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The map label for this gene is msrAB [H]

Identifier: 57652400

GI number: 57652400

Start: 2758398

End: 2758874

Strand: Reverse

Name: msrAB [H]

Synonym: SACOL2683

Alternate gene names: 57652400

Gene position: 2758874-2758398 (Counterclockwise)

Preceding gene: 57652401

Following gene: 57652399

Centisome position: 98.2

GC content: 34.8

Gene sequence:

>477_bases
ATGGCAGTTGTTTATGTAGCAGGAGGATGTTTATGGGGTGTTGAAGCATTTTTTGCAACAATACCTGGAATTATACATAC
AGAAGCAGGAAGAGCAAATGGAAGAAGCTCTAAATTAGACGGTCCGTATGATGGTTATGCTGAATGTGTCAAACTTCATT
TCGATGATCGTATGTTAACAATTACAGACATTATGAATTATTTATTTGAAATCATTGATCCTTACAGTGTGAATCAACAA
GGAAATGATATTGGACAAAAGTATCGAACGGGTTTATATAGTTGTGTAGATGACCACTTAATTGAAGCGCGTCAGTTCAT
TGAACGACGTAAAGACAGAGATCAAATTGCAGTGGAAGTCTTACCGCTGTCTAACTACATTAAAAGTGCTGAAGAACATC
AGCAACATTTAGAAAAATATCCAGAAGATATGCATATGTGTCATATTTCAAAAGATTTGCTAAATAAATACAAGTGA

Upstream 100 bases:

>100_bases
AATATGGGTATCGTAATGAAGGTGTATCAGAATCATGTCATGGCGGTATTAAATGGTATAACCTTGTTAAAAATATAAAA
AAGGATGATGAGGTGTAAAT

Downstream 100 bases:

>100_bases
TTTTCAGAGGAGAATAGATGTTTAAATTAACCAAAATCGGAGAAATACCTAGATATACTTAGAAAAGAGGTAGGTATTAT
GTATACGTTTGATGCACAAT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MAVVYVAGGCLWGVEAFFATIPGIIHTEAGRANGRSSKLDGPYDGYAECVKLHFDDRMLTITDIMNYLFEIIDPYSVNQQ
GNDIGQKYRTGLYSCVDDHLIEARQFIERRKDRDQIAVEVLPLSNYIKSAEEHQQHLEKYPEDMHMCHISKDLLNKYK

Sequences:

>Translated_158_residues
MAVVYVAGGCLWGVEAFFATIPGIIHTEAGRANGRSSKLDGPYDGYAECVKLHFDDRMLTITDIMNYLFEIIDPYSVNQQ
GNDIGQKYRTGLYSCVDDHLIEARQFIERRKDRDQIAVEVLPLSNYIKSAEEHQQHLEKYPEDMHMCHISKDLLNKYK
>Mature_157_residues
AVVYVAGGCLWGVEAFFATIPGIIHTEAGRANGRSSKLDGPYDGYAECVKLHFDDRMLTITDIMNYLFEIIDPYSVNQQG
NDIGQKYRTGLYSCVDDHLIEARQFIERRKDRDQIAVEVLPLSNYIKSAEEHQQHLEKYPEDMHMCHISKDLLNKYK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=28.7581699346405, Blast_Score=77, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=155, Percent_Identity=29.0322580645161, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 18162; Mature: 18031

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVVYVAGGCLWGVEAFFATIPGIIHTEAGRANGRSSKLDGPYDGYAECVKLHFDDRMLT
CEEEEECCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
ITDIMNYLFEIIDPYSVNQQGNDIGQKYRTGLYSCVDDHLIEARQFIERRKDRDQIAVEV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEE
LPLSNYIKSAEEHQQHLEKYPEDMHMCHISKDLLNKYK
ECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVVYVAGGCLWGVEAFFATIPGIIHTEAGRANGRSSKLDGPYDGYAECVKLHFDDRMLT
EEEEECCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
ITDIMNYLFEIIDPYSVNQQGNDIGQKYRTGLYSCVDDHLIEARQFIERRKDRDQIAVEV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEE
LPLSNYIKSAEEHQQHLEKYPEDMHMCHISKDLLNKYK
ECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA