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The map label for this gene is thlA [H]

Identifier: 15920731

GI number: 15920731

Start: 510760

End: 511953

Strand: Reverse

Name: thlA [H]

Synonym: ST0514

Alternate gene names: 15920731

Gene position: 511953-510760 (Counterclockwise)

Preceding gene: 15920732

Following gene: 15920730

Centisome position: 19.0

GC content: 36.26

Gene sequence:

>1194_bases
GTGATTAATATGGATGCATATATTGTTTCCGCTGTAAGAACTCCTATAGGAAAATTTGGTGGAGTATTTAAGGATCTACC
TCCTTATGAGTTAGGAGCTATTGCAATAAAGGAAGCTTTAAAAAGAGCTAACGTTGACCCTGCTAAAGTAGATATAACAA
TAATGGGAAATATACTTAGGGCAGGACATGGGCAGGATTTAGCAAGACAAGCAGCAATAAGAGCTGGAATCCCAATGGAA
ATTGATGGTTATTGTGTTGACATGGTGTGTTCATCTGGTATGGTAAGTGTGATAAACGCAGTACAGATGATAAAAAGTGG
GGATGCAGATATAGTAGTAGCTGGTGGAATGGAGAGTATGAGTCAGGCTATGTTAGCAATTAGAAGTGAGGCAAGATGGG
GAGTCAAAATGCTGTTAGGTAAAAAATTGGACTTTATTGATACAATGTTGATAGATGGGCTTACAGATCCATTCAACATG
AAATTGATGGGACAGGAAGCTGATATGGTTGCAAAGTCACACAATATCAGTAGAAGAGAGTTAGATGAAGTGGCTTATGA
AAGTCATAAGAGAGCAATAATAGCTACTGAAAAAGGATATTTTGCTAAGGAGATAGTATCAGTTAAAGTAGATGGCAAAG
AAGTTACTCAAGATGAAGGAATTAGAAGGGACACATCCATAGAAAAATTATCTCAACTAAAGCCAGCATTTAGTCCTGAT
GGTGTACATACTGCAGGAAACTCATCTCAGATTTCCGATGGTTCATCAGCATTAGTTATAGTAAGTGAAAAAATAGTTAA
AGAATATAAATTGGAACCAATAGCTAAGATTTTAGGTTATAGTTGGGTTGGAATTGAAAGTTGGAGATTTACTGAAGCAC
CTATATTTGCTGTTAAGAAATTACTACAGAAATTAAATATGGAAATTTCACACTTTGATTATTTCGAGAATAATGAAGCT
TTTGCAGTCAACAATGTACTCTATAATAAATATTTAGGTGTTCCGTATGACAGGCTAAACGTATTTGGAGGAGCAATAGC
CTTAGGTCATCCAATAGGTGCTAGTGGTGCCAGAATAATAACGACCCTTATTAATGTGTTATCAACAATGGGAGGAAAAA
GAGGAATAGCTAGTATCTGTCATGGTACTGGAGGAAGTACGGCCATTGCTATTGAATTATTAAGGCCTCTATAA

Upstream 100 bases:

>100_bases
CGTAAAAATTACTGAGGCATCATTTTTTGATTTAAGAGGAAAATTTATTCAATAACGAGACAAATTCAAATGCATAAAAA
TTTAAAATAGTTTAAACAAA

Downstream 100 bases:

>100_bases
CTTTTTAGGTTTAAAAAATAATATGAAAATGGTGGCTAACTGATTGGCTAAAAAGAAAACAAATGAGCAACCTTCTGTAA
AAGAAGTACCTAAACCAGCA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MINMDAYIVSAVRTPIGKFGGVFKDLPPYELGAIAIKEALKRANVDPAKVDITIMGNILRAGHGQDLARQAAIRAGIPME
IDGYCVDMVCSSGMVSVINAVQMIKSGDADIVVAGGMESMSQAMLAIRSEARWGVKMLLGKKLDFIDTMLIDGLTDPFNM
KLMGQEADMVAKSHNISRRELDEVAYESHKRAIIATEKGYFAKEIVSVKVDGKEVTQDEGIRRDTSIEKLSQLKPAFSPD
GVHTAGNSSQISDGSSALVIVSEKIVKEYKLEPIAKILGYSWVGIESWRFTEAPIFAVKKLLQKLNMEISHFDYFENNEA
FAVNNVLYNKYLGVPYDRLNVFGGAIALGHPIGASGARIITTLINVLSTMGGKRGIASICHGTGGSTAIAIELLRPL

Sequences:

>Translated_397_residues
MINMDAYIVSAVRTPIGKFGGVFKDLPPYELGAIAIKEALKRANVDPAKVDITIMGNILRAGHGQDLARQAAIRAGIPME
IDGYCVDMVCSSGMVSVINAVQMIKSGDADIVVAGGMESMSQAMLAIRSEARWGVKMLLGKKLDFIDTMLIDGLTDPFNM
KLMGQEADMVAKSHNISRRELDEVAYESHKRAIIATEKGYFAKEIVSVKVDGKEVTQDEGIRRDTSIEKLSQLKPAFSPD
GVHTAGNSSQISDGSSALVIVSEKIVKEYKLEPIAKILGYSWVGIESWRFTEAPIFAVKKLLQKLNMEISHFDYFENNEA
FAVNNVLYNKYLGVPYDRLNVFGGAIALGHPIGASGARIITTLINVLSTMGGKRGIASICHGTGGSTAIAIELLRPL
>Mature_397_residues
MINMDAYIVSAVRTPIGKFGGVFKDLPPYELGAIAIKEALKRANVDPAKVDITIMGNILRAGHGQDLARQAAIRAGIPME
IDGYCVDMVCSSGMVSVINAVQMIKSGDADIVVAGGMESMSQAMLAIRSEARWGVKMLLGKKLDFIDTMLIDGLTDPFNM
KLMGQEADMVAKSHNISRRELDEVAYESHKRAIIATEKGYFAKEIVSVKVDGKEVTQDEGIRRDTSIEKLSQLKPAFSPD
GVHTAGNSSQISDGSSALVIVSEKIVKEYKLEPIAKILGYSWVGIESWRFTEAPIFAVKKLLQKLNMEISHFDYFENNEA
FAVNNVLYNKYLGVPYDRLNVFGGAIALGHPIGASGARIITTLINVLSTMGGKRGIASICHGTGGSTAIAIELLRPL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=42.7109974424552, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=38.1074168797954, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=37.7833753148615, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI4501853, Length=399, Percent_Identity=36.5914786967419, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI4504327, Length=420, Percent_Identity=32.1428571428571, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI194353979, Length=399, Percent_Identity=28.3208020050125, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=41.8781725888325, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=38.265306122449, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=33.8308457711443, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=34.2569269521411, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1788683, Length=404, Percent_Identity=25.2475247524752, Blast_Score=164, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=41.025641025641, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=37.0277078085642, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=36.6583541147132, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=32.3383084577114, Blast_Score=184, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=41.3366336633663, Blast_Score=275, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=32.4937027707809, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=43.6548223350254, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=38.0710659898477, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=36.9897959183673, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17137578, Length=420, Percent_Identity=31.1904761904762, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 43015; Mature: 43015

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINMDAYIVSAVRTPIGKFGGVFKDLPPYELGAIAIKEALKRANVDPAKVDITIMGNILR
CCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHH
AGHGQDLARQAAIRAGIPMEIDGYCVDMVCSSGMVSVINAVQMIKSGDADIVVAGGMESM
CCCCHHHHHHHHHHCCCCEEECCEEHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SQAMLAIRSEARWGVKMLLGKKLDFIDTMLIDGLTDPFNMKLMGQEADMVAKSHNISRRE
HHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHCCCCHHH
LDEVAYESHKRAIIATEKGYFAKEIVSVKVDGKEVTQDEGIRRDTSIEKLSQLKPAFSPD
HHHHHHHHCCCEEEEECCCCCEEHEEEEEECCHHHHHHCCCCCCCHHHHHHHCCCCCCCC
GVHTAGNSSQISDGSSALVIVSEKIVKEYKLEPIAKILGYSWVGIESWRFTEAPIFAVKK
CCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHCCCEECCCCCCCCCCHHHHHHH
LLQKLNMEISHFDYFENNEAFAVNNVLYNKYLGVPYDRLNVFGGAIALGHPIGASGARII
HHHHHCCCHHCCCCCCCCCEEEEHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCCHHHHH
TTLINVLSTMGGKRGIASICHGTGGSTAIAIELLRPL
HHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MINMDAYIVSAVRTPIGKFGGVFKDLPPYELGAIAIKEALKRANVDPAKVDITIMGNILR
CCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHH
AGHGQDLARQAAIRAGIPMEIDGYCVDMVCSSGMVSVINAVQMIKSGDADIVVAGGMESM
CCCCHHHHHHHHHHCCCCEEECCEEHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SQAMLAIRSEARWGVKMLLGKKLDFIDTMLIDGLTDPFNMKLMGQEADMVAKSHNISRRE
HHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHCCCCHHH
LDEVAYESHKRAIIATEKGYFAKEIVSVKVDGKEVTQDEGIRRDTSIEKLSQLKPAFSPD
HHHHHHHHCCCEEEEECCCCCEEHEEEEEECCHHHHHHCCCCCCCHHHHHHHCCCCCCCC
GVHTAGNSSQISDGSSALVIVSEKIVKEYKLEPIAKILGYSWVGIESWRFTEAPIFAVKK
CCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHCCCEECCCCCCCCCCHHHHHHH
LLQKLNMEISHFDYFENNEAFAVNNVLYNKYLGVPYDRLNVFGGAIALGHPIGASGARII
HHHHHCCCHHCCCCCCCCCEEEEHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCCHHHHH
TTLINVLSTMGGKRGIASICHGTGGSTAIAIELLRPL
HHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]