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The map label for this gene is nuoD [H]

Identifier: 161723847

GI number: 161723847

Start: 477812

End: 478987

Strand: Reverse

Name: nuoD [H]

Synonym: RC0482

Alternate gene names: 161723847

Gene position: 478987-477812 (Counterclockwise)

Preceding gene: 15892406

Following gene: 15892404

Centisome position: 37.75

GC content: 39.12

Gene sequence:

>1176_bases
ATGACTAACAACACCAAAACTATAACTCTAAACATTGGTCCACAGCATCCGGCAACTCACGGAGTTTTAAGGTTAATCCT
TGAGATGGACGGGGAAGTAGTAAATAATGCCGACCCTCATATTGGGTTACTTCATCGTGGTACGGAAAAGCTTATTGAGC
ATAAAACATATTTGCAGGCTATACCATATTTTGATCGTCTTGATTATGTTTCACCGATGTGTCAGGAACATGCATTTGCT
TTAGCTGTTGAGTCGTTATTAGAATGCGAAGTCCCACGAAGAGCTCAGTTTATCAGGGTACTATTCTCAGAGCTAACAAG
AATTTTGAACCATACTTTGAATATTGGCAGCCAAGCTTTAGATATCGGTGCTACTACTCCTTTATTATGGCTCTTTGAAG
AGCGAGAAAAGATCATGGAATTTTACGAGCATGTTTCCGGCTCTCGTATGCATTCAAACTACTTTAGACCGGGCGGGGTT
GCAGCAGATTTACCCGAAGGTTTACTTGAGGATATAGATAAATTTATAGAACAGTTTCCTCCTAAACTTCACGATATTGA
AAGTCTACTAAATGAAAATAGATTATGGAAACAACGTTTAGTAGATATCGGCGTTGCGTCTCAAAAAGAGGCAATGGACT
GGGGGTTTTCAGGACCAATGCTTAGAGGTTCGGGTATAGCTTGGGATTTACGCAAATCAAACCCTTATGACGTTTACGAT
GAAATGGACTTTAAAGTACCAATCGGCAAAAACGGTGATTGTTACGACAGATATTTCGTTCGTATGCTTGAAATGTACGA
ATCAATCAAGATAATCAAGCAATGTATAGAAAAAATGCCGAAAGGTGCAATTAAAACCGATGATCCTAAATTAACACCAC
CGACAAGAGCCAAAATGAAAGAATCTATGGAAGCAATGATTCATCATTTTAAGCTCTATACGGAAGGATATGACGTCCCA
GCCGGCGAGACCTATAAAGCCGTAGAAGCCCCTAAAGGCGAATTTGGTGTATATTTATACTCGCAAGGAGGTAATAGACC
TTATAGATGTCGTATTAAAGCACCCGGCTTTGCTCATTTGCAAGGACTAGATTTTATGTCTAAAGGTCATTTAATGGCAG
ATGTTATTACTATTATTGCAACGCTTGATATAGTATTTGGTGAGATAGATAGGTAA

Upstream 100 bases:

>100_bases
AAAATGAATGTCATCCTGTGACTTGATCGCGGGATCCAGAAAAAATACAAAAGACTGGACCCCGTGGTCAAGCGAACTAG
GTGACAGTAGGAAAAATACT

Downstream 100 bases:

>100_bases
TATATTTGTCATGCCGCGGGCTTGTACTTGCGTTACTCTGTCATTCCTGCGAAAACAGGAATCCATAAAATAAAACAATA
CATTTAAAAAACAAAAAATG

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTNNTKTITLNIGPQHPATHGVLRLILEMDGEVVNNADPHIGLLHRGTEKLIEHKTYLQAIPYFDRLDYVSPMCQEHAFA
LAVESLLECEVPRRAQFIRVLFSELTRILNHTLNIGSQALDIGATTPLLWLFEEREKIMEFYEHVSGSRMHSNYFRPGGV
AADLPEGLLEDIDKFIEQFPPKLHDIESLLNENRLWKQRLVDIGVASQKEAMDWGFSGPMLRGSGIAWDLRKSNPYDVYD
EMDFKVPIGKNGDCYDRYFVRMLEMYESIKIIKQCIEKMPKGAIKTDDPKLTPPTRAKMKESMEAMIHHFKLYTEGYDVP
AGETYKAVEAPKGEFGVYLYSQGGNRPYRCRIKAPGFAHLQGLDFMSKGHLMADVITIIATLDIVFGEIDR

Sequences:

>Translated_391_residues
MTNNTKTITLNIGPQHPATHGVLRLILEMDGEVVNNADPHIGLLHRGTEKLIEHKTYLQAIPYFDRLDYVSPMCQEHAFA
LAVESLLECEVPRRAQFIRVLFSELTRILNHTLNIGSQALDIGATTPLLWLFEEREKIMEFYEHVSGSRMHSNYFRPGGV
AADLPEGLLEDIDKFIEQFPPKLHDIESLLNENRLWKQRLVDIGVASQKEAMDWGFSGPMLRGSGIAWDLRKSNPYDVYD
EMDFKVPIGKNGDCYDRYFVRMLEMYESIKIIKQCIEKMPKGAIKTDDPKLTPPTRAKMKESMEAMIHHFKLYTEGYDVP
AGETYKAVEAPKGEFGVYLYSQGGNRPYRCRIKAPGFAHLQGLDFMSKGHLMADVITIIATLDIVFGEIDR
>Mature_390_residues
TNNTKTITLNIGPQHPATHGVLRLILEMDGEVVNNADPHIGLLHRGTEKLIEHKTYLQAIPYFDRLDYVSPMCQEHAFAL
AVESLLECEVPRRAQFIRVLFSELTRILNHTLNIGSQALDIGATTPLLWLFEEREKIMEFYEHVSGSRMHSNYFRPGGVA
ADLPEGLLEDIDKFIEQFPPKLHDIESLLNENRLWKQRLVDIGVASQKEAMDWGFSGPMLRGSGIAWDLRKSNPYDVYDE
MDFKVPIGKNGDCYDRYFVRMLEMYESIKIIKQCIEKMPKGAIKTDDPKLTPPTRAKMKESMEAMIHHFKLYTEGYDVPA
GETYKAVEAPKGEFGVYLYSQGGNRPYRCRIKAPGFAHLQGLDFMSKGHLMADVITIIATLDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=387, Percent_Identity=66.4082687338501, Blast_Score=553, Evalue=1e-158,
Organism=Homo sapiens, GI260898743, Length=381, Percent_Identity=65.8792650918635, Blast_Score=539, Evalue=1e-153,
Organism=Escherichia coli, GI145693162, Length=391, Percent_Identity=38.8746803069054, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1789076, Length=389, Percent_Identity=26.4781491002571, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788832, Length=391, Percent_Identity=27.8772378516624, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17555284, Length=389, Percent_Identity=60.6683804627249, Blast_Score=524, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17568379, Length=389, Percent_Identity=59.8971722365039, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24638644, Length=389, Percent_Identity=64.0102827763496, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221459469, Length=386, Percent_Identity=61.3989637305699, Blast_Score=520, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44600; Mature: 44469

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNTKTITLNIGPQHPATHGVLRLILEMDGEVVNNADPHIGLLHRGTEKLIEHKTYLQA
CCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEHHHCCHHHHHHHHHHHHH
IPYFDRLDYVSPMCQEHAFALAVESLLECEVPRRAQFIRVLFSELTRILNHTLNIGSQAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHE
DIGATTPLLWLFEEREKIMEFYEHVSGSRMHSNYFRPGGVAADLPEGLLEDIDKFIEQFP
ECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PKLHDIESLLNENRLWKQRLVDIGVASQKEAMDWGFSGPMLRGSGIAWDLRKSNPYDVYD
CHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCC
EMDFKVPIGKNGDCYDRYFVRMLEMYESIKIIKQCIEKMPKGAIKTDDPKLTPPTRAKMK
CCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
ESMEAMIHHFKLYTEGYDVPAGETYKAVEAPKGEFGVYLYSQGGNRPYRCRIKAPGFAHL
HHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEEEEEECCCCCCEEEEECCCCCHHH
QGLDFMSKGHLMADVITIIATLDIVFGEIDR
HCCCHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TNNTKTITLNIGPQHPATHGVLRLILEMDGEVVNNADPHIGLLHRGTEKLIEHKTYLQA
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEHHHCCHHHHHHHHHHHHH
IPYFDRLDYVSPMCQEHAFALAVESLLECEVPRRAQFIRVLFSELTRILNHTLNIGSQAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHE
DIGATTPLLWLFEEREKIMEFYEHVSGSRMHSNYFRPGGVAADLPEGLLEDIDKFIEQFP
ECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PKLHDIESLLNENRLWKQRLVDIGVASQKEAMDWGFSGPMLRGSGIAWDLRKSNPYDVYD
CHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCC
EMDFKVPIGKNGDCYDRYFVRMLEMYESIKIIKQCIEKMPKGAIKTDDPKLTPPTRAKMK
CCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
ESMEAMIHHFKLYTEGYDVPAGETYKAVEAPKGEFGVYLYSQGGNRPYRCRIKAPGFAHL
HHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEEEEEECCCCCCEEEEECCCCCHHH
QGLDFMSKGHLMADVITIIATLDIVFGEIDR
HCCCHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA