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The map label for this gene is glyA [H]

Identifier: 15893069

GI number: 15893069

Start: 1056823

End: 1058085

Strand: Reverse

Name: glyA [H]

Synonym: RC1146

Alternate gene names: 15893069

Gene position: 1058085-1056823 (Counterclockwise)

Preceding gene: 15893070

Following gene: 15893068

Centisome position: 83.4

GC content: 36.82

Gene sequence:

>1263_bases
ATGAATATTTTTAATAATAATTTACACGAAACGGATAAAGAGATTAATGAAATAATAAAGCATGAAAAGCTACGTCAAAG
TAGTGTAATCGAGCTTATTGCATCAGAAAATTTCGTAAGTCCTGCTGTGCTTGAAGCTCAAGGGGCGCTTCTGACTAACA
AATATGCCGAAGGATACCCAAGTAAGCGATTCTATAACGGTTGCGAGGAAGTAGATAAAGCTGAAAATTTAGCTATAGAA
CGAGTAAAAAAACTCTTTAACTGCAAATATGCAAATGTCCAACCTCATTCAGGATCACAAGCAAATCAGGCTGTATATCT
TGCTTTATTACAGCCGGGTGATACGGTTCTTGGTATGTCCTTAGATAGCGGTGGGCATCTAACGCACGGTGCAGCTCCTA
ATATGTCTGGTAAATGGTTTAACGCCGTTTCTTATAGCGTAAATAAAGAGACTTATTTAATCGATTATGATGAGATTGAA
CGCTTAGCGGATTTGCATAAACCAAAATTACTTATAGCCGGTTTTTCTGCTTATCCTCGTAATATTGATTTTGCAAAATT
TAGAGAAATCGTGGATAAAGTAGGAGCTTACTTTATGGCAGATATTGCTCATATTGCAGGACTTGTTGCCACAGGTGAGC
ATCAAAGCCCTATTCCTTATGCTCACGCTGTTACCTCTACTACTCATAAAACACTTAGAGGTCCAAGAGGCGGTTTAATT
TTATCTAACGATGAAGCGATAGGTCACAAAATAAATTCTGCATTATTTCCAGGACTACAAGGTGGTCCGTTAATGCATAT
AATAGCTGCAAAAGCCGTAGCTTTTTTAGAAAATTTGCAGCCTGAATATAAAAGTTATATTCAGCAGGTAATAAGTAACG
CTAAAGCTTTAGCAAGTAGCTTGCAAGAAAGAGGATATGATATATTAACAGGTGGTACCGATAATCATATTGTTTTAGTG
GATTTGCGTAAAGACGGAATCACGGGTAAGCTTGCCGCAAATTCTTTGGATAGAGCAGGGATTACGTGTAATAAGAATGC
TATCCCGTTTGATGAAACTTCGCCTTTTATCACTTCAGGTATTCGCCTTGGTACTCCCGCATGTACTACTAGAGGTTTTA
AAGAAAAGGATTTTGTATTAGTCGGTCATATGGTAGCAGATATTTTAGACGGCTTAAAAAATAATGAAGATAATAGCGCT
CTTGAGCAGAAAGTATTAAATGAAGTGACAAAATTAATTGAATTATTTCCGTTTTATGGCTAA

Upstream 100 bases:

>100_bases
TCAGGATTGTGGTATGAGATTGCTTCGTCAAAATTTTCAATTTTTCCTCGCAATGATGATTAGATATCCACACAACAAAA
CCAAAAAAATATGAGGATGA

Downstream 100 bases:

>100_bases
TTTAAATAAACGACCTGATTGGATAAAAGTAAAAGCTCCTAATTCTACAGAGTACTATAATACAAAAGATTTAATAAAGA
ATCTGAGATTAAATACTGTG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGALLTNKYAEGYPSKRFYNGCEEVDKAENLAIE
RVKKLFNCKYANVQPHSGSQANQAVYLALLQPGDTVLGMSLDSGGHLTHGAAPNMSGKWFNAVSYSVNKETYLIDYDEIE
RLADLHKPKLLIAGFSAYPRNIDFAKFREIVDKVGAYFMADIAHIAGLVATGEHQSPIPYAHAVTSTTHKTLRGPRGGLI
LSNDEAIGHKINSALFPGLQGGPLMHIIAAKAVAFLENLQPEYKSYIQQVISNAKALASSLQERGYDILTGGTDNHIVLV
DLRKDGITGKLAANSLDRAGITCNKNAIPFDETSPFITSGIRLGTPACTTRGFKEKDFVLVGHMVADILDGLKNNEDNSA
LEQKVLNEVTKLIELFPFYG

Sequences:

>Translated_420_residues
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGALLTNKYAEGYPSKRFYNGCEEVDKAENLAIE
RVKKLFNCKYANVQPHSGSQANQAVYLALLQPGDTVLGMSLDSGGHLTHGAAPNMSGKWFNAVSYSVNKETYLIDYDEIE
RLADLHKPKLLIAGFSAYPRNIDFAKFREIVDKVGAYFMADIAHIAGLVATGEHQSPIPYAHAVTSTTHKTLRGPRGGLI
LSNDEAIGHKINSALFPGLQGGPLMHIIAAKAVAFLENLQPEYKSYIQQVISNAKALASSLQERGYDILTGGTDNHIVLV
DLRKDGITGKLAANSLDRAGITCNKNAIPFDETSPFITSGIRLGTPACTTRGFKEKDFVLVGHMVADILDGLKNNEDNSA
LEQKVLNEVTKLIELFPFYG
>Mature_420_residues
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGALLTNKYAEGYPSKRFYNGCEEVDKAENLAIE
RVKKLFNCKYANVQPHSGSQANQAVYLALLQPGDTVLGMSLDSGGHLTHGAAPNMSGKWFNAVSYSVNKETYLIDYDEIE
RLADLHKPKLLIAGFSAYPRNIDFAKFREIVDKVGAYFMADIAHIAGLVATGEHQSPIPYAHAVTSTTHKTLRGPRGGLI
LSNDEAIGHKINSALFPGLQGGPLMHIIAAKAVAFLENLQPEYKSYIQQVISNAKALASSLQERGYDILTGGTDNHIVLV
DLRKDGITGKLAANSLDRAGITCNKNAIPFDETSPFITSGIRLGTPACTTRGFKEKDFVLVGHMVADILDGLKNNEDNSA
LEQKVLNEVTKLIELFPFYG

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=409, Percent_Identity=47.1882640586797, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862352, Length=409, Percent_Identity=47.1882640586797, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI261862350, Length=409, Percent_Identity=47.1882640586797, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI261862348, Length=409, Percent_Identity=47.1882640586797, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=48.3790523690773, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI261862346, Length=409, Percent_Identity=45.9657701711491, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI22547189, Length=387, Percent_Identity=45.4780361757106, Blast_Score=303, Evalue=1e-82,
Organism=Escherichia coli, GI1788902, Length=415, Percent_Identity=55.1807228915663, Blast_Score=448, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI25144729, Length=406, Percent_Identity=47.0443349753695, Blast_Score=354, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI25144732, Length=406, Percent_Identity=47.0443349753695, Blast_Score=354, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6323087, Length=399, Percent_Identity=45.6140350877193, Blast_Score=332, Evalue=6e-92,
Organism=Saccharomyces cerevisiae, GI6319739, Length=438, Percent_Identity=40.8675799086758, Blast_Score=323, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24640005, Length=413, Percent_Identity=48.6682808716707, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221329721, Length=413, Percent_Identity=48.6682808716707, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45958; Mature: 45958

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGALLTNKYAEGYP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCCC
SKRFYNGCEEVDKAENLAIERVKKLFNCKYANVQPHSGSQANQAVYLALLQPGDTVLGMS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LDSGGHLTHGAAPNMSGKWFNAVSYSVNKETYLIDYDEIERLADLHKPKLLIAGFSAYPR
ECCCCCCCCCCCCCCCCCEEEHEEEEECCCEEEEEHHHHHHHHHHCCCEEEEEECCCCCC
NIDFAKFREIVDKVGAYFMADIAHIAGLVATGEHQSPIPYAHAVTSTTHKTLRGPRGGLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
LSNDEAIGHKINSALFPGLQGGPLMHIIAAKAVAFLENLQPEYKSYIQQVISNAKALASS
EECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LQERGYDILTGGTDNHIVLVDLRKDGITGKLAANSLDRAGITCNKNAIPFDETSPFITSG
HHHCCCEEEECCCCCEEEEEEECCCCCCCCHHHCCCCCCCCEECCCCCCCCCCCCHHHCC
IRLGTPACTTRGFKEKDFVLVGHMVADILDGLKNNEDNSALEQKVLNEVTKLIELFPFYG
EECCCCHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGALLTNKYAEGYP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCCC
SKRFYNGCEEVDKAENLAIERVKKLFNCKYANVQPHSGSQANQAVYLALLQPGDTVLGMS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LDSGGHLTHGAAPNMSGKWFNAVSYSVNKETYLIDYDEIERLADLHKPKLLIAGFSAYPR
ECCCCCCCCCCCCCCCCCEEEHEEEEECCCEEEEEHHHHHHHHHHCCCEEEEEECCCCCC
NIDFAKFREIVDKVGAYFMADIAHIAGLVATGEHQSPIPYAHAVTSTTHKTLRGPRGGLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
LSNDEAIGHKINSALFPGLQGGPLMHIIAAKAVAFLENLQPEYKSYIQQVISNAKALASS
EECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LQERGYDILTGGTDNHIVLVDLRKDGITGKLAANSLDRAGITCNKNAIPFDETSPFITSG
HHHCCCEEEECCCCCEEEEEEECCCCCCCCHHHCCCCCCCCEECCCCCCCCCCCCHHHCC
IRLGTPACTTRGFKEKDFVLVGHMVADILDGLKNNEDNSALEQKVLNEVTKLIELFPFYG
EECCCCHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA