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The map label for this gene is pyrC

Identifier: 15921770

GI number: 15921770

Start: 1476492

End: 1477514

Strand: Reverse

Name: pyrC

Synonym: ST1478

Alternate gene names: 15921770

Gene position: 1477514-1476492 (Counterclockwise)

Preceding gene: 15921771

Following gene: 15921769

Centisome position: 54.83

GC content: 32.75

Gene sequence:

>1023_bases
ATGCATGTCCATGTAAGAGGAGCGCAATTATCTTATAAAGAAACTGTCGCAACAGCAACTAGTGAAGCAGCATATGGAGG
CATAGGACTTATTATAGATATGCCAAATACTTTACCACCAGTTAATACTTACGAGAGAGTAATTGAAAGGATAAGAGAAT
TTGAAAATTATTCAAGAACTGATTTCGGAATATATTCTGGTGTAACTAAAGAAATAGAAAAAATAGATACTTTACCTATT
GCTGGATACAAGATTTACCCAGAAGATTTAGACAGAACAGAGACTAAAGTGTTGTTAGAAAAAAGCAAGAAATTAAAAGT
ACTTCACCCAGAAATACCGCTGGCATTAAAAGTACCAAGAAAGTTAAGAAATATATGGATGGAAATAGCAGCTCTTCATT
ATGTTCAAGGAAACGTTCATGTTACACATATTACAAACTACGAAACAGTAAAAATAGCCAAAGAACTAGGTTTCTCTACT
GATATTACGCCACATCATCTTCTAGTTAATGGTGAAAGAGATTGTATTACGAAAGTTAATCCTCCAATAAGAGATTATTT
AACCAGGTTAGGGCTTTGGAAAGCATTATTTGAAGTTGATACAGTTGTGAGTGATCATGCACCTCATTCAAAAGAGGAGA
AAAATCTAAATTATGATCTGTGCCCACCTGGTATTGCGGCTGTTTCGTTTACTACTCCCTTTATTTATTCACTGGTTTTT
AAGGATTTATTAAACATAGAAAGGGCCGTAAATTTACTTTCAAAAAATCCAGCTAAAATTCTTAATATACCTTATGGAGA
AATAAGAATCGGATATGTTGCTAATTTTACAATTATTAGTAAAAATGATTGGAAATATAGGACTAAATTCTCTAAAGTTA
CTGAAACACCTTTAGATAATTTCCCCCTAGAAGCAAAAGTTGAGTTTACTATTGTCCAAGGTAAAATAGCTTTTGATGGG
AAAAATGTATTACCGATAAGAGGTGTAAACGCGTTTGATAAATCTAGCAGGTATCCAGTTTAA

Upstream 100 bases:

>100_bases
CTGTATTCAAATTGATAGATTTATAAAAAATATTAAAAAAGACTGCAAACCAGACATAGAATTTAAGGAAAACCAACTTA
TACTACCAGCCTCAATAGAT

Downstream 100 bases:

>100_bases
AGATCCTATTATCATATCTTCTGGCATAGTAACATTATCTAAAATAAAAGAAGTGTGCAAAAACTACTTGCCATCTGCTA
TAACAACTAAAACATTGACT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MHVHVRGAQLSYKETVATATSEAAYGGIGLIIDMPNTLPPVNTYERVIERIREFENYSRTDFGIYSGVTKEIEKIDTLPI
AGYKIYPEDLDRTETKVLLEKSKKLKVLHPEIPLALKVPRKLRNIWMEIAALHYVQGNVHVTHITNYETVKIAKELGFST
DITPHHLLVNGERDCITKVNPPIRDYLTRLGLWKALFEVDTVVSDHAPHSKEEKNLNYDLCPPGIAAVSFTTPFIYSLVF
KDLLNIERAVNLLSKNPAKILNIPYGEIRIGYVANFTIISKNDWKYRTKFSKVTETPLDNFPLEAKVEFTIVQGKIAFDG
KNVLPIRGVNAFDKSSRYPV

Sequences:

>Translated_340_residues
MHVHVRGAQLSYKETVATATSEAAYGGIGLIIDMPNTLPPVNTYERVIERIREFENYSRTDFGIYSGVTKEIEKIDTLPI
AGYKIYPEDLDRTETKVLLEKSKKLKVLHPEIPLALKVPRKLRNIWMEIAALHYVQGNVHVTHITNYETVKIAKELGFST
DITPHHLLVNGERDCITKVNPPIRDYLTRLGLWKALFEVDTVVSDHAPHSKEEKNLNYDLCPPGIAAVSFTTPFIYSLVF
KDLLNIERAVNLLSKNPAKILNIPYGEIRIGYVANFTIISKNDWKYRTKFSKVTETPLDNFPLEAKVEFTIVQGKIAFDG
KNVLPIRGVNAFDKSSRYPV
>Mature_340_residues
MHVHVRGAQLSYKETVATATSEAAYGGIGLIIDMPNTLPPVNTYERVIERIREFENYSRTDFGIYSGVTKEIEKIDTLPI
AGYKIYPEDLDRTETKVLLEKSKKLKVLHPEIPLALKVPRKLRNIWMEIAALHYVQGNVHVTHITNYETVKIAKELGFST
DITPHHLLVNGERDCITKVNPPIRDYLTRLGLWKALFEVDTVVSDHAPHSKEEKNLNYDLCPPGIAAVSFTTPFIYSLVF
KDLLNIERAVNLLSKNPAKILNIPYGEIRIGYVANFTIISKNDWKYRTKFSKVTETPLDNFPLEAKVEFTIVQGKIAFDG
KNVLPIRGVNAFDKSSRYPV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=347, Percent_Identity=25.6484149855908, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1786722, Length=388, Percent_Identity=23.7113402061856, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=355, Percent_Identity=26.4788732394366, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24642586, Length=357, Percent_Identity=26.0504201680672, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_SULTO (Q970X5)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377439.1
- ProteinModelPortal:   Q970X5
- SMR:   Q970X5
- GeneID:   1459512
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1478
- NMPDR:   fig|273063.1.peg.1607
- HOGENOM:   HBG724623
- ProtClustDB:   PRK00369
- BioCyc:   STOK273063:ST1478-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_A
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 38596; Mature: 38596

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVHVRGAQLSYKETVATATSEAAYGGIGLIIDMPNTLPPVNTYERVIERIREFENYSRT
CEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
DFGIYSGVTKEIEKIDTLPIAGYKIYPEDLDRTETKVLLEKSKKLKVLHPEIPLALKVPR
CCHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCCEEEECCCCCEEEECCH
KLRNIWMEIAALHYVQGNVHVTHITNYETVKIAKELGFSTDITPHHLLVNGERDCITKVN
HHHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHCCCCCCCCCCEEEEECCCCCEECCC
PPIRDYLTRLGLWKALFEVDTVVSDHAPHSKEEKNLNYDLCPPGIAAVSFTTPFIYSLVF
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCEEEEHHHHHHHHHHH
KDLLNIERAVNLLSKNPAKILNIPYGEIRIGYVANFTIISKNDWKYRTKFSKVTETPLDN
HHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEEEEECCCCEEEHHHHHHHCCCCCC
FPLEAKVEFTIVQGKIAFDGKNVLPIRGVNAFDKSSRYPV
CCCCEEEEEEEEEEEEEECCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MHVHVRGAQLSYKETVATATSEAAYGGIGLIIDMPNTLPPVNTYERVIERIREFENYSRT
CEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
DFGIYSGVTKEIEKIDTLPIAGYKIYPEDLDRTETKVLLEKSKKLKVLHPEIPLALKVPR
CCHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCCEEEECCCCCEEEECCH
KLRNIWMEIAALHYVQGNVHVTHITNYETVKIAKELGFSTDITPHHLLVNGERDCITKVN
HHHHHHHHHHHHHEEECCEEEEEECCCHHHHHHHHCCCCCCCCCCEEEEECCCCCEECCC
PPIRDYLTRLGLWKALFEVDTVVSDHAPHSKEEKNLNYDLCPPGIAAVSFTTPFIYSLVF
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCEEEEHHHHHHHHHHH
KDLLNIERAVNLLSKNPAKILNIPYGEIRIGYVANFTIISKNDWKYRTKFSKVTETPLDN
HHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEEEEECCCCEEEHHHHHHHCCCCCC
FPLEAKVEFTIVQGKIAFDGKNVLPIRGVNAFDKSSRYPV
CCCCEEEEEEEEEEEEEECCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479