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The map label for this gene is eIF1A

Identifier: 15920730

GI number: 15920730

Start: 510390

End: 510629

Strand: Reverse

Name: eIF1A

Synonym: STS070

Alternate gene names: 15920730

Gene position: 510629-510390 (Counterclockwise)

Preceding gene: 15920731

Following gene: 15920729

Centisome position: 18.95

GC content: 37.5

Gene sequence:

>240_bases
ATGCTAGGAGCTGAGCATGTACAAGTCATTTGTTTAGATGGAAAAGAAAGACTAGGAAGAATACCAGGAAAAATGAAGAA
AAAGATGTGGGTAAAAGAAGGAGATGTGGTATTAGCAGCACCTTGGGACTTTCAGCCAAATAAATGCGATATTATATATA
AATATAGCGAAAGTGAGGTTAGAAGATTAGAGGAAGAGCAAGTAGTTTCCGCAGATATCATAGAGCAGCTAAGAGGATGA

Upstream 100 bases:

>100_bases
GGTGGCTAACTGATTGGCTAAAAAGAAAACAAATGAGCAACCTTCTGTAAAAGAAGTACCTAAACCAGCAGAAGGAGAAG
TTATTTGTGTAGTAAAGAAA

Downstream 100 bases:

>100_bases
TTTTTTGGAGAGAAAAGGGAAAAAGGAAGAGAAACGAAGGAAAGATGAAGATCTTTTTAAAGTTGTTGACTCAACACTAG
ATACTCGAACTTACTATCTT

Product: translation initiation factor IF-1A

Products: NA

Alternate protein names: aIF-1A

Number of amino acids: Translated: 79; Mature: 79

Protein sequence:

>79_residues
MLGAEHVQVICLDGKERLGRIPGKMKKKMWVKEGDVVLAAPWDFQPNKCDIIYKYSESEVRRLEEEQVVSADIIEQLRG

Sequences:

>Translated_79_residues
MLGAEHVQVICLDGKERLGRIPGKMKKKMWVKEGDVVLAAPWDFQPNKCDIIYKYSESEVRRLEEEQVVSADIIEQLRG
>Mature_79_residues
MLGAEHVQVICLDGKERLGRIPGKMKKKMWVKEGDVVLAAPWDFQPNKCDIIYKYSESEVRRLEEEQVVSADIIEQLRG

Specific function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits

COG id: COG0361

COG function: function code J; Translation initiation factor 1 (IF-1)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1-like domain

Homologues:

Organism=Homo sapiens, GI33356163, Length=64, Percent_Identity=42.1875, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI4503499, Length=64, Percent_Identity=42.1875, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540984, Length=69, Percent_Identity=46.3768115942029, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323916, Length=66, Percent_Identity=40.9090909090909, Blast_Score=70, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45553405, Length=63, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24647907, Length=63, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF1A_SULTO (Q974Z9)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376399.1
- ProteinModelPortal:   Q974Z9
- SMR:   Q974Z9
- GeneID:   1458458
- GenomeReviews:   BA000023_GR
- KEGG:   sto:STS070
- HOGENOM:   HBG521228
- ProtClustDB:   PRK04012
- BioCyc:   STOK273063:STS070-MONOMER
- HAMAP:   MF_00216
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR006196
- InterPro:   IPR001253
- InterPro:   IPR018104
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR21668
- ProDom:   PD005579
- SMART:   SM00652
- TIGRFAMs:   TIGR00523

Pfam domain/function: PF01176 eIF-1a; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 9102; Mature: 9102

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01262 IF1A; PS50832 S1_IF1_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGAEHVQVICLDGKERLGRIPGKMKKKMWVKEGDVVLAAPWDFQPNKCDIIYKYSESEV
CCCCCCEEEEEECCHHHHCCCCCHHHHHEEECCCCEEEECCCCCCCCCEEEEEEECCHHH
RRLEEEQVVSADIIEQLRG
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGAEHVQVICLDGKERLGRIPGKMKKKMWVKEGDVVLAAPWDFQPNKCDIIYKYSESEV
CCCCCCEEEEEECCHHHHCCCCCHHHHHEEECCCCEEEECCCCCCCCCEEEEEEECCHHH
RRLEEEQVVSADIIEQLRG
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479