Click here to switch to the map view.

The map label for this gene is trpE [H]

Identifier: 15921492

GI number: 15921492

Start: 1230187

End: 1231488

Strand: Reverse

Name: trpE [H]

Synonym: ST1229

Alternate gene names: 15921492

Gene position: 1231488-1230187 (Counterclockwise)

Preceding gene: 15921493

Following gene: 15921491

Centisome position: 45.7

GC content: 34.25

Gene sequence:

>1302_bases
ATGGAAATCTATCCTATAACTTCTTTTGCTCAACCTTATGAAGTATTTAAATGTATATTAGATGAGGCAGATATAGCAGC
ACTATTAGAAAGTGGTTCTGGTCCTCAACATAAATCGAGATATAGTATAATAGCATGGGGAAAGAAAGGGTATCTTAATA
TAAACGGAGTTAGGTCTTCTGGCGATATTAATGATAGCTTCTATGACCCTATCGAGGTCTTAGAGAAGTTTCTTTCCAAA
GCTCCTTTGCTTAATTTACCTGGAAGATTCAAAGGAGGTATAATTGGGTACGTTAGCTATGACGCTGTGAGATATTGGGA
ATCTATAAGAGATTTGAAGAGAGAGGCAGAAGAATGGCCTAATATGGAATTTTTTATACCAGAGAATGTTATAGTCTATG
ATCATATTGAAGGCAAAGTATATGTTGAGGGTGAGCTACCTAAGGTTACAATATGTAAGGATATTGGTAATGTGAAGTTC
GAATTTGAAATAGAATCTTTAGATAAAACGCAATTTGAAAAAGCTGTTTCGGACATCTTGGATTACATAAAAAATGGATA
TGCTTTTCAGATAGTAATTTCTAGGTTTTTAAGATATATTTACAGAGGAGATTTAATGAGTTTCTATTACAACCTAAGGA
AAATAAATCCATCTCCCTATATGTATTATTTAAAGTTTTATGATAGACATGTTATCGGATCTAGCCCAGAAACATTATTT
AGTTTGCAAGATGGTATAGTTGAGACGTATCCTATAGCTGGATCAAGACCTAGAGGAGCGACACCAGAAGAAGATTTGAA
TTTAGAAAAAGAACTTTTAGCTTCTGAGAAAGAAAGGGCTGAACATATAATGCTAGTTGATTTAGCTAGGAATGATATAG
GTAAAGTTTGTTACATGGGCTCAGTTAAGGTTCCTGAATTTATGTACATAGAAAAATATAGTCATGTACAACATATAGTA
AGTAAGGTAGTAGGTACATTAAAAAGAAATTATAGTGCATTTGACGTTTTAAAGGCTGTATTCCCTGCCGGTACTGTAAG
TGGAGCACCAAAACCCATGGCTATGAATGTTATTGAATTATTAGAGCCGTTTAAGAGAGGACCCTATGCTGGAGGAGTAG
GTTTCTTTTCGGCTAATGGTGATGCAGAATTTGCAATAACTATAAGAAGTGCTTTTGTAAATAAAGATTTATTCAGAATT
CAAGCCGGTGCTGGTATAGTTTATGACTCAATACCGGAAATGGAATATTATGAGACTGAACATAAAATGAGAGCCTTAAA
AGTTGCTATGGGGGTAGTTTAG

Upstream 100 bases:

>100_bases
GCTTAAACCCTTATTGGATAGATATTTCTTCTGGTATTGAAAAGTATAAATCAAAGAAAGATCACGATAAAATGATTAGA
ATAGCTGAAAAGGTGAAAGA

Downstream 100 bases:

>100_bases
ATGGATTTAACGCTCATCATAGATAACTATGATAGTTTTGTATATAATATTGCTCAAATAGTAGGAGAATTAGGAAGCTA
TCCTATAGTTATAAGGAACG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MEIYPITSFAQPYEVFKCILDEADIAALLESGSGPQHKSRYSIIAWGKKGYLNINGVRSSGDINDSFYDPIEVLEKFLSK
APLLNLPGRFKGGIIGYVSYDAVRYWESIRDLKREAEEWPNMEFFIPENVIVYDHIEGKVYVEGELPKVTICKDIGNVKF
EFEIESLDKTQFEKAVSDILDYIKNGYAFQIVISRFLRYIYRGDLMSFYYNLRKINPSPYMYYLKFYDRHVIGSSPETLF
SLQDGIVETYPIAGSRPRGATPEEDLNLEKELLASEKERAEHIMLVDLARNDIGKVCYMGSVKVPEFMYIEKYSHVQHIV
SKVVGTLKRNYSAFDVLKAVFPAGTVSGAPKPMAMNVIELLEPFKRGPYAGGVGFFSANGDAEFAITIRSAFVNKDLFRI
QAGAGIVYDSIPEMEYYETEHKMRALKVAMGVV

Sequences:

>Translated_433_residues
MEIYPITSFAQPYEVFKCILDEADIAALLESGSGPQHKSRYSIIAWGKKGYLNINGVRSSGDINDSFYDPIEVLEKFLSK
APLLNLPGRFKGGIIGYVSYDAVRYWESIRDLKREAEEWPNMEFFIPENVIVYDHIEGKVYVEGELPKVTICKDIGNVKF
EFEIESLDKTQFEKAVSDILDYIKNGYAFQIVISRFLRYIYRGDLMSFYYNLRKINPSPYMYYLKFYDRHVIGSSPETLF
SLQDGIVETYPIAGSRPRGATPEEDLNLEKELLASEKERAEHIMLVDLARNDIGKVCYMGSVKVPEFMYIEKYSHVQHIV
SKVVGTLKRNYSAFDVLKAVFPAGTVSGAPKPMAMNVIELLEPFKRGPYAGGVGFFSANGDAEFAITIRSAFVNKDLFRI
QAGAGIVYDSIPEMEYYETEHKMRALKVAMGVV
>Mature_433_residues
MEIYPITSFAQPYEVFKCILDEADIAALLESGSGPQHKSRYSIIAWGKKGYLNINGVRSSGDINDSFYDPIEVLEKFLSK
APLLNLPGRFKGGIIGYVSYDAVRYWESIRDLKREAEEWPNMEFFIPENVIVYDHIEGKVYVEGELPKVTICKDIGNVKF
EFEIESLDKTQFEKAVSDILDYIKNGYAFQIVISRFLRYIYRGDLMSFYYNLRKINPSPYMYYLKFYDRHVIGSSPETLF
SLQDGIVETYPIAGSRPRGATPEEDLNLEKELLASEKERAEHIMLVDLARNDIGKVCYMGSVKVPEFMYIEKYSHVQHIV
SKVVGTLKRNYSAFDVLKAVFPAGTVSGAPKPMAMNVIELLEPFKRGPYAGGVGFFSANGDAEFAITIRSAFVNKDLFRI
QAGAGIVYDSIPEMEYYETEHKMRALKVAMGVV

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=401, Percent_Identity=33.9152119700748, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1788114, Length=420, Percent_Identity=31.6666666666667, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI87082077, Length=268, Percent_Identity=27.6119402985075, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786809, Length=270, Percent_Identity=28.8888888888889, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320935, Length=433, Percent_Identity=36.9515011547344, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6324361, Length=365, Percent_Identity=24.9315068493151, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR010116
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 49212; Mature: 49212

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIYPITSFAQPYEVFKCILDEADIAALLESGSGPQHKSRYSIIAWGKKGYLNINGVRSS
CEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCC
GDINDSFYDPIEVLEKFLSKAPLLNLPGRFKGGIIGYVSYDAVRYWESIRDLKREAEEWP
CCCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCC
NMEFFIPENVIVYDHIEGKVYVEGELPKVTICKDIGNVKFEFEIESLDKTQFEKAVSDIL
CCEEECCCCEEEEEECCCEEEEECCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHH
DYIKNGYAFQIVISRFLRYIYRGDLMSFYYNLRKINPSPYMYYLKFYDRHVIGSSPETLF
HHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHCCCCCHHHH
SLQDGIVETYPIAGSRPRGATPEEDLNLEKELLASEKERAEHIMLVDLARNDIGKVCYMG
HHHCCCEEEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEC
SVKVPEFMYIEKYSHVQHIVSKVVGTLKRNYSAFDVLKAVFPAGTVSGAPKPMAMNVIEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LEPFKRGPYAGGVGFFSANGDAEFAITIRSAFVNKDLFRIQAGAGIVYDSIPEMEYYETE
HHHHHCCCCCCCEEEEECCCCCEEEEEEEHHHHCCCCEEEECCCCEEECCCCCCHHHHHH
HKMRALKVAMGVV
HHHHHHHHHHCCC
>Mature Secondary Structure
MEIYPITSFAQPYEVFKCILDEADIAALLESGSGPQHKSRYSIIAWGKKGYLNINGVRSS
CEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCC
GDINDSFYDPIEVLEKFLSKAPLLNLPGRFKGGIIGYVSYDAVRYWESIRDLKREAEEWP
CCCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCC
NMEFFIPENVIVYDHIEGKVYVEGELPKVTICKDIGNVKFEFEIESLDKTQFEKAVSDIL
CCEEECCCCEEEEEECCCEEEEECCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHH
DYIKNGYAFQIVISRFLRYIYRGDLMSFYYNLRKINPSPYMYYLKFYDRHVIGSSPETLF
HHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHCCCCCHHHH
SLQDGIVETYPIAGSRPRGATPEEDLNLEKELLASEKERAEHIMLVDLARNDIGKVCYMG
HHHCCCEEEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEC
SVKVPEFMYIEKYSHVQHIVSKVVGTLKRNYSAFDVLKAVFPAGTVSGAPKPMAMNVIEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LEPFKRGPYAGGVGFFSANGDAEFAITIRSAFVNKDLFRIQAGAGIVYDSIPEMEYYETE
HHHHHCCCCCCCEEEEECCCCCEEEEEEEHHHHCCCCEEEECCCCEEECCCCCCHHHHHH
HKMRALKVAMGVV
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8416906; 9016772; 11427726; 10449718 [H]