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The map label for this gene is adh

Identifier: 41410290

GI number: 41410290

Start: 4661901

End: 4663133

Strand: Direct

Name: adh

Synonym: MAP4192

Alternate gene names: 41410290

Gene position: 4661901-4663133 (Clockwise)

Preceding gene: 41410286

Following gene: 41410293

Centisome position: 96.52

GC content: 72.91

Gene sequence:

>1233_bases
ATGAAGGCACTGGTCTATGGCGTCGCGCCGGAGCCCGTCGCGGTGCCCGACGACGCCAACCCGCTGGTCCAGAACCTGGC
CCGCACCCCGACCGGGCTGCGCGACATGCCGGAACCCGTGCTGCCGCACGAGGATTGGGTGCTCACCCGGCCGCGGCTGA
CCGGCATCTGCGGGTCGGACGCCAAGCAGATCCTGATGGACTTCGGCGAGGGCGACGCCGACAACGCCATGTCCGCCTTC
TGCTCGTTCCCGCAAGTCATGGGCCACGAGGTGGTGGCCGACGTGGTGGCGCTGGGACCCGGGGCGCGGGGGTTGGCGGT
GGGGCAGCGGGTGGTGCTCAACCCGTGGCTGTCCTGCGGGCCGCGCGGCATCCAACCGCCCTGCCCCGCATGCGAAGCCG
GCGACTACAGCCTGTGCTGGAGCTTCGCCGACGGCGACCTCAAACCCGGCATCCACACCGGCGTCTCGGCCGACGTGACC
GGCGGCTACGCCGAGCTGATGCCGGCCCACGACAGCATGCTGTTCGCGGTGCCGGAGCGGGTCCCCGACGAGATGGCCGT
GTTCGCCGACCCGTTCTCGGTGTCGCTGCACGCGATCACGCGCCACCCGCCGCCCCGCTCGGGGCGGGCGCTGGTGTACG
GCGCCGGCTCGCTCGGGCTGTGCGCGGTGGCGATCCTGCGGGCGCTCTACCCGGAGGTCGCCGTGGCCGTGGTGGCCCGC
TTCGACGCCCAGGCGGAGCTGGCCCGGCGCTTCGGTGCCGCCAAAGTCGTTGCGCACGAACCGCGTACGGCCGTCATCGA
AGAACTGGTCGGCTGGGGCGGTGGCCGGCTGCGCCGGCCGCTGCTGGGTCTGCCGATGGCCCACCCCGGCGCGGTCGACG
TCGTCTACGACACCGTCGGCAAACCCGAGACGTTAGAGGTCGCCGTCCGCCTGCTGCGGTCGCGGGGCACCCTGGTGAAG
GCCGGTGTGCACGCGCCCGGGCGCTGGGAGGACAGCCCCTTGTATTTCAAGGAGATCGCGCTGGTCGGCTCCAACGCCTT
CGGGGTCGAGGAGGTCGACGGGCAGCGCCGGCACGCCATCGCGCACTACCTCGACCTGGCCGCGGCGGGGCGGGTGGACC
TGCGCCCGATGCTCACCCACACGTTCACGCTGGACCGCTGGCGCGACGCGTTCCACGCCCTGGCCGACCAGGGCCGGACC
GGCGCGGTGAAGGTGGCGTTCGACCAGCGTTAG

Upstream 100 bases:

>100_bases
ATAACAAGCTGCCCCCACTGTACGCTTCCCGCGATTCGCGGCAACCTTTACTGATGACGTACGCGGGCAAGAGGGTGTTG
ATCGCCGGGGCGGCGGCGCC

Downstream 100 bases:

>100_bases
CCCAGCGCGCCCCGGGATCCGAGGCGTCAGGGGTTGGCGCGCAGATAGCCGTACACGGCGGCGAAGTTGCGGTTGACGTC
CGCGGGAATTGGCACCGGAC

Product: Adh

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKALVYGVAPEPVAVPDDANPLVQNLARTPTGLRDMPEPVLPHEDWVLTRPRLTGICGSDAKQILMDFGEGDADNAMSAF
CSFPQVMGHEVVADVVALGPGARGLAVGQRVVLNPWLSCGPRGIQPPCPACEAGDYSLCWSFADGDLKPGIHTGVSADVT
GGYAELMPAHDSMLFAVPERVPDEMAVFADPFSVSLHAITRHPPPRSGRALVYGAGSLGLCAVAILRALYPEVAVAVVAR
FDAQAELARRFGAAKVVAHEPRTAVIEELVGWGGGRLRRPLLGLPMAHPGAVDVVYDTVGKPETLEVAVRLLRSRGTLVK
AGVHAPGRWEDSPLYFKEIALVGSNAFGVEEVDGQRRHAIAHYLDLAAAGRVDLRPMLTHTFTLDRWRDAFHALADQGRT
GAVKVAFDQR

Sequences:

>Translated_410_residues
MKALVYGVAPEPVAVPDDANPLVQNLARTPTGLRDMPEPVLPHEDWVLTRPRLTGICGSDAKQILMDFGEGDADNAMSAF
CSFPQVMGHEVVADVVALGPGARGLAVGQRVVLNPWLSCGPRGIQPPCPACEAGDYSLCWSFADGDLKPGIHTGVSADVT
GGYAELMPAHDSMLFAVPERVPDEMAVFADPFSVSLHAITRHPPPRSGRALVYGAGSLGLCAVAILRALYPEVAVAVVAR
FDAQAELARRFGAAKVVAHEPRTAVIEELVGWGGGRLRRPLLGLPMAHPGAVDVVYDTVGKPETLEVAVRLLRSRGTLVK
AGVHAPGRWEDSPLYFKEIALVGSNAFGVEEVDGQRRHAIAHYLDLAAAGRVDLRPMLTHTFTLDRWRDAFHALADQGRT
GAVKVAFDQR
>Mature_410_residues
MKALVYGVAPEPVAVPDDANPLVQNLARTPTGLRDMPEPVLPHEDWVLTRPRLTGICGSDAKQILMDFGEGDADNAMSAF
CSFPQVMGHEVVADVVALGPGARGLAVGQRVVLNPWLSCGPRGIQPPCPACEAGDYSLCWSFADGDLKPGIHTGVSADVT
GGYAELMPAHDSMLFAVPERVPDEMAVFADPFSVSLHAITRHPPPRSGRALVYGAGSLGLCAVAILRALYPEVAVAVVAR
FDAQAELARRFGAAKVVAHEPRTAVIEELVGWGGGRLRRPLLGLPMAHPGAVDVVYDTVGKPETLEVAVRLLRSRGTLVK
AGVHAPGRWEDSPLYFKEIALVGSNAFGVEEVDGQRRHAIAHYLDLAAAGRVDLRPMLTHTFTLDRWRDAFHALADQGRT
GAVKVAFDQR

Specific function: Not Known; Probable Catabolic Enzyme. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=364, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787863, Length=379, Percent_Identity=26.1213720316623, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788075, Length=370, Percent_Identity=26.4864864864865, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790045, Length=381, Percent_Identity=25.9842519685039, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788407, Length=388, Percent_Identity=22.9381443298969, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI226510992, Length=367, Percent_Identity=26.158038147139, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788073, Length=381, Percent_Identity=23.3595800524934, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790718, Length=369, Percent_Identity=23.8482384823848, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=366, Percent_Identity=24.0437158469945, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=254, Percent_Identity=25.1968503937008, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=384, Percent_Identity=27.0833333333333, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=364, Percent_Identity=26.6483516483516, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=377, Percent_Identity=24.9336870026525, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=377, Percent_Identity=24.6684350132626, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=363, Percent_Identity=22.3140495867769, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137530, Length=390, Percent_Identity=25.6410256410256, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17737897, Length=390, Percent_Identity=24.6153846153846, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 43824; Mature: 43824

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVYGVAPEPVAVPDDANPLVQNLARTPTGLRDMPEPVLPHEDWVLTRPRLTGICGSD
CCEEEEECCCCCEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
AKQILMDFGEGDADNAMSAFCSFPQVMGHEVVADVVALGPGARGLAVGQRVVLNPWLSCG
HHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCEECHHHHCC
PRGIQPPCPACEAGDYSLCWSFADGDLKPGIHTGVSADVTGGYAELMPAHDSMLFAVPER
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCHH
VPDEMAVFADPFSVSLHAITRHPPPRSGRALVYGAGSLGLCAVAILRALYPEVAVAVVAR
CCCCCEEEECCCEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
FDAQAELARRFGAAKVVAHEPRTAVIEELVGWGGGRLRRPLLGLPMAHPGAVDVVYDTVG
CCHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCHHCCHHHCCCCCCCCCEEEEECCCC
KPETLEVAVRLLRSRGTLVKAGVHAPGRWEDSPLYFKEIALVGSNAFGVEEVDGQRRHAI
CCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHEEHEEEECCCCCCCHHCCCHHHHHH
AHYLDLAAAGRVDLRPMLTHTFTLDRWRDAFHALADQGRTGAVKVAFDQR
HHHHHHHHCCCCCCCHHHHHHEEHHHHHHHHHHHHHCCCCCEEEEEECCC
>Mature Secondary Structure
MKALVYGVAPEPVAVPDDANPLVQNLARTPTGLRDMPEPVLPHEDWVLTRPRLTGICGSD
CCEEEEECCCCCEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
AKQILMDFGEGDADNAMSAFCSFPQVMGHEVVADVVALGPGARGLAVGQRVVLNPWLSCG
HHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCEECHHHHCC
PRGIQPPCPACEAGDYSLCWSFADGDLKPGIHTGVSADVTGGYAELMPAHDSMLFAVPER
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCHH
VPDEMAVFADPFSVSLHAITRHPPPRSGRALVYGAGSLGLCAVAILRALYPEVAVAVVAR
CCCCCEEEECCCEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
FDAQAELARRFGAAKVVAHEPRTAVIEELVGWGGGRLRRPLLGLPMAHPGAVDVVYDTVG
CCHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCHHCCHHHCCCCCCCCCEEEEECCCC
KPETLEVAVRLLRSRGTLVKAGVHAPGRWEDSPLYFKEIALVGSNAFGVEEVDGQRRHAI
CCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHEEHEEEECCCCCCCHHCCCHHHHHH
AHYLDLAAAGRVDLRPMLTHTFTLDRWRDAFHALADQGRTGAVKVAFDQR
HHHHHHHHCCCCCCCHHHHHHEEHHHHHHHHHHHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA