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The map label for this gene is atpB [H]

Identifier: 15891950

GI number: 15891950

Start: 27598

End: 28326

Strand: Reverse

Name: atpB [H]

Synonym: RC0027

Alternate gene names: 15891950

Gene position: 28326-27598 (Counterclockwise)

Preceding gene: 15891951

Following gene: 161723852

Centisome position: 2.23

GC content: 30.45

Gene sequence:

>729_bases
ATGACTCATAGCCCTTTAGCACAATTTGATATCAAAAAATTAATAGACATCAAAATGTTCGGTTTTGACGTCAGCTTTAC
TAATTCGAGTATCTATATGTTACTTGCTAGCATCTTAGCTCTAACTTATTTTTACTTAGCTTTTTATAACCGGAAATTAG
TACCTTCTAGATTACAAGTGAGTGCTGAAATAGTTTATAATCTTGTAGCTGATATGTTAAATCAGAATATAGGAGTAAAA
GGACGTAAATTTATTCCGTTAGTTTTTAGTTTATTTATTTTCATTTTATTCTGTAATTTACTTGGTATGACACCTTATAG
CTTTACTACTACTAGTCATATTATCGTTACTTTTACCTTGGCAATTCTAGTATTTTTAATGGTAACTATAGTCGGTTTTG
TAAAACACGGCTTACGTTTTTTAACCCTTTTTTTACCGCATGGTACTCCTCTATGGTTAGCACCGTTGATGATAGTAATT
GAACTATTTACATATTTAGCAAGACCGGTTAGTTTATCATTGCGACTTGCCGCTAATATGATGGCAGGACATGTTTTATT
AAAAGTAATAGCCGGTTTTACCGTGTCATTAATGATTTACTTGAAATTTCTGCCAATCCCTATTATGGTGATACTAATTG
GGTTTGAAATTTTTGTTGCAATACTTCAAGCTTATATTTTTACTATTTTATCTTGTATGTATCTTAATGATGCTATTAAT
TTACACTAG

Upstream 100 bases:

>100_bases
TTTAATTCTAAACCTTTATTCCTTATTATATTTACAATAATAGGAATGATTGCCGGCTTTAACATTATAAGGAAAAAAGT
AAATAATAAAAAGTAAGGAA

Downstream 100 bases:

>100_bases
GCTTTTTGCACAACTTGCTTCTAAAGGTAATTTGTACGTCAATCCGATGCTTGAATCCTCACGTACTTTTTTGTACTCTG
CAGTTCTGTGCTTCGTGTTT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTHSPLAQFDIKKLIDIKMFGFDVSFTNSSIYMLLASILALTYFYLAFYNRKLVPSRLQVSAEIVYNLVADMLNQNIGVK
GRKFIPLVFSLFIFILFCNLLGMTPYSFTTTSHIIVTFTLAILVFLMVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVI
ELFTYLARPVSLSLRLAANMMAGHVLLKVIAGFTVSLMIYLKFLPIPIMVILIGFEIFVAILQAYIFTILSCMYLNDAIN
LH

Sequences:

>Translated_242_residues
MTHSPLAQFDIKKLIDIKMFGFDVSFTNSSIYMLLASILALTYFYLAFYNRKLVPSRLQVSAEIVYNLVADMLNQNIGVK
GRKFIPLVFSLFIFILFCNLLGMTPYSFTTTSHIIVTFTLAILVFLMVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVI
ELFTYLARPVSLSLRLAANMMAGHVLLKVIAGFTVSLMIYLKFLPIPIMVILIGFEIFVAILQAYIFTILSCMYLNDAIN
LH
>Mature_241_residues
THSPLAQFDIKKLIDIKMFGFDVSFTNSSIYMLLASILALTYFYLAFYNRKLVPSRLQVSAEIVYNLVADMLNQNIGVKG
RKFIPLVFSLFIFILFCNLLGMTPYSFTTTSHIIVTFTLAILVFLMVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVIE
LFTYLARPVSLSLRLAANMMAGHVLLKVIAGFTVSLMIYLKFLPIPIMVILIGFEIFVAILQAYIFTILSCMYLNDAINL
H

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=222, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1790176, Length=216, Percent_Identity=26.8518518518519, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6226527, Length=249, Percent_Identity=36.5461847389558, Blast_Score=171, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 27411; Mature: 27280

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CC
>Mature Secondary Structure 
THSPLAQFDIKKLIDIKMFGFDVSFTNSSIYMLLASILALTYFYLAFYNRKLVPSRLQV
CCCCHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SAEIVYNLVADMLNQNIGVKGRKFIPLVFSLFIFILFCNLLGMTPYSFTTTSHIIVTFTL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AILVFLMVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVIELFTYLARPVSLSLRLAANM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAGHVLLKVIAGFTVSLMIYLKFLPIPIMVILIGFEIFVAILQAYIFTILSCMYLNDAIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LH
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA