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The map label for this gene is thrB

Identifier: 15920722

GI number: 15920722

Start: 504513

End: 505433

Strand: Direct

Name: thrB

Synonym: ST0505

Alternate gene names: 15920722

Gene position: 504513-505433 (Clockwise)

Preceding gene: 15920721

Following gene: 15920723

Centisome position: 18.72

GC content: 35.5

Gene sequence:

>921_bases
ATGATTGTAAAAGCTTTCTCGTCATCGGCAAACTTAGGTGCAGGTTATGATATACTAGCTCTGGCACATGATGCTTTTGA
AGATACAATTGAAATTTACGCTCAAAATTCTAGTGAATTAGATATAAAAGTAGAGGGAAATGGTGTACCACTATCAATAG
ATAAGAATTCAGCTAGTTTTGCTTTGCTTGAATTGCTAAGGTCATATGATATTAAAGCAAAGATTAGGTTAAAGATTATA
AAAGGGATTCCAGCTGGTTTGGGCTTAGGTAGTAGTGGCGCGTCTGCTGCCGCTGCGGTTTATGCGGCCAATGAGATTTT
TAAACTTAATTTAAGCCGACAAGAATTAGTTAACTTTGCTATGAAAGGGGAAATAGCCTCATCTGGTTCTCCACATCCAG
ACAATGTAGCAGCAAGTCTGGTGGGCGGTCTAGTAAGTGTATTAAATTCTAATCCCGTTAAGGTTGAGCAAGTACCTCTC
AATCTTGAGTTTCAAATAATACTTATTATACCATTTGTTAGAATAGAAGCAAAAACTAAAAAAGCAAGAGAGATGGTTCC
AAAACAAATTGATACATCTAAATATGTTACTAATGCTAGATATCTATCATCTCTTTTACTAGGCTTCATTAAGGGTGATA
GAGAATTGGTTAGGTTAGGTTTAAATGATGAAATTATTGAAAAAGCTAGAGAACCCTTATTCCCTCACTATCCCAAAATA
AAGGAAATTTCACTATTATATGATGCTATCGGTGCATGCGTTAGTGGTGCTGGTCCAACAATTGCTATTTTCGTTGATTC
AAAGTCAGATAAAAATAAAATTCTTGGGGAATCACTTAATGTTTGTAAAGCTTATGGATATGAATGCACATATAAAATAG
CTAAAGTTTCAGGAGGTGCATGGGTTGAGAGAAGGGACTAA

Upstream 100 bases:

>100_bases
TTATCAGTGAAGGTAAGGAAATTGGTGAAGAAAAGCTGATTATTGTTTGTAAAGATGAATATAAATCAAAACTTAAAACT
CTATCTTAATATTATCGTTT

Downstream 100 bases:

>100_bases
AGTTACAACGGAAGGATATGATGAAGAGACTGGTGCTATAACTACTCCAATATATCAGACTACTTCTTATATTTATCCTA
TAGGTGAGAAATATCGGTAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIVKAFSSSANLGAGYDILALAHDAFEDTIEIYAQNSSELDIKVEGNGVPLSIDKNSASFALLELLRSYDIKAKIRLKII
KGIPAGLGLGSSGASAAAAVYAANEIFKLNLSRQELVNFAMKGEIASSGSPHPDNVAASLVGGLVSVLNSNPVKVEQVPL
NLEFQIILIIPFVRIEAKTKKAREMVPKQIDTSKYVTNARYLSSLLLGFIKGDRELVRLGLNDEIIEKAREPLFPHYPKI
KEISLLYDAIGACVSGAGPTIAIFVDSKSDKNKILGESLNVCKAYGYECTYKIAKVSGGAWVERRD

Sequences:

>Translated_306_residues
MIVKAFSSSANLGAGYDILALAHDAFEDTIEIYAQNSSELDIKVEGNGVPLSIDKNSASFALLELLRSYDIKAKIRLKII
KGIPAGLGLGSSGASAAAAVYAANEIFKLNLSRQELVNFAMKGEIASSGSPHPDNVAASLVGGLVSVLNSNPVKVEQVPL
NLEFQIILIIPFVRIEAKTKKAREMVPKQIDTSKYVTNARYLSSLLLGFIKGDRELVRLGLNDEIIEKAREPLFPHYPKI
KEISLLYDAIGACVSGAGPTIAIFVDSKSDKNKILGESLNVCKAYGYECTYKIAKVSGGAWVERRD
>Mature_306_residues
MIVKAFSSSANLGAGYDILALAHDAFEDTIEIYAQNSSELDIKVEGNGVPLSIDKNSASFALLELLRSYDIKAKIRLKII
KGIPAGLGLGSSGASAAAAVYAANEIFKLNLSRQELVNFAMKGEIASSGSPHPDNVAASLVGGLVSVLNSNPVKVEQVPL
NLEFQIILIIPFVRIEAKTKKAREMVPKQIDTSKYVTNARYLSSLLLGFIKGDRELVRLGLNDEIIEKAREPLFPHYPKI
KEISLLYDAIGACVSGAGPTIAIFVDSKSDKNKILGESLNVCKAYGYECTYKIAKVSGGAWVERRD

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=280, Percent_Identity=26.4285714285714, Blast_Score=94, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6321814, Length=361, Percent_Identity=27.4238227146814, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_SULTO (Q975A7)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376391.1
- ProteinModelPortal:   Q975A7
- GeneID:   1458450
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0505
- NMPDR:   fig|273063.1.peg.559
- HOGENOM:   HBG646290
- OMA:   HYSACAK
- ProtClustDB:   PRK01212
- BioCyc:   STOK273063:ST0505-MONOMER
- BRENDA:   2.7.1.39
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 33020; Mature: 33020

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVKAFSSSANLGAGYDILALAHDAFEDTIEIYAQNSSELDIKVEGNGVPLSIDKNSASF
CEEEEECCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCEEEEECCCCHHH
ALLELLRSYDIKAKIRLKIIKGIPAGLGLGSSGASAAAAVYAANEIFKLNLSRQELVNFA
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHEECCEEEEEECCHHHHHHHH
MKGEIASSGSPHPDNVAASLVGGLVSVLNSNPVKVEQVPLNLEFQIILIIPFVRIEAKTK
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEEEEEECHHH
KAREMVPKQIDTSKYVTNARYLSSLLLGFIKGDRELVRLGLNDEIIEKAREPLFPHYPKI
HHHHHCCHHCCCHHHHHHHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHHCCCCCCCCCH
KEISLLYDAIGACVSGAGPTIAIFVDSKSDKNKILGESLNVCKAYGYECTYKIAKVSGGA
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCC
WVERRD
EEEECC
>Mature Secondary Structure
MIVKAFSSSANLGAGYDILALAHDAFEDTIEIYAQNSSELDIKVEGNGVPLSIDKNSASF
CEEEEECCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCEEEEECCCCHHH
ALLELLRSYDIKAKIRLKIIKGIPAGLGLGSSGASAAAAVYAANEIFKLNLSRQELVNFA
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHEECCEEEEEECCHHHHHHHH
MKGEIASSGSPHPDNVAASLVGGLVSVLNSNPVKVEQVPLNLEFQIILIIPFVRIEAKTK
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEEEEEECHHH
KAREMVPKQIDTSKYVTNARYLSSLLLGFIKGDRELVRLGLNDEIIEKAREPLFPHYPKI
HHHHHCCHHCCCHHHHHHHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHHCCCCCCCCCH
KEISLLYDAIGACVSGAGPTIAIFVDSKSDKNKILGESLNVCKAYGYECTYKIAKVSGGA
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCC
WVERRD
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479