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The map label for this gene is nuoE

Identifier: 15892404

GI number: 15892404

Start: 476884

End: 477387

Strand: Reverse

Name: nuoE

Synonym: RC0481

Alternate gene names: 15892404

Gene position: 477387-476884 (Counterclockwise)

Preceding gene: 161723847

Following gene: 15892403

Centisome position: 37.63

GC content: 34.72

Gene sequence:

>504_bases
ATGAATACAAAAATTACAAATTTTACATTTGATAAGAAAAATTTAAATCTAGCAGAAGAGATTATAAAAAAATATCCACC
GCATGGAAAAAGAAGTGCAATACTTCCGCTGCTTGATCTAGCACAACGTCAAAACGGCGGCTGGCTACCTGTTCCTGCTA
TCGAATATGTCGCAAATATGTTAGCAATGCCTTATATACGGGCTTATGAGGTTGCAACATTTTATACTATGTTTAACTTA
AAGCGAGTTGGTAAATATCATATCCAAGTATGTACTACTACTCCTTGCTGGCTGCGTGGTAGTGATGATATAATGAAAAT
TTGCGAAAAGAAATTAGGTGTAAAACTCAAAGAAACTACTGAAGATCAAAAATTTACTTTAAGCGAGATAGAATGTTTGG
GAGCATGCGTTAACGCTCCGGTCGTACAGATTAATGACGATTATTATGAAGATCTAACTCAAGACAAAATGGGGAAAATA
ATAGACAAGCTTCAAAATGACTAG

Upstream 100 bases:

>100_bases
GATAGAAAAAACTAATCCTGAATGGAAAGATTTAATTAAATAGTTCTACGGATTCCTGCTTGCGCAGAAATGACATAAAA
CTATACCGTACTAAAAATAT

Downstream 100 bases:

>100_bases
AATCTTATTATTATTACTTAGATTTTATCAATATTTCATTTCTCCACTACTTGGCAATAATTGCCGGTTTCACCCCACTT
GTTCTGAATATGCCAAAGAA

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MNTKITNFTFDKKNLNLAEEIIKKYPPHGKRSAILPLLDLAQRQNGGWLPVPAIEYVANMLAMPYIRAYEVATFYTMFNL
KRVGKYHIQVCTTTPCWLRGSDDIMKICEKKLGVKLKETTEDQKFTLSEIECLGACVNAPVVQINDDYYEDLTQDKMGKI
IDKLQND

Sequences:

>Translated_167_residues
MNTKITNFTFDKKNLNLAEEIIKKYPPHGKRSAILPLLDLAQRQNGGWLPVPAIEYVANMLAMPYIRAYEVATFYTMFNL
KRVGKYHIQVCTTTPCWLRGSDDIMKICEKKLGVKLKETTEDQKFTLSEIECLGACVNAPVVQINDDYYEDLTQDKMGKI
IDKLQND
>Mature_167_residues
MNTKITNFTFDKKNLNLAEEIIKKYPPHGKRSAILPLLDLAQRQNGGWLPVPAIEYVANMLAMPYIRAYEVATFYTMFNL
KRVGKYHIQVCTTTPCWLRGSDDIMKICEKKLGVKLKETTEDQKFTLSEIECLGACVNAPVVQINDDYYEDLTQDKMGKI
IDKLQND

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family

Homologues:

Organism=Homo sapiens, GI222080062, Length=164, Percent_Identity=60.9756097560976, Blast_Score=204, Evalue=2e-53,
Organism=Escherichia coli, GI1788621, Length=133, Percent_Identity=33.8345864661654, Blast_Score=85, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561328, Length=158, Percent_Identity=56.9620253164557, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI18859877, Length=160, Percent_Identity=61.25, Blast_Score=210, Evalue=4e-55,
Organism=Drosophila melanogaster, GI21355353, Length=164, Percent_Identity=46.3414634146341, Blast_Score=157, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOE_RICCN (Q92ID9)

Other databases:

- EMBL:   AE006914
- PIR:   A97760
- RefSeq:   NP_360118.1
- ProteinModelPortal:   Q92ID9
- SMR:   Q92ID9
- GeneID:   928706
- GenomeReviews:   AE006914_GR
- KEGG:   rco:RC0481
- NMPDR:   fig|272944.1.peg.481
- OMA:   VMIVNNT
- ProtClustDB:   PRK07539
- BioCyc:   RCON272944:RC0481-MONOMER
- BRENDA:   1.6.99.5
- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10371
- PIRSF:   PIRSF000216
- TIGRFAMs:   TIGR01958

Pfam domain/function: PF01257 Complex1_24kDa; SSF52833 Thiordxn-like_fd

EC number: =1.6.99.5

Molecular weight: Translated: 19157; Mature: 19157

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKITNFTFDKKNLNLAEEIIKKYPPHGKRSAILPLLDLAQRQNGGWLPVPAIEYVANM
CCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LAMPYIRAYEVATFYTMFNLKRVGKYHIQVCTTTPCWLRGSDDIMKICEKKLGVKLKETT
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCEECCCHHHHHHHHHHHCCEECCCC
EDQKFTLSEIECLGACVNAPVVQINDDYYEDLTQDKMGKIIDKLQND
CCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTKITNFTFDKKNLNLAEEIIKKYPPHGKRSAILPLLDLAQRQNGGWLPVPAIEYVANM
CCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LAMPYIRAYEVATFYTMFNLKRVGKYHIQVCTTTPCWLRGSDDIMKICEKKLGVKLKETT
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCEECCCHHHHHHHHHHHCCEECCCC
EDQKFTLSEIECLGACVNAPVVQINDDYYEDLTQDKMGKIIDKLQND
CCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893