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The map label for this gene is gabP [H]

Identifier: 41410112

GI number: 41410112

Start: 4476996

End: 4477946

Strand: Direct

Name: gabP [H]

Synonym: MAP4014

Alternate gene names: 41410112

Gene position: 4476996-4477946 (Clockwise)

Preceding gene: 41410111

Following gene: 41410113

Centisome position: 92.7

GC content: 67.82

Gene sequence:

>951_bases
ATGCTCGCTCTGGGCGGGGTGATCGGCGCCGGCTTGTTCGTCGGGTCCGGCGTGGTGATCAAGGACACCGGGCCGGCCGC
GTTCCTCACCTACGCCCTGTGCGGCCTGCTCATCGTGCTGGTGATGCGGATGCTCGGCGAGATGGCGGCCGCGAACCCGT
CCACCGGATCGTTCGCCGACTACGCGGCTGCGGCGCTGGGCCGCTGGGCCGGATTCTCGGTCGCCTGGCTGTATTGGTAC
TTCTGGGTGATCGTGGTCGGCTTCGAGGCGGTCGCCGGCGGCAAGGTGCTCAACTACTGGTTCCACGCCCCGCTGTGGGT
GCTGTCGCTGGGCCTGATGCTGTTGATGACCGCGACCAACCTGTTCTCGGTGTCGTCGTTCGGCGAGTTCGAATTCTGGT
TCGCCGGAATCAAAGTCGCCACCATCGTCATCTTCCTGGCGGTGGGCGCGGCCTATGTCGTCGGATTGGTGCCGGGGCAT
CACGACGGCCTGACCAACCTGGTGTCGCACGGCGGGTTCTTTCCCCGCGGGGTGGGCGCGGTGTTCGCCGCCATCGTGGT
GGTGATCTTCTCCATGGTCGGCGCCGAGATCGTCACCGTCGCCGCCGCGGAAAGCCGCGACCCGCGGCGGGCGGTGCAGA
AGGCGACCAGATCGGTCGTCACCCGGATCGGGATCTTCTTCGTCGGCTCGGTGTTTCTGCTCGTGGCGATCCTGCCGTGG
GACTCGGTGGAACTCGGCGCCTCGCCGTATGTGGCCGCGCTCAAACACCTGGGCCTGGCGGGGGCCGATCAGGTGATGAA
CGCGGTCGTGCTCACCGCGGTGTTGTCCTGCCTGAACTCCGGGCTGTACACCGCGTCACGCATGTTGTTCGTGCTCGCCG
AGCGGGGCGAGGCACCCGCCCGGTTGGTGCGGCTGAGCGGGCGCGGCGTTCCCCACATCGCCATCCTGTGA

Upstream 100 bases:

>100_bases
GCGGCCCTCGGCTGGCGCTGCCGATCCCGATGTGCTGTGGTTGATGCTCATGGCGGGCACTTCGCAACTGCGCCAAGGGC
TGTCGCAGCGGCAACTGAGC

Downstream 100 bases:

>100_bases
TCCTCGGCGGTCGGCTTCCTGTGCGTCGTCATGGCCCGGGTCGCACCCAACACCGTGTTCCTGTTCCTGCTCAACTCCTC
GGGCGCCATCATCCTGTTCG

Product: hypothetical protein

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MLALGGVIGAGLFVGSGVVIKDTGPAAFLTYALCGLLIVLVMRMLGEMAAANPSTGSFADYAAAALGRWAGFSVAWLYWY
FWVIVVGFEAVAGGKVLNYWFHAPLWVLSLGLMLLMTATNLFSVSSFGEFEFWFAGIKVATIVIFLAVGAAYVVGLVPGH
HDGLTNLVSHGGFFPRGVGAVFAAIVVVIFSMVGAEIVTVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVFLLVAILPW
DSVELGASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNSGLYTASRMLFVLAERGEAPARLVRLSGRGVPHIAIL

Sequences:

>Translated_316_residues
MLALGGVIGAGLFVGSGVVIKDTGPAAFLTYALCGLLIVLVMRMLGEMAAANPSTGSFADYAAAALGRWAGFSVAWLYWY
FWVIVVGFEAVAGGKVLNYWFHAPLWVLSLGLMLLMTATNLFSVSSFGEFEFWFAGIKVATIVIFLAVGAAYVVGLVPGH
HDGLTNLVSHGGFFPRGVGAVFAAIVVVIFSMVGAEIVTVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVFLLVAILPW
DSVELGASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNSGLYTASRMLFVLAERGEAPARLVRLSGRGVPHIAIL
>Mature_316_residues
MLALGGVIGAGLFVGSGVVIKDTGPAAFLTYALCGLLIVLVMRMLGEMAAANPSTGSFADYAAAALGRWAGFSVAWLYWY
FWVIVVGFEAVAGGKVLNYWFHAPLWVLSLGLMLLMTATNLFSVSSFGEFEFWFAGIKVATIVIFLAVGAAYVVGLVPGH
HDGLTNLVSHGGFFPRGVGAVFAAIVVVIFSMVGAEIVTVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVFLLVAILPW
DSVELGASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNSGLYTASRMLFVLAERGEAPARLVRLSGRGVPHIAIL

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=319, Percent_Identity=47.6489028213166, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI1786302, Length=317, Percent_Identity=40.6940063091483, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI87081708, Length=321, Percent_Identity=40.1869158878505, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1786789, Length=312, Percent_Identity=40.7051282051282, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI87081915, Length=321, Percent_Identity=40.809968847352, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1790653, Length=315, Percent_Identity=39.0476190476191, Blast_Score=223, Evalue=9e-60,
Organism=Escherichia coli, GI1788480, Length=329, Percent_Identity=39.5136778115502, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1786602, Length=318, Percent_Identity=39.3081761006289, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI48994972, Length=314, Percent_Identity=38.5350318471338, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320772, Length=335, Percent_Identity=33.134328358209, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324061, Length=338, Percent_Identity=31.9526627218935, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322892, Length=335, Percent_Identity=33.7313432835821, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324990, Length=342, Percent_Identity=31.5789473684211, Blast_Score=145, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6324924, Length=342, Percent_Identity=30.1169590643275, Blast_Score=142, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324059, Length=315, Percent_Identity=30.7936507936508, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319824, Length=336, Percent_Identity=30.952380952381, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321629, Length=337, Percent_Identity=31.4540059347181, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324553, Length=324, Percent_Identity=30.8641975308642, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6320717, Length=341, Percent_Identity=29.9120234604106, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6321053, Length=333, Percent_Identity=31.8318318318318, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6319543, Length=322, Percent_Identity=27.3291925465839, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319608, Length=340, Percent_Identity=26.7647058823529, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320251, Length=335, Percent_Identity=27.4626865671642, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319542, Length=342, Percent_Identity=27.1929824561404, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322967, Length=329, Percent_Identity=29.1793313069909, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324981, Length=332, Percent_Identity=29.8192771084337, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320364, Length=398, Percent_Identity=21.356783919598, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 33214; Mature: 33214

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHEECCCCCCEEEEC
>Mature Secondary Structure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HHHEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]