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The map label for this gene is purE [H]

Identifier: 15921041

GI number: 15921041

Start: 784171

End: 784644

Strand: Direct

Name: purE [H]

Synonym: ST0806

Alternate gene names: 15921041

Gene position: 784171-784644 (Clockwise)

Preceding gene: 15921037

Following gene: 15921042

Centisome position: 29.1

GC content: 37.76

Gene sequence:

>474_bases
ATGCCTAAAGTAGCTGTTATTATGGGTAGTAAATCAGACTGGGAATATATGAAAGAAGCAGTAGAACTTTTAAAACAATT
TGGTGTTGAAGTTGAGGCTAGAGTAGTTTCAGCCCACAGAACACCAGAATTTATGATGGAATTTGCTAAAACCGCATCAG
AGAAGGGAATAGAAGTTATTATAGCTGGTGCAGGTGGTGCGGCTCATTTACCTGGTATGACAGCATCATTAACTCATTTG
CCAGTAATTGGTGTTCCGATTCCTTCAAAGAATTTGAATGGCTTAGATTCTCTCCTCTCTATTGTTCAAATGCCTTATGG
TGTACCAGTCGCGACAGTTGCTATTGGTGGGGCTAAAAATGCTGCACTTTTGGCATTAAGAATTTTAGGACTAAAATACC
CAGATATAGCTGAAAAAGTTAAAAAGTTTATGGAGGATGTGAAAAATGAAGTCCTTAACACAAAACTCGATTAA

Upstream 100 bases:

>100_bases
GGAATATTTGAATAACTGTAGAATAAATTTTCTCATGCAAAAGTAGCACTTGTAAGCTAATAAAACTATACTTTATATTC
TCTTTCTCTCTTATTCTCAT

Downstream 100 bases:

>100_bases
AATTGGAATTTTAGGAGGAGGACAATTAGGCTGGATGATGATTTTAGAAGGGAGAAAATATCCCTTCGCTTTTTACGTAA
TGGACGAGCCAGAAGCTCCT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MPKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHL
PVIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLNTKLD

Sequences:

>Translated_157_residues
MPKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHL
PVIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLNTKLD
>Mature_156_residues
PKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVIIAGAGGAAHLPGMTASLTHLP
VIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLALRILGLKYPDIAEKVKKFMEDVKNEVLNTKLD

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=57.6576576576577, Blast_Score=132, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=56.953642384106, Blast_Score=164, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16784; Mature: 16653

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVI
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEE
IAGAGGAAHLPGMTASLTHLPVIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKN
EECCCCCCCCCCCCCHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCH
AALLALRILGLKYPDIAEKVKKFMEDVKNEVLNTKLD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PKVAVIMGSKSDWEYMKEAVELLKQFGVEVEARVVSAHRTPEFMMEFAKTASEKGIEVI
CCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEE
IAGAGGAAHLPGMTASLTHLPVIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKN
EECCCCCCCCCCCCCHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCH
AALLALRILGLKYPDIAEKVKKFMEDVKNEVLNTKLD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9311113; 11427726 [H]