| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is yqhE [C]
Identifier: 41410247
GI number: 41410247
Start: 4627602
End: 4628462
Strand: Direct
Name: yqhE [C]
Synonym: MAP4149
Alternate gene names: 41410247
Gene position: 4627602-4628462 (Clockwise)
Preceding gene: 41410245
Following gene: 41410250
Centisome position: 95.81
GC content: 65.97
Gene sequence:
>861_bases GTGACAGTGATTGATGAGATATACAGCTCTTCCAGCGCGATTCCGACCGTCGCTCTCAATGACGAGGCGAAGAAGCCAGT ACTCGGCTTGGGGGTGGCCAAGCTGTCCGATGAGGAGACGGAAAGCTCGGTTCTCGCGGCGCTGGAAGCCGGCTGCCGCC TCATCGACACCGCTGCCTCCTACGGAAACGAAGCCGCCGTCGGCCGGGCCATCGCCGCGTCGGGCATCCCTCGCGAGGAA CTGTTCGTCACCACCAAACTGGGCACCTCGCGGCAGGGCTTCCATAGTGCCCAGGAGTCGTGCAAGGAGAGCCTGGACAG GTTGGGGCTGGACTACCTCGACCTCTACCTGATCCACTGGCCGGCCCCGACGCTGGGTAAGTACGTGGAGAGCTTCGAGG GCATGATCGAGGCCCGCGAGCGGGGCCACGTGCGCTCGATCGGCGTCTCGAACTTCACCGAGGACCTGCTGGCCACGGTG ATCGAGGAGACCAACGAGGTGCCCGCGGTGAACCAGGTCGAGCTGCACCCGCGGCTCAACCAGGCCGAGCTGCGTCAGGT GCACGCCCAGCACGACGTGACCACGCAGTCCTACAGCCCGTTGGGCGTCGGCCGGCTGATCGAGGAGCCGACCGTGACGA CGATTGCGGCCGAGTACGGCCGCACGCCGGCGCAGGTGCTGGTGCGGTGGAACCTGCAACTGGACAACGTGGTGGTCTCG CGGTCGTCCAAGCCGGAGCGGGTCGCCGAAAACCTGGACGTGTTCGACTTCACCCTGGAGCCCGAGCACATGGAGGCCAT CGAGGGACTGCACGACGGCACCCGGGTGCTGCACGACCCGATGACCTTCATGGGGACCTGA
Upstream 100 bases:
>100_bases GCTGTCGGGCGATATCGAGGGGCCTTCGGGCAAGTCGGCTCCGAATCGTTCTCATCGAAGGAAAATCCAGCACGCGACTT GGCAGGCAGGTGATTGACCA
Downstream 100 bases:
>100_bases CGGTTTCGCGAAAACCCCAGCGCCCCTTGGCTTTTAGAGCCAGTCGACCGGCGGGCCGTGCGGATGGCACTGTGCCAGCA CGCGCGGCCCGCCGTCCGGC
Product: hypothetical protein
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 286; Mature: 285
Protein sequence:
>286_residues MTVIDEIYSSSSAIPTVALNDEAKKPVLGLGVAKLSDEETESSVLAALEAGCRLIDTAASYGNEAAVGRAIAASGIPREE LFVTTKLGTSRQGFHSAQESCKESLDRLGLDYLDLYLIHWPAPTLGKYVESFEGMIEARERGHVRSIGVSNFTEDLLATV IEETNEVPAVNQVELHPRLNQAELRQVHAQHDVTTQSYSPLGVGRLIEEPTVTTIAAEYGRTPAQVLVRWNLQLDNVVVS RSSKPERVAENLDVFDFTLEPEHMEAIEGLHDGTRVLHDPMTFMGT
Sequences:
>Translated_286_residues MTVIDEIYSSSSAIPTVALNDEAKKPVLGLGVAKLSDEETESSVLAALEAGCRLIDTAASYGNEAAVGRAIAASGIPREE LFVTTKLGTSRQGFHSAQESCKESLDRLGLDYLDLYLIHWPAPTLGKYVESFEGMIEARERGHVRSIGVSNFTEDLLATV IEETNEVPAVNQVELHPRLNQAELRQVHAQHDVTTQSYSPLGVGRLIEEPTVTTIAAEYGRTPAQVLVRWNLQLDNVVVS RSSKPERVAENLDVFDFTLEPEHMEAIEGLHDGTRVLHDPMTFMGT >Mature_285_residues TVIDEIYSSSSAIPTVALNDEAKKPVLGLGVAKLSDEETESSVLAALEAGCRLIDTAASYGNEAAVGRAIAASGIPREEL FVTTKLGTSRQGFHSAQESCKESLDRLGLDYLDLYLIHWPAPTLGKYVESFEGMIEARERGHVRSIGVSNFTEDLLATVI EETNEVPAVNQVELHPRLNQAELRQVHAQHDVTTQSYSPLGVGRLIEEPTVTTIAAEYGRTPAQVLVRWNLQLDNVVVSR SSKPERVAENLDVFDFTLEPEHMEAIEGLHDGTRVLHDPMTFMGT
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family
Homologues:
Organism=Homo sapiens, GI24497577, Length=303, Percent_Identity=34.3234323432343, Blast_Score=174, Evalue=8e-44, Organism=Homo sapiens, GI5174391, Length=303, Percent_Identity=34.3234323432343, Blast_Score=174, Evalue=8e-44, Organism=Homo sapiens, GI310109922, Length=286, Percent_Identity=35.6643356643357, Blast_Score=163, Evalue=1e-40, Organism=Homo sapiens, GI310109920, Length=304, Percent_Identity=34.2105263157895, Blast_Score=158, Evalue=5e-39, Organism=Homo sapiens, GI45446745, Length=304, Percent_Identity=34.2105263157895, Blast_Score=158, Evalue=6e-39, Organism=Homo sapiens, GI4503285, Length=304, Percent_Identity=34.2105263157895, Blast_Score=158, Evalue=6e-39, Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=33.7883959044369, Blast_Score=158, Evalue=6e-39, Organism=Homo sapiens, GI5453543, Length=304, Percent_Identity=33.5526315789474, Blast_Score=153, Evalue=2e-37, Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=31.5789473684211, Blast_Score=152, Evalue=2e-37, Organism=Homo sapiens, GI24497585, Length=297, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=1e-35, Organism=Homo sapiens, GI24497583, Length=302, Percent_Identity=34.7682119205298, Blast_Score=147, Evalue=1e-35, Organism=Homo sapiens, GI4502049, Length=292, Percent_Identity=35.2739726027397, Blast_Score=144, Evalue=9e-35, Organism=Homo sapiens, GI5174695, Length=306, Percent_Identity=31.0457516339869, Blast_Score=144, Evalue=9e-35, Organism=Homo sapiens, GI291291012, Length=273, Percent_Identity=31.1355311355311, Blast_Score=134, Evalue=7e-32, Organism=Homo sapiens, GI300116273, Length=283, Percent_Identity=30.3886925795053, Blast_Score=124, Evalue=1e-28, Organism=Homo sapiens, GI300116271, Length=286, Percent_Identity=29.020979020979, Blast_Score=118, Evalue=5e-27, Organism=Homo sapiens, GI310109924, Length=156, Percent_Identity=35.2564102564103, Blast_Score=101, Evalue=8e-22, Organism=Homo sapiens, GI310109926, Length=117, Percent_Identity=39.3162393162393, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI207028673, Length=117, Percent_Identity=39.3162393162393, Blast_Score=72, Evalue=4e-13, Organism=Escherichia coli, GI87082198, Length=276, Percent_Identity=43.8405797101449, Blast_Score=236, Evalue=9e-64, Organism=Escherichia coli, GI1786400, Length=254, Percent_Identity=40.1574803149606, Blast_Score=179, Evalue=2e-46, Organism=Escherichia coli, GI1788081, Length=268, Percent_Identity=30.9701492537313, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI87081735, Length=291, Percent_Identity=28.1786941580756, Blast_Score=72, Evalue=5e-14, Organism=Escherichia coli, GI1788070, Length=289, Percent_Identity=26.643598615917, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI1789199, Length=227, Percent_Identity=29.5154185022026, Blast_Score=62, Evalue=6e-11, Organism=Escherichia coli, GI48994888, Length=255, Percent_Identity=29.0196078431373, Blast_Score=61, Evalue=8e-11, Organism=Caenorhabditis elegans, GI71998625, Length=277, Percent_Identity=34.6570397111913, Blast_Score=174, Evalue=3e-44, Organism=Caenorhabditis elegans, GI17552492, Length=272, Percent_Identity=35.2941176470588, Blast_Score=156, Evalue=1e-38, Organism=Caenorhabditis elegans, GI17537075, Length=303, Percent_Identity=34.3234323432343, Blast_Score=150, Evalue=5e-37, Organism=Caenorhabditis elegans, GI17537077, Length=297, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=6e-37, Organism=Caenorhabditis elegans, GI17564128, Length=302, Percent_Identity=31.4569536423841, Blast_Score=148, Evalue=3e-36, Organism=Caenorhabditis elegans, GI17566692, Length=299, Percent_Identity=32.4414715719064, Blast_Score=144, Evalue=5e-35, Organism=Caenorhabditis elegans, GI17561298, Length=278, Percent_Identity=31.294964028777, Blast_Score=140, Evalue=6e-34, Organism=Caenorhabditis elegans, GI17550248, Length=305, Percent_Identity=32.7868852459016, Blast_Score=135, Evalue=2e-32, Organism=Caenorhabditis elegans, GI17537079, Length=301, Percent_Identity=29.5681063122924, Blast_Score=129, Evalue=1e-30, Organism=Caenorhabditis elegans, GI17562292, Length=275, Percent_Identity=28, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=29.7794117647059, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17538386, Length=276, Percent_Identity=30.7971014492754, Blast_Score=115, Evalue=4e-26, Organism=Saccharomyces cerevisiae, GI6320576, Length=295, Percent_Identity=37.6271186440678, Blast_Score=188, Evalue=1e-48, Organism=Saccharomyces cerevisiae, GI6324694, Length=297, Percent_Identity=37.3737373737374, Blast_Score=177, Evalue=1e-45, Organism=Saccharomyces cerevisiae, GI6321896, Length=316, Percent_Identity=30.379746835443, Blast_Score=140, Evalue=2e-34, Organism=Saccharomyces cerevisiae, GI6319625, Length=279, Percent_Identity=34.7670250896057, Blast_Score=138, Evalue=1e-33, Organism=Saccharomyces cerevisiae, GI6322556, Length=259, Percent_Identity=31.6602316602317, Blast_Score=138, Evalue=1e-33, Organism=Saccharomyces cerevisiae, GI6320079, Length=294, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=5e-26, Organism=Drosophila melanogaster, GI24663317, Length=294, Percent_Identity=37.4149659863946, Blast_Score=188, Evalue=4e-48, Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=36.6666666666667, Blast_Score=184, Evalue=7e-47, Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=34.6875, Blast_Score=176, Evalue=2e-44, Organism=Drosophila melanogaster, GI24657054, Length=290, Percent_Identity=33.7931034482759, Blast_Score=172, Evalue=2e-43, Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=32.8767123287671, Blast_Score=169, Evalue=2e-42, Organism=Drosophila melanogaster, GI20129731, Length=289, Percent_Identity=35.9861591695502, Blast_Score=165, Evalue=3e-41, Organism=Drosophila melanogaster, GI21356425, Length=303, Percent_Identity=33.003300330033, Blast_Score=164, Evalue=9e-41, Organism=Drosophila melanogaster, GI24662789, Length=298, Percent_Identity=31.2080536912752, Blast_Score=144, Evalue=7e-35, Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=31.25, Blast_Score=139, Evalue=2e-33, Organism=Drosophila melanogaster, GI24662781, Length=281, Percent_Identity=35.2313167259786, Blast_Score=129, Evalue=2e-30, Organism=Drosophila melanogaster, GI24662785, Length=279, Percent_Identity=35.4838709677419, Blast_Score=125, Evalue=4e-29,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): Y4149_MYCPA (Q73SC5)
Other databases:
- EMBL: AE016958 - RefSeq: NP_963083.1 - HSSP: P06632 - ProteinModelPortal: Q73SC5 - SMR: Q73SC5 - EnsemblBacteria: EBMYCT00000036541 - GeneID: 2719380 - GenomeReviews: AE016958_GR - KEGG: mpa:MAP4149 - NMPDR: fig|262316.1.peg.4149 - GeneTree: EBGT00050000017291 - HOGENOM: HBG605727 - OMA: ALNYGNE - ProtClustDB: CLSK792199 - InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 - Gene3D: G3DSA:3.20.20.100 - PANTHER: PTHR11732 - PIRSF: PIRSF000097 - PRINTS: PR00069
Pfam domain/function: PF00248 Aldo_ket_red; SSF51430 Aldo/ket_red
EC number: NA
Molecular weight: Translated: 31310; Mature: 31179
Theoretical pI: Translated: 4.47; Mature: 4.47
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1; PS00062 ALDOKETO_REDUCTASE_2; PS00063 ALDOKETO_REDUCTASE_3
Important sites: ACT_SITE 61-61 BINDING 119-119
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTVIDEIYSSSSAIPTVALNDEAKKPVLGLGVAKLSDEETESSVLAALEAGCRLIDTAAS CCCHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCHHHHHHHH YGNEAAVGRAIAASGIPREELFVTTKLGTSRQGFHSAQESCKESLDRLGLDYLDLYLIHW CCCHHHHHHHHHHCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHEEEEEC PAPTLGKYVESFEGMIEARERGHVRSIGVSNFTEDLLATVIEETNEVPAVNQVELHPRLN CCHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC QAELRQVHAQHDVTTQSYSPLGVGRLIEEPTVTTIAAEYGRTPAQVLVRWNLQLDNVVVS HHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHCCCHHHEEEEECCEECCEEEE RSSKPERVAENLDVFDFTLEPEHMEAIEGLHDGTRVLHDPMTFMGT CCCCHHHHHHCCCEEEEEECHHHHHHHHHHCCCHHHHHCCHHHHCC >Mature Secondary Structure TVIDEIYSSSSAIPTVALNDEAKKPVLGLGVAKLSDEETESSVLAALEAGCRLIDTAAS CCHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCHHHHHHHH YGNEAAVGRAIAASGIPREELFVTTKLGTSRQGFHSAQESCKESLDRLGLDYLDLYLIHW CCCHHHHHHHHHHCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHEEEEEC PAPTLGKYVESFEGMIEARERGHVRSIGVSNFTEDLLATVIEETNEVPAVNQVELHPRLN CCHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC QAELRQVHAQHDVTTQSYSPLGVGRLIEEPTVTTIAAEYGRTPAQVLVRWNLQLDNVVVS HHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHCCCHHHEEEEECCEECCEEEE RSSKPERVAENLDVFDFTLEPEHMEAIEGLHDGTRVLHDPMTFMGT CCCCHHHHHHCCCEEEEEECHHHHHHHHHHCCCHHHHHCCHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA