Click here to switch to the map view.

The map label for this gene is fadA2

Identifier: 41409791

GI number: 41409791

Start: 4107460

End: 4108806

Strand: Direct

Name: fadA2

Synonym: MAP3693

Alternate gene names: 41409791

Gene position: 4107460-4108806 (Clockwise)

Preceding gene: 41409788

Following gene: 41409793

Centisome position: 85.04

GC content: 71.79

Gene sequence:

>1347_bases
GTGGCCCCTGCAAGTTCCGAGGCAAGCAAACCGGCTGCTCAGCGCAGTGCGCAGCGGCGGCCAGTGGCCGTCCTGGGTGG
CAACCGGATTCCGTTCGCCCGCTCCGACGGCGCCTATGCCGAGGCGTCCAACCAGGACATGCTCACCGCCGCGCTGGAGG
GGTTGGTGGACCGCTTCGGGCTGGCCGGTGAGCGGCTGGGCGTGGTGGTCGGCGGCGCGGTGCTCAAGCACAGCCGGGAC
TTCAACCTGACCCGCGAATGCGTGCTGGGTTCACAGCTGTCGTCCTACACGCCGGCGTTCGACCTGCAGCAGGCCTGCGG
CACCGGGTTGCAGGCCGCGATGGCGGCCGCCGAGGGCATCGCCGCCGGCCGCTACGACGTGGCCGCCGCCGGCGGGGTGG
ACACCACCTCGGACGCGCCGATCGGCCTGGGCGACAACCTGCGCCGCACGCTGCTGAAGTTGCGCCGGGCCAAGTCGAAC
GTGCAGCGACTCAAGCTGGTGGGCACGCTGCCGGCGACCCTGGGCGTCGAGATCCCGGTCAACAGCGAGCCGCGCACCGG
CCTGTCCATGGGCGAGCACCAGGCGATCACCGCCAAGCAGATGGGCATCACCCGGGTCGCCCAGGACGAGCTGGCCGCCG
CCAGCCACCGCAACATGGCCGCCGCCTACGACCGCGGCTTCTTCGACGACCTGGTCACCCCGTTCCTGGGCCTGTACCGC
GACGACAACCTGCGGCCCGACTCGTCGCCGGAGAAGCTGGCCAAGCTGCGGCCGGTGTTCGGGGTGAAGGCCGGCGACGC
GACGATGACGGCGGGTAACTCGACCCCGCTGACTGACGGCGCCTCGGTGGCGCTGCTGGGCACCGAGGAGTGGGCGGCCG
CGCACTCGCTGACCCCGCTGGCCTACCTGGTGGATGCCGAGACAGCCGCGGTCGACTACGTCAACGGGCGCGACGGCCTG
CTGATGGCCCCCACCTACGCGGTGCCGCGGCTGCTCGCCCGCAACGGCCTGAGCCTGCAGGACTTCGACTTCTACGAGAT
CCACGAGGCGTTCGCCTCGGTGGTGCTGGCCCATCTGCAGGCCTGGGAATCCGAGGACTACTGCAAGGAACGGCTGGGCC
TGGACGCCGCGCTGGGCTCCATCGACCGCTCCAAGCTCAACGTCAACGGGTCCTCGCTGGCCGCCGGTCACCCGTTCGCG
GCCACCGGCGGGCGGATCCTGGCGCAGGCCGCCAAGCAGGTCGCGCAGCGTAAGGCCGAGCTCAAGGGCGCCGACAAACC
GGTGCGCGCCCTGATCTCGATCTGCGCGGCCGGCGGCCAGGGCGTGGCCGCGATCCTCGAGGCCTGA

Upstream 100 bases:

>100_bases
GTATCGAGGACGAACTTACTTCAGAGTAAGAACAGTGGGTAGTATGGCCCGAGACGGGCGACCCGCAAACCGACCAACCG
CAGACACACGGAGAACACAA

Downstream 100 bases:

>100_bases
CGGGCCGGGCCCATGAGTTGGGTCACATCGCGTTAGCAAGGGTTAGTAACCGGAGGCCGCGGGTATCCGTGACCCCGGAT
AGCCCCGTGTTGTGGTCTGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAPASSEASKPAAQRSAQRRPVAVLGGNRIPFARSDGAYAEASNQDMLTAALEGLVDRFGLAGERLGVVVGGAVLKHSRD
FNLTRECVLGSQLSSYTPAFDLQQACGTGLQAAMAAAEGIAAGRYDVAAAGGVDTTSDAPIGLGDNLRRTLLKLRRAKSN
VQRLKLVGTLPATLGVEIPVNSEPRTGLSMGEHQAITAKQMGITRVAQDELAAASHRNMAAAYDRGFFDDLVTPFLGLYR
DDNLRPDSSPEKLAKLRPVFGVKAGDATMTAGNSTPLTDGASVALLGTEEWAAAHSLTPLAYLVDAETAAVDYVNGRDGL
LMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLQAWESEDYCKERLGLDAALGSIDRSKLNVNGSSLAAGHPFA
ATGGRILAQAAKQVAQRKAELKGADKPVRALISICAAGGQGVAAILEA

Sequences:

>Translated_448_residues
MAPASSEASKPAAQRSAQRRPVAVLGGNRIPFARSDGAYAEASNQDMLTAALEGLVDRFGLAGERLGVVVGGAVLKHSRD
FNLTRECVLGSQLSSYTPAFDLQQACGTGLQAAMAAAEGIAAGRYDVAAAGGVDTTSDAPIGLGDNLRRTLLKLRRAKSN
VQRLKLVGTLPATLGVEIPVNSEPRTGLSMGEHQAITAKQMGITRVAQDELAAASHRNMAAAYDRGFFDDLVTPFLGLYR
DDNLRPDSSPEKLAKLRPVFGVKAGDATMTAGNSTPLTDGASVALLGTEEWAAAHSLTPLAYLVDAETAAVDYVNGRDGL
LMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLQAWESEDYCKERLGLDAALGSIDRSKLNVNGSSLAAGHPFA
ATGGRILAQAAKQVAQRKAELKGADKPVRALISICAAGGQGVAAILEA
>Mature_447_residues
APASSEASKPAAQRSAQRRPVAVLGGNRIPFARSDGAYAEASNQDMLTAALEGLVDRFGLAGERLGVVVGGAVLKHSRDF
NLTRECVLGSQLSSYTPAFDLQQACGTGLQAAMAAAEGIAAGRYDVAAAGGVDTTSDAPIGLGDNLRRTLLKLRRAKSNV
QRLKLVGTLPATLGVEIPVNSEPRTGLSMGEHQAITAKQMGITRVAQDELAAASHRNMAAAYDRGFFDDLVTPFLGLYRD
DNLRPDSSPEKLAKLRPVFGVKAGDATMTAGNSTPLTDGASVALLGTEEWAAAHSLTPLAYLVDAETAAVDYVNGRDGLL
MAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLQAWESEDYCKERLGLDAALGSIDRSKLNVNGSSLAAGHPFAA
TGGRILAQAAKQVAQRKAELKGADKPVRALISICAAGGQGVAAILEA

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=451, Percent_Identity=36.8070953436807, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI167614485, Length=440, Percent_Identity=29.0909090909091, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501853, Length=440, Percent_Identity=28.8636363636364, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4557237, Length=446, Percent_Identity=26.9058295964126, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI148539872, Length=436, Percent_Identity=27.9816513761468, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1788683, Length=414, Percent_Identity=37.6811594202899, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87082165, Length=439, Percent_Identity=29.6127562642369, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788554, Length=429, Percent_Identity=31.002331002331, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787663, Length=442, Percent_Identity=28.7330316742081, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI48994986, Length=440, Percent_Identity=27.0454545454545, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=35.9154929577465, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI133906874, Length=436, Percent_Identity=26.8348623853211, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17535921, Length=439, Percent_Identity=26.6514806378132, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=25.4408060453401, Blast_Score=121, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6322031, Length=446, Percent_Identity=28.47533632287, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6325229, Length=438, Percent_Identity=25.3424657534247, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17137578, Length=441, Percent_Identity=38.0952380952381, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17648125, Length=451, Percent_Identity=27.9379157427938, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24640423, Length=444, Percent_Identity=26.3513513513513, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24655093, Length=442, Percent_Identity=26.9230769230769, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46851; Mature: 46719

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPASSEASKPAAQRSAQRRPVAVLGGNRIPFARSDGAYAEASNQDMLTAALEGLVDRFG
CCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
LAGERLGVVVGGAVLKHSRDFNLTRECVLGSQLSSYTPAFDLQQACGTGLQAAMAAAEGI
CCCCHHHHEECHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHC
AAGRYDVAAAGGVDTTSDAPIGLGDNLRRTLLKLRRAKSNVQRLKLVGTLPATLGVEIPV
CCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHEEEECC
NSEPRTGLSMGEHQAITAKQMGITRVAQDELAAASHRNMAAAYDRGFFDDLVTPFLGLYR
CCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHC
DDNLRPDSSPEKLAKLRPVFGVKAGDATMTAGNSTPLTDGASVALLGTEEWAAAHSLTPL
CCCCCCCCCHHHHHHHCHHHEECCCCCEEECCCCCCCCCCCCEEEEECHHHHHHHCCCCC
AYLVDAETAAVDYVNGRDGLLMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLQ
CEEEECCHHEEEEECCCCCEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AWESEDYCKERLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRILAQAAKQVAQRKAE
HCCCHHHHHHHHCHHHHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LKGADKPVRALISICAAGGQGVAAILEA
HCCCCHHHHHHHHHHHCCCCCHHHHCCC
>Mature Secondary Structure 
APASSEASKPAAQRSAQRRPVAVLGGNRIPFARSDGAYAEASNQDMLTAALEGLVDRFG
CCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
LAGERLGVVVGGAVLKHSRDFNLTRECVLGSQLSSYTPAFDLQQACGTGLQAAMAAAEGI
CCCCHHHHEECHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHC
AAGRYDVAAAGGVDTTSDAPIGLGDNLRRTLLKLRRAKSNVQRLKLVGTLPATLGVEIPV
CCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHEEEECC
NSEPRTGLSMGEHQAITAKQMGITRVAQDELAAASHRNMAAAYDRGFFDDLVTPFLGLYR
CCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHC
DDNLRPDSSPEKLAKLRPVFGVKAGDATMTAGNSTPLTDGASVALLGTEEWAAAHSLTPL
CCCCCCCCCHHHHHHHCHHHEECCCCCEEECCCCCCCCCCCCEEEEECHHHHHHHCCCCC
AYLVDAETAAVDYVNGRDGLLMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLQ
CEEEECCHHEEEEECCCCCEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AWESEDYCKERLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRILAQAAKQVAQRKAE
HCCCHHHHHHHHCHHHHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LKGADKPVRALISICAAGGQGVAAILEA
HCCCCHHHHHHHHHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]