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The map label for this gene is pyrD [H]

Identifier: 15921769

GI number: 15921769

Start: 1475654

End: 1476439

Strand: Reverse

Name: pyrD [H]

Synonym: ST1477

Alternate gene names: 15921769

Gene position: 1476439-1475654 (Counterclockwise)

Preceding gene: 15921770

Following gene: 15921768

Centisome position: 54.79

GC content: 35.37

Gene sequence:

>786_bases
GTGTGCAAAAACTACTTGCCATCTGCTATAACAACTAAAACATTGACTCTTAAGCCACTTAACCCCCATGATCCACCTAC
ATTAGTGAAATTTCATGATAAGTGTTATCTTAATGCTATCGGTCTTGGAAACCCAGGAATAGACGAACTAAAGAAAATAA
ATGAAATGGAATGCAAGTTAATTGTTAGTGTTGGTGGAAGTAGTATTGATGAGATAATAGAAGTTATAAAGAAAGTTGAT
AGAGGGGAGATTATTGAATTAAACCTGAGTAGCCCTAATAGGAAGGGGTATGGAGAAAGTCTAGCTTCTTACGTTTATGA
GGTCGTAAAGAATGTGAAAGGAGTAACTAATAAACCCGTATTTGTTAAGTTAGGGCCTTGGGATAATATAATAGAGATTG
CTGGTCGAGCTATATCTGCTGGAGCTGACGGGCTTTCACTTATTAACACAGTAAAAGGAATGGTCATAGATGTAGAGACA
TTTAAGAAAGTCATGCATTATGGTACTGGAGGAATATCTGGGAAATGCATTCATCCTCTAGCCGTAAGAATTATCCATGA
CGTGTATAAAGAGTATAACGTTGATATTATAGGTATGGGTGGTGTCTTTTCCGGGATAGACGCTATTGAGCTAATGTCTG
TTGGTGCAAAGTTAATAGGGCTTGGTACTGTAATCATTGATGAAGGATATTCTAGTATTATAAGGATAAGAAAAGAAATG
GAAGAATATTTAAAAGAAAAAGGATTAAAATATTCAGATATAATAGGTGTAGCAGTGAAAAAATGA

Upstream 100 bases:

>100_bases
ATAAGAGGTGTAAACGCGTTTGATAAATCTAGCAGGTATCCAGTTTAAAGATCCTATTATCATATCTTCTGGCATAGTAA
CATTATCTAAAATAAAAGAA

Downstream 100 bases:

>100_bases
CAAGAATGACTATGAAAGGAAGAGATATAGAATCTCTTCTTTTTATGGGTAAGATAAAATCGGTTAACGTTGAATATTGC
GATGAAAGTAAAAAGATGGC

Product: dihydroorotate dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MCKNYLPSAITTKTLTLKPLNPHDPPTLVKFHDKCYLNAIGLGNPGIDELKKINEMECKLIVSVGGSSIDEIIEVIKKVD
RGEIIELNLSSPNRKGYGESLASYVYEVVKNVKGVTNKPVFVKLGPWDNIIEIAGRAISAGADGLSLINTVKGMVIDVET
FKKVMHYGTGGISGKCIHPLAVRIIHDVYKEYNVDIIGMGGVFSGIDAIELMSVGAKLIGLGTVIIDEGYSSIIRIRKEM
EEYLKEKGLKYSDIIGVAVKK

Sequences:

>Translated_261_residues
MCKNYLPSAITTKTLTLKPLNPHDPPTLVKFHDKCYLNAIGLGNPGIDELKKINEMECKLIVSVGGSSIDEIIEVIKKVD
RGEIIELNLSSPNRKGYGESLASYVYEVVKNVKGVTNKPVFVKLGPWDNIIEIAGRAISAGADGLSLINTVKGMVIDVET
FKKVMHYGTGGISGKCIHPLAVRIIHDVYKEYNVDIIGMGGVFSGIDAIELMSVGAKLIGLGTVIIDEGYSSIIRIRKEM
EEYLKEKGLKYSDIIGVAVKK
>Mature_261_residues
MCKNYLPSAITTKTLTLKPLNPHDPPTLVKFHDKCYLNAIGLGNPGIDELKKINEMECKLIVSVGGSSIDEIIEVIKKVD
RGEIIELNLSSPNRKGYGESLASYVYEVVKNVKGVTNKPVFVKLGPWDNIIEIAGRAISAGADGLSLINTVKGMVIDVET
FKKVMHYGTGGISGKCIHPLAVRIIHDVYKEYNVDIIGMGGVFSGIDAIELMSVGAKLIGLGTVIIDEGYSSIIRIRKEM
EEYLKEKGLKYSDIIGVAVKK

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=282, Percent_Identity=26.5957446808511, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI87082059, Length=218, Percent_Identity=27.5229357798165, Blast_Score=67, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17509475, Length=189, Percent_Identity=30.6878306878307, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322633, Length=232, Percent_Identity=31.0344827586207, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24640763, Length=166, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI18858217, Length=166, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 28437; Mature: 28437

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKNYLPSAITTKTLTLKPLNPHDPPTLVKFHDKCYLNAIGLGNPGIDELKKINEMECKL
CCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCEEEEEEECCCCCCHHHHHHHCCCCEEE
IVSVGGSSIDEIIEVIKKVDRGEIIELNLSSPNRKGYGESLASYVYEVVKNVKGVTNKPV
EEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
FVKLGPWDNIIEIAGRAISAGADGLSLINTVKGMVIDVETFKKVMHYGTGGISGKCIHPL
EEEECCCCHHHHHCCCHHCCCCCHHHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCHHHHH
AVRIIHDVYKEYNVDIIGMGGVFSGIDAIELMSVGAKLIGLGTVIIDEGYSSIIRIRKEM
HHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHH
EEYLKEKGLKYSDIIGVAVKK
HHHHHHCCCCCHHEEEEEECC
>Mature Secondary Structure
MCKNYLPSAITTKTLTLKPLNPHDPPTLVKFHDKCYLNAIGLGNPGIDELKKINEMECKL
CCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCEEEEEEECCCCCCHHHHHHHCCCCEEE
IVSVGGSSIDEIIEVIKKVDRGEIIELNLSSPNRKGYGESLASYVYEVVKNVKGVTNKPV
EEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
FVKLGPWDNIIEIAGRAISAGADGLSLINTVKGMVIDVETFKKVMHYGTGGISGKCIHPL
EEEECCCCHHHHHCCCHHCCCCCHHHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCHHHHH
AVRIIHDVYKEYNVDIIGMGGVFSGIDAIELMSVGAKLIGLGTVIIDEGYSSIIRIRKEM
HHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHH
EEYLKEKGLKYSDIIGVAVKK
HHHHHHCCCCCHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12142413 [H]