Click here to switch to the map view.

The map label for this gene is purK [H]

Identifier: 15921042

GI number: 15921042

Start: 784616

End: 785710

Strand: Direct

Name: purK [H]

Synonym: ST0807

Alternate gene names: 15921042

Gene position: 784616-785710 (Clockwise)

Preceding gene: 15921041

Following gene: 15921043

Centisome position: 29.12

GC content: 34.52

Gene sequence:

>1095_bases
ATGAAGTCCTTAACACAAAACTCGATTAAAATTGGAATTTTAGGAGGAGGACAATTAGGCTGGATGATGATTTTAGAAGG
GAGAAAATATCCCTTCGCTTTTTACGTAATGGACGAGCCAGAAGCTCCTGCATGTAAAGTAGCGGATAAATGTTTTACGC
CAGATGACTATAAGAAAATGATAGATGAAGTTGACGTAGTAACTTTTGAGTTCGAACATGTCAAAGAAGAGGCATTACAG
TATGCTGAAGATCAAGGGAAACTTTTGCCCAGGTTAAATACTGTTGAATTAAAAAGGGAAAGATGGAAGGAAAAAACATA
TTATAAGGAACATAATTTGCCAACTCCTAGATTTTACATTGCTAACGACGGAGAAGAGGCATTAAGAATTCTTAAGGACG
AGTTTAATAACGTTGGTGTTTTGAAACAGAGTAGGGGAGGATATGACGGTAAAGGACAGTATTTTATAAAGGGAGATGTC
GAAAAATACGGATTCATTAAGGATATGAAGTGTAAATTTGTAGTTGAAGAATTTGTTAATTTTAATTATGAGGCTTCTAT
AATAGCTGTTAGAGATCGAAATGGAAATTTTAAGGCATATCCACCAACATTCAACTATAACGAAAAAGGAATCCTGGTAT
ACAACTACGGTCCCCTTAAAGATAACAGATTTGCTGAGATTGCAAAGAGGTTAATGGATTCTTTAGAATATGTAGGTACA
ATTGGTATTGAGTTTTTTGTAAGAGATGGGGAAATTCTAATAAATGAGTTTGCTCCTAGAGTTCATAATACTGGTCACTA
TACTCTAGATGCAGCATTTGTTTCACAATTTGAACAACATTTGCGAGCAATAACTGGCCTGGAAATAGGTGCTACAGAGC
TACTCTCATATGGAGGTATGGTGAATATTTTAGGTACAGATAATGTTCCTCTTGAAGTTCTTAAATATGGTAAAGTGTAT
TGGTATGGGAAGAAAGAAGTTAGAAAGAGGAGAAAGTTGGGGCATGTCAATGTAGTTGGAAGTAACTTAGAAGATGTTAA
GCAAAAAATTGATATTATTATGAAACTAATTTATCCTCAAGGTTTAGATTTATGA

Upstream 100 bases:

>100_bases
GGTGGGGCTAAAAATGCTGCACTTTTGGCATTAAGAATTTTAGGACTAAAATACCCAGATATAGCTGAAAAAGTTAAAAA
GTTTATGGAGGATGTGAAAA

Downstream 100 bases:

>100_bases
AGTTTAAGTTTAAAATATGGTTAGAAACTGATGACGGAAAACCTGTTATTGGTAAAGGTGGAATTTCTCTGATGAAGAAC
ATCATAGAAACGGGCTCAAT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKSLTQNSIKIGILGGGQLGWMMILEGRKYPFAFYVMDEPEAPACKVADKCFTPDDYKKMIDEVDVVTFEFEHVKEEALQ
YAEDQGKLLPRLNTVELKRERWKEKTYYKEHNLPTPRFYIANDGEEALRILKDEFNNVGVLKQSRGGYDGKGQYFIKGDV
EKYGFIKDMKCKFVVEEFVNFNYEASIIAVRDRNGNFKAYPPTFNYNEKGILVYNYGPLKDNRFAEIAKRLMDSLEYVGT
IGIEFFVRDGEILINEFAPRVHNTGHYTLDAAFVSQFEQHLRAITGLEIGATELLSYGGMVNILGTDNVPLEVLKYGKVY
WYGKKEVRKRRKLGHVNVVGSNLEDVKQKIDIIMKLIYPQGLDL

Sequences:

>Translated_364_residues
MKSLTQNSIKIGILGGGQLGWMMILEGRKYPFAFYVMDEPEAPACKVADKCFTPDDYKKMIDEVDVVTFEFEHVKEEALQ
YAEDQGKLLPRLNTVELKRERWKEKTYYKEHNLPTPRFYIANDGEEALRILKDEFNNVGVLKQSRGGYDGKGQYFIKGDV
EKYGFIKDMKCKFVVEEFVNFNYEASIIAVRDRNGNFKAYPPTFNYNEKGILVYNYGPLKDNRFAEIAKRLMDSLEYVGT
IGIEFFVRDGEILINEFAPRVHNTGHYTLDAAFVSQFEQHLRAITGLEIGATELLSYGGMVNILGTDNVPLEVLKYGKVY
WYGKKEVRKRRKLGHVNVVGSNLEDVKQKIDIIMKLIYPQGLDL
>Mature_364_residues
MKSLTQNSIKIGILGGGQLGWMMILEGRKYPFAFYVMDEPEAPACKVADKCFTPDDYKKMIDEVDVVTFEFEHVKEEALQ
YAEDQGKLLPRLNTVELKRERWKEKTYYKEHNLPTPRFYIANDGEEALRILKDEFNNVGVLKQSRGGYDGKGQYFIKGDV
EKYGFIKDMKCKFVVEEFVNFNYEASIIAVRDRNGNFKAYPPTFNYNEKGILVYNYGPLKDNRFAEIAKRLMDSLEYVGT
IGIEFFVRDGEILINEFAPRVHNTGHYTLDAAFVSQFEQHLRAITGLEIGATELLSYGGMVNILGTDNVPLEVLKYGKVY
WYGKKEVRKRRKLGHVNVVGSNLEDVKQKIDIIMKLIYPQGLDL

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=357, Percent_Identity=29.1316526610644, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1788155, Length=379, Percent_Identity=24.802110817942, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324702, Length=399, Percent_Identity=29.5739348370927, Blast_Score=162, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41927; Mature: 41927

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLTQNSIKIGILGGGQLGWMMILEGRKYPFAFYVMDEPEAPACKVADKCFTPDDYKKM
CCCCCCCCEEEEEEECCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHH
IDEVDVVTFEFEHVKEEALQYAEDQGKLLPRLNTVELKRERWKEKTYYKEHNLPTPRFYI
HHHHHEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
ANDGEEALRILKDEFNNVGVLKQSRGGYDGKGQYFIKGDVEKYGFIKDMKCKFVVEEFVN
ECCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEECCHHHCCEECCHHHHHHHHHHC
FNYEASIIAVRDRNGNFKAYPPTFNYNEKGILVYNYGPLKDNRFAEIAKRLMDSLEYVGT
CCCEEEEEEEEECCCCEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHEE
IGIEFFVRDGEILINEFAPRVHNTGHYTLDAAFVSQFEQHLRAITGLEIGATELLSYGGM
EEEEEEEECCEEEEEHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCE
VNILGTDNVPLEVLKYGKVYWYGKKEVRKRRKLGHVNVVGSNLEDVKQKIDIIMKLIYPQ
EEEEECCCCCHHHEECCCEEEECHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCC
GLDL
CCCC
>Mature Secondary Structure
MKSLTQNSIKIGILGGGQLGWMMILEGRKYPFAFYVMDEPEAPACKVADKCFTPDDYKKM
CCCCCCCCEEEEEEECCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHH
IDEVDVVTFEFEHVKEEALQYAEDQGKLLPRLNTVELKRERWKEKTYYKEHNLPTPRFYI
HHHHHEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
ANDGEEALRILKDEFNNVGVLKQSRGGYDGKGQYFIKGDVEKYGFIKDMKCKFVVEEFVN
ECCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEECCHHHCCEECCHHHHHHHHHHC
FNYEASIIAVRDRNGNFKAYPPTFNYNEKGILVYNYGPLKDNRFAEIAKRLMDSLEYVGT
CCCEEEEEEEEECCCCEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHEE
IGIEFFVRDGEILINEFAPRVHNTGHYTLDAAFVSQFEQHLRAITGLEIGATELLSYGGM
EEEEEEEECCEEEEEHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCE
VNILGTDNVPLEVLKYGKVYWYGKKEVRKRRKLGHVNVVGSNLEDVKQKIDIIMKLIYPQ
EEEEECCCCCHHHEECCCEEEECHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCC
GLDL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9311113; 11427726 [H]