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The map label for this gene is adk [H]

Identifier: 15892908

GI number: 15892908

Start: 923038

End: 923676

Strand: Reverse

Name: adk [H]

Synonym: RC0985

Alternate gene names: 15892908

Gene position: 923676-923038 (Counterclockwise)

Preceding gene: 15892909

Following gene: 15892907

Centisome position: 72.8

GC content: 25.82

Gene sequence:

>639_bases
GTGATGGTAATTTTTTTAGGTCCTCCAGGAGCGGGAAAGGGCACACAAGGAAAAAAGATAGCTAAAAAAATTGATTTACC
ACATATAGCAATCGGTGATATATTTAGAACAATTATTAAAACATCAACTAGCGAAGCAGAGTTAATTAATAATTATGTTA
AGCAAGGGGAGCTTATCCCTAATGAAATAGTTAATCAAGTAATCAAAAATTTTTTATTATCCTCTGAATATAAAAACGGC
TACATATTAGATGGATATCCGCGTAATTTAGAGCAAGCGAAATTTTTTGAATCATTTATTAAAGAAAAAATTAAAATAAT
ATATTTTGATGTTTCAGATGAATTATTAATTAAAAGAATTTTAGGAAGATATAGTTGTAAAAATTGCGGTAAAATATATA
ATAGGTACTTCGTGCAGCCTAAAACTGATAATGTATGTGATGTTTGCGGTTCAAGTACATTTGATTATAGAAAAGACGAT
AATGAAGAAGTAATAAAAAAAAGAATTGAAGTATATAAAACAGAAACATATCCATTAATAGATTATTATAAGAATAGTGG
TAATTTTTATATAGTTAATGGAAGTAAAAATGAACAAGAAATAGAAATTGATATACAGAAAATACTAAAAATAAATTGA

Upstream 100 bases:

>100_bases
ACTTGATACTATGACTCAGATTCAAACTTACTTATTTAGTAGTAAGTATGAAGGTTTAATGAAGAAAGTAAAATTAAAAA
ATTAAAAATGAGCTTAAATA

Downstream 100 bases:

>100_bases
CTTTATCAAAGATTTTTATATTATTTTTTAGTTACCAGTAAAATTTTGGAGATTATTTGTGGCAAGAATTGCAAGTGTTA
ATATTCCTGATAATAAACGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MMVIFLGPPGAGKGTQGKKIAKKIDLPHIAIGDIFRTIIKTSTSEAELINNYVKQGELIPNEIVNQVIKNFLLSSEYKNG
YILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRILGRYSCKNCGKIYNRYFVQPKTDNVCDVCGSSTFDYRKDD
NEEVIKKRIEVYKTETYPLIDYYKNSGNFYIVNGSKNEQEIEIDIQKILKIN

Sequences:

>Translated_212_residues
MMVIFLGPPGAGKGTQGKKIAKKIDLPHIAIGDIFRTIIKTSTSEAELINNYVKQGELIPNEIVNQVIKNFLLSSEYKNG
YILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRILGRYSCKNCGKIYNRYFVQPKTDNVCDVCGSSTFDYRKDD
NEEVIKKRIEVYKTETYPLIDYYKNSGNFYIVNGSKNEQEIEIDIQKILKIN
>Mature_212_residues
MMVIFLGPPGAGKGTQGKKIAKKIDLPHIAIGDIFRTIIKTSTSEAELINNYVKQGELIPNEIVNQVIKNFLLSSEYKNG
YILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRILGRYSCKNCGKIYNRYFVQPKTDNVCDVCGSSTFDYRKDD
NEEVIKKRIEVYKTETYPLIDYYKNSGNFYIVNGSKNEQEIEIDIQKILKIN

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=199, Percent_Identity=35.1758793969849, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI4502013, Length=199, Percent_Identity=35.1758793969849, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=29.8507462686567, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=29.8507462686567, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=29.8507462686567, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=29.8507462686567, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI19923437, Length=201, Percent_Identity=29.3532338308458, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI4502011, Length=194, Percent_Identity=28.3505154639175, Blast_Score=103, Evalue=8e-23,
Organism=Homo sapiens, GI7706497, Length=209, Percent_Identity=30.1435406698565, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI28144899, Length=201, Percent_Identity=24.8756218905473, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI28144897, Length=201, Percent_Identity=24.8756218905473, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI22749187, Length=194, Percent_Identity=22.1649484536082, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=35.981308411215, Blast_Score=144, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=33.175355450237, Blast_Score=133, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=198, Percent_Identity=31.8181818181818, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17550688, Length=212, Percent_Identity=26.8867924528302, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=26.9767441860465, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537943, Length=203, Percent_Identity=28.0788177339901, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25147457, Length=212, Percent_Identity=20.7547169811321, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=208, Percent_Identity=36.0576923076923, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321018, Length=201, Percent_Identity=34.8258706467662, Blast_Score=122, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=212, Percent_Identity=30.6603773584906, Blast_Score=104, Evalue=9e-24,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=33.4905660377358, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=32.6633165829146, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=32.6633165829146, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221459597, Length=212, Percent_Identity=26.8867924528302, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356893, Length=212, Percent_Identity=26.8867924528302, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24663208, Length=184, Percent_Identity=25, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=184, Percent_Identity=25, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24582962, Length=213, Percent_Identity=23.943661971831, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24498; Mature: 24498

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVIFLGPPGAGKGTQGKKIAKKIDLPHIAIGDIFRTIIKTSTSEAELINNYVKQGELIP
CEEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
NEIVNQVIKNFLLSSEYKNGYILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRI
HHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHCEEEEEEECCHHHHHHHH
LGRYSCKNCGKIYNRYFVQPKTDNVCDVCGSSTFDYRKDDNEEVIKKRIEVYKTETYPLI
HHHHCCHHHHHHHHHEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEE
DYYKNSGNFYIVNGSKNEQEIEIDIQKILKIN
EEEECCCCEEEEECCCCCCHHHEEHHHHHCCC
>Mature Secondary Structure
MMVIFLGPPGAGKGTQGKKIAKKIDLPHIAIGDIFRTIIKTSTSEAELINNYVKQGELIP
CEEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
NEIVNQVIKNFLLSSEYKNGYILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRI
HHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHCEEEEEEECCHHHHHHHH
LGRYSCKNCGKIYNRYFVQPKTDNVCDVCGSSTFDYRKDDNEEVIKKRIEVYKTETYPLI
HHHHCCHHHHHHHHHEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEE
DYYKNSGNFYIVNGSKNEQEIEIDIQKILKIN
EEEECCCCEEEEECCCCCCHHHEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA