.2910798122066, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787076, Length=261, Percent_Identity=28.735632183908, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013651
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011870
- InterPro:   IPR016185
- InterPro:   IPR004666 [H]

Pfam domain/function: PF08443 RimK [H]

EC number: NA

Molecular weight: Translated: 31535; Mature: 31535

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVLIVDIVRQEEKLIAKALEENKVQYDIINVAQEPLPFNKALGRYDVAIIRPVSMYRA
CEEEEEEHHHHHHHHHHHHHHHHCCCEEHHHHHHCCCCCHHHHCCCCCHHEECHHHHHHH
LYSSAVLEAAGVHTINSSDVINVCGDKILTYSKLYREGIPIPDSIIALSAEAALKAYEQR
HHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
GFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHRELMGNSALKAHIVQEYIQYKGRDIRCI
CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEE
AIGEELLGCYARNIPPNEWRANVALGGTPSNIEVDEKLKETVVKAVSIVHGEFVSIDILE
EECHHHHHHHHCCCCCCCCEECEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEE
HPNKGYVVNELNDVPEFKGFMVATNINVAQKLVEYIKENYSK
CCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVVLIVDIVRQEEKLIAKALEENKVQYDIINVAQEPLPFNKALGRYDVAIIRPVSMYRA
CEEEEEEHHHHHHHHHHHHHHHHCCCEEHHHHHHCCCCCHHHHCCCCCHHEECHHHHHHH
LYSSAVLEAAGVHTINSSDVINVCGDKILTYSKLYREGIPIPDSIIALSAEAALKAYEQR
HHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
GFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHRELMGNSALKAHIVQEYIQYKGRDIRCI
CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEE
AIGEELLGCYARNIPPNEWRANVALGGTPSNIEVDEKLKETVVKAVSIVHGEFVSIDILE
EECHHHHHHHHCCCCCCCCEECEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEE
HPNKGYVVNELNDVPEFKGFMVATNINVAQKLVEYIKENYSK
CCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Glu; Ribosomal protein S6 [C]

Specific reaction: Catalyzes the addition of glutamic acids to the carboxyl end of ribosomal protein S6 [C]

General reaction: Ligases; Forming Carbon-Nitrogen Bonds; Acid-D-Amino-Acid Ligases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]