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The map label for this gene is leuS [H]

Identifier: 15921749

GI number: 15921749

Start: 1459792

End: 1462476

Strand: Direct

Name: leuS [H]

Synonym: ST1455

Alternate gene names: 15921749

Gene position: 1459792-1462476 (Clockwise)

Preceding gene: 15921747

Following gene: 15921751

Centisome position: 54.17

GC content: 32.14

Gene sequence:

>2685_bases
GTGACTTGTGATATTTACGCAAGATATATGAGAATGAAGGGTTATAACGTACTTTTCCCCATGGGATTTCATTATACTGG
AACGCCGATAATTGCTATGGCTGATGATGTAGCTAAAGGAGATAAAGAGTTGATAGACATTTTCAAAAATATATATGAGA
TTCCAGATAATGTAATTTCAAAATTAGCTGATCCTCTCTTTATGGCTAACTATTTCAGAGATGAAATAAAGAAGGCTATG
AAAGAAATAGGTTTAAGCATTGATTGGAGAAGAGAATTTACGACTATAGACCCAGAGTTCTCATCATTCATAGTATGGCA
GTTTAATAAGCTACAAGAGAAAGGATATATAGTTAGAGACACACATCCAGTTGGATGGTGTCCAGTTCACCACATTCCAG
TAGGAATGCATGATACTAAAGGAGATATGGAACCTGAAATTGGCGAGTTTGTATTAATTTACTTTAATAGTGATCTAGGA
ATTTTACCTGCTGCTACATTAAGACCAGAGACCGTGTTTGGTGCTATAGGAATATGGGTAAATCCGGATGTCACATATTC
TATCATAGAATTAGATGGCAAAAAGATGATTGTTAGTGAAAGGGCCGCATTCAAATTAACTTTCCAATTTGATAATATAA
AGAATTTAGGAAGTATAAAAGGTTCTGAATTAACTAAATATAAGGCTGTTAATCCAATAACTGGAAAAGAAATTCCTATA
ATGGCAGCTGATTTTGTTGATCCTAATGTTGCTACAGGCATAGTGATGAGTGTTCCAGCCCATGCTCCTTTCGATTATTA
CTATTTGAAGAAAAATAAGCAACAAGATATGCAAATAGTTTCTGTTATTCAAGTTGAAGGTCAAGGTGACACTTTAGCTA
AAGATCTTGTAGAGAAGACTAATCCAAAAAACAAAGATGATCTTCAAAAATTAACTGAACAAGTTTATAGAATAGAATAT
AATAAGGGTAAGATGAAAGATGTGAGCTCGCTAGTAAAACCAGAATTTGTTAACTACTTTAAGTCGTTTATTGGCTTATC
AGTTCCAGAGGCAAGGCAAAAAGTAACTGAGTTCTTAATAGAGAAAGGCTTAGGTAGGAAAATTTATGAAATTATGAATA
GACCGGTTTATTGTAGGTGTGGTAACGAGGTTGTAGTTAAAATACTAAAGGATCAATGGTTCTTAGACTATGGTAACCCA
CAATGGAAGGCTTTAGCTAAAAAATTAATTTCTAATATGAAATTTATTCCGCCAGAGATAAGGAAAGATTTTGAGTTTGT
CACAGATTGGTTACAAAAAAGGGCATGTGCTAGAACAAGAGGATTAGGTACGCCATTACCTTGGGATAAAAAATGGATTA
TTGAAAGTTTAAGTGATTCCACTATCTATATGGCCTACTATACAATTTCACATAAAATAAGGCAATATCAATTAAAACCC
TCTCAACTTACTTATGATTTCTGGAATTATATAATGCTAGGTATTGGAGATATTGATAAGATTTCCAGCGAAACTGGTAT
ATCTAAAGAAATAATTAGGGAAATGAGGAATGAATTTCTATATTGGTATCCATTAGATATACGCCATAGTGGTAAGGATT
TAATTCCTAATCATTTATCGTTCTTCATATTTAATCATGCAGCAATTTTCCCAGAAGAATTATGGCCGAAAGCTATAGCA
GTCAACGGTTTTGTTTTATATGAAGGAAAGAAAATGAGTAAATCATTAAGGAACATTATCCCATTAAGAAAAGCTCTGAG
AATTTATAGTCCAGACGTTGTAAGAATAGCATTGACATCTACTGCCGATATGGGTTCTGATGTAAACTTTAGTGACTCTT
ATGCAAAGTCAGTAGGAGAAATATTAAGGAGGTATTACGAATTTATAAAGGAGTTACCTAAGTATGATGGTGAAGGTAGT
GAATTTGCTAATAACTGGTTAAAGGCTCAAGTAAGTAGTATTGTACTCAGTTCTACTAAGAATATGGATAATATTGATTT
TAGAAGTACTATTAATGATATATTATATTCATTTGATTCTTATTTAAGAGAATATATTGATATGTGTAAAGCCGATGGAA
AAGAACCAAATGGAAAATTATTAAGAGAAGTAATAGAGACATGGATAAAACTATTAGCACCTTTTGCTCCTCACTTTGCT
GAAGAAATTTGGCATGAATTAGGTCATACAACTTTCATCTCATTAGAGAAATGGCCTACAGCTGAAGAGTCATCTGAGGA
CTTATATTATATTTTAATCCATGAATATCATAAGAGAATAATTGAGGATTCCCAGAAGATTATAAACTATTACTATAAAG
GTAAGCCTAGTATCGTAAAAATATATGTTGCAGAACAAGAATTAATGAAGGTATTGAGAGAAGCTGTGCAAATACTATCT
AATGGTGGTACATTAAAGCAGTTAATGGAGAAAGAGAGACCATCAGATAAAAAACTAGCTAATATAATCAGAAAGATTTA
CGAACTAGCAGTAGAATTAGATGACAATATGAAAAAGTTAATCTTAGGTTATAATATTAATGAGAGAGAAATCCTTGAGT
TAGGAACTAAATATATGAGTTACAAACTAGGTATACCAGTTGAAGTATATGATGTATCAAAACTAGATAAAAGTAAATAT
AATAAAGAAGCCTTACCTCTTAAGCCAGCTATTATTGTTGAGTAA

Upstream 100 bases:

>100_bases
CTTTGAAGCAAACCCAGATAGAACAAGGAATAAATTCTTTACGACAGTTGCCTTCCCATATCCTAATTCTCCATTTCACC
TAGGTCATGGAAGAACTTAT

Downstream 100 bases:

>100_bases
AACTTTTCCATTTTTTATTTCAATAACTCCAATATCTTTTAGAAAATAAATCTCTTTTCTTATATTATCTCTGCTACTAT
TTGTCTTATGATATAGTATG

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase 2; LeuRS 2 [H]

Number of amino acids: Translated: 894; Mature: 893

Protein sequence:

>894_residues
MTCDIYARYMRMKGYNVLFPMGFHYTGTPIIAMADDVAKGDKELIDIFKNIYEIPDNVISKLADPLFMANYFRDEIKKAM
KEIGLSIDWRREFTTIDPEFSSFIVWQFNKLQEKGYIVRDTHPVGWCPVHHIPVGMHDTKGDMEPEIGEFVLIYFNSDLG
ILPAATLRPETVFGAIGIWVNPDVTYSIIELDGKKMIVSERAAFKLTFQFDNIKNLGSIKGSELTKYKAVNPITGKEIPI
MAADFVDPNVATGIVMSVPAHAPFDYYYLKKNKQQDMQIVSVIQVEGQGDTLAKDLVEKTNPKNKDDLQKLTEQVYRIEY
NKGKMKDVSSLVKPEFVNYFKSFIGLSVPEARQKVTEFLIEKGLGRKIYEIMNRPVYCRCGNEVVVKILKDQWFLDYGNP
QWKALAKKLISNMKFIPPEIRKDFEFVTDWLQKRACARTRGLGTPLPWDKKWIIESLSDSTIYMAYYTISHKIRQYQLKP
SQLTYDFWNYIMLGIGDIDKISSETGISKEIIREMRNEFLYWYPLDIRHSGKDLIPNHLSFFIFNHAAIFPEELWPKAIA
VNGFVLYEGKKMSKSLRNIIPLRKALRIYSPDVVRIALTSTADMGSDVNFSDSYAKSVGEILRRYYEFIKELPKYDGEGS
EFANNWLKAQVSSIVLSSTKNMDNIDFRSTINDILYSFDSYLREYIDMCKADGKEPNGKLLREVIETWIKLLAPFAPHFA
EEIWHELGHTTFISLEKWPTAEESSEDLYYILIHEYHKRIIEDSQKIINYYYKGKPSIVKIYVAEQELMKVLREAVQILS
NGGTLKQLMEKERPSDKKLANIIRKIYELAVELDDNMKKLILGYNINEREILELGTKYMSYKLGIPVEVYDVSKLDKSKY
NKEALPLKPAIIVE

Sequences:

>Translated_894_residues
MTCDIYARYMRMKGYNVLFPMGFHYTGTPIIAMADDVAKGDKELIDIFKNIYEIPDNVISKLADPLFMANYFRDEIKKAM
KEIGLSIDWRREFTTIDPEFSSFIVWQFNKLQEKGYIVRDTHPVGWCPVHHIPVGMHDTKGDMEPEIGEFVLIYFNSDLG
ILPAATLRPETVFGAIGIWVNPDVTYSIIELDGKKMIVSERAAFKLTFQFDNIKNLGSIKGSELTKYKAVNPITGKEIPI
MAADFVDPNVATGIVMSVPAHAPFDYYYLKKNKQQDMQIVSVIQVEGQGDTLAKDLVEKTNPKNKDDLQKLTEQVYRIEY
NKGKMKDVSSLVKPEFVNYFKSFIGLSVPEARQKVTEFLIEKGLGRKIYEIMNRPVYCRCGNEVVVKILKDQWFLDYGNP
QWKALAKKLISNMKFIPPEIRKDFEFVTDWLQKRACARTRGLGTPLPWDKKWIIESLSDSTIYMAYYTISHKIRQYQLKP
SQLTYDFWNYIMLGIGDIDKISSETGISKEIIREMRNEFLYWYPLDIRHSGKDLIPNHLSFFIFNHAAIFPEELWPKAIA
VNGFVLYEGKKMSKSLRNIIPLRKALRIYSPDVVRIALTSTADMGSDVNFSDSYAKSVGEILRRYYEFIKELPKYDGEGS
EFANNWLKAQVSSIVLSSTKNMDNIDFRSTINDILYSFDSYLREYIDMCKADGKEPNGKLLREVIETWIKLLAPFAPHFA
EEIWHELGHTTFISLEKWPTAEESSEDLYYILIHEYHKRIIEDSQKIINYYYKGKPSIVKIYVAEQELMKVLREAVQILS
NGGTLKQLMEKERPSDKKLANIIRKIYELAVELDDNMKKLILGYNINEREILELGTKYMSYKLGIPVEVYDVSKLDKSKY
NKEALPLKPAIIVE
>Mature_893_residues
TCDIYARYMRMKGYNVLFPMGFHYTGTPIIAMADDVAKGDKELIDIFKNIYEIPDNVISKLADPLFMANYFRDEIKKAMK
EIGLSIDWRREFTTIDPEFSSFIVWQFNKLQEKGYIVRDTHPVGWCPVHHIPVGMHDTKGDMEPEIGEFVLIYFNSDLGI
LPAATLRPETVFGAIGIWVNPDVTYSIIELDGKKMIVSERAAFKLTFQFDNIKNLGSIKGSELTKYKAVNPITGKEIPIM
AADFVDPNVATGIVMSVPAHAPFDYYYLKKNKQQDMQIVSVIQVEGQGDTLAKDLVEKTNPKNKDDLQKLTEQVYRIEYN
KGKMKDVSSLVKPEFVNYFKSFIGLSVPEARQKVTEFLIEKGLGRKIYEIMNRPVYCRCGNEVVVKILKDQWFLDYGNPQ
WKALAKKLISNMKFIPPEIRKDFEFVTDWLQKRACARTRGLGTPLPWDKKWIIESLSDSTIYMAYYTISHKIRQYQLKPS
QLTYDFWNYIMLGIGDIDKISSETGISKEIIREMRNEFLYWYPLDIRHSGKDLIPNHLSFFIFNHAAIFPEELWPKAIAV
NGFVLYEGKKMSKSLRNIIPLRKALRIYSPDVVRIALTSTADMGSDVNFSDSYAKSVGEILRRYYEFIKELPKYDGEGSE
FANNWLKAQVSSIVLSSTKNMDNIDFRSTINDILYSFDSYLREYIDMCKADGKEPNGKLLREVIETWIKLLAPFAPHFAE
EIWHELGHTTFISLEKWPTAEESSEDLYYILIHEYHKRIIEDSQKIINYYYKGKPSIVKIYVAEQELMKVLREAVQILSN
GGTLKQLMEKERPSDKKLANIIRKIYELAVELDDNMKKLILGYNINEREILELGTKYMSYKLGIPVEVYDVSKLDKSKYN
KEALPLKPAIIVE

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI108773810, Length=1020, Percent_Identity=29.7058823529412, Blast_Score=378, Evalue=1e-104,
Organism=Escherichia coli, GI2367096, Length=705, Percent_Identity=19.8581560283688, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17554638, Length=762, Percent_Identity=30.9711286089239, Blast_Score=352, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6325097, Length=840, Percent_Identity=30.952380952381, Blast_Score=350, Evalue=6e-97,
Organism=Drosophila melanogaster, GI28574733, Length=835, Percent_Identity=30.1796407185629, Blast_Score=359, Evalue=4e-99,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002300
- InterPro:   IPR020791
- InterPro:   IPR004493
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 103503; Mature: 103372

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCDIYARYMRMKGYNVLFPMGFHYTGTPIIAMADDVAKGDKELIDIFKNIYEIPDNVIS
CCHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCHHHCCHHHHHHHHHHHHHCCHHHHH
KLADPLFMANYFRDEIKKAMKEIGLSIDWRREFTTIDPEFSSFIVWQFNKLQEKGYIVRD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEHHHHHCCEEEEC
THPVGWCPVHHIPVGMHDTKGDMEPEIGEFVLIYFNSDLGILPAATLRPETVFGAIGIWV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHEEEEEEEE
NPDVTYSIIELDGKKMIVSERAAFKLTFQFDNIKNLGSIKGSELTKYKAVNPITGKEIPI
CCCCEEEEEEECCCEEEEECCCEEEEEEEECCCCCCCCCCCCCCHHEECCCCCCCCCCCE
MAADFVDPNVATGIVMSVPAHAPFDYYYLKKNKQQDMQIVSVIQVEGQGDTLAKDLVEKT
EEECCCCCCHHCCEEEECCCCCCCCEEEECCCCCHHHEEEEEEEECCCCCHHHHHHHHHC
NPKNKDDLQKLTEQVYRIEYNKGKMKDVSSLVKPEFVNYFKSFIGLSVPEARQKVTEFLI
CCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHH
EKGLGRKIYEIMNRPVYCRCGNEVVVKILKDQWFLDYGNPQWKALAKKLISNMKFIPPEI
HHCCCHHHHHHHCCCEEEECCHHHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCCCCHHH
RKDFEFVTDWLQKRACARTRGLGTPLPWDKKWIIESLSDSTIYMAYYTISHKIRQYQLKP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEEEEHHHHHHHHCCCC
SQLTYDFWNYIMLGIGDIDKISSETGISKEIIREMRNEFLYWYPLDIRHSGKDLIPNHLS
HHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCEEEEEEEEECCCCCCCCCHHHH
FFIFNHAAIFPEELWPKAIAVNGFVLYEGKKMSKSLRNIIPLRKALRIYSPDVVRIALTS
HHHHHHHHCCCHHHCCCCEEECCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
TADMGSDVNFSDSYAKSVGEILRRYYEFIKELPKYDGEGSEFANNWLKAQVSSIVLSSTK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
NMDNIDFRSTINDILYSFDSYLREYIDMCKADGKEPNGKLLREVIETWIKLLAPFAPHFA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
EEIWHELGHTTFISLEKWPTAEESSEDLYYILIHEYHKRIIEDSQKIINYYYKGKPSIVK
HHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IYVAEQELMKVLREAVQILSNGGTLKQLMEKERPSDKKLANIIRKIYELAVELDDNMKKL
EEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEE
ILGYNINEREILELGTKYMSYKLGIPVEVYDVSKLDKSKYNKEALPLKPAIIVE
EEECCCCHHHHHHHHHHHHEEECCCCEEEEECHHHHHHHCCCCCCCCCCEEEEC
>Mature Secondary Structure 
TCDIYARYMRMKGYNVLFPMGFHYTGTPIIAMADDVAKGDKELIDIFKNIYEIPDNVIS
CHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCHHHCCHHHHHHHHHHHHHCCHHHHH
KLADPLFMANYFRDEIKKAMKEIGLSIDWRREFTTIDPEFSSFIVWQFNKLQEKGYIVRD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEHHHHHCCEEEEC
THPVGWCPVHHIPVGMHDTKGDMEPEIGEFVLIYFNSDLGILPAATLRPETVFGAIGIWV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHEEEEEEEE
NPDVTYSIIELDGKKMIVSERAAFKLTFQFDNIKNLGSIKGSELTKYKAVNPITGKEIPI
CCCCEEEEEEECCCEEEEECCCEEEEEEEECCCCCCCCCCCCCCHHEECCCCCCCCCCCE
MAADFVDPNVATGIVMSVPAHAPFDYYYLKKNKQQDMQIVSVIQVEGQGDTLAKDLVEKT
EEECCCCCCHHCCEEEECCCCCCCCEEEECCCCCHHHEEEEEEEECCCCCHHHHHHHHHC
NPKNKDDLQKLTEQVYRIEYNKGKMKDVSSLVKPEFVNYFKSFIGLSVPEARQKVTEFLI
CCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHH
EKGLGRKIYEIMNRPVYCRCGNEVVVKILKDQWFLDYGNPQWKALAKKLISNMKFIPPEI
HHCCCHHHHHHHCCCEEEECCHHHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCCCCHHH
RKDFEFVTDWLQKRACARTRGLGTPLPWDKKWIIESLSDSTIYMAYYTISHKIRQYQLKP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEEEEHHHHHHHHCCCC
SQLTYDFWNYIMLGIGDIDKISSETGISKEIIREMRNEFLYWYPLDIRHSGKDLIPNHLS
HHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCEEEEEEEEECCCCCCCCCHHHH
FFIFNHAAIFPEELWPKAIAVNGFVLYEGKKMSKSLRNIIPLRKALRIYSPDVVRIALTS
HHHHHHHHCCCHHHCCCCEEECCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
TADMGSDVNFSDSYAKSVGEILRRYYEFIKELPKYDGEGSEFANNWLKAQVSSIVLSSTK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
NMDNIDFRSTINDILYSFDSYLREYIDMCKADGKEPNGKLLREVIETWIKLLAPFAPHFA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
EEIWHELGHTTFISLEKWPTAEESSEDLYYILIHEYHKRIIEDSQKIINYYYKGKPSIVK
HHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IYVAEQELMKVLREAVQILSNGGTLKQLMEKERPSDKKLANIIRKIYELAVELDDNMKKL
EEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEE
ILGYNINEREILELGTKYMSYKLGIPVEVYDVSKLDKSKYNKEALPLKPAIIVE
EEECCCCHHHHHHHHHHHHEEECCCCEEEEECHHHHHHHCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]