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The map label for this gene is rmlC

Identifier: 41410322

GI number: 41410322

Start: 4694713

End: 4695318

Strand: Reverse

Name: rmlC

Synonym: MAP4224c

Alternate gene names: 41410322

Gene position: 4695318-4694713 (Counterclockwise)

Preceding gene: 41410323

Following gene: 41410321

Centisome position: 97.22

GC content: 67.66

Gene sequence:

>606_bases
GTGTCGGCCCGCGAACTGAAAGTCCCCGGCGCCTGGGAGATCACCCCCACCGTGCACGGCGATGCCCGCGGCCATTTCTT
TGAATGGCTGACCGACAAGGGGTTTCGCTCCTTCGCCGGTCATCGGCTCGACGTCCGGCAAGCCAACTGCTCGGTGTCCG
CGGCGGGTGTGCTGCGCGGCCTGCACTTCGCCCAGGTGCCGCTCAGCCAGGCCAAATACGTGACCTGCGTGCGTGGTTCG
GTGTTCGACGTGGTCGTCGACATCCGGGTGGGCTCGCCCACGTTCGGGCAATGGGATTCGGTGCTGCTCGACGACGCCGA
GCACCGCACGATCTACATCTCCGAGGGTCTGGGGCACGGATTCCTTGCGCTGCAAGACAATTCGACGGTGATGTACCTGT
GCTCGGCGGAATACAACCCGGGGCGCGAACACACCATCTGCGCCACCGATCCCGCGTTGGGGATCGACTGGCCGCTGGTG
GCCGGCGCCGCGCCCACGCTGTCCGAGCGCGACGCCGCGGCCCCCAGCCTGGAGGAGGTTCGCGCCTCGGGGTTGCTGCC
CACCTGGGCGGAGACGCAAGCATTCATCGAGGGTTTGCCGCGCTGA

Upstream 100 bases:

>100_bases
GGCCTGCGTGAGACCATCGACTGGTATCGCGCGAACGAATCGTGGTGGCGGCCGTTGAAAGACGCCTCGGAAGCGCGCTA
CGAAGAACGCGGGCAGTGAC

Downstream 100 bases:

>100_bases
TCGTCTCGACCCGCATTGCCCGCAACCGTTATCCCGCAACGCAGTTGGCGCTCGCCGTGCGCACAACCCGGGATCGCCAC
CCGACCGTTTTATTCAACAC

Product: RmlC

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSARELKVPGAWEITPTVHGDARGHFFEWLTDKGFRSFAGHRLDVRQANCSVSAAGVLRGLHFAQVPLSQAKYVTCVRGS
VFDVVVDIRVGSPTFGQWDSVLLDDAEHRTIYISEGLGHGFLALQDNSTVMYLCSAEYNPGREHTICATDPALGIDWPLV
AGAAPTLSERDAAAPSLEEVRASGLLPTWAETQAFIEGLPR

Sequences:

>Translated_201_residues
MSARELKVPGAWEITPTVHGDARGHFFEWLTDKGFRSFAGHRLDVRQANCSVSAAGVLRGLHFAQVPLSQAKYVTCVRGS
VFDVVVDIRVGSPTFGQWDSVLLDDAEHRTIYISEGLGHGFLALQDNSTVMYLCSAEYNPGREHTICATDPALGIDWPLV
AGAAPTLSERDAAAPSLEEVRASGLLPTWAETQAFIEGLPR
>Mature_200_residues
SARELKVPGAWEITPTVHGDARGHFFEWLTDKGFRSFAGHRLDVRQANCSVSAAGVLRGLHFAQVPLSQAKYVTCVRGSV
FDVVVDIRVGSPTFGQWDSVLLDDAEHRTIYISEGLGHGFLALQDNSTVMYLCSAEYNPGREHTICATDPALGIDWPLVA
GAAPTLSERDAAAPSLEEVRASGLLPTWAETQAFIEGLPR

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N- acetylglucosamine-L-r

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=180, Percent_Identity=36.6666666666667, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17550412, Length=174, Percent_Identity=37.3563218390805, Blast_Score=110, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21808; Mature: 21677

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARELKVPGAWEITPTVHGDARGHFFEWLTDKGFRSFAGHRLDVRQANCSVSAAGVLRG
CCCCEECCCCCEEECCCCCCCCCCHHHHHHHCCCHHHHCCCEEEEEECCCCEEHHHHHHC
LHFAQVPLSQAKYVTCVRGSVFDVVVDIRVGSPTFGQWDSVLLDDAEHRTIYISEGLGHG
CHHHHCCCCCCEEEEEECCCEEEEEEEEEECCCCCCCCCCEEECCCCCCEEEEECCCCCC
FLALQDNSTVMYLCSAEYNPGREHTICATDPALGIDWPLVAGAAPTLSERDAAAPSLEEV
EEEEECCCEEEEEEECCCCCCCCCEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHH
RASGLLPTWAETQAFIEGLPR
HHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SARELKVPGAWEITPTVHGDARGHFFEWLTDKGFRSFAGHRLDVRQANCSVSAAGVLRG
CCCEECCCCCEEECCCCCCCCCCHHHHHHHCCCHHHHCCCEEEEEECCCCEEHHHHHHC
LHFAQVPLSQAKYVTCVRGSVFDVVVDIRVGSPTFGQWDSVLLDDAEHRTIYISEGLGHG
CHHHHCCCCCCEEEEEECCCEEEEEEEEEECCCCCCCCCCEEECCCCCCEEEEECCCCCC
FLALQDNSTVMYLCSAEYNPGREHTICATDPALGIDWPLVAGAAPTLSERDAAAPSLEEV
EEEEECCCEEEEEEECCCCCCCCCEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHH
RASGLLPTWAETQAFIEGLPR
HHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]