Click here to switch to the map view.

The map label for this gene is mdtB [H]

Identifier: 15892490

GI number: 15892490

Start: 558725

End: 559237

Strand: Reverse

Name: mdtB [H]

Synonym: RC0567

Alternate gene names: 15892490

Gene position: 559237-558725 (Counterclockwise)

Preceding gene: 15892491

Following gene: 15892489

Centisome position: 44.08

GC content: 39.57

Gene sequence:

>513_bases
ATGTCTTTAATGGCTCTAACGCTTGCGATGAGTTTTGTCGTGGATGATGCAATAGTAGTGCTTGAAAATATCACACGACA
TATGGGAAAAGGCGAGAGTAAAATAGCAGGATGTATTAACGGTACTAAAGAAATAGGATTTACTATCGTCTCAAGGACTT
TATCCCTAATGACGATATTCATCACAATATTATTTATGAGCGGAATTTTAGGGAAGCTACTGCACGAACTTGCCATTGTT
ATTACTACCTCTATTTTGCTTTCGGGAGTTATCTCGATAACCGTAACTCCTATGTTATGTAATGTGTTTTTGAGGGATCG
TCATTGCGAGGAACGTAGTGACGAAGCACTCTCAGGGCAACCAACCGAGATTGCCACGGCGCCTTTGACGCCTCGCAATA
ACGACCTACCACTAACCGAAAAAGCCTTTGAATATGTCAAACAAAAATATGGTAGCAGTCTAACAACAGTAGTAGAGCAT
TCAAAAACTACTATGCTTATATTTTTCTCTTAG

Upstream 100 bases:

>100_bases
TTCTACATAACTGACGGTCCGTGATTATTCCGACTATTGCCCTTCCTTTATCAGTTGTCGGTACTTTTGCCTTTATCTAT
TCGGTTATAGCATCGATAAT

Downstream 100 bases:

>100_bases
TAATCATCGCAACGGCTTATTTATTTGGGAAAGTACGCAAAGGCTTTATGCCTTATTCCTATACGGGACAAATCTTAGTT
TTTACCGACGCCGCTCAAAC

Product: RND efflux transporter

Products: NA

Alternate protein names: Multidrug transporter MdtB [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MSLMALTLAMSFVVDDAIVVLENITRHMGKGESKIAGCINGTKEIGFTIVSRTLSLMTIFITILFMSGILGKLLHELAIV
ITTSILLSGVISITVTPMLCNVFLRDRHCEERSDEALSGQPTEIATAPLTPRNNDLPLTEKAFEYVKQKYGSSLTTVVEH
SKTTMLIFFS

Sequences:

>Translated_170_residues
MSLMALTLAMSFVVDDAIVVLENITRHMGKGESKIAGCINGTKEIGFTIVSRTLSLMTIFITILFMSGILGKLLHELAIV
ITTSILLSGVISITVTPMLCNVFLRDRHCEERSDEALSGQPTEIATAPLTPRNNDLPLTEKAFEYVKQKYGSSLTTVVEH
SKTTMLIFFS
>Mature_169_residues
SLMALTLAMSFVVDDAIVVLENITRHMGKGESKIAGCINGTKEIGFTIVSRTLSLMTIFITILFMSGILGKLLHELAIVI
TTSILLSGVISITVTPMLCNVFLRDRHCEERSDEALSGQPTEIATAPLTPRNNDLPLTEKAFEYVKQKYGSSLTTVVEHS
KTTMLIFFS

Specific function: Could Be A Drug Efflux Pump (By Similarity). [C]

COG id: COG0841

COG function: function code V; Cation/multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family [H]

Homologues:

Organism=Escherichia coli, GI1788390, Length=167, Percent_Identity=41.3173652694611, Blast_Score=117, Evalue=3e-28,
Organism=Escherichia coli, GI1788391, Length=105, Percent_Identity=48.5714285714286, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001036
- InterPro:   IPR022831 [H]

Pfam domain/function: PF00873 ACR_tran [H]

EC number: NA

Molecular weight: Translated: 18627; Mature: 18496

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMALTLAMSFVVDDAIVVLENITRHMGKGESKIAGCINGTKEIGFTIVSRTLSLMTIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ITILFMSGILGKLLHELAIVITTSILLSGVISITVTPMLCNVFLRDRHCEERSDEALSGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCC
PTEIATAPLTPRNNDLPLTEKAFEYVKQKYGSSLTTVVEHSKTTMLIFFS
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEC
>Mature Secondary Structure 
SLMALTLAMSFVVDDAIVVLENITRHMGKGESKIAGCINGTKEIGFTIVSRTLSLMTIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ITILFMSGILGKLLHELAIVITTSILLSGVISITVTPMLCNVFLRDRHCEERSDEALSGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCC
PTEIATAPLTPRNNDLPLTEKAFEYVKQKYGSSLTTVVEHSKTTMLIFFS
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA