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The map label for this gene is ptrB [H]

Identifier: 15892300

GI number: 15892300

Start: 377223

End: 379412

Strand: Reverse

Name: ptrB [H]

Synonym: RC0377

Alternate gene names: 15892300

Gene position: 379412-377223 (Counterclockwise)

Preceding gene: 15892301

Following gene: 15892299

Centisome position: 29.9

GC content: 33.47

Gene sequence:

>2190_bases
ATGAAACCACCAATAACAGACAAACAAAATTACAACTTTGAAGTTCACGAAACAACAATAAACGATGATTATCACTGGCT
GCGTGATCCTAAGTGGCCAAATGTAGAAGACTCTAAAATTTTAGATTATTTAAAAGCTGAGAATCAATATACCGAAAATT
TCTTTGCCGATCTGCAAAATGATAAGGAAAAGATTTTTGAAGAATTAAAAGGACGGGTTAAATTAGACGATGAATCGGTT
TATGTTAAGAACAAAGATTATTACTATTACCATAGAGTAGAGGAGAATAAAAATTATCCGATATATTGCAGAAAGCATAA
TAATATGGATTCAGCAGAAGAAGTAATATTAGATGTCAACCTTCTTGCTCCAAATAGCAGTTTTACTGATGTTGCTACAG
TTGCAATGTCACCTGATCACAATTTAATGGCTTATAGTGTTAATTTTACAGGTAATGAACAATACAATATCAAAATATAC
AACCTTAAAGAACAAAAATACTTACCTGATGAATTAGGCAATGTACAGCTAAATCTCGATCGCTTCAGACAAGATGAATT
TCAGGACAAGCCTGCGGAACGTACAAATGTACGTGAGCATAGGCGAATGCCGCAAAATTCGCTTGTATCAAGCGATCGAA
ATTTAGCTGTAGCTCCTACTATAATTTGGCATGAACACTTAAACGGCTTTTTCTATATTACTATTAATGAGAATCAACGC
TGGGATAAGGTAATGTTTCACCGTCTAGGTGAAGAGGTCACTCAGGATAAATTAATATTCGAGGTAAAAAACCCTCTTCA
TTTTATCAGCTGCAAGAAATCAGCAAGTCATGAATATATTTTTATAAATTCAGGCGATCATAATGAAAATGAAATTTACG
TAATTTCTATGCAGGATGATAGTTTTACGCCTAAATTAGTACGAGCTGCAGAAAACAAAATATTCTATGAAATAGAATAT
AATGGCGATTATTTTTATATTAAAACTAATTATAAAGCTAAAAATTTCCATGTTATAAAACTGCCGGTAAATAATTTTGA
AAATACTAGCTGGGATGATTGGGATGATATTTATATTAAGGAAGAACAAGACAAATATTTAAAAAGCTTTAATGTTACAA
ATAATTATTTAATCTTAAACTATCGTGACCAAGGTTTACCGCTAATTAAAATAAAGCGATTTAAAGATTTACAAGAAAAT
ACAATTTATTTTCCCGACGAAAGTTTCCAAGCAAGTAGTTTTTCTACAAACTTTGAGGAAGACGATATCAGAATAGATTA
CTCTTCTCTAGCAAGACCCAATACCACTTATAGTTACGATTTTAATAGCGATAAATTAACGATATTAAAGAGCCACGAAA
TACCTTCAGGCTTTAACCCGGAGGAGTATAAAGTAGAGAGAATATTTGCAGATAATGAAGATGTAAAAGTACCTATAACC
TTGTTTTATAAAAAATCTTTATTTAAAAAAGACGGTTCAAATCCTTTATATCTAATGGGTTACGGTGCTTATGGCATCGC
TATGCCCGTCAATTTTAGAAATACAGCAGTGACACTTGCCGATCGCGGTTTTATTTACGCAGTTGCTCATATTAGAGGTG
GCGATGATCTAGGTCATGATTGGTATGAAGCTGCTAAGTTTTTAACCAAAAAAAGAACATTTGAAGACTTCATAGCCTGT
AGTAGAGCTTTAATTAACGAGCAATATACAAGTAACAACAATATAGTAATAATGGGCGGTAGTGCCGGCGGTATGTTAAT
CGGTTACATACTCAACGAAAAACCGGAAATCTATAGAGCAGCAATCGCGCATGTACCGTTTGTTGATGTTTTGAGTACCA
TGCTTGACGAAAGCTTACCGTTAACTCTCTTGGAATATAACGAGTGGGGTAATCCGAAAGAGAAAGAATATTTTGAATAT
ATTAAATCATATTCCCCTTATGATAACGTAAAAGCACAAAACTACCCTGCTCTATTCGTTACTTGCGGTATATCCGACCC
ACGTGTAGGTTACTGGGAACCTGCTAAATGGGTAGCAAAATTACGAGCACTAAAAATGGACAATAATCCCTTATTATTAA
AAACAAATATGGATACGGGACATAAAGGTTCTGCCGGTCGTTTTGATTATCTGAAAGAGATAGCTGACGAATTAGTATTT
ATTTTTAAGGTGTTTGATGTTGAGGTTTAG

Upstream 100 bases:

>100_bases
CTGATTACAGAATTTTTTTATTATTTTACTAGATTGCCGCGTCGCCTACGGCTCCTCGCAATGACGACTTTAGGCATAAC
AACACAAAAAAATAAAAAAC

Downstream 100 bases:

>100_bases
TTAGCAGATTTGTGGCTGGAATCCTGTTATGTCATTCCTGCGCAAGCAGGAAGCCAGGAACAAGCGCAATAAATTGAGCT
TTTAAAAAGCTTTAAAGTAC

Product: protease II

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 729; Mature: 729

Protein sequence:

>729_residues
MKPPITDKQNYNFEVHETTINDDYHWLRDPKWPNVEDSKILDYLKAENQYTENFFADLQNDKEKIFEELKGRVKLDDESV
YVKNKDYYYYHRVEENKNYPIYCRKHNNMDSAEEVILDVNLLAPNSSFTDVATVAMSPDHNLMAYSVNFTGNEQYNIKIY
NLKEQKYLPDELGNVQLNLDRFRQDEFQDKPAERTNVREHRRMPQNSLVSSDRNLAVAPTIIWHEHLNGFFYITINENQR
WDKVMFHRLGEEVTQDKLIFEVKNPLHFISCKKSASHEYIFINSGDHNENEIYVISMQDDSFTPKLVRAAENKIFYEIEY
NGDYFYIKTNYKAKNFHVIKLPVNNFENTSWDDWDDIYIKEEQDKYLKSFNVTNNYLILNYRDQGLPLIKIKRFKDLQEN
TIYFPDESFQASSFSTNFEEDDIRIDYSSLARPNTTYSYDFNSDKLTILKSHEIPSGFNPEEYKVERIFADNEDVKVPIT
LFYKKSLFKKDGSNPLYLMGYGAYGIAMPVNFRNTAVTLADRGFIYAVAHIRGGDDLGHDWYEAAKFLTKKRTFEDFIAC
SRALINEQYTSNNNIVIMGGSAGGMLIGYILNEKPEIYRAAIAHVPFVDVLSTMLDESLPLTLLEYNEWGNPKEKEYFEY
IKSYSPYDNVKAQNYPALFVTCGISDPRVGYWEPAKWVAKLRALKMDNNPLLLKTNMDTGHKGSAGRFDYLKEIADELVF
IFKVFDVEV

Sequences:

>Translated_729_residues
MKPPITDKQNYNFEVHETTINDDYHWLRDPKWPNVEDSKILDYLKAENQYTENFFADLQNDKEKIFEELKGRVKLDDESV
YVKNKDYYYYHRVEENKNYPIYCRKHNNMDSAEEVILDVNLLAPNSSFTDVATVAMSPDHNLMAYSVNFTGNEQYNIKIY
NLKEQKYLPDELGNVQLNLDRFRQDEFQDKPAERTNVREHRRMPQNSLVSSDRNLAVAPTIIWHEHLNGFFYITINENQR
WDKVMFHRLGEEVTQDKLIFEVKNPLHFISCKKSASHEYIFINSGDHNENEIYVISMQDDSFTPKLVRAAENKIFYEIEY
NGDYFYIKTNYKAKNFHVIKLPVNNFENTSWDDWDDIYIKEEQDKYLKSFNVTNNYLILNYRDQGLPLIKIKRFKDLQEN
TIYFPDESFQASSFSTNFEEDDIRIDYSSLARPNTTYSYDFNSDKLTILKSHEIPSGFNPEEYKVERIFADNEDVKVPIT
LFYKKSLFKKDGSNPLYLMGYGAYGIAMPVNFRNTAVTLADRGFIYAVAHIRGGDDLGHDWYEAAKFLTKKRTFEDFIAC
SRALINEQYTSNNNIVIMGGSAGGMLIGYILNEKPEIYRAAIAHVPFVDVLSTMLDESLPLTLLEYNEWGNPKEKEYFEY
IKSYSPYDNVKAQNYPALFVTCGISDPRVGYWEPAKWVAKLRALKMDNNPLLLKTNMDTGHKGSAGRFDYLKEIADELVF
IFKVFDVEV
>Mature_729_residues
MKPPITDKQNYNFEVHETTINDDYHWLRDPKWPNVEDSKILDYLKAENQYTENFFADLQNDKEKIFEELKGRVKLDDESV
YVKNKDYYYYHRVEENKNYPIYCRKHNNMDSAEEVILDVNLLAPNSSFTDVATVAMSPDHNLMAYSVNFTGNEQYNIKIY
NLKEQKYLPDELGNVQLNLDRFRQDEFQDKPAERTNVREHRRMPQNSLVSSDRNLAVAPTIIWHEHLNGFFYITINENQR
WDKVMFHRLGEEVTQDKLIFEVKNPLHFISCKKSASHEYIFINSGDHNENEIYVISMQDDSFTPKLVRAAENKIFYEIEY
NGDYFYIKTNYKAKNFHVIKLPVNNFENTSWDDWDDIYIKEEQDKYLKSFNVTNNYLILNYRDQGLPLIKIKRFKDLQEN
TIYFPDESFQASSFSTNFEEDDIRIDYSSLARPNTTYSYDFNSDKLTILKSHEIPSGFNPEEYKVERIFADNEDVKVPIT
LFYKKSLFKKDGSNPLYLMGYGAYGIAMPVNFRNTAVTLADRGFIYAVAHIRGGDDLGHDWYEAAKFLTKKRTFEDFIAC
SRALINEQYTSNNNIVIMGGSAGGMLIGYILNEKPEIYRAAIAHVPFVDVLSTMLDESLPLTLLEYNEWGNPKEKEYFEY
IKSYSPYDNVKAQNYPALFVTCGISDPRVGYWEPAKWVAKLRALKMDNNPLLLKTNMDTGHKGSAGRFDYLKEIADELVF
IFKVFDVEV

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=744, Percent_Identity=25, Blast_Score=195, Evalue=2e-49,
Organism=Homo sapiens, GI284172420, Length=460, Percent_Identity=28.695652173913, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI284172413, Length=460, Percent_Identity=28.695652173913, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI70778815, Length=460, Percent_Identity=28.695652173913, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI284172438, Length=460, Percent_Identity=28.695652173913, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI284172431, Length=460, Percent_Identity=28.695652173913, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI108860686, Length=272, Percent_Identity=37.1323529411765, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI108860692, Length=210, Percent_Identity=39.5238095238095, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1788150, Length=731, Percent_Identity=33.9261285909713, Blast_Score=426, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24583414, Length=756, Percent_Identity=25.5291005291005, Blast_Score=196, Evalue=5e-50,
Organism=Drosophila melanogaster, GI221510989, Length=755, Percent_Identity=23.7086092715232, Blast_Score=178, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 85540; Mature: 85540

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPITDKQNYNFEVHETTINDDYHWLRDPKWPNVEDSKILDYLKAENQYTENFFADLQN
CCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCC
DKEKIFEELKGRVKLDDESVYVKNKDYYYYHRVEENKNYPIYCRKHNNMDSAEEVILDVN
CHHHHHHHHCCCEEECCCEEEEECCCEEEEEEEECCCCCCEEEEECCCCCCCCEEEEEEE
LLAPNSSFTDVATVAMSPDHNLMAYSVNFTGNEQYNIKIYNLKEQKYLPDELGNVQLNLD
EECCCCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEEEEEECCCCCCCHHHCCEEEEHH
RFRQDEFQDKPAERTNVREHRRMPQNSLVSSDRNLAVAPTIIWHEHLNGFFYITINENQR
HHCCHHHCCCCCCCCCCHHHHCCCHHHHHCCCCCEEEEEEEEEEECCCEEEEEEECCCCC
WDKVMFHRLGEEVTQDKLIFEVKNPLHFISCKKSASHEYIFINSGDHNENEIYVISMQDD
HHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEEECCC
SFTPKLVRAAENKIFYEIEYNGDYFYIKTNYKAKNFHVIKLPVNNFENTSWDDWDDIYIK
CCCHHHHHHCCCEEEEEEEECCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCEEEE
EEQDKYLKSFNVTNNYLILNYRDQGLPLIKIKRFKDLQENTIYFPDESFQASSFSTNFEE
CCHHHHHHHCCCCCCEEEEEECCCCCCEEEEHHHCCCCCCEEECCCCCCCCCCCCCCCCC
DDIRIDYSSLARPNTTYSYDFNSDKLTILKSHEIPSGFNPEEYKVERIFADNEDVKVPIT
CCEEEEHHHCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEE
LFYKKSLFKKDGSNPLYLMGYGAYGIAMPVNFRNTAVTLADRGFIYAVAHIRGGDDLGHD
EEEEHHHHHCCCCCCEEEEEECCCEEEEEEECCCEEEEEECCCEEEEEEEECCCCCCCHH
WYEAAKFLTKKRTFEDFIACSRALINEQYTSNNNIVIMGGSAGGMLIGYILNEKPEIYRA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCHHHHH
AIAHVPFVDVLSTMLDESLPLTLLEYNEWGNPKEKEYFEYIKSYSPYDNVKAQNYPALFV
HHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEE
TCGISDPRVGYWEPAKWVAKLRALKMDNNPLLLKTNMDTGHKGSAGRFDYLKEIADELVF
EECCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHEE
IFKVFDVEV
EEHEEEECC
>Mature Secondary Structure
MKPPITDKQNYNFEVHETTINDDYHWLRDPKWPNVEDSKILDYLKAENQYTENFFADLQN
CCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCC
DKEKIFEELKGRVKLDDESVYVKNKDYYYYHRVEENKNYPIYCRKHNNMDSAEEVILDVN
CHHHHHHHHCCCEEECCCEEEEECCCEEEEEEEECCCCCCEEEEECCCCCCCCEEEEEEE
LLAPNSSFTDVATVAMSPDHNLMAYSVNFTGNEQYNIKIYNLKEQKYLPDELGNVQLNLD
EECCCCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEEEEEECCCCCCCHHHCCEEEEHH
RFRQDEFQDKPAERTNVREHRRMPQNSLVSSDRNLAVAPTIIWHEHLNGFFYITINENQR
HHCCHHHCCCCCCCCCCHHHHCCCHHHHHCCCCCEEEEEEEEEEECCCEEEEEEECCCCC
WDKVMFHRLGEEVTQDKLIFEVKNPLHFISCKKSASHEYIFINSGDHNENEIYVISMQDD
HHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEEECCC
SFTPKLVRAAENKIFYEIEYNGDYFYIKTNYKAKNFHVIKLPVNNFENTSWDDWDDIYIK
CCCHHHHHHCCCEEEEEEEECCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCEEEE
EEQDKYLKSFNVTNNYLILNYRDQGLPLIKIKRFKDLQENTIYFPDESFQASSFSTNFEE
CCHHHHHHHCCCCCCEEEEEECCCCCCEEEEHHHCCCCCCEEECCCCCCCCCCCCCCCCC
DDIRIDYSSLARPNTTYSYDFNSDKLTILKSHEIPSGFNPEEYKVERIFADNEDVKVPIT
CCEEEEHHHCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEE
LFYKKSLFKKDGSNPLYLMGYGAYGIAMPVNFRNTAVTLADRGFIYAVAHIRGGDDLGHD
EEEEHHHHHCCCCCCEEEEEECCCEEEEEEECCCEEEEEECCCEEEEEEEECCCCCCCHH
WYEAAKFLTKKRTFEDFIACSRALINEQYTSNNNIVIMGGSAGGMLIGYILNEKPEIYRA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCHHHHH
AIAHVPFVDVLSTMLDESLPLTLLEYNEWGNPKEKEYFEYIKSYSPYDNVKAQNYPALFV
HHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEE
TCGISDPRVGYWEPAKWVAKLRALKMDNNPLLLKTNMDTGHKGSAGRFDYLKEIADELVF
EECCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHEE
IFKVFDVEV
EEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7629037 [H]