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The map label for this gene is uppS

Identifier: 15892513

GI number: 15892513

Start: 578028

End: 578735

Strand: Reverse

Name: uppS

Synonym: RC0590

Alternate gene names: 15892513

Gene position: 578735-578028 (Counterclockwise)

Preceding gene: 15892514

Following gene: 15892512

Centisome position: 45.61

GC content: 30.37

Gene sequence:

>708_bases
ATGCAGCAACATCTAAAATATAAAATAATGACTAATATAAAACATTTAGCAATAATAATGGACGGTAATGCTCGTTGGGC
AGATCAGCATAACTTAACAAAATCTGAAGGGCATAAAGCAGGAGCCGATAAAATTCGTGAATTACTGCCTGAGTTTCTTA
ACCTTAACATACCTTATATAACTTTATATACTTTCTCTTCCGAAAATTGGCAACGCTCAAGCACGGAAGTAGATTTCTTA
ATAAAATTATTAAGTATTTATTTAAAAACCGAATTAAATAATTTACATAAAAACGGCGTTAAAATAAAAGTAATAGGTAG
ACTGACTTTATTAAGTAGCTCATTGCAAAAACAAATAAATAATGCTATAGAATTAACAAAAAATAATAATAAAATAACGC
TTTGTATAGCTTTTAGTTATGGAAGTCGTCAAGAAATAGTTGATGCCTGCACAAAAATTATTACAAGCGGTAAAAAAGCA
GTAAGTGACAGCGATATACAACACGCTTTATATGATCCTGAAATGCCGGATGTAGATTTATTAATAAGACCGGGCGGGGT
TTATCGCATCAGTAATTTCTTGCTTTGGCAAGCAGCTTATGCTGAATTATATTTCTCACCCAAATATTGGCCTGATTTTA
ATAAATATGATATACAAGAAGCTATAAATGATTACTCAAAAAGGAAAAGAACATTTGGTAAAAGATAA

Upstream 100 bases:

>100_bases
ATAGGCAAAGCCGAGGGCGTGACAATCTCAGAAATTTTATATTGTTTCATGAGATTGCCACACTCCTTGCAGTCGCTCGC
AATGACGGAAAAATCGATCC

Downstream 100 bases:

>100_bases
ACAAAAATCAAACATATATTTAAGAATCCTGTCCGGTATAGTTTTAGTTCCGTTATTTGTCATAGCTATATTATGGTGTA
AGCCTTTATTCTATATTCTA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MQQHLKYKIMTNIKHLAIIMDGNARWADQHNLTKSEGHKAGADKIRELLPEFLNLNIPYITLYTFSSENWQRSSTEVDFL
IKLLSIYLKTELNNLHKNGVKIKVIGRLTLLSSSLQKQINNAIELTKNNNKITLCIAFSYGSRQEIVDACTKIITSGKKA
VSDSDIQHALYDPEMPDVDLLIRPGGVYRISNFLLWQAAYAELYFSPKYWPDFNKYDIQEAINDYSKRKRTFGKR

Sequences:

>Translated_235_residues
MQQHLKYKIMTNIKHLAIIMDGNARWADQHNLTKSEGHKAGADKIRELLPEFLNLNIPYITLYTFSSENWQRSSTEVDFL
IKLLSIYLKTELNNLHKNGVKIKVIGRLTLLSSSLQKQINNAIELTKNNNKITLCIAFSYGSRQEIVDACTKIITSGKKA
VSDSDIQHALYDPEMPDVDLLIRPGGVYRISNFLLWQAAYAELYFSPKYWPDFNKYDIQEAINDYSKRKRTFGKR
>Mature_235_residues
MQQHLKYKIMTNIKHLAIIMDGNARWADQHNLTKSEGHKAGADKIRELLPEFLNLNIPYITLYTFSSENWQRSSTEVDFL
IKLLSIYLKTELNNLHKNGVKIKVIGRLTLLSSSLQKQINNAIELTKNNNKITLCIAFSYGSRQEIVDACTKIITSGKKA
VSDSDIQHALYDPEMPDVDLLIRPGGVYRISNFLLWQAAYAELYFSPKYWPDFNKYDIQEAINDYSKRKRTFGKR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=218, Percent_Identity=41.2844036697248, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI45580742, Length=218, Percent_Identity=41.2844036697248, Blast_Score=155, Evalue=2e-38,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=41.3793103448276, Blast_Score=187, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71993029, Length=236, Percent_Identity=31.3559322033898, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319474, Length=208, Percent_Identity=38.9423076923077, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=30.2222222222222, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18857969, Length=221, Percent_Identity=34.841628959276, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_RICCN (Q92I30)

Other databases:

- EMBL:   AE006914
- PIR:   F97773
- RefSeq:   NP_360227.1
- ProteinModelPortal:   Q92I30
- SMR:   Q92I30
- GeneID:   927686
- GenomeReviews:   AE006914_GR
- KEGG:   rco:RC0590
- OMA:   RVRWAGR
- ProtClustDB:   CLSK870918
- BioCyc:   RCON272944:RC0590-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27150; Mature: 27150

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 21-21

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQHLKYKIMTNIKHLAIIMDGNARWADQHNLTKSEGHKAGADKIRELLPEFLNLNIPYI
CCCCHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCEE
TLYTFSSENWQRSSTEVDFLIKLLSIYLKTELNNLHKNGVKIKVIGRLTLLSSSLQKQIN
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
NAIELTKNNNKITLCIAFSYGSRQEIVDACTKIITSGKKAVSDSDIQHALYDPEMPDVDL
HHEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHCCCCCCCCEE
LIRPGGVYRISNFLLWQAAYAELYFSPKYWPDFNKYDIQEAINDYSKRKRTFGKR
EECCCCCEEHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQQHLKYKIMTNIKHLAIIMDGNARWADQHNLTKSEGHKAGADKIRELLPEFLNLNIPYI
CCCCHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCEE
TLYTFSSENWQRSSTEVDFLIKLLSIYLKTELNNLHKNGVKIKVIGRLTLLSSSLQKQIN
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
NAIELTKNNNKITLCIAFSYGSRQEIVDACTKIITSGKKAVSDSDIQHALYDPEMPDVDL
HHEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHCCCCCCCCEE
LIRPGGVYRISNFLLWQAAYAELYFSPKYWPDFNKYDIQEAINDYSKRKRTFGKR
EECCCCCEEHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893