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The map label for this gene is guaB3

Identifier: 41410377

GI number: 41410377

Start: 4746093

End: 4747220

Strand: Direct

Name: guaB3

Synonym: MAP4279

Alternate gene names: 41410377

Gene position: 4746093-4747220 (Clockwise)

Preceding gene: 41410376

Following gene: 41410378

Centisome position: 98.27

GC content: 73.14

Gene sequence:

>1128_bases
ATGGTCGAGATCGGGATGGGCCGCACCGCCCGTCGCAGCTATGAACTGAGCGAAGTCAGCATCGTGGCCTCCCGGCGCAC
CCGCTCCTCGCAGGACGTGTCGACGGCCTGGCAGCTGGACGCCTACCGGTTCGAGATCCCGGTGCTGGCGCACCCGACCG
ACGCGCTGGTGTCACCGGAGTTCGCCATCGAGCTGGGCCGACTCGGCGGCCTGGGCGTGCTCAACGGCGAGGGCCTGATC
GGCCGGCACGCCGACGTCGAGGCCAAGATCGCTCAGCTGGTCGAGGCCGCCAGCAAGGAACCCGAACCCTCCGCGGCGAT
CCGGCTGCTGCAGGAGCTGCACGCCGCGCCGCTCAACCCCGACCTGCTGGGCTCGGCCGTCGCCCGCATCCGGGAGGCCG
GGGTGACCACCGCGGTGCGGGTCAGCCCGCAAAACGCCCAGGCACTCACCCCGGTCCTGCTGCAGGCCGGCATCGACCTG
CTGGTCATCCAGGGCACCATCGTCTCCGCCGAGCGGGTGGCTAGCGACGGCGAGCCGCTGAACCTCAAGACCTTCATCTC
CGAGCTCGACGTGCCGGTGGTCGCCGGCGGCGTGCAGGACCACCGCACCGCGCTGCACCTGATGCGCACCGGCGCCGCCG
GCGTCATCGTCGGCTACGGCGCCACCCGCGGCGTGACCACCAGCGACGAGGTGCTGGGCATCAGCGTGCCGATGGCCACC
GCGATCGCCGACGCCGCCGCCGCGCGCCGGGAGTACCTCGACGAGACCGGCGGTCGCTACGTGCACGTGCTGGCCGACGG
CGACATCCACACCTCCGGCGAGCTGGCCAAGGCGATCGCCTGCGGCGCCGACGCAGTGGTGCTGGGCACCCCGCTCGCCG
AGGCCGCCGAGGCGCTCGGCGAGGGCTGGTTCTGGCCGGCCGCCGCCGCGCACCCGTCGCTGCCGCGCGGCGCGCTGCTG
CAGGTCGCGATCGGGGAGCGCCCGCCGCTGCGCCAGGTGCTCAACGGGCCGTCCGACGACCCGTTCGGCTCGCTGAACCT
GGTCGGCGGGCTGCGCCGGTCGATGGCGAAGGCCGGTTACTGCGATCTCAAGGAATTCCAGAAGGTGGGCCTGACGGTCG
GCAGCTAG

Upstream 100 bases:

>100_bases
CAGTTCGTCCGGATCACGGCGGCGGGCCTGCGGGAAAGCCACCCGCACGACGTCGCCATGACCGTCGAAGCCCCCAACTA
CTACGCGCGCTGAGGCCCAC

Downstream 100 bases:

>100_bases
TCGCGCCTTGAGGCGCCCTTGCGCCGCCACCGGCCGAGCGTCACGCTGGCGTGACGGCCGGCGCCGAGTGTCACGCCAGC
GTGACGCTCGGGCGCGGCGG

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MVEIGMGRTARRSYELSEVSIVASRRTRSSQDVSTAWQLDAYRFEIPVLAHPTDALVSPEFAIELGRLGGLGVLNGEGLI
GRHADVEAKIAQLVEAASKEPEPSAAIRLLQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQNAQALTPVLLQAGIDL
LVIQGTIVSAERVASDGEPLNLKTFISELDVPVVAGGVQDHRTALHLMRTGAAGVIVGYGATRGVTTSDEVLGISVPMAT
AIADAAAARREYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAEAAEALGEGWFWPAAAAHPSLPRGALL
QVAIGERPPLRQVLNGPSDDPFGSLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGS

Sequences:

>Translated_375_residues
MVEIGMGRTARRSYELSEVSIVASRRTRSSQDVSTAWQLDAYRFEIPVLAHPTDALVSPEFAIELGRLGGLGVLNGEGLI
GRHADVEAKIAQLVEAASKEPEPSAAIRLLQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQNAQALTPVLLQAGIDL
LVIQGTIVSAERVASDGEPLNLKTFISELDVPVVAGGVQDHRTALHLMRTGAAGVIVGYGATRGVTTSDEVLGISVPMAT
AIADAAAARREYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAEAAEALGEGWFWPAAAAHPSLPRGALL
QVAIGERPPLRQVLNGPSDDPFGSLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGS
>Mature_375_residues
MVEIGMGRTARRSYELSEVSIVASRRTRSSQDVSTAWQLDAYRFEIPVLAHPTDALVSPEFAIELGRLGGLGVLNGEGLI
GRHADVEAKIAQLVEAASKEPEPSAAIRLLQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQNAQALTPVLLQAGIDL
LVIQGTIVSAERVASDGEPLNLKTFISELDVPVVAGGVQDHRTALHLMRTGAAGVIVGYGATRGVTTSDEVLGISVPMAT
AIADAAAARREYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAEAAEALGEGWFWPAAAAHPSLPRGALL
QVAIGERPPLRQVLNGPSDDPFGSLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 39095; Mature: 39095

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEIGMGRTARRSYELSEVSIVASRRTRSSQDVSTAWQLDAYRFEIPVLAHPTDALVSPE
CEEECCCCCHHCCCCHHHHEEEEHHCCCCCCCCHHHEEECEEEEEEEEEECCCHHHCCCH
FAIELGRLGGLGVLNGEGLIGRHADVEAKIAQLVEAASKEPEPSAAIRLLQELHAAPLNP
HHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCH
DLLGSAVARIREAGVTTAVRVSPQNAQALTPVLLQAGIDLLVIQGTIVSAERVASDGEPL
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECEEEEHHHHCCCCCCC
NLKTFISELDVPVVAGGVQDHRTALHLMRTGAAGVIVGYGATRGVTTSDEVLGISVPMAT
CHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECHHHH
AIADAAAARREYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAEAAEALG
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHC
EGWFWPAAAAHPSLPRGALLQVAIGERPPLRQVLNGPSDDPFGSLNLVGGLRRSMAKAGY
CCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
CDLKEFQKVGLTVGS
CCHHHHHHHCCCCCC
>Mature Secondary Structure
MVEIGMGRTARRSYELSEVSIVASRRTRSSQDVSTAWQLDAYRFEIPVLAHPTDALVSPE
CEEECCCCCHHCCCCHHHHEEEEHHCCCCCCCCHHHEEECEEEEEEEEEECCCHHHCCCH
FAIELGRLGGLGVLNGEGLIGRHADVEAKIAQLVEAASKEPEPSAAIRLLQELHAAPLNP
HHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCH
DLLGSAVARIREAGVTTAVRVSPQNAQALTPVLLQAGIDLLVIQGTIVSAERVASDGEPL
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECEEEEHHHHCCCCCCC
NLKTFISELDVPVVAGGVQDHRTALHLMRTGAAGVIVGYGATRGVTTSDEVLGISVPMAT
CHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECHHHH
AIADAAAARREYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAEAAEALG
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHC
EGWFWPAAAAHPSLPRGALLQVAIGERPPLRQVLNGPSDDPFGSLNLVGGLRRSMAKAGY
CCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
CDLKEFQKVGLTVGS
CCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA