Click here to switch to the map view.

The map label for this gene is htpX

Identifier: 41410157

GI number: 41410157

Start: 4519543

End: 4520406

Strand: Direct

Name: htpX

Synonym: MAP4059

Alternate gene names: 41410157

Gene position: 4519543-4520406 (Clockwise)

Preceding gene: 41410156

Following gene: 41410163

Centisome position: 93.58

GC content: 68.87

Gene sequence:

>864_bases
ATGACCTGGCATCCGCATGCCAACAGGTTCAAGACGTTCGCCCTGTTGGTCGGCATGTCCGCGTTGATCGTGTTCGTGGG
GTCGTTGTTCGGCAGGACCGCGATGTTCTTCGCGGTGCTGTTCGCCATCGGCATGAACGTCTACACCTACTACAACAGCG
ACAAGCTGGCGCTGCGCGCCATGCACGCGCAGCCGGTCTCCGAGCTGCAGGCGCCGGCGATGTACCGGATCGTGCGCGAG
CTGGCCACCGCCGCGCACCAGCCGATGCCCCGGCTCTACATCAGCGACACCAACGCGCCCAACGCGTTTGCCACCGGCCG
CAACCCGCGCAACGCCGCGGTCTGCTGCACCACCGGCATCCTGGGCATCCTCAACGAGCGTGAGCTGCGCGCCGTGCTGG
GACACGAGCTGTCCCACGTCTACAACCGCGACATCCTGATCTCGTGCATCGCCGGCGCGATGGCGTCGGTGATCACCGCG
CTGGCCAACATGGCCATGTTCGCCGGCATGTTCGGCGGCAACGACCGCGACGGCGAGAATCCCTTTGCGCTGCTGCTGGT
TTCGCTGCTGGGCCCGATCGCGGCCACCGTGGTGCGGCTGGCGGTGTCCCGGTCGCGCGAATACCAGGCCGACGAGTCGG
GCGCGGTGCTGACCGGCGACCCGTTGGCCCTGGCGTCGGCGCTGCGCAAGATCTCCGGCGGGGTGCAGGCGGCGCCGCTG
CCGCCCGAGCCGCAGCTGGCCAGCCAGGCGCACCTGATGATCGCCAACCCGTTCCGGGCCGGTGAACGGATCGGCTCGCT
GTTCTCCACGCACCCGCCGATCGAGGACCGGATCCGCCGCCTGGAATCCATGGCGGGGCGCTGA

Upstream 100 bases:

>100_bases
CGGCTAGCGCGTCGCGGAACCAACCGGGCCGTCTCGAGCGTTCAATTAGCGCAAGTCAGCAAGAGCGCGTGTGTGCCCGT
GCACTGCGAGGAGGACAGCG

Downstream 100 bases:

>100_bases
CGTCGGCCGCGCGTGCCCGCGGTCATGCGCGGGCAATCGCTGCGCCCGCCGCCACCACGGCAGTAGCATCGGGGATGTAT
GCGGTCCTCGAGCTGGCCGT

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTWHPHANRFKTFALLVGMSALIVFVGSLFGRTAMFFAVLFAIGMNVYTYYNSDKLALRAMHAQPVSELQAPAMYRIVRE
LATAAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGILGILNERELRAVLGHELSHVYNRDILISCIAGAMASVITA
LANMAMFAGMFGGNDRDGENPFALLLVSLLGPIAATVVRLAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPL
PPEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLESMAGR

Sequences:

>Translated_287_residues
MTWHPHANRFKTFALLVGMSALIVFVGSLFGRTAMFFAVLFAIGMNVYTYYNSDKLALRAMHAQPVSELQAPAMYRIVRE
LATAAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGILGILNERELRAVLGHELSHVYNRDILISCIAGAMASVITA
LANMAMFAGMFGGNDRDGENPFALLLVSLLGPIAATVVRLAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPL
PPEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLESMAGR
>Mature_286_residues
TWHPHANRFKTFALLVGMSALIVFVGSLFGRTAMFFAVLFAIGMNVYTYYNSDKLALRAMHAQPVSELQAPAMYRIVREL
ATAAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGILGILNERELRAVLGHELSHVYNRDILISCIAGAMASVITAL
ANMAMFAGMFGGNDRDGENPFALLLVSLLGPIAATVVRLAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPLP
PEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLESMAGR

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=291, Percent_Identity=28.8659793814433, Blast_Score=98, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 30947; Mature: 30816

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWHPHANRFKTFALLVGMSALIVFVGSLFGRTAMFFAVLFAIGMNVYTYYNSDKLALRA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHH
MHAQPVSELQAPAMYRIVRELATAAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGI
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
LGILNERELRAVLGHELSHVYNRDILISCIAGAMASVITALANMAMFAGMFGGNDRDGEN
HHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PFALLLVSLLGPIAATVVRLAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCC
PPEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLESMAGR
CCCCCHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TWHPHANRFKTFALLVGMSALIVFVGSLFGRTAMFFAVLFAIGMNVYTYYNSDKLALRA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHH
MHAQPVSELQAPAMYRIVRELATAAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGI
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
LGILNERELRAVLGHELSHVYNRDILISCIAGAMASVITALANMAMFAGMFGGNDRDGEN
HHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PFALLLVSLLGPIAATVVRLAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCC
PPEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLESMAGR
CCCCCHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]