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The map label for this gene is hemA

Identifier: 15920395

GI number: 15920395

Start: 235558

End: 236796

Strand: Direct

Name: hemA

Synonym: ST0212

Alternate gene names: 15920395

Gene position: 235558-236796 (Clockwise)

Preceding gene: 15920394

Following gene: 15920396

Centisome position: 8.74

GC content: 26.8

Gene sequence:

>1239_bases
ATGAGTGACGAATTTATAGATATAAACAATTATATAGCAATAGTATATACATACAAAACAGTTGGAATAAGTAAGTTATA
TGAACATTATGTTAAAGATCAAGAATTGTTATTGCTAAAGGGACTAATAAAGGGAGAAATTAGTGTATTACAAACATGTA
ACAGAGCAGAGACATACTTATATACATATAACAAAGAAGAATTTAAAGATTTTTTACAGAAATTAGATGAAATTCATGGA
AAACAGATTAGTAAAGATGCTATGATCTTAAAAGGGGAAGATGCAGTAAAGCATTTGTTTGAGGTAGCATCTGGTTTAGA
CTCACTTGCTATAGGCGAATACGAAATACTTAGACAATTGAAAGAAAGCATTGAAAAAAGTAAAAAACTTGGATTAAGCA
GTGAAAAACTAGAATTTCTTTTTAAAAATGCTATAAAGGTAGGAAGAAAAATTAGACAACAAACGGAAATTTCAAAAGGA
AAAACTGGTATATATGCATTAGCTGTTGAATATGCTAAACATGTATCAAATAATAACATAGGCAATGTAAAAATTGCTAT
AGTAGGAGCCGGAGAAATTGGAAATAAACTAGCTCTAATGTTGAAGAATGAAGGAGCTCAAAATGTTACAATATTTAACA
GAACATACGAAAAAGCGTTAGAAGTTGCCAATAAGTATGGTTTTAAAGCAGAACCATTAGATTTTTATAAAATAAATAAT
TATGATATTGTATTTGTTGCAATATATTATGATAAAAAAATAAATCTACCAAATCCTAAACTAGTAATTGATCTTTCTGT
TCCCCAGATTGTTTTAGGTAACAATGTTATTACGTTAGAAAATTTGAGATCTATCTCAGATAAAATAATGGAAACAAAAA
TATTAAGTTTACAGAAAGCTGAGGAATTAATCCATATAGAGATAGAGAATTTTAAGAATGAAATTATTAAATATAATCAA
AATAGACTTATTTCTAAATTTATGAAAAGAATAGAAGATATTAGGGAAGCTGAAATAAATAGAGCTTATGCAGAAATTTT
AAAACATGCTAATGATAAAGAAGAGATAAAGAATATTATTGATAAAATGACTAATTCAATGCTTAAAAAAATCTTTTCAC
CGCTTTTTGAAACCGTTAGAAAAAATGAAGATATGGCAAATTACATTAACAACATTTTCGAAATATTAAGTAATGGTAAC
ATTTCCAACTCTAAGACCGAGGAGGCTAAGGAAAAATAA

Upstream 100 bases:

>100_bases
TTTACATATTATAGTAAAATATTTAATGATGAAATTTTTAGAAATTATATAAAAGAAAAGAAATTAGATTTAGCAATAGA
TAGAGCAAAGGTGATTATAA

Downstream 100 bases:

>100_bases
GTTAATAAGAGACTTAGTCGCAGAAACAAACTTAACTGCTTCTGGGTTAATACAGCCTATTTTCATAAAAGAAAATATAA
ATGAACCAGAAAAGATAGAT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSDEFIDINNYIAIVYTYKTVGISKLYEHYVKDQELLLLKGLIKGEISVLQTCNRAETYLYTYNKEEFKDFLQKLDEIHG
KQISKDAMILKGEDAVKHLFEVASGLDSLAIGEYEILRQLKESIEKSKKLGLSSEKLEFLFKNAIKVGRKIRQQTEISKG
KTGIYALAVEYAKHVSNNNIGNVKIAIVGAGEIGNKLALMLKNEGAQNVTIFNRTYEKALEVANKYGFKAEPLDFYKINN
YDIVFVAIYYDKKINLPNPKLVIDLSVPQIVLGNNVITLENLRSISDKIMETKILSLQKAEELIHIEIENFKNEIIKYNQ
NRLISKFMKRIEDIREAEINRAYAEILKHANDKEEIKNIIDKMTNSMLKKIFSPLFETVRKNEDMANYINNIFEILSNGN
ISNSKTEEAKEK

Sequences:

>Translated_412_residues
MSDEFIDINNYIAIVYTYKTVGISKLYEHYVKDQELLLLKGLIKGEISVLQTCNRAETYLYTYNKEEFKDFLQKLDEIHG
KQISKDAMILKGEDAVKHLFEVASGLDSLAIGEYEILRQLKESIEKSKKLGLSSEKLEFLFKNAIKVGRKIRQQTEISKG
KTGIYALAVEYAKHVSNNNIGNVKIAIVGAGEIGNKLALMLKNEGAQNVTIFNRTYEKALEVANKYGFKAEPLDFYKINN
YDIVFVAIYYDKKINLPNPKLVIDLSVPQIVLGNNVITLENLRSISDKIMETKILSLQKAEELIHIEIENFKNEIIKYNQ
NRLISKFMKRIEDIREAEINRAYAEILKHANDKEEIKNIIDKMTNSMLKKIFSPLFETVRKNEDMANYINNIFEILSNGN
ISNSKTEEAKEK
>Mature_411_residues
SDEFIDINNYIAIVYTYKTVGISKLYEHYVKDQELLLLKGLIKGEISVLQTCNRAETYLYTYNKEEFKDFLQKLDEIHGK
QISKDAMILKGEDAVKHLFEVASGLDSLAIGEYEILRQLKESIEKSKKLGLSSEKLEFLFKNAIKVGRKIRQQTEISKGK
TGIYALAVEYAKHVSNNNIGNVKIAIVGAGEIGNKLALMLKNEGAQNVTIFNRTYEKALEVANKYGFKAEPLDFYKINNY
DIVFVAIYYDKKINLPNPKLVIDLSVPQIVLGNNVITLENLRSISDKIMETKILSLQKAEELIHIEIENFKNEIIKYNQN
RLISKFMKRIEDIREAEINRAYAEILKHANDKEEIKNIIDKMTNSMLKKIFSPLFETVRKNEDMANYINNIFEILSNGNI
SNSKTEEAKEK

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=379, Percent_Identity=25.065963060686, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_SULTO (Q976H4)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376064.1
- ProteinModelPortal:   Q976H4
- GeneID:   1458103
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0212
- NMPDR:   fig|273063.1.peg.232
- HOGENOM:   HBG553533
- OMA:   GEDQIIG
- ProtClustDB:   PRK00045
- BioCyc:   STOK273063:ST0212-MONOMER
- BRENDA:   1.2.1.70
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47333; Mature: 47202

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 53-53 BINDING 108-108 BINDING 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEFIDINNYIAIVYTYKTVGISKLYEHYVKDQELLLLKGLIKGEISVLQTCNRAETYL
CCCCEEECCCEEEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
YTYNKEEFKDFLQKLDEIHGKQISKDAMILKGEDAVKHLFEVASGLDSLAIGEYEILRQL
EECCHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHCCCCHHCCCHHHHHHHH
KESIEKSKKLGLSSEKLEFLFKNAIKVGRKIRQQTEISKGKTGIYALAVEYAKHVSNNNI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
GNVKIAIVGAGEIGNKLALMLKNEGAQNVTIFNRTYEKALEVANKYGFKAEPLDFYKINN
CEEEEEEEECCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCEEEECC
YDIVFVAIYYDKKINLPNPKLVIDLSVPQIVLGNNVITLENLRSISDKIMETKILSLQKA
CCEEEEEEEECCCCCCCCCCEEEEECCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHH
EELIHIEIENFKNEIIKYNQNRLISKFMKRIEDIREAEINRAYAEILKHANDKEEIKNII
HHHEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKMTNSMLKKIFSPLFETVRKNEDMANYINNIFEILSNGNISNSKTEEAKEK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SDEFIDINNYIAIVYTYKTVGISKLYEHYVKDQELLLLKGLIKGEISVLQTCNRAETYL
CCCEEECCCEEEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
YTYNKEEFKDFLQKLDEIHGKQISKDAMILKGEDAVKHLFEVASGLDSLAIGEYEILRQL
EECCHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHCCCCHHCCCHHHHHHHH
KESIEKSKKLGLSSEKLEFLFKNAIKVGRKIRQQTEISKGKTGIYALAVEYAKHVSNNNI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
GNVKIAIVGAGEIGNKLALMLKNEGAQNVTIFNRTYEKALEVANKYGFKAEPLDFYKINN
CEEEEEEEECCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCEEEECC
YDIVFVAIYYDKKINLPNPKLVIDLSVPQIVLGNNVITLENLRSISDKIMETKILSLQKA
CCEEEEEEEECCCCCCCCCCEEEEECCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHH
EELIHIEIENFKNEIIKYNQNRLISKFMKRIEDIREAEINRAYAEILKHANDKEEIKNII
HHHEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKMTNSMLKKIFSPLFETVRKNEDMANYINNIFEILSNGNISNSKTEEAKEK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479