Click here to switch to the map view.

The map label for this gene is lcfB [H]

Identifier: 15921677

GI number: 15921677

Start: 1392684

End: 1394048

Strand: Reverse

Name: lcfB [H]

Synonym: ST1388

Alternate gene names: 15921677

Gene position: 1394048-1392684 (Counterclockwise)

Preceding gene: 15921682

Following gene: 15921676

Centisome position: 51.73

GC content: 32.82

Gene sequence:

>1365_bases
ATGAGCTTAGCCAGATTAGTGTATGAGTGGAGTAAAAAAACTCCTAGTAAGACTTTTTTAATAAGTGAAGATAAAAATTT
AACTTATGAGCAAGCGGTACAGGAAATAGCAAAAATAGCATCTAACATCTCGCCAGGTGGCACAGTAGTGCATATAATGT
TCAATACAGTAGAATCCATTCTGGCTTATTTAGCTATATTGTGGGCTGGAGGAAAAATTGTTGCAGTCGATCCATTAACT
TCTGCAGAAGACTTAAAGTTTATATTAGAAGACTCCAAACCAGATTTAGTCTTCACAGACCATGAGGTATATGAAAGAGA
AAAAAATATACTAAAGGATTATAAAACAGTAGTTGAAGTACCTAGAAAAAATGTATTCTCTTCACCTTATGAATATAGAG
AAGATGAAGTAGGATTAATATATTATTATGCTGGAATAGCTGGAAGAACAATGCAAGTTTTACATAGTGCAGAAAGAATG
GAATTGAATTCTTTATCTCTATATAGAGCAACTAAGTTAAAAGAAGTTAGAAGCATTTTAACAGTACCAATTGCTCATGT
TCTCGGTAATAGCGTTTTAGGTGTAACTTTAGAAGCAGGTGGAGCAATGTACATAGTAAAAAAATTTGAACCGAAAAGTG
TAGCTAGTGTGATAGAGAAATACTCTATTAACTATCTTTCAACGGTTCCAATGGTATACGATTCCTTAAACACAATAGAT
GCTAATCTTTCAAGCTTAGAATTATGTGTAAGTAGCGCAGCTCCTTTGTTCCCTAATACAGTAAATACATTTTTCAATAA
ATTTGGCAAAAAGATAGTTCAACAATACGGATTTACTGAAGGATTTGTACTTACTTTTCAGCCATTAGAATATGCAGATG
TAATTAGCGTAGGAAAACCGTTACCAGAAGTCGAGGTAAAGATTGTTAAAGATGATGGAAAAGAGGCAAAAACTGGTGAA
GTAGGAGAATTATGGGTAAAGGCACCATGGTTAATGCTAGGATATAAAGACATAGAAGAAACAAATAAAGTATTTTCTAA
TGGATGGTTAAAAACTGGAGACCTAATGAGTATGGATGATAAGGGATTATTGTATTTTAGAGGGATTAAAAAAAGAATGC
TGAAATATAAGGGTTATCCTATATTTCCAAGAGACTTAGAGGAAATATTAAAGACTCATCCTAATGTAATAGATGCTAAA
GTAATTGGAGAAGATGCTGGTCAACTAGGACAGCAACCTATAGCAATTGTCGTGGTAAAAGAGAAAAAAGATGGTATTGA
AGAAGAGCTTCTGAATTATGTTAACACAAAGGTAGCATTTTATAAGAAGTTGAAGAAAGTATATATAGTGGATAAAATTG
AGTGA

Upstream 100 bases:

>100_bases
CAAGTCTTCCAAATTTACCTTCTAAGTCAATAAGAGTTATATGAATTCTTGATAACCCAATAATTTTTATCATACAAAAC
ACTTCATATATGAGAGACTT

Downstream 100 bases:

>100_bases
GATTGACACACTAGTTAGAGAAATAGCCAAAAGATTAGAAGAAAAAGCCGAAAAAATATTAAAAAAGGAGGAAGCTACTA
TAACTATAACTGATAGTAAC

Product: acyl-CoA synthase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSLARLVYEWSKKTPSKTFLISEDKNLTYEQAVQEIAKIASNISPGGTVVHIMFNTVESILAYLAILWAGGKIVAVDPLT
SAEDLKFILEDSKPDLVFTDHEVYEREKNILKDYKTVVEVPRKNVFSSPYEYREDEVGLIYYYAGIAGRTMQVLHSAERM
ELNSLSLYRATKLKEVRSILTVPIAHVLGNSVLGVTLEAGGAMYIVKKFEPKSVASVIEKYSINYLSTVPMVYDSLNTID
ANLSSLELCVSSAAPLFPNTVNTFFNKFGKKIVQQYGFTEGFVLTFQPLEYADVISVGKPLPEVEVKIVKDDGKEAKTGE
VGELWVKAPWLMLGYKDIEETNKVFSNGWLKTGDLMSMDDKGLLYFRGIKKRMLKYKGYPIFPRDLEEILKTHPNVIDAK
VIGEDAGQLGQQPIAIVVVKEKKDGIEEELLNYVNTKVAFYKKLKKVYIVDKIE

Sequences:

>Translated_454_residues
MSLARLVYEWSKKTPSKTFLISEDKNLTYEQAVQEIAKIASNISPGGTVVHIMFNTVESILAYLAILWAGGKIVAVDPLT
SAEDLKFILEDSKPDLVFTDHEVYEREKNILKDYKTVVEVPRKNVFSSPYEYREDEVGLIYYYAGIAGRTMQVLHSAERM
ELNSLSLYRATKLKEVRSILTVPIAHVLGNSVLGVTLEAGGAMYIVKKFEPKSVASVIEKYSINYLSTVPMVYDSLNTID
ANLSSLELCVSSAAPLFPNTVNTFFNKFGKKIVQQYGFTEGFVLTFQPLEYADVISVGKPLPEVEVKIVKDDGKEAKTGE
VGELWVKAPWLMLGYKDIEETNKVFSNGWLKTGDLMSMDDKGLLYFRGIKKRMLKYKGYPIFPRDLEEILKTHPNVIDAK
VIGEDAGQLGQQPIAIVVVKEKKDGIEEELLNYVNTKVAFYKKLKKVYIVDKIE
>Mature_453_residues
SLARLVYEWSKKTPSKTFLISEDKNLTYEQAVQEIAKIASNISPGGTVVHIMFNTVESILAYLAILWAGGKIVAVDPLTS
AEDLKFILEDSKPDLVFTDHEVYEREKNILKDYKTVVEVPRKNVFSSPYEYREDEVGLIYYYAGIAGRTMQVLHSAERME
LNSLSLYRATKLKEVRSILTVPIAHVLGNSVLGVTLEAGGAMYIVKKFEPKSVASVIEKYSINYLSTVPMVYDSLNTIDA
NLSSLELCVSSAAPLFPNTVNTFFNKFGKKIVQQYGFTEGFVLTFQPLEYADVISVGKPLPEVEVKIVKDDGKEAKTGEV
GELWVKAPWLMLGYKDIEETNKVFSNGWLKTGDLMSMDDKGLLYFRGIKKRMLKYKGYPIFPRDLEEILKTHPNVIDAKV
IGEDAGQLGQQPIAIVVVKEKKDGIEEELLNYVNTKVAFYKKLKKVYIVDKIE

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=511, Percent_Identity=25.440313111546, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI187761345, Length=483, Percent_Identity=25.4658385093168, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI187761343, Length=483, Percent_Identity=25.4658385093168, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI42544132, Length=453, Percent_Identity=22.075055187638, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI38505220, Length=451, Percent_Identity=22.3946784922395, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI115511026, Length=411, Percent_Identity=24.0875912408759, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI157311624, Length=344, Percent_Identity=24.1279069767442, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI157311622, Length=344, Percent_Identity=24.1279069767442, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI58082049, Length=342, Percent_Identity=24.2690058479532, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI122937307, Length=248, Percent_Identity=26.2096774193548, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788107, Length=497, Percent_Identity=24.5472837022133, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI145693145, Length=289, Percent_Identity=28.3737024221453, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1786810, Length=295, Percent_Identity=27.4576271186441, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI221142682, Length=470, Percent_Identity=22.9787234042553, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788595, Length=267, Percent_Identity=25.0936329588015, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17557194, Length=462, Percent_Identity=26.6233766233766, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17531443, Length=482, Percent_Identity=26.5560165975104, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17560140, Length=491, Percent_Identity=25.2545824847251, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=460, Percent_Identity=24.5652173913043, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17559526, Length=279, Percent_Identity=31.1827956989247, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17538037, Length=457, Percent_Identity=26.0393873085339, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=432, Percent_Identity=24.7685185185185, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=471, Percent_Identity=25.2653927813163, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=330, Percent_Identity=26.969696969697, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=170, Percent_Identity=30.5882352941176, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=373, Percent_Identity=27.8820375335121, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI18859661, Length=343, Percent_Identity=29.4460641399417, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21355181, Length=435, Percent_Identity=27.816091954023, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24581924, Length=328, Percent_Identity=28.6585365853659, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356947, Length=492, Percent_Identity=22.3577235772358, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356441, Length=494, Percent_Identity=22.4696356275304, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24648676, Length=427, Percent_Identity=24.1217798594848, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648253, Length=256, Percent_Identity=26.953125, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI20130357, Length=399, Percent_Identity=24.0601503759398, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648255, Length=256, Percent_Identity=27.34375, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24653035, Length=506, Percent_Identity=23.5177865612648, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358303, Length=497, Percent_Identity=23.3400402414487, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648260, Length=471, Percent_Identity=23.3545647558386, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI161076582, Length=457, Percent_Identity=23.4135667396061, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281365686, Length=473, Percent_Identity=23.6786469344609, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24656500, Length=378, Percent_Identity=22.7513227513227, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 51127; Mature: 50996

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLARLVYEWSKKTPSKTFLISEDKNLTYEQAVQEIAKIASNISPGGTVVHIMFNTVESI
CCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHH
LAYLAILWAGGKIVAVDPLTSAEDLKFILEDSKPDLVFTDHEVYEREKNILKDYKTVVEV
HHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHC
PRKNVFSSPYEYREDEVGLIYYYAGIAGRTMQVLHSAERMELNSLSLYRATKLKEVRSIL
CHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TVPIAHVLGNSVLGVTLEAGGAMYIVKKFEPKSVASVIEKYSINYLSTVPMVYDSLNTID
HHHHHHHHCCCEEEEEEECCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHC
ANLSSLELCVSSAAPLFPNTVNTFFNKFGKKIVQQYGFTEGFVLTFQPLEYADVISVGKP
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCC
LPEVEVKIVKDDGKEAKTGEVGELWVKAPWLMLGYKDIEETNKVFSNGWLKTGDLMSMDD
CCCEEEEEEECCCCCCCCCCCHHHHEECCCCEECCHHHHHHHHHHHCCCEECCCCCCCCC
KGLLYFRGIKKRMLKYKGYPIFPRDLEEILKTHPNVIDAKVIGEDAGQLGQQPIAIVVVK
CCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHCCCCCEEEEEEE
EKKDGIEEELLNYVNTKVAFYKKLKKVYIVDKIE
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECC
>Mature Secondary Structure 
SLARLVYEWSKKTPSKTFLISEDKNLTYEQAVQEIAKIASNISPGGTVVHIMFNTVESI
CHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHH
LAYLAILWAGGKIVAVDPLTSAEDLKFILEDSKPDLVFTDHEVYEREKNILKDYKTVVEV
HHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHC
PRKNVFSSPYEYREDEVGLIYYYAGIAGRTMQVLHSAERMELNSLSLYRATKLKEVRSIL
CHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TVPIAHVLGNSVLGVTLEAGGAMYIVKKFEPKSVASVIEKYSINYLSTVPMVYDSLNTID
HHHHHHHHCCCEEEEEEECCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHC
ANLSSLELCVSSAAPLFPNTVNTFFNKFGKKIVQQYGFTEGFVLTFQPLEYADVISVGKP
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCC
LPEVEVKIVKDDGKEAKTGEVGELWVKAPWLMLGYKDIEETNKVFSNGWLKTGDLMSMDD
CCCEEEEEEECCCCCCCCCCCHHHHEECCCCEECCHHHHHHHHHHHCCCEECCCCCCCCC
KGLLYFRGIKKRMLKYKGYPIFPRDLEEILKTHPNVIDAKVIGEDAGQLGQQPIAIVVVK
CCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHCCCCCEEEEEEE
EKKDGIEEELLNYVNTKVAFYKKLKKVYIVDKIE
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]