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The map label for this gene is rnhA [H]

Identifier: 15893031

GI number: 15893031

Start: 1029683

End: 1030150

Strand: Reverse

Name: rnhA [H]

Synonym: RC1108

Alternate gene names: 15893031

Gene position: 1030150-1029683 (Counterclockwise)

Preceding gene: 15893032

Following gene: 15893030

Centisome position: 81.19

GC content: 34.4

Gene sequence:

>468_bases
ATGCATATTATGGATTCAAAAGTAGTGATATATACTGATGGTGCATGTGCAGGTAATCCAGGTCCCGGAGGGTGGGGAGC
TTTGCTTCAATTTAATGATACTAGCAAAGAAGTATTTGGGTATGAGTTAGATACGACTAATAATCGTATGGAAATTACGG
CAGCACTTGAAGCCTTGAGGATTTTAAAAAAATCTTGTAATATTGAGATTTATACCGATAGTAAATATTTGCAACAAGGA
ATTACCGCTTGGATTCATAATTGGATAAAAAATAATTGGTGTAAAAGCAACAATGAACCCGTTAAAAATGCCGATTTATG
GCAAAAATTATACGCAGAATTGAGTAAACATACTATTATTTGGAAATGGGTAAAAGGTCATGCAAATAATAGCGGTAATA
TTGCTGCCGATAAACTTGCAGTGCAAGGAAGAGAAACTGCTATAGAAATTTTAAAATGTCGTGGATAG

Upstream 100 bases:

>100_bases
AAGAGGCAATAAGTAATAATAAAAGTGATCAGACTTCATCATCTTCAAGTCCAAATGTTATAATGTTAGATAAGTTTCGT
AATTCTTCTAAACCTAGTTA

Downstream 100 bases:

>100_bases
ATAAGTGTTTTATTACTTTTTTTCACAAAAAAGTAGGAGAAGATGAGTTTTTGAATCAATATTATGAAAGCCGTAATATT
GATTATTTGGGGCGTCCAAG

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MHIMDSKVVIYTDGACAGNPGPGGWGALLQFNDTSKEVFGYELDTTNNRMEITAALEALRILKKSCNIEIYTDSKYLQQG
ITAWIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTIIWKWVKGHANNSGNIAADKLAVQGRETAIEILKCRG

Sequences:

>Translated_155_residues
MHIMDSKVVIYTDGACAGNPGPGGWGALLQFNDTSKEVFGYELDTTNNRMEITAALEALRILKKSCNIEIYTDSKYLQQG
ITAWIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTIIWKWVKGHANNSGNIAADKLAVQGRETAIEILKCRG
>Mature_155_residues
MHIMDSKVVIYTDGACAGNPGPGGWGALLQFNDTSKEVFGYELDTTNNRMEITAALEALRILKKSCNIEIYTDSKYLQQG
ITAWIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTIIWKWVKGHANNSGNIAADKLAVQGRETAIEILKCRG

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=152, Percent_Identity=36.1842105263158, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786408, Length=137, Percent_Identity=51.8248175182482, Blast_Score=152, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI115532542, Length=146, Percent_Identity=34.2465753424658, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17505482, Length=132, Percent_Identity=34.0909090909091, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=37.6712328767123, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=37.6712328767123, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 17439; Mature: 17439

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIMDSKVVIYTDGACAGNPGPGGWGALLQFNDTSKEVFGYELDTTNNRMEITAALEALR
CCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHEEEEECCCCCEEHHHHHHHHHH
ILKKSCNIEIYTDSKYLQQGITAWIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTII
HHHHHCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEE
WKWVKGHANNSGNIAADKLAVQGRETAIEILKCRG
EEEEECCCCCCCCEEHHHEECCCHHHHHHHEECCC
>Mature Secondary Structure
MHIMDSKVVIYTDGACAGNPGPGGWGALLQFNDTSKEVFGYELDTTNNRMEITAALEALR
CCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHEEEEECCCCCEEHHHHHHHHHH
ILKKSCNIEIYTDSKYLQQGITAWIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTII
HHHHHCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEE
WKWVKGHANNSGNIAADKLAVQGRETAIEILKCRG
EEEEECCCCCCCCEEHHHEECCCHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA