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The map label for this gene is hisC

Identifier: 15921751

GI number: 15921751

Start: 1463314

End: 1464174

Strand: Direct

Name: hisC

Synonym: ST1458

Alternate gene names: 15921751

Gene position: 1463314-1464174 (Clockwise)

Preceding gene: 15921749

Following gene: 15921752

Centisome position: 54.3

GC content: 32.87

Gene sequence:

>861_bases
ATGGCAGAATATAACAGAGTAGAACCAAAGAATATATATCCAACTCCAGGAGGAGATGGGGCATTAAGGGCAGTATTTTA
TAACCTTATACAGACTGGAGATAAAGTTGTAATAAATAATCCATCTTATAGCATGTATAAAGTATATGCTTCAGTCAGAG
GGTTAAAATTAACTCGAGTAAATCTGATAGAAAATGATAACTGGTGGAAGATGAATTTTGAAAAGTTTTTAGATGAGGCA
AAAAATGCAAGACTTGTTATAATTGATGATCCAAATAATCCTACTGGTTCACCTATGTTGAAGGCAGAGGAAGACAAAGT
AAGAGCCTTAGCGGAAAGTATTAATGGCTTTATACTTATTGATGAGGCATATTACGAGTTCTCTGGCTATACAGTTGCTA
AACTTATTAACAAATATCCTAACCTACTCATAGTAAGAACGTTAAGTAAGGCTTTTTCATTAGCATCCTACAGGGTCGGG
TATTTAATTGGGAATGAAGAAGTTATTAAGAATCTAATGAAGGGAGCTACACCATTTGACATTTCGCTACCAGGATACAT
AGCTGGTATTACGGCTTTAGAAAATCCTTCATATGTTAGAAAAATAGTAGAAGAAATAACTAAGAATAGAGAATACCTTC
TTAATGGTCTCAGAAAACTTGGATTAAAAGTATACAATTCTCTTACAAATTTTGTTTTTGTAAAGGATGAGAGAGACTTA
TTATCCCCATTACTGAATAAGGGTGTAGCGATTAGAAAACCAATTATAGGTTATTATAGGATAAGTGTAGGCACAAAGGA
ACAGGTTGATACTCTATTAAAATATTTAGGTGAGATAATTGAAAATGGCAATTCCAAATAA

Upstream 100 bases:

>100_bases
TTTTCCACCACCAGATTTTATAATAGAGGAAGTAAAGAAATATTTGCATTTAGGTAATAGATATCAACACCCTTCATTAC
TAGAAAGATTAAGAGAATTA

Downstream 100 bases:

>100_bases
AGGCAGATTAAAAGATCCTGTTGTTCAATTTTTAGCTTCAGTAGGAGTGAAAGGGAATTTCTCCGATGATAGAGCTTTAA
TAATACCCACTAATTGGGAG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MAEYNRVEPKNIYPTPGGDGALRAVFYNLIQTGDKVVINNPSYSMYKVYASVRGLKLTRVNLIENDNWWKMNFEKFLDEA
KNARLVIIDDPNNPTGSPMLKAEEDKVRALAESINGFILIDEAYYEFSGYTVAKLINKYPNLLIVRTLSKAFSLASYRVG
YLIGNEEVIKNLMKGATPFDISLPGYIAGITALENPSYVRKIVEEITKNREYLLNGLRKLGLKVYNSLTNFVFVKDERDL
LSPLLNKGVAIRKPIIGYYRISVGTKEQVDTLLKYLGEIIENGNSK

Sequences:

>Translated_286_residues
MAEYNRVEPKNIYPTPGGDGALRAVFYNLIQTGDKVVINNPSYSMYKVYASVRGLKLTRVNLIENDNWWKMNFEKFLDEA
KNARLVIIDDPNNPTGSPMLKAEEDKVRALAESINGFILIDEAYYEFSGYTVAKLINKYPNLLIVRTLSKAFSLASYRVG
YLIGNEEVIKNLMKGATPFDISLPGYIAGITALENPSYVRKIVEEITKNREYLLNGLRKLGLKVYNSLTNFVFVKDERDL
LSPLLNKGVAIRKPIIGYYRISVGTKEQVDTLLKYLGEIIENGNSK
>Mature_285_residues
AEYNRVEPKNIYPTPGGDGALRAVFYNLIQTGDKVVINNPSYSMYKVYASVRGLKLTRVNLIENDNWWKMNFEKFLDEAK
NARLVIIDDPNNPTGSPMLKAEEDKVRALAESINGFILIDEAYYEFSGYTVAKLINKYPNLLIVRTLSKAFSLASYRVGY
LIGNEEVIKNLMKGATPFDISLPGYIAGITALENPSYVRKIVEEITKNREYLLNGLRKLGLKVYNSLTNFVFVKDERDLL
SPLLNKGVAIRKPIIGYYRISVGTKEQVDTLLKYLGEIIENGNSK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Homo sapiens, GI95147551, Length=276, Percent_Identity=21.3768115942029, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI169881279, Length=276, Percent_Identity=21.3768115942029, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788332, Length=290, Percent_Identity=32.0689655172414, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1788722, Length=220, Percent_Identity=28.1818181818182, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322075, Length=296, Percent_Identity=26.3513513513513, Blast_Score=102, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SULTO (Q970Z4)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377420.1
- ProteinModelPortal:   Q970Z4
- SMR:   Q970Z4
- GeneID:   1459493
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1458
- NMPDR:   fig|273063.1.peg.1588
- HOGENOM:   HBG646350
- OMA:   QIGLFNG
- ProtClustDB:   CLSK802777
- BioCyc:   STOK273063:ST1458-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 32357; Mature: 32226

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEYNRVEPKNIYPTPGGDGALRAVFYNLIQTGDKVVINNPSYSMYKVYASVRGLKLTRV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCEEEEEE
NLIENDNWWKMNFEKFLDEAKNARLVIIDDPNNPTGSPMLKAEEDKVRALAESINGFILI
EEEECCCEEEECHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEE
DEAYYEFSGYTVAKLINKYPNLLIVRTLSKAFSLASYRVGYLIGNEEVIKNLMKGATPFD
ECHHHHCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCCCCE
ISLPGYIAGITALENPSYVRKIVEEITKNREYLLNGLRKLGLKVYNSLTNFVFVKDERDL
EECCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEEEECCHHH
LSPLLNKGVAIRKPIIGYYRISVGTKEQVDTLLKYLGEIIENGNSK
HHHHHHCCCEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEYNRVEPKNIYPTPGGDGALRAVFYNLIQTGDKVVINNPSYSMYKVYASVRGLKLTRV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCEEEEEE
NLIENDNWWKMNFEKFLDEAKNARLVIIDDPNNPTGSPMLKAEEDKVRALAESINGFILI
EEEECCCEEEECHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEE
DEAYYEFSGYTVAKLINKYPNLLIVRTLSKAFSLASYRVGYLIGNEEVIKNLMKGATPFD
ECHHHHCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCCCCE
ISLPGYIAGITALENPSYVRKIVEEITKNREYLLNGLRKLGLKVYNSLTNFVFVKDERDL
EECCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEEEECCHHH
LSPLLNKGVAIRKPIIGYYRISVGTKEQVDTLLKYLGEIIENGNSK
HHHHHHCCCEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479