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The map label for this gene is hemE [H]

Identifier: 15893297

GI number: 15893297

Start: 1267320

End: 1268360

Strand: Reverse

Name: hemE [H]

Synonym: RC1374

Alternate gene names: 15893297

Gene position: 1268360-1267320 (Counterclockwise)

Preceding gene: NA

Following gene: 15893296

Centisome position: 99.97

GC content: 28.63

Gene sequence:

>1041_bases
ATGAAGCAAATTATAAATCCGTTAAAAGGAAATAATAATAAAGTACCTATTTGGTTTATGCGTCAAGCAGGTAGATATTT
GCCGGAATATAAAAAAGTAAGAGAAACAACAAAAAATTTTCTAGATTTTTGTTATGATGTTAGCAAAGCAACAGAAGTAA
CCTTACAACCGATAAAACGTTATGGATTTGATGCAGCTATTATTTTTTCCGATATATTAGTTTTACCTCATGCTCTTGGA
TGGGAAGTGGATTTTAAAGAAAATATAGGGCCTATATTAAAGCAATTCAAATCACAAGAAGATTTTAAATATCTGCAAAT
CAATCCGAATTATAAATTAGAAAAGGTTTATGAAATAATAAAAAAAGTAAAAAAAGAATTACCATCCCCCATTTCTTTAA
TAGGATTTGCAGGTAGTCCTTGGACAGTGATGAGTTACATGCTAGAAGGAAAAGGAAAACAGGATTTTAAAACGAGCAAA
AAATTCATATATGAAAATAAAATACTTGCTGAAGAATTATTAAATTTTATTACGGAAAAAACAGCTGATCATCTTATAAA
TCAAGCAAAATCTGGAGCAGATGTTTTAAAGCTTTTTGATTCATGGTCAGGAGTACTTGCAGAAGAGGAATTTACTGAAT
TTGTAATAGAGCCGACAAAAAAGATTATACTAAAAGTAAAAGAAGTTTTTCCAAAAACTCCTATAATTGCTTTTCCTAAA
GGAGCAGGATTATTGTACGAAAAATTTATAAAAGAAGTACCGATAGATGTTTTAGCCGTAGATCAAATGGTCCCTCTTGA
AAAAATGAAAGAGTGGAGTGATAAAGTAATAGTACAAGGTAATTTAGATCCGGTTGTATTATTAACTAATAAAGAAATTA
TTAAAGAAAAAACTTATAAAATTCTTCAGGTAATGAAAGGAAAGAATTTTATCTTTAATTTAGGACATGGTATTTTGCCT
GAAACACCTACGGAAAATGTAGAATTTTTGACAGAATATGTTAGGTTATATGAAGAAAAGAATAGCAATAGTACTTTTTA
A

Upstream 100 bases:

>100_bases
TTGTTGATAACTCCGTTTAAAACATTTAATCTACATAATTCTATTTACATAAACAACAAATAATAAATATATTTATTATT
TTAATATTTTTAGTAATAGT

Downstream 100 bases:

>100_bases
TTTAGGCGGTCCAAAAAACCTTAAATCAGTGAAGCCTTTTCTATTTAATCTATTCTATGACAAAGCTATAATTAATCTAC
CAAATCCTTTGCGTTATATT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKQIINPLKGNNNKVPIWFMRQAGRYLPEYKKVRETTKNFLDFCYDVSKATEVTLQPIKRYGFDAAIIFSDILVLPHALG
WEVDFKENIGPILKQFKSQEDFKYLQINPNYKLEKVYEIIKKVKKELPSPISLIGFAGSPWTVMSYMLEGKGKQDFKTSK
KFIYENKILAEELLNFITEKTADHLINQAKSGADVLKLFDSWSGVLAEEEFTEFVIEPTKKIILKVKEVFPKTPIIAFPK
GAGLLYEKFIKEVPIDVLAVDQMVPLEKMKEWSDKVIVQGNLDPVVLLTNKEIIKEKTYKILQVMKGKNFIFNLGHGILP
ETPTENVEFLTEYVRLYEEKNSNSTF

Sequences:

>Translated_346_residues
MKQIINPLKGNNNKVPIWFMRQAGRYLPEYKKVRETTKNFLDFCYDVSKATEVTLQPIKRYGFDAAIIFSDILVLPHALG
WEVDFKENIGPILKQFKSQEDFKYLQINPNYKLEKVYEIIKKVKKELPSPISLIGFAGSPWTVMSYMLEGKGKQDFKTSK
KFIYENKILAEELLNFITEKTADHLINQAKSGADVLKLFDSWSGVLAEEEFTEFVIEPTKKIILKVKEVFPKTPIIAFPK
GAGLLYEKFIKEVPIDVLAVDQMVPLEKMKEWSDKVIVQGNLDPVVLLTNKEIIKEKTYKILQVMKGKNFIFNLGHGILP
ETPTENVEFLTEYVRLYEEKNSNSTF
>Mature_346_residues
MKQIINPLKGNNNKVPIWFMRQAGRYLPEYKKVRETTKNFLDFCYDVSKATEVTLQPIKRYGFDAAIIFSDILVLPHALG
WEVDFKENIGPILKQFKSQEDFKYLQINPNYKLEKVYEIIKKVKKELPSPISLIGFAGSPWTVMSYMLEGKGKQDFKTSK
KFIYENKILAEELLNFITEKTADHLINQAKSGADVLKLFDSWSGVLAEEEFTEFVIEPTKKIILKVKEVFPKTPIIAFPK
GAGLLYEKFIKEVPIDVLAVDQMVPLEKMKEWSDKVIVQGNLDPVVLLTNKEIIKEKTYKILQVMKGKNFIFNLGHGILP
ETPTENVEFLTEYVRLYEEKNSNSTF

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=334, Percent_Identity=33.8323353293413, Blast_Score=205, Evalue=4e-53,
Organism=Escherichia coli, GI2367337, Length=332, Percent_Identity=36.144578313253, Blast_Score=214, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6320252, Length=348, Percent_Identity=35.3448275862069, Blast_Score=199, Evalue=4e-52,
Organism=Drosophila melanogaster, GI221330099, Length=334, Percent_Identity=36.5269461077844, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI19921920, Length=334, Percent_Identity=36.5269461077844, Blast_Score=214, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39965; Mature: 39965

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQIINPLKGNNNKVPIWFMRQAGRYLPEYKKVRETTKNFLDFCYDVSKATEVTLQPIKR
CCCCCCCCCCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGFDAAIIFSDILVLPHALGWEVDFKENIGPILKQFKSQEDFKYLQINPNYKLEKVYEII
HCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
KKVKKELPSPISLIGFAGSPWTVMSYMLEGKGKQDFKTSKKFIYENKILAEELLNFITEK
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TADHLINQAKSGADVLKLFDSWSGVLAEEEFTEFVIEPTKKIILKVKEVFPKTPIIAFPK
HHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
GAGLLYEKFIKEVPIDVLAVDQMVPLEKMKEWSDKVIVQGNLDPVVLLTNKEIIKEKTYK
CCCHHHHHHHHHCCCCCEEHHHCCCHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHH
ILQVMKGKNFIFNLGHGILPETPTENVEFLTEYVRLYEEKNSNSTF
HHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKQIINPLKGNNNKVPIWFMRQAGRYLPEYKKVRETTKNFLDFCYDVSKATEVTLQPIKR
CCCCCCCCCCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGFDAAIIFSDILVLPHALGWEVDFKENIGPILKQFKSQEDFKYLQINPNYKLEKVYEII
HCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
KKVKKELPSPISLIGFAGSPWTVMSYMLEGKGKQDFKTSKKFIYENKILAEELLNFITEK
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TADHLINQAKSGADVLKLFDSWSGVLAEEEFTEFVIEPTKKIILKVKEVFPKTPIIAFPK
HHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
GAGLLYEKFIKEVPIDVLAVDQMVPLEKMKEWSDKVIVQGNLDPVVLLTNKEIIKEKTYK
CCCHHHHHHHHHCCCCCEEHHHCCCHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHH
ILQVMKGKNFIFNLGHGILPETPTENVEFLTEYVRLYEEKNSNSTF
HHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA