Click here to switch to the map view.

The map label for this gene is moeA [C]

Identifier: 15920721

GI number: 15920721

Start: 502864

End: 504501

Strand: Direct

Name: moeA [C]

Synonym: ST0504

Alternate gene names: 15920721

Gene position: 502864-504501 (Clockwise)

Preceding gene: 15920720

Following gene: 15920722

Centisome position: 18.66

GC content: 31.81

Gene sequence:

>1638_bases
ATGCGAGCCATATTAGACGATAAGAACTTACTTTTGGCTGAAGATGCATTAAGAATTTTCATTAATGAAACTTCTCCTAA
ACCCATTGGGGTAGAAGAGGTTGATATACTAGACTCATTAAATAGGGTTTCTGCTGAATATGTTTTTTCTCCAATTGACT
TACCACCATTTTCAAGATCTACTGTTGATGGTTATGCTATAATTGACTCTGAAACTCCAGGAGAGTTTACTGTAATTGAT
AAGATTAGTATAGGAGAATATAAGGAGATTGAAATAAAAGATAAAGAAGCTGTAGAAGTTGATACTGGTTCTATAATTCC
AGAAAATGCTACAGCTGTAATTAAGGTCGAAGAAACTGAAAGAAAGGGAGATAAAATCTTTGTAGGAAGAAAAGTAAGAT
TTGGGGAAAATATTGGATTTATAGGAAGCGATATTCCTAAAGGGTTTGAAATTTTAAAGCCTGGAGAAATTATTAAGGCT
GAAAAAATAGCACTTTTAGCTTCTGTTGGAATAACAAAGGTTAAAGTATTTAAAAGACCTAAAATCTATATAATAACAAC
CGGAGATGAACTAATAGAGCCTGGAAAGCCGTTACAGAAAGGAAAGATTTATGAATCTAATTCATTTTATCTTTATGCTA
AACTAAAATCAGAAGGATATGAGATTATTGGTTATACTCATGTAAGGGACGATAAGGAGTTGATCAAAGAAGAGTTACTT
AAAGGTTTAGATTTAGCAGATGTGGTGATATTGACTGGAGGTACAAGTGCTGGTGAGAAGGATTTTGTTCATCAAGTAAT
TAGAGAATTAGGTAAAATTATAGTTCATGGATTAAAGTTTAAACCGGGAAAACCAACAATATTAGCCACCGTAAAAGGAA
AACCAGTAATAGGTCTTCCTGGCAATATTGTTTCAACTGTTATGATAACTGAAAGGGTAATAAATAAATACCTCTCAATA
GTAGCTGGAAAAGAATTAACAGACGAAATTAAAGTTAAAGCAATATTACTAAACGATGCAAAAGCTGATAAGAACCGTTA
CACTTATCTTCCAGTATATTTGTTTAAAAAAGATGAAAAATACTTTGCTTTAAGTATACCCTTTGATAGCTATATGATAG
GAACTTTTTCAGTGGCTGATGGTTATATAGGTCTTGAGCCTGCTGAAGAGCATAAAGAGGGTGAAGAAGTTTATGTATAT
TTAAAGAGATTAGATTTAAGACCTACTTATATAGGAGAAGAAGAACCTAAATTGCTTAAATTGTTCTCAGAATTTAGAAA
AATTCCCTTAGGTTCTTACCCAGCATTAAAAGCTCTTAAATACGGAATCGGTGACGTTATTGTAATTAGTAGTCTTTACG
ATAACTCAATATCTGGTGAATATGTGTATAAGAGAAAAATATTACAGAACGGTAATGGAGAAAAGATTGTGGGTTATCAT
GATTGGATTGGATTAAGTAGAATGATCCAAAATTCTTCTATAAAATTGCGCTATATATCTTTATCTCCTAATTTTATCGG
TAAGGCTACAGTAATAGCGCCAGACACTATTATCAGTGAAGGTAAGGAAATTGGTGAAGAAAAGCTGATTATTGTTTGTA
AAGATGAATATAAATCAAAACTTAAAACTCTATCTTAA

Upstream 100 bases:

>100_bases
TGAACAAGTTCGTGACCCTATATTAATGGTTCTAGATGAGTTGAAAAAAGCCTCACTCATAAGTATGTAAAGTTATAAGT
TTTGTTTTTTATTTTCTTTT

Downstream 100 bases:

>100_bases
TATTATCGTTTATGATTGTAAAAGCTTTCTCGTCATCGGCAAACTTAGGTGCAGGTTATGATATACTAGCTCTGGCACAT
GATGCTTTTGAAGATACAAT

Product: putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MRAILDDKNLLLAEDALRIFINETSPKPIGVEEVDILDSLNRVSAEYVFSPIDLPPFSRSTVDGYAIIDSETPGEFTVID
KISIGEYKEIEIKDKEAVEVDTGSIIPENATAVIKVEETERKGDKIFVGRKVRFGENIGFIGSDIPKGFEILKPGEIIKA
EKIALLASVGITKVKVFKRPKIYIITTGDELIEPGKPLQKGKIYESNSFYLYAKLKSEGYEIIGYTHVRDDKELIKEELL
KGLDLADVVILTGGTSAGEKDFVHQVIRELGKIIVHGLKFKPGKPTILATVKGKPVIGLPGNIVSTVMITERVINKYLSI
VAGKELTDEIKVKAILLNDAKADKNRYTYLPVYLFKKDEKYFALSIPFDSYMIGTFSVADGYIGLEPAEEHKEGEEVYVY
LKRLDLRPTYIGEEEPKLLKLFSEFRKIPLGSYPALKALKYGIGDVIVISSLYDNSISGEYVYKRKILQNGNGEKIVGYH
DWIGLSRMIQNSSIKLRYISLSPNFIGKATVIAPDTIISEGKEIGEEKLIIVCKDEYKSKLKTLS

Sequences:

>Translated_545_residues
MRAILDDKNLLLAEDALRIFINETSPKPIGVEEVDILDSLNRVSAEYVFSPIDLPPFSRSTVDGYAIIDSETPGEFTVID
KISIGEYKEIEIKDKEAVEVDTGSIIPENATAVIKVEETERKGDKIFVGRKVRFGENIGFIGSDIPKGFEILKPGEIIKA
EKIALLASVGITKVKVFKRPKIYIITTGDELIEPGKPLQKGKIYESNSFYLYAKLKSEGYEIIGYTHVRDDKELIKEELL
KGLDLADVVILTGGTSAGEKDFVHQVIRELGKIIVHGLKFKPGKPTILATVKGKPVIGLPGNIVSTVMITERVINKYLSI
VAGKELTDEIKVKAILLNDAKADKNRYTYLPVYLFKKDEKYFALSIPFDSYMIGTFSVADGYIGLEPAEEHKEGEEVYVY
LKRLDLRPTYIGEEEPKLLKLFSEFRKIPLGSYPALKALKYGIGDVIVISSLYDNSISGEYVYKRKILQNGNGEKIVGYH
DWIGLSRMIQNSSIKLRYISLSPNFIGKATVIAPDTIISEGKEIGEEKLIIVCKDEYKSKLKTLS
>Mature_545_residues
MRAILDDKNLLLAEDALRIFINETSPKPIGVEEVDILDSLNRVSAEYVFSPIDLPPFSRSTVDGYAIIDSETPGEFTVID
KISIGEYKEIEIKDKEAVEVDTGSIIPENATAVIKVEETERKGDKIFVGRKVRFGENIGFIGSDIPKGFEILKPGEIIKA
EKIALLASVGITKVKVFKRPKIYIITTGDELIEPGKPLQKGKIYESNSFYLYAKLKSEGYEIIGYTHVRDDKELIKEELL
KGLDLADVVILTGGTSAGEKDFVHQVIRELGKIIVHGLKFKPGKPTILATVKGKPVIGLPGNIVSTVMITERVINKYLSI
VAGKELTDEIKVKAILLNDAKADKNRYTYLPVYLFKKDEKYFALSIPFDSYMIGTFSVADGYIGLEPAEEHKEGEEVYVY
LKRLDLRPTYIGEEEPKLLKLFSEFRKIPLGSYPALKALKYGIGDVIVISSLYDNSISGEYVYKRKILQNGNGEKIVGYH
DWIGLSRMIQNSSIKLRYISLSPNFIGKATVIAPDTIISEGKEIGEEKLIIVCKDEYKSKLKTLS

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=399, Percent_Identity=33.0827067669173, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI10880983, Length=399, Percent_Identity=33.0827067669173, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1787049, Length=319, Percent_Identity=31.3479623824451, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25147659, Length=330, Percent_Identity=33.030303030303, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=243, Percent_Identity=27.1604938271605, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17136978, Length=312, Percent_Identity=31.0897435897436, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24638841, Length=312, Percent_Identity=31.0897435897436, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 60836; Mature: 60836

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAILDDKNLLLAEDALRIFINETSPKPIGVEEVDILDSLNRVSAEYVFSPIDLPPFSRS
CCCEECCCCEEEECCEEEEEEECCCCCCCCCHHHHHHHHHHHHCHHHEEECCCCCCCCCC
TVDGYAIIDSETPGEFTVIDKISIGEYKEIEIKDKEAVEVDTGSIIPENATAVIKVEETE
CCCCEEEEECCCCCCEEEEEEEECCCEEEEEECCCCEEEECCCCCCCCCCEEEEEEECCC
RKGDKIFVGRKVRFGENIGFIGSDIPKGFEILKPGEIIKAEKIALLASVGITKVKVFKRP
CCCCEEEEEEEEEECCCCCCCCCCCCCCCEEECCCCEEEHHHEEEEECCCCEEEEEEECC
KIYIITTGDELIEPGKPLQKGKIYESNSFYLYAKLKSEGYEIIGYTHVRDDKELIKEELL
EEEEEECCHHHCCCCCCCCCCEEEECCCEEEEEEECCCCEEEEEEEEECCHHHHHHHHHH
KGLDLADVVILTGGTSAGEKDFVHQVIRELGKIIVHGLKFKPGKPTILATVKGKPVIGLP
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHEECCEECCCCCEEEEEECCCEEEECC
GNIVSTVMITERVINKYLSIVAGKELTDEIKVKAILLNDAKADKNRYTYLPVYLFKKDEK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEEECCCC
YFALSIPFDSYMIGTFSVADGYIGLEPAEEHKEGEEVYVYLKRLDLRPTYIGEEEPKLLK
EEEEECCCCCEEEEEEEECCCEECCCCCHHCCCCCEEEEEEEEECCCCCCCCCCCHHHHH
LFSEFRKIPLGSYPALKALKYGIGDVIVISSLYDNSISGEYVYKRKILQNGNGEKIVGYH
HHHHHHHCCCCCCHHHHHHHCCCCCEEEEEEHHCCCCCCCEEEEEHHHHCCCCCEEEEEH
DWIGLSRMIQNSSIKLRYISLSPNFIGKATVIAPDTIISEGKEIGEEKLIIVCKDEYKSK
HHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCHHHHHCHHHCCCCEEEEEECHHHHHH
LKTLS
HHCCC
>Mature Secondary Structure
MRAILDDKNLLLAEDALRIFINETSPKPIGVEEVDILDSLNRVSAEYVFSPIDLPPFSRS
CCCEECCCCEEEECCEEEEEEECCCCCCCCCHHHHHHHHHHHHCHHHEEECCCCCCCCCC
TVDGYAIIDSETPGEFTVIDKISIGEYKEIEIKDKEAVEVDTGSIIPENATAVIKVEETE
CCCCEEEEECCCCCCEEEEEEEECCCEEEEEECCCCEEEECCCCCCCCCCEEEEEEECCC
RKGDKIFVGRKVRFGENIGFIGSDIPKGFEILKPGEIIKAEKIALLASVGITKVKVFKRP
CCCCEEEEEEEEEECCCCCCCCCCCCCCCEEECCCCEEEHHHEEEEECCCCEEEEEEECC
KIYIITTGDELIEPGKPLQKGKIYESNSFYLYAKLKSEGYEIIGYTHVRDDKELIKEELL
EEEEEECCHHHCCCCCCCCCCEEEECCCEEEEEEECCCCEEEEEEEEECCHHHHHHHHHH
KGLDLADVVILTGGTSAGEKDFVHQVIRELGKIIVHGLKFKPGKPTILATVKGKPVIGLP
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHEECCEECCCCCEEEEEECCCEEEECC
GNIVSTVMITERVINKYLSIVAGKELTDEIKVKAILLNDAKADKNRYTYLPVYLFKKDEK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEEECCCC
YFALSIPFDSYMIGTFSVADGYIGLEPAEEHKEGEEVYVYLKRLDLRPTYIGEEEPKLLK
EEEEECCCCCEEEEEEEECCCEECCCCCHHCCCCCEEEEEEEEECCCCCCCCCCCHHHHH
LFSEFRKIPLGSYPALKALKYGIGDVIVISSLYDNSISGEYVYKRKILQNGNGEKIVGYH
HHHHHHHCCCCCCHHHHHHHCCCCCEEEEEEHHCCCCCCCEEEEEHHHHCCCCCEEEEEH
DWIGLSRMIQNSSIKLRYISLSPNFIGKATVIAPDTIISEGKEIGEEKLIIVCKDEYKSK
HHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCHHHHHCHHHCCCCEEEEEECHHHHHH
LKTLS
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]