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The map label for this gene is nadC [H]

Identifier: 15921461

GI number: 15921461

Start: 1200573

End: 1201403

Strand: Reverse

Name: nadC [H]

Synonym: ST1198

Alternate gene names: 15921461

Gene position: 1201403-1200573 (Counterclockwise)

Preceding gene: 15921462

Following gene: 15921460

Centisome position: 44.58

GC content: 31.77

Gene sequence:

>831_bases
ATGATAAAACAAATAATGATAAACAAACTCTTATCATTACTTGAAGAAGACACATACCCAGAAGACGTGACAAGTAAAAT
AGTTTCTGGGATAAAATGTAAAGCCATAATAATATCTAAAGATGAGGGAATATTAGCCGGTCAAAAGTTCATTATTCCTT
TCTTAGAATATTTAGGAATAAAGATAGAAAATTATATGAAAGATGGAACACAAATAAAGAAAAAAGATATAGTATTAGAG
ATAGAAGGAGACGCAGAAACAATCTTAGGAGTAGAGAGATTAGTACTGAATCTATTAGGCAAATTATCTGGTATATCTAC
AGTAACCCACTTGATGACAAGACTGGCTAAGAGTGTAAACCCTTATGTTAGAATAGCTGGGACCAGGAAAACAACTCCAG
GTTTAAGAGTATTTGAAAAATACGCAATTGAAGTAGGTGGAGGAGATCCTCACAGATTTAATCTTTCCGATGCAGTGTTA
ATAAAAGATAATCACATTGCTCTAATCGGAAGTGTAAAAGAAGCTATAAGGAGAGCTAAAGAAATAACAAGTTTTACTAA
AAAAATTGAGGTTGAAGTATCAAGTTTAAAAGATGCATTAGAAGCATATCAAGCTGGTGCAGATGCTATACTTTTAGATA
ATATGAAACCAGAAGAAATAATACCAGTAGTAAATGAATTAAAAGGGAAAGTAATAGTAGAAGCTTCTGGCGGAATAAAT
CCAGATAATGTAATTGAATATGCAAAAACGGGGGTTGACATTATTTCAAGTGGTTATATAACCCATAGTTCAAGGTCATT
AGACTTCTCTCTTGATGTATATAAATCATAA

Upstream 100 bases:

>100_bases
AAAAATATTACGAAATAAGATATAAAGTTTATTTTTGCTTTGATTGACCGACATGTTTTAAAGACTAATTTTTATTTTCA
CTATAACTCACTTTTCGTAA

Downstream 100 bases:

>100_bases
AAACAAATTTTCGATAGTAATATTTAAAAACTTAAAATGCACAGAACACATGTTCGGGGATATATGCCAGACGCAGTGGA
GTTAATAAAAGAAATAAAGA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MIKQIMINKLLSLLEEDTYPEDVTSKIVSGIKCKAIIISKDEGILAGQKFIIPFLEYLGIKIENYMKDGTQIKKKDIVLE
IEGDAETILGVERLVLNLLGKLSGISTVTHLMTRLAKSVNPYVRIAGTRKTTPGLRVFEKYAIEVGGGDPHRFNLSDAVL
IKDNHIALIGSVKEAIRRAKEITSFTKKIEVEVSSLKDALEAYQAGADAILLDNMKPEEIIPVVNELKGKVIVEASGGIN
PDNVIEYAKTGVDIISSGYITHSSRSLDFSLDVYKS

Sequences:

>Translated_276_residues
MIKQIMINKLLSLLEEDTYPEDVTSKIVSGIKCKAIIISKDEGILAGQKFIIPFLEYLGIKIENYMKDGTQIKKKDIVLE
IEGDAETILGVERLVLNLLGKLSGISTVTHLMTRLAKSVNPYVRIAGTRKTTPGLRVFEKYAIEVGGGDPHRFNLSDAVL
IKDNHIALIGSVKEAIRRAKEITSFTKKIEVEVSSLKDALEAYQAGADAILLDNMKPEEIIPVVNELKGKVIVEASGGIN
PDNVIEYAKTGVDIISSGYITHSSRSLDFSLDVYKS
>Mature_276_residues
MIKQIMINKLLSLLEEDTYPEDVTSKIVSGIKCKAIIISKDEGILAGQKFIIPFLEYLGIKIENYMKDGTQIKKKDIVLE
IEGDAETILGVERLVLNLLGKLSGISTVTHLMTRLAKSVNPYVRIAGTRKTTPGLRVFEKYAIEVGGGDPHRFNLSDAVL
IKDNHIALIGSVKEAIRRAKEITSFTKKIEVEVSSLKDALEAYQAGADAILLDNMKPEEIIPVVNELKGKVIVEASGGIN
PDNVIEYAKTGVDIISSGYITHSSRSLDFSLDVYKS

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=267, Percent_Identity=39.7003745318352, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI1786299, Length=254, Percent_Identity=34.251968503937, Blast_Score=144, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6321162, Length=272, Percent_Identity=39.3382352941176, Blast_Score=179, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30318; Mature: 30318

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQIMINKLLSLLEEDTYPEDVTSKIVSGIKCKAIIISKDEGILAGQKFIIPFLEYLGI
CHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCC
KIENYMKDGTQIKKKDIVLEIEGDAETILGVERLVLNLLGKLSGISTVTHLMTRLAKSVN
HHHHHHCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PYVRIAGTRKTTPGLRVFEKYAIEVGGGDPHRFNLSDAVLIKDNHIALIGSVKEAIRRAK
CEEEEECCCCCCCCHHHHHHHEEEECCCCCCEECCCCEEEEECCCEEEEHHHHHHHHHHH
EITSFTKKIEVEVSSLKDALEAYQAGADAILLDNMKPEEIIPVVNELKGKVIVEASGGIN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCCC
PDNVIEYAKTGVDIISSGYITHSSRSLDFSLDVYKS
HHHHHHHHHHCHHHHHCCCEEECCCCEEEEEEEECC
>Mature Secondary Structure
MIKQIMINKLLSLLEEDTYPEDVTSKIVSGIKCKAIIISKDEGILAGQKFIIPFLEYLGI
CHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCC
KIENYMKDGTQIKKKDIVLEIEGDAETILGVERLVLNLLGKLSGISTVTHLMTRLAKSVN
HHHHHHCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PYVRIAGTRKTTPGLRVFEKYAIEVGGGDPHRFNLSDAVLIKDNHIALIGSVKEAIRRAK
CEEEEECCCCCCCCHHHHHHHEEEECCCCCCEECCCCEEEEECCCEEEEHHHHHHHHHHH
EITSFTKKIEVEVSSLKDALEAYQAGADAILLDNMKPEEIIPVVNELKGKVIVEASGGIN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCCC
PDNVIEYAKTGVDIISSGYITHSSRSLDFSLDVYKS
HHHHHHHHHHCHHHHHCCCEEECCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]