Click here to switch to the map view.

The map label for this gene is grpE

Identifier: 41409939

GI number: 41409939

Start: 4297412

End: 4298095

Strand: Direct

Name: grpE

Synonym: MAP3841

Alternate gene names: 41409939

Gene position: 4297412-4298095 (Clockwise)

Preceding gene: 41409938

Following gene: 41409940

Centisome position: 88.98

GC content: 70.18

Gene sequence:

>684_bases
GTGACACAAGGAAATCAGAAGACGGAAGGCAACCCGCCGGAACAGGTGACGGTTACCGACAAGCGGCGGATCGATCCCGA
GACCGGTGAGGTCCGGCACGTCCCTCCCGGCGACACGCCGGGAGGGACGGCGCCGCAAGCCGCGACCGCCGAGTCGGGCG
GCGCCGCGACCGACAAGGTCGCCGAGCTCACCGCCGACCTGCAACGCGTGCAGGCCGACTTCGCCAACTACCGCAAGCGG
GCGCTGCGCGACCAGCAGGCCGCGGCGGACCGGGCCAAGGCCGCCGTGGTCAACCAATTGCTGGGCGTGCTCGACGATTT
GGAGCGGGCACGCAAGCACGGCGACCTGGAGTCGGGGCCGCTGAAGTCGGTGGCCGACAAGCTGGAAAGCGCGCTGACGG
GCCTGGGCCTGACCGCATTCGGTGAGGAGGGCGAAGAGTTCGACCCGGTGCTGCACGAAGCCGTGCAGCACGAGGGTGAC
GGCTCCAAACCCGTCATCGGCACCGTCATGCGGCAGGGCTACAAGCTCGGCGATCAGGTGCTGCGCCACGCCTTGGTCGG
CGTCGTGGACACGGTCACCGAGGAAGGCGACGGGGAAGCCGCGGCCACCGACGAGCCCACCGCCGCGGCCGCCGAAACCC
GTCCGCCCGAATCGGACGATAACGCCGGCGCATCCGGTGACTAG

Upstream 100 bases:

>100_bases
CCCAGGCTGGCGGGCCGGACGGTGCCGCGGCCGGCGGCGGGTCCGGATCCGCCGACGATGTTGTGGACGCGGAGGTGGTC
GACGATGACCGGGAGTCCAA

Downstream 100 bases:

>100_bases
ATCACACAATCAGCACATTGGAAGACAGACCAAGAGAAAGTGGTGAGGGGGTGACGCGGCATGGCCCAGCGTGAATGGGT
CGAAAAAGACTTCTACAAGG

Product: heat shock protein GrpE

Products: NA

Alternate protein names: HSP-70 cofactor

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTQGNQKTEGNPPEQVTVTDKRRIDPETGEVRHVPPGDTPGGTAPQAATAESGGAATDKVAELTADLQRVQADFANYRKR
ALRDQQAAADRAKAAVVNQLLGVLDDLERARKHGDLESGPLKSVADKLESALTGLGLTAFGEEGEEFDPVLHEAVQHEGD
GSKPVIGTVMRQGYKLGDQVLRHALVGVVDTVTEEGDGEAAATDEPTAAAAETRPPESDDNAGASGD

Sequences:

>Translated_227_residues
MTQGNQKTEGNPPEQVTVTDKRRIDPETGEVRHVPPGDTPGGTAPQAATAESGGAATDKVAELTADLQRVQADFANYRKR
ALRDQQAAADRAKAAVVNQLLGVLDDLERARKHGDLESGPLKSVADKLESALTGLGLTAFGEEGEEFDPVLHEAVQHEGD
GSKPVIGTVMRQGYKLGDQVLRHALVGVVDTVTEEGDGEAAATDEPTAAAAETRPPESDDNAGASGD
>Mature_226_residues
TQGNQKTEGNPPEQVTVTDKRRIDPETGEVRHVPPGDTPGGTAPQAATAESGGAATDKVAELTADLQRVQADFANYRKRA
LRDQQAAADRAKAAVVNQLLGVLDDLERARKHGDLESGPLKSVADKLESALTGLGLTAFGEEGEEFDPVLHEAVQHEGDG
SKPVIGTVMRQGYKLGDQVLRHALVGVVDTVTEEGDGEAAATDEPTAAAAETRPPESDDNAGASGD

Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with dnaK and grpE. It is the nucleotide exchange factor for dnaK and may function as a thermosensor. Unfolded

COG id: COG0576

COG function: function code O; Molecular chaperone GrpE (heat shock protein)

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the grpE family

Homologues:

None

Paralogues:

None

Copy number: 2359 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): GRPE_MYCPA (Q73T78)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_962775.1
- ProteinModelPortal:   Q73T78
- SMR:   Q73T78
- EnsemblBacteria:   EBMYCT00000036276
- GeneID:   2719890
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP3841
- NMPDR:   fig|262316.1.peg.3841
- GeneTree:   EBGT00050000017239
- HOGENOM:   HBG732630
- OMA:   IGRARDH
- ProtClustDB:   PRK14142
- GO:   GO:0005739
- HAMAP:   MF_01151
- InterPro:   IPR000740
- InterPro:   IPR013805
- InterPro:   IPR009012
- Gene3D:   G3DSA:3.90.20.20
- Gene3D:   G3DSA:2.30.22.10
- PANTHER:   PTHR21237
- PRINTS:   PR00773

Pfam domain/function: PF01025 GrpE; SSF51064 GrpE_head

EC number: NA

Molecular weight: Translated: 23709; Mature: 23578

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS01071 GRPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQGNQKTEGNPPEQVTVTDKRRIDPETGEVRHVPPGDTPGGTAPQAATAESGGAATDKV
CCCCCCCCCCCCCCEEEECHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHH
AELTADLQRVQADFANYRKRALRDQQAAADRAKAAVVNQLLGVLDDLERARKHGDLESGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LKSVADKLESALTGLGLTAFGEEGEEFDPVLHEAVQHEGDGSKPVIGTVMRQGYKLGDQV
HHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LRHALVGVVDTVTEEGDGEAAATDEPTAAAAETRPPESDDNAGASGD
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQGNQKTEGNPPEQVTVTDKRRIDPETGEVRHVPPGDTPGGTAPQAATAESGGAATDKV
CCCCCCCCCCCCCEEEECHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHH
AELTADLQRVQADFANYRKRALRDQQAAADRAKAAVVNQLLGVLDDLERARKHGDLESGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LKSVADKLESALTGLGLTAFGEEGEEFDPVLHEAVQHEGDGSKPVIGTVMRQGYKLGDQV
HHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LRHALVGVVDTVTEEGDGEAAATDEPTAAAAETRPPESDDNAGASGD
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA