Click here to switch to the map view.

The map label for this gene is guaB2

Identifier: 41410376

GI number: 41410376

Start: 4744490

End: 4746085

Strand: Direct

Name: guaB2

Synonym: MAP4278

Alternate gene names: 41410376

Gene position: 4744490-4746085 (Clockwise)

Preceding gene: 41410374

Following gene: 41410377

Centisome position: 98.23

GC content: 71.62

Gene sequence:

>1596_bases
ATGACCCGTGGCACGTCCCACCTGGAAGACAGCTCTGACCTGGTTGGCAGTGCGTACGTGCGGGTGGGTGGCCTCGTCGA
CGATCCGGTGCCCACCGGGGGCGACAACCCGCACAAGATCGCCATGCTCGGCCTGACGTTCGACGACGTGCTGCTGCTGC
CCGCGGCCTCCGACGTGGTGCCCGCCACCGCCGACACTTCCAGCCAGCTCACCAAGAAGATCAGGCTCAAGGTGCCGCTG
GTCAGCTCGGCGATGGACACCGTCACCGAGTCGCGGATGGCCATCGCGATGGCCCGGGCGGGCGGCATGGGCGTGCTGCA
CCGCAACCTGCCGGTGGCCGAACAGGCCGGCCAGGTCGAGATGGTCAAGCGCTCCGAGGCCGGCATGGTCACCGACCCGG
TCACCTGCCGCCCCGACAACACGCTGGCCCAGGTCGACGCGCTGTGCGCGCGGTTCCGCATCTCCGGGCTGCCGGTGGTG
GACGACTCCGGCGCGCTGGTCGGCATCATCACCAACCGCGACATGCGGTTCGAGGTCGACCAGACCAAGAAGGTCGCCGA
GGTGATGACCAAGGCCCCGCTGATCACCGCCCAGGAGGGCGTGTCCGCCGACGCGGCGCTGGGGCTGTTGCGGCGCAACA
AGATCGAGAAGCTGCCCATCGTCGACGGGCACGGCCGGCTGACCGGGCTGATCACCGTCAAGGACTTCGTCAAGACCGAA
CAGCACCCGCTGGCCACCAAGGACAGCGACGGCCGGCTGCTGGTCGGCGCGGCCGTCGGGGTCGGCGGCGACGCCTGGGT
ACGGGCCATGATGCTGGTCGACGCCGGGGTGGACGTGCTGGTCGTGGACACCGCGCACGCGCACAACCGGCTGGTGCTCG
ACATGGTCGGCAAACTCAAGGCCGAGGTGGGCGAGCGCGTCGAGGTGATCGGCGGCAACGTCGCCACCCGGGCCGCGGCC
GCCGCCCTGGTGGCCGCCGGCGCCGACGCGGTGAAGGTGGGGGTGGGGCCCGGCTCGATCTGCACCACCCGGGTGGTGGC
CGGCGTCGGCGCGCCACAGATCACCGCGATCCTGGAAGCCGTGGCCGCCTGCGGGCCGGCGGGCGTGCCGGTGATCGCCG
ACGGCGGGCTGCAGTACTCCGGCGACATCGCCAAGGCGCTGGCCGCCGGCGCGTCGACGGCCATGCTGGGCTCGCTGCTG
GCCGGCACCGCCGAGGCGCCCGGCGAGCTGATCTTCGTCAACGGCAAGCAGTTCAAGAGCTACCGCGGCATGGGGTCGCT
GGGCGCGATGGCCGGCCGCGGTTCCGGCGCCGGCAAGTCCTACTCCAAGGACCGCTACTTCGCCGACGACGCCCTCTCCG
AGGACAAGCTGGTGCCCGAGGGCATCGAGGGCCGGGTGCCGTTCCGCGGCCCGCTGTCCTCGGTGATCCACCAACTCACC
GGCGGCCTGCGGGCGGCGATGGGTTACACGGGCTCGCCGACCATCGAGGCGCTGCAACAGGCGCAGTTCGTCCGGATCAC
GGCGGCGGGCCTGCGGGAAAGCCACCCGCACGACGTCGCCATGACCGTCGAAGCCCCCAACTACTACGCGCGCTGA

Upstream 100 bases:

>100_bases
TCCGTTTGGCCCGCACGGCGCGCCCGAGCAAGCGGACTGCCGGGGCGGCCGAGCCGATAGGATGGGTCTCTCACCCCGCA
TCGTATGGAGGACCCCACTG

Downstream 100 bases:

>100_bases
GGCCCACATGGTCGAGATCGGGATGGGCCGCACCGCCCGTCGCAGCTATGAACTGAGCGAAGTCAGCATCGTGGCCTCCC
GGCGCACCCGCTCCTCGCAG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTRGTSHLEDSSDLVGSAYVRVGGLVDDPVPTGGDNPHKIAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPL
VSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVV
DDSGALVGIITNRDMRFEVDQTKKVAEVMTKAPLITAQEGVSADAALGLLRRNKIEKLPIVDGHGRLTGLITVKDFVKTE
QHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKAEVGERVEVIGGNVATRAAA
AALVAAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLL
AGTAEAPGELIFVNGKQFKSYRGMGSLGAMAGRGSGAGKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLT
GGLRAAMGYTGSPTIEALQQAQFVRITAAGLRESHPHDVAMTVEAPNYYAR

Sequences:

>Translated_531_residues
MTRGTSHLEDSSDLVGSAYVRVGGLVDDPVPTGGDNPHKIAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPL
VSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVV
DDSGALVGIITNRDMRFEVDQTKKVAEVMTKAPLITAQEGVSADAALGLLRRNKIEKLPIVDGHGRLTGLITVKDFVKTE
QHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKAEVGERVEVIGGNVATRAAA
AALVAAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLL
AGTAEAPGELIFVNGKQFKSYRGMGSLGAMAGRGSGAGKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLT
GGLRAAMGYTGSPTIEALQQAQFVRITAAGLRESHPHDVAMTVEAPNYYAR
>Mature_530_residues
TRGTSHLEDSSDLVGSAYVRVGGLVDDPVPTGGDNPHKIAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLV
SSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVD
DSGALVGIITNRDMRFEVDQTKKVAEVMTKAPLITAQEGVSADAALGLLRRNKIEKLPIVDGHGRLTGLITVKDFVKTEQ
HPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKAEVGERVEVIGGNVATRAAAA
ALVAAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLA
GTAEAPGELIFVNGKQFKSYRGMGSLGAMAGRGSGAGKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTG
GLRAAMGYTGSPTIEALQQAQFVRITAAGLRESHPHDVAMTVEAPNYYAR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=487, Percent_Identity=41.8891170431211, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI217035146, Length=467, Percent_Identity=41.9700214132762, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI34328928, Length=467, Percent_Identity=41.9700214132762, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI156616279, Length=467, Percent_Identity=41.9700214132762, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI34328930, Length=467, Percent_Identity=41.9700214132762, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI217035152, Length=462, Percent_Identity=41.7748917748918, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI217035148, Length=467, Percent_Identity=41.3276231263383, Blast_Score=318, Evalue=9e-87,
Organism=Homo sapiens, GI217035150, Length=467, Percent_Identity=39.8286937901499, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI50541956, Length=277, Percent_Identity=32.129963898917, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI50541954, Length=277, Percent_Identity=32.129963898917, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI50541952, Length=277, Percent_Identity=32.129963898917, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI50541948, Length=277, Percent_Identity=32.129963898917, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI156104880, Length=232, Percent_Identity=34.9137931034483, Blast_Score=137, Evalue=4e-32,
Organism=Escherichia coli, GI1788855, Length=492, Percent_Identity=54.0650406504065, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1786293, Length=240, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71994385, Length=494, Percent_Identity=35.2226720647773, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=441, Percent_Identity=36.9614512471655, Blast_Score=261, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=286, Percent_Identity=33.2167832167832, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323585, Length=461, Percent_Identity=40.7809110629067, Blast_Score=335, Evalue=9e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=461, Percent_Identity=40.1301518438178, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=38.0658436213992, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=37.4631268436578, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=40.6779661016949, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24641071, Length=487, Percent_Identity=41.2731006160164, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24641073, Length=487, Percent_Identity=41.2731006160164, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI28571163, Length=446, Percent_Identity=40.5829596412556, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 54763; Mature: 54631

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGTSHLEDSSDLVGSAYVRVGGLVDDPVPTGGDNPHKIAMLGLTFDDVLLLPAASDVV
CCCCCCCCCCCHHHHHEEHEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCC
PATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVE
CCCCCCHHHHHHHHEEECCHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHCCCEE
MVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDSGALVGIITNRDMRFEVD
EEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCEEEEHH
QTKKVAEVMTKAPLITAQEGVSADAALGLLRRNKIEKLPIVDGHGRLTGLITVKDFVKTE
HHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEHHHHCCC
QHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLK
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHH
AEVGERVEVIGGNVATRAAAAALVAAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEA
HHHCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHH
VAACGPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQFKS
HHHCCCCCCCEEECCCCEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHH
YRGMGSLGAMAGRGSGAGKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLT
HCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
GGLRAAMGYTGSPTIEALQQAQFVRITAAGLRESHPHDVAMTVEAPNYYAR
CCHHHHCCCCCCHHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
TRGTSHLEDSSDLVGSAYVRVGGLVDDPVPTGGDNPHKIAMLGLTFDDVLLLPAASDVV
CCCCCCCCCCHHHHHEEHEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCC
PATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVE
CCCCCCHHHHHHHHEEECCHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHCCCEE
MVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDSGALVGIITNRDMRFEVD
EEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCEEEEHH
QTKKVAEVMTKAPLITAQEGVSADAALGLLRRNKIEKLPIVDGHGRLTGLITVKDFVKTE
HHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEHHHHCCC
QHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLK
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHH
AEVGERVEVIGGNVATRAAAAALVAAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEA
HHHCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHH
VAACGPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQFKS
HHHCCCCCCCEEECCCCEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHH
YRGMGSLGAMAGRGSGAGKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLT
HCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
GGLRAAMGYTGSPTIEALQQAQFVRITAAGLRESHPHDVAMTVEAPNYYAR
CCHHHHCCCCCCHHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]