Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 15921676

GI number: 15921676

Start: 1392293

End: 1392553

Strand: Reverse

Name: trxA [H]

Synonym: STS171

Alternate gene names: 15921676

Gene position: 1392553-1392293 (Counterclockwise)

Preceding gene: 15921677

Following gene: 15921675

Centisome position: 51.68

GC content: 36.4

Gene sequence:

>261_bases
GTGTTTGTAGATTGCTGGGCACCCTGGTGTGCTCCTTGCCATATCTACGAACCAATATTTAACAAAATGGCCGAGAAGTA
TAAGGATAAGATAGTATTTGGAAGGCTTAACGTTGACGAAAATCCAAAAACAGCAGATAAATATGGTGTCATGAATATAC
CAACTACCTTGATCTTTCTTAACGGTAATCTAGTAGATCAAATAGTAGGAGCCGTAGATGAGACTACGCTAGAAGAATAT
ATTAAAAAATATTTGTCATGA

Upstream 100 bases:

>100_bases
AAGATTAGAAGAAAAAGCCGAAAAAATATTAAAAAAGGAGGAAGCTACTATAACTATAACTGATAGTAACATAGACGACA
TAATAACAAAAAATAGAGTA

Downstream 100 bases:

>100_bases
GGAGTTTTCTTTAACTTTGTACTACTTAATCAATTATTTTTTATAATGCATTTTTAAGCAAAATTTTACATTTGCATAAT
CTGTAATTAAGAATTATATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 86; Mature: 86

Protein sequence:

>86_residues
MFVDCWAPWCAPCHIYEPIFNKMAEKYKDKIVFGRLNVDENPKTADKYGVMNIPTTLIFLNGNLVDQIVGAVDETTLEEY
IKKYLS

Sequences:

>Translated_86_residues
MFVDCWAPWCAPCHIYEPIFNKMAEKYKDKIVFGRLNVDENPKTADKYGVMNIPTTLIFLNGNLVDQIVGAVDETTLEEY
IKKYLS
>Mature_86_residues
MFVDCWAPWCAPCHIYEPIFNKMAEKYKDKIVFGRLNVDENPKTADKYGVMNIPTTLIFLNGNLVDQIVGAVDETTLEEY
IKKYLS

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=86, Percent_Identity=38.3720930232558, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082331, Length=86, Percent_Identity=41.8604651162791, Blast_Score=88, Evalue=8e-20,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=34.1176470588235, Blast_Score=75, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=44.1860465116279, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639826, Length=70, Percent_Identity=35.7142857142857, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 9922; Mature: 9922

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDCWAPWCAPCHIYEPIFNKMAEKYKDKIVFGRLNVDENPKTADKYGVMNIPTTLIFL
CEECCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCEEEEEE
NGNLVDQIVGAVDETTLEEYIKKYLS
CCCHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFVDCWAPWCAPCHIYEPIFNKMAEKYKDKIVFGRLNVDENPKTADKYGVMNIPTTLIFL
CEECCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCEEEEEE
NGNLVDQIVGAVDETTLEEYIKKYLS
CCCHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8756494; 8590279; 8905231; 9298645 [H]