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The map label for this gene is serA [H]

Identifier: 15921482

GI number: 15921482

Start: 1220650

End: 1221591

Strand: Reverse

Name: serA [H]

Synonym: ST1218

Alternate gene names: 15921482

Gene position: 1221591-1220650 (Counterclockwise)

Preceding gene: 15921483

Following gene: 15921481

Centisome position: 45.33

GC content: 31.74

Gene sequence:

>942_bases
ATGGCTATCTATACTGTTAAGGCCTTAATAACAGATCCTATAGATGAAATTCTAATTAAAACTTTGAGAGAAAAAGGAAT
TCAAGTAGATTATATGCCAGAAATAAGCAAAGAAGAATTACTTAATATAATCGGTAATTATGATATTATAGTAGTGAGAA
GTAGAACTAAAGTGACTAAAGATGTTATAGAAAAAGGCAAAAAACTAAAAATTATTGCTAGGGCTGGAATTGGACTTGAT
AATATAGATACTGAAGAGGCTGAAAAAAGAAATATAAAAGTTGTTTATGCTCCTGGTGCCTCTACTGATTCTGCAGTAGA
ATTAACTATTGGACTCATGATAGCGGCAGCAAGGAAAATGTACACTTCTATGGCTTTAGCAAAATCTGGTATATTTAAAA
AAATTGAGGGACTAGAATTAGCGGGAAAAACTATCGGGATTGTAGGTTTCGGAAGAATTGGTACTAAGGTTGGAATAATA
GCAAATGCAATGGGAATGAAAGTATTAGCTTACGATATTTTAGATATAAGAGAGAAAGCCGAGAAAATAAACGCAAAAGC
AGTAAGTTTAGAGGAATTATTAAAAAATTCTGATGTAATAAGTCTTCATGTTACTGTGAGTAAAGATGCAAAACCAATAA
TTGACTATCCGCAATTTGAACTAATGAAAGATAATGTTATAATTGTAAACACCAGTAGAGCAGTTGCCGTTAATGGTAAA
GCACTTTTAGATTATATTAAGAAAGGAAAAGTTTATGCTTATGCTACTGATGTATTTTGGAATGAACCACCAAAGGAAGA
ATGGGAATTAGAATTATTAAAACATGAAAGAGTTATTGTTACAACTCATATTGGTGCTCAAACCAAAGAGGCTCAAAAAA
GGGTAGCAGAAATGACTACTCAAAACTTGCTTAACGCTATGAAAGAGTTAGGGATGATATAA

Upstream 100 bases:

>100_bases
ACTATACTTCTTATTATTATGACTTCTTCTTCTCTTCTTCATTTTCATCATCATGTTAAACTTCTTTCTCTATTTATAAA
TAAAAAGGGGTGTTCTATGC

Downstream 100 bases:

>100_bases
AATGCTTTTAATTCCTGGACCAGTTGAAGTACCAAGAAGCGTAAGAGAAGCCTCAACATTAGTAGTTAATCACAGAAGTG
AAAAATTTAGAGAGATAGTA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MAIYTVKALITDPIDEILIKTLREKGIQVDYMPEISKEELLNIIGNYDIIVVRSRTKVTKDVIEKGKKLKIIARAGIGLD
NIDTEEAEKRNIKVVYAPGASTDSAVELTIGLMIAAARKMYTSMALAKSGIFKKIEGLELAGKTIGIVGFGRIGTKVGII
ANAMGMKVLAYDILDIREKAEKINAKAVSLEELLKNSDVISLHVTVSKDAKPIIDYPQFELMKDNVIIVNTSRAVAVNGK
ALLDYIKKGKVYAYATDVFWNEPPKEEWELELLKHERVIVTTHIGAQTKEAQKRVAEMTTQNLLNAMKELGMI

Sequences:

>Translated_313_residues
MAIYTVKALITDPIDEILIKTLREKGIQVDYMPEISKEELLNIIGNYDIIVVRSRTKVTKDVIEKGKKLKIIARAGIGLD
NIDTEEAEKRNIKVVYAPGASTDSAVELTIGLMIAAARKMYTSMALAKSGIFKKIEGLELAGKTIGIVGFGRIGTKVGII
ANAMGMKVLAYDILDIREKAEKINAKAVSLEELLKNSDVISLHVTVSKDAKPIIDYPQFELMKDNVIIVNTSRAVAVNGK
ALLDYIKKGKVYAYATDVFWNEPPKEEWELELLKHERVIVTTHIGAQTKEAQKRVAEMTTQNLLNAMKELGMI
>Mature_312_residues
AIYTVKALITDPIDEILIKTLREKGIQVDYMPEISKEELLNIIGNYDIIVVRSRTKVTKDVIEKGKKLKIIARAGIGLDN
IDTEEAEKRNIKVVYAPGASTDSAVELTIGLMIAAARKMYTSMALAKSGIFKKIEGLELAGKTIGIVGFGRIGTKVGIIA
NAMGMKVLAYDILDIREKAEKINAKAVSLEELLKNSDVISLHVTVSKDAKPIIDYPQFELMKDNVIIVNTSRAVAVNGKA
LLDYIKKGKVYAYATDVFWNEPPKEEWELELLKHERVIVTTHIGAQTKEAQKRVAEMTTQNLLNAMKELGMI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=293, Percent_Identity=37.8839590443686, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI6912396, Length=283, Percent_Identity=27.5618374558304, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI61743967, Length=217, Percent_Identity=31.3364055299539, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4557497, Length=217, Percent_Identity=31.3364055299539, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI145580578, Length=217, Percent_Identity=29.4930875576037, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557499, Length=217, Percent_Identity=29.4930875576037, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580575, Length=217, Percent_Identity=29.4930875576037, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1789279, Length=298, Percent_Identity=33.8926174496644, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1787645, Length=321, Percent_Identity=26.1682242990654, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI87082289, Length=261, Percent_Identity=28.3524904214559, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788660, Length=256, Percent_Identity=27.34375, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=301, Percent_Identity=35.8803986710963, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI25147481, Length=213, Percent_Identity=32.3943661971831, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=305, Percent_Identity=33.1147540983607, Blast_Score=172, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6322116, Length=302, Percent_Identity=31.7880794701987, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324055, Length=247, Percent_Identity=28.3400809716599, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6324964, Length=274, Percent_Identity=28.1021897810219, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=188, Percent_Identity=29.7872340425532, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921140, Length=299, Percent_Identity=35.4515050167224, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI28571528, Length=313, Percent_Identity=31.3099041533546, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24646446, Length=263, Percent_Identity=30.4182509505703, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646448, Length=263, Percent_Identity=30.4182509505703, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646452, Length=263, Percent_Identity=30.4182509505703, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646450, Length=263, Percent_Identity=30.4182509505703, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI62472511, Length=263, Percent_Identity=30.4182509505703, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28574286, Length=300, Percent_Identity=27.3333333333333, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585514, Length=321, Percent_Identity=26.1682242990654, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574282, Length=321, Percent_Identity=26.1682242990654, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574284, Length=321, Percent_Identity=26.1682242990654, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45552429, Length=321, Percent_Identity=26.1682242990654, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45551003, Length=321, Percent_Identity=26.1682242990654, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24585516, Length=323, Percent_Identity=26.0061919504644, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34658; Mature: 34527

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIYTVKALITDPIDEILIKTLREKGIQVDYMPEISKEELLNIIGNYDIIVVRSRTKVTK
CCEEEEHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECCCHHHH
DVIEKGKKLKIIARAGIGLDNIDTEEAEKRNIKVVYAPGASTDSAVELTIGLMIAAARKM
HHHHCCCEEEEEEECCCCCCCCCCCCHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHH
YTSMALAKSGIFKKIEGLELAGKTIGIVGFGRIGTKVGIIANAMGMKVLAYDILDIREKA
HHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKINAKAVSLEELLKNSDVISLHVTVSKDAKPIIDYPQFELMKDNVIIVNTSRAVAVNGK
HHHCCHHCCHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEECCCEEEEECCCEEEECCH
ALLDYIKKGKVYAYATDVFWNEPPKEEWELELLKHERVIVTTHIGAQTKEAQKRVAEMTT
HHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
QNLLNAMKELGMI
HHHHHHHHHHCCC
>Mature Secondary Structure 
AIYTVKALITDPIDEILIKTLREKGIQVDYMPEISKEELLNIIGNYDIIVVRSRTKVTK
CEEEEHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECCCHHHH
DVIEKGKKLKIIARAGIGLDNIDTEEAEKRNIKVVYAPGASTDSAVELTIGLMIAAARKM
HHHHCCCEEEEEEECCCCCCCCCCCCHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHH
YTSMALAKSGIFKKIEGLELAGKTIGIVGFGRIGTKVGIIANAMGMKVLAYDILDIREKA
HHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKINAKAVSLEELLKNSDVISLHVTVSKDAKPIIDYPQFELMKDNVIIVNTSRAVAVNGK
HHHCCHHCCHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEECCCEEEEECCCEEEECCH
ALLDYIKKGKVYAYATDVFWNEPPKEEWELELLKHERVIVTTHIGAQTKEAQKRVAEMTT
HHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
QNLLNAMKELGMI
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]