| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
Click here to switch to the map view.
The map label for this gene is sppA
Identifier: 41410286
GI number: 41410286
Start: 4657177
End: 4658964
Strand: Direct
Name: sppA
Synonym: MAP4188
Alternate gene names: 41410286
Gene position: 4657177-4658964 (Clockwise)
Preceding gene: 41410284
Following gene: 41410290
Centisome position: 96.43
GC content: 72.54
Gene sequence:
>1788_bases ATGTTCGCTGTGCTGTCCTCGATACCCGGCCTGTCCAAAGGCGCCGACGAGATCCGTGCCCTGGCCGGGCGCGTCGACAC CGCCCGCCATCACGGCGTGCCCAACGGCTGTGTGCTCGAGCTGGATCTGCGGTCGATGCCGCCGGAGACGTCCGGCTTCG ACCCGCTGGCGCTCGTCACCGGCGGCAGCCGGCCGGCATCGCTGCGCGACACGGTGGACGCCATCCACCGGGCGGCCGAG GACCCGCGGGTGGCCGGGCTGATCGCCCGGGTGCAGCTGGCGCCGTCGCCGTCGGCCGCGGTGCAGGAGCTGCGCGAGGC GATCGTCGCCTTCACCGCCGCCAAGCCGTCCCTGGCCTGGGCCGAGACCTATCCGGGCACGCTGTCGTACTACCTGGCGT CGGCGTTCGGCGAGATCTGGATGCAGCCCGGCGGCAGCGTCGGGCTGATCGGCTTCGCCAGCAACGCCACCTTCCTGCGC GACGCGCTCGACAAGGCGGGCATCGAGGCCCAATTCGTCGCCCGCGGCGAATACAAGTCCGCGGTAAACCGTTTCACCGA ACACGGCTTCACCGAGGCGCACCGCGAGGCCGTCACCCGGATGCTGGACAGCGTCCAGGAACAGGTGTGGCAGGCGGTAG CCGAATCACGCAAGCTCGACACCGACGCGCTGGACGCGCTGGCCGACCGCGCGCCGCTGCTGCGCCAGGACGCGCTGGAC TCCGGCCTGGTCGACCGGATCGGCTTCCGCGACCAGGCGTACGACCGGATCGCGGAACTCGTTGGCGTACAAGATGTTTC ACCGGACACCGAGCCGCCCCGGCTGTATGTGTCGCGCTACGCCGGCGCGGCCCGGTCCCGGCTGTCCCCGCCGGTGCCCT CGCTACCGGGGCGCCGCCGCCCACCGACGGTGGCGGTCATCAACGTCGACGGCACCCTCGTCGACGGGCGCGGCGGGCCC CATTTCCTGCCGTTCGGCGCCGCCACCGTGGGCAGCGACACCATCGCGCCGGCGCTGCGGGAGGCCGCCGCCGACGATGC GGTGTCGGCGATCGTGCTGCGGGTCAACAGCCCCGGCGGCTCGGTCACCGCGTCGGAAACCCTTTGGCGCGAAGTGAAAA GGGCCCGTGAACGCGGCAAGCCGGTGGTGGCGTCGATGGGTGCGGTGGCCGCCTCCGGCGGCTACTACGTGTCGGTGGCC GCCGACGCGATCGTCGCCAACCCGGCAACGATCACCGGTTCGATCGGCGTCATCACCGGCAAGCTGGTGATCCGCGACCT GCTGGGGCGGCTGGGCGTCGGGTCGGACACCGTGCGCACCAACGCCAATGCCGACGCGTGGTCGATCGACGCGCCGTTCA CCCCGGAGCAGCGCGCCCACCGCGAGGCCGAGGCCGACCTGGTGTACACCGACTTCGTGTCCCGGGTGGCCGAGGGCCGC AACCTGACCACCGACGCCGTCGAACGGGTGGCCCGGGGCCGGGTCTGGACGGGCGCCGACGCCCACGAGCGGGGGCTGGT CGACGAACTGGGCGGCTTTCGAATCGCGGTGCGGCGGGCCAAGATTCTCGCCGGGCTGGACGAGGACGCCGACGTGCGCA TCGTCACCTATCCGAGCGGCTCGCTGCTGGACGTACTGCGGCCGCGGGCCTCGTCGCAACCGGCGGCGGTGTCGCTGCCC GACGCGCTGGGCGCCCTGACGGTCAAGACCCTGGGCGCGATCCTGGACAACGTCGAGCGATCCTGCAGCGGTGCCAGCGC GCTGTGGCTGGGGCCGTCGCGGCTCTAG
Upstream 100 bases:
>100_bases CGCAGCCCCGCCCCGTCGAAGCCGTCGTAGTCGAACTGGGGGATGGCGATGGAAAACCTCACCCGACCACCGTACGGCCG TTCGTCGGTAGTCTGCAGAC
Downstream 100 bases:
>100_bases CGGGTCCGTGTGGCGCTGATGAAGATGATCTCGCCGAGCGGGTCGTCGTTCTCGGGGGCGGGCACCTCGATGCCGTGCCG GTGGAACAGTTCGGTGCGGG
Product: hypothetical protein
Products: NA
Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]
Number of amino acids: Translated: 595; Mature: 595
Protein sequence:
>595_residues MFAVLSSIPGLSKGADEIRALAGRVDTARHHGVPNGCVLELDLRSMPPETSGFDPLALVTGGSRPASLRDTVDAIHRAAE DPRVAGLIARVQLAPSPSAAVQELREAIVAFTAAKPSLAWAETYPGTLSYYLASAFGEIWMQPGGSVGLIGFASNATFLR DALDKAGIEAQFVARGEYKSAVNRFTEHGFTEAHREAVTRMLDSVQEQVWQAVAESRKLDTDALDALADRAPLLRQDALD SGLVDRIGFRDQAYDRIAELVGVQDVSPDTEPPRLYVSRYAGAARSRLSPPVPSLPGRRRPPTVAVINVDGTLVDGRGGP HFLPFGAATVGSDTIAPALREAAADDAVSAIVLRVNSPGGSVTASETLWREVKRARERGKPVVASMGAVAASGGYYVSVA ADAIVANPATITGSIGVITGKLVIRDLLGRLGVGSDTVRTNANADAWSIDAPFTPEQRAHREAEADLVYTDFVSRVAEGR NLTTDAVERVARGRVWTGADAHERGLVDELGGFRIAVRRAKILAGLDEDADVRIVTYPSGSLLDVLRPRASSQPAAVSLP DALGALTVKTLGAILDNVERSCSGASALWLGPSRL
Sequences:
>Translated_595_residues MFAVLSSIPGLSKGADEIRALAGRVDTARHHGVPNGCVLELDLRSMPPETSGFDPLALVTGGSRPASLRDTVDAIHRAAE DPRVAGLIARVQLAPSPSAAVQELREAIVAFTAAKPSLAWAETYPGTLSYYLASAFGEIWMQPGGSVGLIGFASNATFLR DALDKAGIEAQFVARGEYKSAVNRFTEHGFTEAHREAVTRMLDSVQEQVWQAVAESRKLDTDALDALADRAPLLRQDALD SGLVDRIGFRDQAYDRIAELVGVQDVSPDTEPPRLYVSRYAGAARSRLSPPVPSLPGRRRPPTVAVINVDGTLVDGRGGP HFLPFGAATVGSDTIAPALREAAADDAVSAIVLRVNSPGGSVTASETLWREVKRARERGKPVVASMGAVAASGGYYVSVA ADAIVANPATITGSIGVITGKLVIRDLLGRLGVGSDTVRTNANADAWSIDAPFTPEQRAHREAEADLVYTDFVSRVAEGR NLTTDAVERVARGRVWTGADAHERGLVDELGGFRIAVRRAKILAGLDEDADVRIVTYPSGSLLDVLRPRASSQPAAVSLP DALGALTVKTLGAILDNVERSCSGASALWLGPSRL >Mature_595_residues MFAVLSSIPGLSKGADEIRALAGRVDTARHHGVPNGCVLELDLRSMPPETSGFDPLALVTGGSRPASLRDTVDAIHRAAE DPRVAGLIARVQLAPSPSAAVQELREAIVAFTAAKPSLAWAETYPGTLSYYLASAFGEIWMQPGGSVGLIGFASNATFLR DALDKAGIEAQFVARGEYKSAVNRFTEHGFTEAHREAVTRMLDSVQEQVWQAVAESRKLDTDALDALADRAPLLRQDALD SGLVDRIGFRDQAYDRIAELVGVQDVSPDTEPPRLYVSRYAGAARSRLSPPVPSLPGRRRPPTVAVINVDGTLVDGRGGP HFLPFGAATVGSDTIAPALREAAADDAVSAIVLRVNSPGGSVTASETLWREVKRARERGKPVVASMGAVAASGGYYVSVA ADAIVANPATITGSIGVITGKLVIRDLLGRLGVGSDTVRTNANADAWSIDAPFTPEQRAHREAEADLVYTDFVSRVAEGR NLTTDAVERVARGRVWTGADAHERGLVDELGGFRIAVRRAKILAGLDEDADVRIVTYPSGSLLDVLRPRASSQPAAVSLP DALGALTVKTLGAILDNVERSCSGASALWLGPSRL
Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]
COG id: COG0616
COG function: function code OU; Periplasmic serine proteases (ClpP class)
Gene ontology:
Cell location: Cell inner membrane; Single-pass membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the peptidase S49 family [H]
Homologues:
Organism=Escherichia coli, GI1788064, Length=532, Percent_Identity=32.8947368421053, Blast_Score=222, Evalue=5e-59, Organism=Escherichia coli, GI1787527, Length=164, Percent_Identity=32.3170731707317, Blast_Score=75, Evalue=9e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004634 - InterPro: IPR004635 - InterPro: IPR002142 [H]
Pfam domain/function: PF01343 Peptidase_S49 [H]
EC number: 3.4.21.-
Molecular weight: Translated: 62791; Mature: 62791
Theoretical pI: Translated: 5.76; Mature: 5.76
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 0.8 %Met (Translated Protein) 1.2 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 1.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MFAVLSSIPGLSKGADEIRALAGRVDTARHHGVPNGCVLELDLRSMPPETSGFDPLALVT CCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEE GGSRPASLRDTVDAIHRAAEDPRVAGLIARVQLAPSPSAAVQELREAIVAFTAAKPSLAW CCCCCCHHHHHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCC AETYPGTLSYYLASAFGEIWMQPGGSVGLIGFASNATFLRDALDKAGIEAQFVARGEYKS HHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEECCHHHH AVNRFTEHGFTEAHREAVTRMLDSVQEQVWQAVAESRKLDTDALDALADRAPLLRQDALD HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHC SGLVDRIGFRDQAYDRIAELVGVQDVSPDTEPPRLYVSRYAGAARSRLSPPVPSLPGRRR CCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC PPTVAVINVDGTLVDGRGGPHFLPFGAATVGSDTIAPALREAAADDAVSAIVLRVNSPGG CCEEEEEECCCEEEECCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHCEEEEEEEEECCCC SVTASETLWREVKRARERGKPVVASMGAVAASGGYYVSVAADAIVANPATITGSIGVITG CCCHHHHHHHHHHHHHHCCCCEEEECCHHHCCCCEEEEEECCHHCCCCCEEECCHHHHHH KLVIRDLLGRLGVGSDTVRTNANADAWSIDAPFTPEQRAHREAEADLVYTDFVSRVAEGR HHHHHHHHHHCCCCCCCEECCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCC NLTTDAVERVARGRVWTGADAHERGLVDELGGFRIAVRRAKILAGLDEDADVRIVTYPSG CCCHHHHHHHHCCCEECCCCHHHCCCHHHHCCEEEHHHHHHHHHCCCCCCCEEEEECCCC SLLDVLRPRASSQPAAVSLPDALGALTVKTLGAILDNVERSCSGASALWLGPSRL CHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC >Mature Secondary Structure MFAVLSSIPGLSKGADEIRALAGRVDTARHHGVPNGCVLELDLRSMPPETSGFDPLALVT CCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEE GGSRPASLRDTVDAIHRAAEDPRVAGLIARVQLAPSPSAAVQELREAIVAFTAAKPSLAW CCCCCCHHHHHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCC AETYPGTLSYYLASAFGEIWMQPGGSVGLIGFASNATFLRDALDKAGIEAQFVARGEYKS HHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEECCHHHH AVNRFTEHGFTEAHREAVTRMLDSVQEQVWQAVAESRKLDTDALDALADRAPLLRQDALD HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHC SGLVDRIGFRDQAYDRIAELVGVQDVSPDTEPPRLYVSRYAGAARSRLSPPVPSLPGRRR CCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC PPTVAVINVDGTLVDGRGGPHFLPFGAATVGSDTIAPALREAAADDAVSAIVLRVNSPGG CCEEEEEECCCEEEECCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHCEEEEEEEEECCCC SVTASETLWREVKRARERGKPVVASMGAVAASGGYYVSVAADAIVANPATITGSIGVITG CCCHHHHHHHHHHHHHHCCCCEEEECCHHHCCCCEEEEEECCHHCCCCCEEECCHHHHHH KLVIRDLLGRLGVGSDTVRTNANADAWSIDAPFTPEQRAHREAEADLVYTDFVSRVAEGR HHHHHHHHHHCCCCCCCEECCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCC NLTTDAVERVARGRVWTGADAHERGLVDELGGFRIAVRRAKILAGLDEDADVRIVTYPSG CCCHHHHHHHHCCCEECCCCHHHCCCHHHHCCEEEHHHHHHHHHCCCCCCCEEEEECCCC SLLDVLRPRASSQPAAVSLPDALGALTVKTLGAILDNVERSCSGASALWLGPSRL CHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 8905231 [H]