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Identifier: 15921483

GI number: 15921483

Start: 1221782

End: 1222396

Strand: Reverse

Name: ogg

Synonym: ST1219

Alternate gene names: 15921483

Gene position: 1222396-1221782 (Counterclockwise)

Preceding gene: 15921484

Following gene: 15921482

Centisome position: 45.36

GC content: 27.97

Gene sequence:

>615_bases
GTGCTAAGAGAGCTAGTAAAAAACAAAAAGCTAAGAGCAAGAGTGCTAGAAAGAGCAGAAGAGTTTAAATTAAATAACAG
AGCTGAAGAGAATGTTTGGTTTAGAGAATTAATTTTATGTATTTTAACCTCAAATAGTTCTTTTATATCTGCGTATAAAG
CTCTAAATTATATAATGGACGAAATTTTTTCTCTAAGTGAAGATCAGATGAGCAAAAGACTTAGATTAGCCGGTTATAGA
TTTTACAATTTAAAAGCAAAATATATAGCAAATGCAAGAAAATTATATGGAAATTTGAAAACAAAAATAAAACCTATTGC
TGATTATTCACAAGAAGAAGCCAGGCAGTATATCATAAATAACATTGACGGATTAGGATTGAAAGAATCTAGCCATTTCT
TGAGAAACGTAGGCTATTTCGATTTAGCAATTATAGATAGACATGTGCTACATTTCCTTAACGAAATTGGCACTAGTAAT
TTAAAAATTAAAAATAAAAAGGACTATTATTTAGCTGAAAGTATACTTAAATCAATTAGTATTAATCTTGGTATTCAAGT
TGGACTACTTGATTTGTATATATTTTTTAAACAAACCAATACAATCGTAAAGTAG

Upstream 100 bases:

>100_bases
GAGTTTGATGAAGGTTACACTAAAGTTGTGTTAAAAGATGAATTTTCAGAGGTTAAACCTAAGAAGGAGAAAATAAAGAA
GGCTAAGAGGAAGAAGAAAG

Downstream 100 bases:

>100_bases
AATAAAAAAATATAAAAATGAGTAGCAAATGGATATCATGAATTAAAATGAACACAAATAAGTTCCTAGAAAATTTTGAG
AAGTTATATAACTATACTTC

Product: N-glycosylase/DNA lyase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLRELVKNKKLRARVLERAEEFKLNNRAEENVWFRELILCILTSNSSFISAYKALNYIMDEIFSLSEDQMSKRLRLAGYR
FYNLKAKYIANARKLYGNLKTKIKPIADYSQEEARQYIINNIDGLGLKESSHFLRNVGYFDLAIIDRHVLHFLNEIGTSN
LKIKNKKDYYLAESILKSISINLGIQVGLLDLYIFFKQTNTIVK

Sequences:

>Translated_204_residues
MLRELVKNKKLRARVLERAEEFKLNNRAEENVWFRELILCILTSNSSFISAYKALNYIMDEIFSLSEDQMSKRLRLAGYR
FYNLKAKYIANARKLYGNLKTKIKPIADYSQEEARQYIINNIDGLGLKESSHFLRNVGYFDLAIIDRHVLHFLNEIGTSN
LKIKNKKDYYLAESILKSISINLGIQVGLLDLYIFFKQTNTIVK
>Mature_204_residues
MLRELVKNKKLRARVLERAEEFKLNNRAEENVWFRELILCILTSNSSFISAYKALNYIMDEIFSLSEDQMSKRLRLAGYR
FYNLKAKYIANARKLYGNLKTKIKPIADYSQEEARQYIINNIDGLGLKESSHFLRNVGYFDLAIIDRHVLHFLNEIGTSN
LKIKNKKDYYLAESILKSISINLGIQVGLLDLYIFFKQTNTIVK

Specific function: Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites)

COG id: COG1059

COG function: function code L; Thermostable 8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-2 OGG1 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OGG1_SULTO (Q972A8)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377152.1
- ProteinModelPortal:   Q972A8
- GeneID:   1459218
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1219
- NMPDR:   fig|273063.1.peg.1320
- HOGENOM:   HBG430608
- OMA:   FSELSFC
- ProtClustDB:   PRK01229
- BioCyc:   STOK273063:ST1219-MONOMER
- BRENDA:   4.2.99.18
- HAMAP:   MF_00241
- InterPro:   IPR012092
- InterPro:   IPR011257
- PIRSF:   PIRSF005954

Pfam domain/function: SSF48150 DNA_glycsylse

EC number: =4.2.99.18

Molecular weight: Translated: 23886; Mature: 23886

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRELVKNKKLRARVLERAEEFKLNNRAEENVWFRELILCILTSNSSFISAYKALNYIMD
CCHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EIFSLSEDQMSKRLRLAGYRFYNLKAKYIANARKLYGNLKTKIKPIADYSQEEARQYIIN
HHHCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NIDGLGLKESSHFLRNVGYFDLAIIDRHVLHFLNEIGTSNLKIKNKKDYYLAESILKSIS
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHH
INLGIQVGLLDLYIFFKQTNTIVK
HHCCEEEHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLRELVKNKKLRARVLERAEEFKLNNRAEENVWFRELILCILTSNSSFISAYKALNYIMD
CCHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EIFSLSEDQMSKRLRLAGYRFYNLKAKYIANARKLYGNLKTKIKPIADYSQEEARQYIIN
HHHCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NIDGLGLKESSHFLRNVGYFDLAIIDRHVLHFLNEIGTSNLKIKNKKDYYLAESILKSIS
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHH
INLGIQVGLLDLYIFFKQTNTIVK
HHCCEEEHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479