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The map label for this gene is hemH [H]

Identifier: 15893296

GI number: 15893296

Start: 1266323

End: 1267363

Strand: Reverse

Name: hemH [H]

Synonym: RC1373

Alternate gene names: 15893296

Gene position: 1267363-1266323 (Counterclockwise)

Preceding gene: 15893297

Following gene: 15893295

Centisome position: 99.89

GC content: 27.76

Gene sequence:

>1041_bases
ATGTTAGGTTATATGAAGAAAAGAATAGCAATAGTACTTTTTAATTTAGGCGGTCCAAAAAACCTTAAATCAGTGAAGCC
TTTTCTATTTAATCTATTCTATGACAAAGCTATAATTAATCTACCAAATCCTTTGCGTTATATTATCGCTAAAATAATTT
CTATTACTAGAGAGAAAAAATCTCAAAAAATTTATTCTTTAATCGGTGGTAAATCTTCTTTACTTCAGGAAACAGAGGAG
CAGAAATTAGCACTAACCGAAAAGCTAAAGCAACTTATAAAAGAAGATTTCGCTATTTTTATAAATATGAGGTATTCAGC
ACCGTTTGCTAAAGAAGTAATAGGTCAAATAAAAAAATATAATCCAAGCGAAATAATATTATTGCCTCTATATTCTCAAT
TTTCAAGTACTACGACAGGATCATCGGTTAAAAATTTTTTACAAAACCTTGATATTGATATTCCAATTAAAACAATTTGC
TGTTATCCTCTAGAAAAAGATTTTATAAAAGCCCATGTTTCATTAATTAAAGAAAAACTATACGATAAAAATTTTCGTAT
ATTATTTTCTGCTCACGGGTTACCCGAAAAAATAATAAAAGCAGGCGATCCTTATAGTTTTCAGATAAAAGAAACAGTAC
AAGCAATAGTTAAAGAATTAAATATAAAAGATCTAGATTATAAGATAACTTATCAAAGTAGAGTAGGACCTATAGAGTGG
TTAAAACCGAATACGGAAGACGAAATAGAGCTAGCAGGAAAGTTAAAAAAAGACATAATTATCGTACCTATATCCTTTGT
ATCCGAGCATGTTGAAACACTAGTAGAGCTTGATATTGAATATAAATTAATCGCAGATAAATATGAAATTCAATATATCC
GAATTCCGACACTTGGAACAAATAAAATTTTTATTAATAGTTTGACAAATATATTGCTACGATTTATTAATAAGGTTGAT
ACTAATTTAGTTATGAGTAGCTCTAGTACAAGAATATGTCCAAACGAATTTACTAAATGTTTGTGTAAATTAACAAGTTA
A

Upstream 100 bases:

>100_bases
AAAATTCTTCAGGTAATGAAAGGAAAGAATTTTATCTTTAATTTAGGACATGGTATTTTGCCTGAAACACCTACGGAAAA
TGTAGAATTTTTGACAGAAT

Downstream 100 bases:

>100_bases
TAAGGAAAAGAATGGCAAGTTACTATCTATGGTTTAAGTCATTTCATCTGATATCTGCTATATGTTGGATGGCAGGGCTT
CTTTATTTACCTAGAATATA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MLGYMKKRIAIVLFNLGGPKNLKSVKPFLFNLFYDKAIINLPNPLRYIIAKIISITREKKSQKIYSLIGGKSSLLQETEE
QKLALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKKYNPSEIILLPLYSQFSSTTTGSSVKNFLQNLDIDIPIKTIC
CYPLEKDFIKAHVSLIKEKLYDKNFRILFSAHGLPEKIIKAGDPYSFQIKETVQAIVKELNIKDLDYKITYQSRVGPIEW
LKPNTEDEIELAGKLKKDIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYIRIPTLGTNKIFINSLTNILLRFINKVD
TNLVMSSSSTRICPNEFTKCLCKLTS

Sequences:

>Translated_346_residues
MLGYMKKRIAIVLFNLGGPKNLKSVKPFLFNLFYDKAIINLPNPLRYIIAKIISITREKKSQKIYSLIGGKSSLLQETEE
QKLALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKKYNPSEIILLPLYSQFSSTTTGSSVKNFLQNLDIDIPIKTIC
CYPLEKDFIKAHVSLIKEKLYDKNFRILFSAHGLPEKIIKAGDPYSFQIKETVQAIVKELNIKDLDYKITYQSRVGPIEW
LKPNTEDEIELAGKLKKDIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYIRIPTLGTNKIFINSLTNILLRFINKVD
TNLVMSSSSTRICPNEFTKCLCKLTS
>Mature_346_residues
MLGYMKKRIAIVLFNLGGPKNLKSVKPFLFNLFYDKAIINLPNPLRYIIAKIISITREKKSQKIYSLIGGKSSLLQETEE
QKLALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKKYNPSEIILLPLYSQFSSTTTGSSVKNFLQNLDIDIPIKTIC
CYPLEKDFIKAHVSLIKEKLYDKNFRILFSAHGLPEKIIKAGDPYSFQIKETVQAIVKELNIKDLDYKITYQSRVGPIEW
LKPNTEDEIELAGKLKKDIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYIRIPTLGTNKIFINSLTNILLRFINKVD
TNLVMSSSSTRICPNEFTKCLCKLTS

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=345, Percent_Identity=31.304347826087, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI60499025, Length=345, Percent_Identity=31.304347826087, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI1786681, Length=324, Percent_Identity=24.6913580246914, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324750, Length=316, Percent_Identity=30.0632911392405, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI17864156, Length=329, Percent_Identity=33.434650455927, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24651774, Length=263, Percent_Identity=30.7984790874525, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI45552018, Length=131, Percent_Identity=42.7480916030534, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39703; Mature: 39703

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGYMKKRIAIVLFNLGGPKNLKSVKPFLFNLFYDKAIINLPNPLRYIIAKIISITREKK
CCCHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SQKIYSLIGGKSSLLQETEEQKLALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKKY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCC
NPSEIILLPLYSQFSSTTTGSSVKNFLQNLDIDIPIKTICCYPLEKDFIKAHVSLIKEKL
CCCCEEEEEEHHHCCCCCCCHHHHHHHHHCCCCCCHHHEEECCCHHHHHHHHHHHHHHHH
YDKNFRILFSAHGLPEKIIKAGDPYSFQIKETVQAIVKELNIKDLDYKITYQSRVGPIEW
CCCCEEEEEECCCCCHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHC
LKPNTEDEIELAGKLKKDIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYIRIPTLGT
CCCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCEEEEECEEEEEEEEECCCCC
NKIFINSLTNILLRFINKVDTNLVMSSSSTRICPNEFTKCLCKLTS
CHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLGYMKKRIAIVLFNLGGPKNLKSVKPFLFNLFYDKAIINLPNPLRYIIAKIISITREKK
CCCHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SQKIYSLIGGKSSLLQETEEQKLALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKKY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCC
NPSEIILLPLYSQFSSTTTGSSVKNFLQNLDIDIPIKTICCYPLEKDFIKAHVSLIKEKL
CCCCEEEEEEHHHCCCCCCCHHHHHHHHHCCCCCCHHHEEECCCHHHHHHHHHHHHHHHH
YDKNFRILFSAHGLPEKIIKAGDPYSFQIKETVQAIVKELNIKDLDYKITYQSRVGPIEW
CCCCEEEEEECCCCCHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHC
LKPNTEDEIELAGKLKKDIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYIRIPTLGT
CCCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCEEEEECEEEEEEEEECCCCC
NKIFINSLTNILLRFINKVDTNLVMSSSSTRICPNEFTKCLCKLTS
CHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]