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The map label for this gene is proP [H]

Identifier: 15893244

GI number: 15893244

Start: 1223497

End: 1223988

Strand: Reverse

Name: proP [H]

Synonym: RC1321

Alternate gene names: 15893244

Gene position: 1223988-1223497 (Counterclockwise)

Preceding gene: 15893245

Following gene: 15893243

Centisome position: 96.47

GC content: 32.72

Gene sequence:

>492_bases
ATGCAAACACTCGGTTATACTAATCAGCAAAGCACAATTGTTAGTAGTATAATATTAATCGTAATAATGATAGTATTTCC
TATATCTGCGTATGTTTCGGATAAGGTGGGGCGACGTCCTGTACTAATATTGGGGATTATCTTGTTAATTTTATCAGTCT
ATACTATTTTTGTAGCCTTAGGGTCGATGAATTTTACTTTAGCTATAATATCTCAAGTAATATTTGCTGGAGTTATTAGC
ATCTATATGGGGCCTATTCCAACGGTTTTAGTAGAGATATTTCTGACTAGCATAAGATTTACCGGTGTTGCACTTTCATA
CAACCTTGCAGCTGCTATATTTGGCGGTACTGCTCCAATGTTAGCAATGATATTAACGAAAGTTACCGGAGACAATTATG
CTATTGCATATTATTTAATTGCACTTGCCTTGTTATCTTCTATAATTCTAAAATTCTATAAAGAAACCTATAAAAAGAAT
CTAGTAAATTAA

Upstream 100 bases:

>100_bases
AACATTAACAAAATACCCAAAAGAACTAATTATCGCACTTGGTCTGTATATTACCGTAACTGCTTCTTTTTATACTTCTA
CGGTTTTTATTGGTAATTTT

Downstream 100 bases:

>100_bases
TATGAGCGAAGTTTTTGAAATACCAAACGGTGAAAGCAAGGTTTTACTCCATTGTTGTTGTGCTCCTTGTGTTGGCCCTT
TAATGGAAAAAATGATCGAT

Product: putative proline/betaine transporter

Products: betaine [Cytoplasm]; Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MQTLGYTNQQSTIVSSIILIVIMIVFPISAYVSDKVGRRPVLILGIILLILSVYTIFVALGSMNFTLAIISQVIFAGVIS
IYMGPIPTVLVEIFLTSIRFTGVALSYNLAAAIFGGTAPMLAMILTKVTGDNYAIAYYLIALALLSSIILKFYKETYKKN
LVN

Sequences:

>Translated_163_residues
MQTLGYTNQQSTIVSSIILIVIMIVFPISAYVSDKVGRRPVLILGIILLILSVYTIFVALGSMNFTLAIISQVIFAGVIS
IYMGPIPTVLVEIFLTSIRFTGVALSYNLAAAIFGGTAPMLAMILTKVTGDNYAIAYYLIALALLSSIILKFYKETYKKN
LVN
>Mature_163_residues
MQTLGYTNQQSTIVSSIILIVIMIVFPISAYVSDKVGRRPVLILGIILLILSVYTIFVALGSMNFTLAIISQVIFAGVIS
IYMGPIPTVLVEIFLTSIRFTGVALSYNLAAAIFGGTAPMLAMILTKVTGDNYAIAYYLIALALLSSIILKFYKETYKKN
LVN

Specific function: May be a proton symporter invoved in the uptake of osmolytes such as proline and glycine betaine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 17740; Mature: 17740

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLGYTNQQSTIVSSIILIVIMIVFPISAYVSDKVGRRPVLILGIILLILSVYTIFVAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
GSMNFTLAIISQVIFAGVISIYMGPIPTVLVEIFLTSIRFTGVALSYNLAAAIFGGTAPM
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LAMILTKVTGDNYAIAYYLIALALLSSIILKFYKETYKKNLVN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTLGYTNQQSTIVSSIILIVIMIVFPISAYVSDKVGRRPVLILGIILLILSVYTIFVAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
GSMNFTLAIISQVIFAGVISIYMGPIPTVLVEIFLTSIRFTGVALSYNLAAAIFGGTAPM
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LAMILTKVTGDNYAIAYYLIALALLSSIILKFYKETYKKNLVN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: betaine [Periplasm]; Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + betaine [Periplasm] = Proton [Cytoplasm] + betaine [Cytoplasm] Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]