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The map label for this gene is glmU [H]

Identifier: 15920664

GI number: 15920664

Start: 456368

End: 457573

Strand: Reverse

Name: glmU [H]

Synonym: ST0452

Alternate gene names: 15920664

Gene position: 457573-456368 (Counterclockwise)

Preceding gene: 15920665

Following gene: 15920662

Centisome position: 16.98

GC content: 32.5

Gene sequence:

>1206_bases
ATGAAGGCATTTATTCTTGCTGCAGGTTCTGGTGAAAGATTAGAACCAATAACGCATACAAGGCCTAAAGCTTTTGTTCC
AATTCTCTCAAAGCCGTTAATCGAGTACCAGATAGAGTATTTAAGAAAATGTGGAATCAGAGATATAACTGTAATAGTTT
CTTCTAAAAATAAAGAATATTTTGAGAAAAAACTTAAAGAAATATCTATAGTTACTCAGAAAGATGATATAAAAGGGACA
GGTGCGGCCATATTGTCTGCAAAGTTTAACGATGAAGCACTTATAATTTATGGAGATTTATTCTTTTCAAACGAGAAAGA
AATATGTAACATAATAACTCTAAAAGAAAATGCAATAATAGGTGTTAAAGTTAGTAATCCAAAAGATTACGGTGTACTTG
TATTAGACAATCAGAATAACTTATCTAAAATTATAGAAAAACCAGAGATACCTCCATCAAATCTTATAAACGCTGGTATT
TACAAACTCAATTCTGATATTTTTACATATCTAGATAAAATATCTATCTCGGAAAGAGGAGAACTTGAACTTACTGATGC
CATAAACCTTATGGCAAAAGATCATAGAGTAAAGGTAATAGAATATGAAGGATATTGGATGGATATAGGAAAACCTTGGA
ACATAATTGATGTAAATAAATGGGCTTTAGATAATCTTGTATTTAGTCAAAATCTTGGTAATGTTGAAGATAACGTAAAG
ATAAAAGGAAAAGTTATCATTGAGGAAGACGCAGAAATTAAGTCTGGAACTTACATAGAAGGACCAGTTTATATTGGAAA
AGGAAGCGAAATTGGACCAAATTCCTATTTAAGACCTTATACTATACTAGTTGAGAAAAACAAAATAGGAGCATCAGTTG
AAGTAAAAGAAAGTGTGATTATGGAAGGATCTAAGATTCCGCACCTTAGCTATGTTGGTGATTCTGTCATTGCAGAAGAT
GTAAATTTTGGTGCAGGCACTTTAATAGCTAACTTAAGGTTTGACGAAAAAGAAGTTAAGGTTAATGTAAAAGGAAAAAG
AATAAGTAGTGGAAGAAGAAAACTAGGGGCATTTATTGGAGGGCATGTTAGAACTGGAATAAACGTTACCATATTGCCTG
GCGTAAAAATTGGTGCTTATGCTAGAATATATCCTGGTGCGGTTGTAAACAGAGATGTCGGCTATGGTGAGTTTTTCAAG
GTCTAG

Upstream 100 bases:

>100_bases
TCTCTTAAAACCTTAGATGAAAGCTAGGTAAAGATTACTATAAACCCGTAGTTCAAGTTAGGATTAATGAAATATAATAG
GTTTAACTTATAAATAGTGG

Downstream 100 bases:

>100_bases
CAGTTGATGACACTATTTTTATTACATCCCCATCTTGTAATTGATATTCCTCACCTACTCTTACTTTCTTTTTAACGTTT
ATCGCAAAGAGAAAACCTTT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKAFILAAGSGERLEPITHTRPKAFVPILSKPLIEYQIEYLRKCGIRDITVIVSSKNKEYFEKKLKEISIVTQKDDIKGT
GAAILSAKFNDEALIIYGDLFFSNEKEICNIITLKENAIIGVKVSNPKDYGVLVLDNQNNLSKIIEKPEIPPSNLINAGI
YKLNSDIFTYLDKISISERGELELTDAINLMAKDHRVKVIEYEGYWMDIGKPWNIIDVNKWALDNLVFSQNLGNVEDNVK
IKGKVIIEEDAEIKSGTYIEGPVYIGKGSEIGPNSYLRPYTILVEKNKIGASVEVKESVIMEGSKIPHLSYVGDSVIAED
VNFGAGTLIANLRFDEKEVKVNVKGKRISSGRRKLGAFIGGHVRTGINVTILPGVKIGAYARIYPGAVVNRDVGYGEFFK
V

Sequences:

>Translated_401_residues
MKAFILAAGSGERLEPITHTRPKAFVPILSKPLIEYQIEYLRKCGIRDITVIVSSKNKEYFEKKLKEISIVTQKDDIKGT
GAAILSAKFNDEALIIYGDLFFSNEKEICNIITLKENAIIGVKVSNPKDYGVLVLDNQNNLSKIIEKPEIPPSNLINAGI
YKLNSDIFTYLDKISISERGELELTDAINLMAKDHRVKVIEYEGYWMDIGKPWNIIDVNKWALDNLVFSQNLGNVEDNVK
IKGKVIIEEDAEIKSGTYIEGPVYIGKGSEIGPNSYLRPYTILVEKNKIGASVEVKESVIMEGSKIPHLSYVGDSVIAED
VNFGAGTLIANLRFDEKEVKVNVKGKRISSGRRKLGAFIGGHVRTGINVTILPGVKIGAYARIYPGAVVNRDVGYGEFFK
V
>Mature_401_residues
MKAFILAAGSGERLEPITHTRPKAFVPILSKPLIEYQIEYLRKCGIRDITVIVSSKNKEYFEKKLKEISIVTQKDDIKGT
GAAILSAKFNDEALIIYGDLFFSNEKEICNIITLKENAIIGVKVSNPKDYGVLVLDNQNNLSKIIEKPEIPPSNLINAGI
YKLNSDIFTYLDKISISERGELELTDAINLMAKDHRVKVIEYEGYWMDIGKPWNIIDVNKWALDNLVFSQNLGNVEDNVK
IKGKVIIEEDAEIKSGTYIEGPVYIGKGSEIGPNSYLRPYTILVEKNKIGASVEVKESVIMEGSKIPHLSYVGDSVIAED
VNFGAGTLIANLRFDEKEVKVNVKGKRISSGRRKLGAFIGGHVRTGINVTILPGVKIGAYARIYPGAVVNRDVGYGEFFK
V

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=362, Percent_Identity=25.414364640884, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI11761619, Length=344, Percent_Identity=25.5813953488372, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1790224, Length=236, Percent_Identity=30.0847457627119, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788351, Length=235, Percent_Identity=28.936170212766, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1790168, Length=450, Percent_Identity=24.8888888888889, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI133931050, Length=353, Percent_Identity=27.1954674220963, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6320148, Length=359, Percent_Identity=27.2980501392758, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355443, Length=335, Percent_Identity=27.4626865671642, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644084, Length=335, Percent_Identity=27.4626865671642, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 44516; Mature: 44516

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFILAAGSGERLEPITHTRPKAFVPILSKPLIEYQIEYLRKCGIRDITVIVSSKNKEY
CCEEEEECCCCCCCCCCCCCCCCEEHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCHHH
FEKKLKEISIVTQKDDIKGTGAAILSAKFNDEALIIYGDLFFSNEKEICNIITLKENAII
HHHHHHHEEEEEECCCCCCCCEEEEEEECCCCEEEEEEEEEECCCCCEEEEEEEECCEEE
GVKVSNPKDYGVLVLDNQNNLSKIIEKPEIPPSNLINAGIYKLNSDIFTYLDKISISERG
EEEECCCCCEEEEEEECCCCHHHHHCCCCCCHHHHHCCCEEEECCHHHHHHHHCCCCCCC
ELELTDAINLMAKDHRVKVIEYEGYWMDIGKPWNIIDVNKWALDNLVFSQNLGNVEDNVK
CEEEHHHHHEEECCCEEEEEEECCEEEECCCCCCEEECCHHHHHHEEEECCCCCCCCCEE
IKGKVIIEEDAEIKSGTYIEGPVYIGKGSEIGPNSYLRPYTILVEKNKIGASVEVKESVI
EEEEEEEECCCCCCCCCEEECCEEECCCCCCCCCCCCCEEEEEEECCCCCCEEEECHHHH
MEGSKIPHLSYVGDSVIAEDVNFGAGTLIANLRFDEKEVKVNVKGKRISSGRRKLGAFIG
CCCCCCCEEEECCCCCEECCCCCCCCEEEEEEEECCEEEEEEECCCEECCCHHHHHHHHC
GHVRTGINVTILPGVKIGAYARIYPGAVVNRDVGYGEFFKV
CEEECCEEEEEECCCEECCEEEECCCCEEECCCCCCCEECC
>Mature Secondary Structure
MKAFILAAGSGERLEPITHTRPKAFVPILSKPLIEYQIEYLRKCGIRDITVIVSSKNKEY
CCEEEEECCCCCCCCCCCCCCCCEEHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCHHH
FEKKLKEISIVTQKDDIKGTGAAILSAKFNDEALIIYGDLFFSNEKEICNIITLKENAII
HHHHHHHEEEEEECCCCCCCCEEEEEEECCCCEEEEEEEEEECCCCCEEEEEEEECCEEE
GVKVSNPKDYGVLVLDNQNNLSKIIEKPEIPPSNLINAGIYKLNSDIFTYLDKISISERG
EEEECCCCCEEEEEEECCCCHHHHHCCCCCCHHHHHCCCEEEECCHHHHHHHHCCCCCCC
ELELTDAINLMAKDHRVKVIEYEGYWMDIGKPWNIIDVNKWALDNLVFSQNLGNVEDNVK
CEEEHHHHHEEECCCEEEEEEECCEEEECCCCCCEEECCHHHHHHEEEECCCCCCCCCEE
IKGKVIIEEDAEIKSGTYIEGPVYIGKGSEIGPNSYLRPYTILVEKNKIGASVEVKESVI
EEEEEEEECCCCCCCCCEEECCEEECCCCCCCCCCCCCEEEEEEECCCCCCEEEECHHHH
MEGSKIPHLSYVGDSVIAEDVNFGAGTLIANLRFDEKEVKVNVKGKRISSGRRKLGAFIG
CCCCCCCEEEECCCCCEECCCCCCCCEEEEEEEECCEEEEEEECCCEECCCHHHHHHHHC
GHVRTGINVTILPGVKIGAYARIYPGAVVNRDVGYGEFFKV
CEEECCEEEEEECCCEECCEEEECCCCEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]