| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is budC [H]
Identifier: 41409691
GI number: 41409691
Start: 3990201
End: 3990947
Strand: Direct
Name: budC [H]
Synonym: MAP3593
Alternate gene names: 41409691
Gene position: 3990201-3990947 (Clockwise)
Preceding gene: 41409690
Following gene: 41409692
Centisome position: 82.62
GC content: 72.02
Gene sequence:
>747_bases ATGACCGGCGGATCGGCCCAGCCGCCGCGGGTGGCGCTGGTGACCGGCGCGGCCGGCGGTCAGGGCCGGGCCATCGCCGA ACGGCTGCGCGGCAACGGGTATGCGGTGGCCGCGTGTGATCGGCGCATCGACGAACTGGCCGCCACGGTGGCTGCATCGG GCGACGACCGGCTGATCGCGGTCGAGCTCGACGTCACCTCCGAGCAACAATGGCGCTCGGCCGTCGAACGCGTGGTGGAC CGCTTCGGTGCGCTGAGCGCGCTGGTGAACTGCGCCGGCGTGCTGCACCGCACCCCGCTGCCGCAGGAGACCGCCGACGC CTTCGAAAACGCCTGGCGGGTCAACTGTTTCGGTGCCTTCCTAGGCATGCGCGCGGCGCTGGAACGGCTCCGCGGGACAC CCGGCGCGTCGATCGTCAACATCTGCAGCACCGGTGCGATCCACCCGTTCCCGCAGCACTGCGCCTACGGCTCGTCGAAA TGGGCGCTGCGCGGCCTGACCCAAACCGCCGCCGCCGAACTCGCCCCGGCCGGTATCCGGGTCAACGCGGTGTTCCCCGG CCCGATCGCCACACCGATGCTCGACCAGGCCACCCAGACCCGGCTGGCCGCGGCCGCGTCCTTCGGGCGGATCGGGCAGC CCCGTGAGGTCGCCGACGCGGTGGCGTTCCTGGTGTCCGCCGAGGCGTCGTTCATCACCGGCGCCGAACTCATCGTCGAT GGCGGGCAATGCCTGCAGATCCGATGA
Upstream 100 bases:
>100_bases GACATGCCATGGCGCAGTTGGGATTCGACATGATCACGCTGGCCGCCGAGGCACAGGCACTGCGCCGCGGCGCCGCCGAA CACCTGCGTGAGGCGACGCA
Downstream 100 bases:
>100_bases GCGAGCTGTCGATCGGCATCATCGGCGCCGGTCCGGGCGGCCTGGCGCTGGGAATCCTGCTGTCGCAGGCCGGGTTTGGT GACTTCACCATCTTCGACCG
Product: hypothetical protein
Products: NA
Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]
Number of amino acids: Translated: 248; Mature: 247
Protein sequence:
>248_residues MTGGSAQPPRVALVTGAAGGQGRAIAERLRGNGYAVAACDRRIDELAATVAASGDDRLIAVELDVTSEQQWRSAVERVVD RFGALSALVNCAGVLHRTPLPQETADAFENAWRVNCFGAFLGMRAALERLRGTPGASIVNICSTGAIHPFPQHCAYGSSK WALRGLTQTAAAELAPAGIRVNAVFPGPIATPMLDQATQTRLAAAASFGRIGQPREVADAVAFLVSAEASFITGAELIVD GGQCLQIR
Sequences:
>Translated_248_residues MTGGSAQPPRVALVTGAAGGQGRAIAERLRGNGYAVAACDRRIDELAATVAASGDDRLIAVELDVTSEQQWRSAVERVVD RFGALSALVNCAGVLHRTPLPQETADAFENAWRVNCFGAFLGMRAALERLRGTPGASIVNICSTGAIHPFPQHCAYGSSK WALRGLTQTAAAELAPAGIRVNAVFPGPIATPMLDQATQTRLAAAASFGRIGQPREVADAVAFLVSAEASFITGAELIVD GGQCLQIR >Mature_247_residues TGGSAQPPRVALVTGAAGGQGRAIAERLRGNGYAVAACDRRIDELAATVAASGDDRLIAVELDVTSEQQWRSAVERVVDR FGALSALVNCAGVLHRTPLPQETADAFENAWRVNCFGAFLGMRAALERLRGTPGASIVNICSTGAIHPFPQHCAYGSSKW ALRGLTQTAAAELAPAGIRVNAVFPGPIATPMLDQATQTRLAAAASFGRIGQPREVADAVAFLVSAEASFITGAELIVDG GQCLQIR
Specific function: Catalyzes the reversible reduction of (S)-acetoin to 2,3-butanediol in the presence of NADH [H]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=248, Percent_Identity=38.3064516129032, Blast_Score=117, Evalue=8e-27, Organism=Homo sapiens, GI40254992, Length=233, Percent_Identity=32.618025751073, Blast_Score=112, Evalue=4e-25, Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=32.1705426356589, Blast_Score=110, Evalue=1e-24, Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=32.6530612244898, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI59889578, Length=224, Percent_Identity=35.2678571428571, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI31542939, Length=228, Percent_Identity=31.5789473684211, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI126723750, Length=245, Percent_Identity=29.3877551020408, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI7705925, Length=242, Percent_Identity=33.8842975206612, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI66933014, Length=194, Percent_Identity=29.3814432989691, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=31.9672131147541, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI4758504, Length=252, Percent_Identity=30.5555555555556, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI224922801, Length=171, Percent_Identity=33.9181286549708, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI109715829, Length=238, Percent_Identity=27.7310924369748, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI83715985, Length=249, Percent_Identity=28.9156626506024, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI40254986, Length=185, Percent_Identity=27.5675675675676, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=34.3915343915344, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI7706318, Length=194, Percent_Identity=26.8041237113402, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI4503817, Length=221, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=7e-11, Organism=Homo sapiens, GI7657478, Length=192, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=8e-11, Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=33.7448559670782, Blast_Score=107, Evalue=6e-25, Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=32, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=31.8181818181818, Blast_Score=99, Evalue=3e-22, Organism=Escherichia coli, GI1786812, Length=246, Percent_Identity=31.7073170731707, Blast_Score=95, Evalue=4e-21, Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=32.1138211382114, Blast_Score=94, Evalue=7e-21, Organism=Escherichia coli, GI1790717, Length=242, Percent_Identity=28.9256198347107, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=30.6772908366534, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=32.2448979591837, Blast_Score=83, Evalue=1e-17, Organism=Escherichia coli, GI1787905, Length=241, Percent_Identity=30.2904564315353, Blast_Score=81, Evalue=5e-17, Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=27.7551020408163, Blast_Score=74, Evalue=7e-15, Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=25.8964143426295, Blast_Score=68, Evalue=7e-13, Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=27.7992277992278, Blast_Score=65, Evalue=5e-12, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=34.8178137651822, Blast_Score=129, Evalue=9e-31, Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=34.8, Blast_Score=117, Evalue=7e-27, Organism=Caenorhabditis elegans, GI17555706, Length=239, Percent_Identity=33.8912133891213, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI25147288, Length=240, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=31.7073170731707, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=31.5384615384615, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17561402, Length=245, Percent_Identity=30.2040816326531, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=30, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=29.1187739463602, Blast_Score=94, Evalue=8e-20, Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17560220, Length=261, Percent_Identity=30.2681992337165, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI115534694, Length=242, Percent_Identity=33.0578512396694, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=29.1187739463602, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=30.0380228136882, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=28.7878787878788, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=27.8625954198473, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=30.6273062730627, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17538182, Length=248, Percent_Identity=31.0483870967742, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17562904, Length=259, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17508651, Length=248, Percent_Identity=28.6290322580645, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=28.0898876404494, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=29.6577946768061, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=28.4090909090909, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17536651, Length=251, Percent_Identity=28.6852589641434, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=7e-14, Organism=Caenorhabditis elegans, GI17562990, Length=255, Percent_Identity=28.6274509803922, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=26.5384615384615, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17536025, Length=253, Percent_Identity=28.4584980237154, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI71982365, Length=188, Percent_Identity=24.468085106383, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=258, Percent_Identity=28.2945736434109, Blast_Score=92, Evalue=6e-20, Organism=Saccharomyces cerevisiae, GI6322067, Length=198, Percent_Identity=31.3131313131313, Blast_Score=83, Evalue=4e-17, Organism=Saccharomyces cerevisiae, GI6322861, Length=202, Percent_Identity=28.2178217821782, Blast_Score=65, Evalue=9e-12, Organism=Drosophila melanogaster, GI23397609, Length=243, Percent_Identity=37.037037037037, Blast_Score=129, Evalue=1e-30, Organism=Drosophila melanogaster, GI24639444, Length=239, Percent_Identity=33.0543933054393, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=34.5528455284553, Blast_Score=117, Evalue=5e-27, Organism=Drosophila melanogaster, GI24643142, Length=241, Percent_Identity=34.0248962655602, Blast_Score=114, Evalue=4e-26, Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=33.0677290836653, Blast_Score=110, Evalue=6e-25, Organism=Drosophila melanogaster, GI21355319, Length=244, Percent_Identity=32.7868852459016, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=31.7073170731707, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI17737361, Length=247, Percent_Identity=33.6032388663968, Blast_Score=95, Evalue=5e-20, Organism=Drosophila melanogaster, GI24644337, Length=190, Percent_Identity=34.2105263157895, Blast_Score=94, Evalue=9e-20, Organism=Drosophila melanogaster, GI21357673, Length=243, Percent_Identity=27.1604938271605, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24648944, Length=222, Percent_Identity=25.6756756756757, Blast_Score=64, Evalue=7e-11, Organism=Drosophila melanogaster, GI24663911, Length=229, Percent_Identity=26.2008733624454, Blast_Score=64, Evalue=1e-10,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR014007 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.304 [H]
Molecular weight: Translated: 25809; Mature: 25677
Theoretical pI: Translated: 7.31; Mature: 7.31
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.4 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 2.4 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTGGSAQPPRVALVTGAAGGQGRAIAERLRGNGYAVAACDRRIDELAATVAASGDDRLIA CCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEE VELDVTSEQQWRSAVERVVDRFGALSALVNCAGVLHRTPLPQETADAFENAWRVNCFGAF EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCEEHHHHHHH LGMRAALERLRGTPGASIVNICSTGAIHPFPQHCAYGSSKWALRGLTQTAAAELAPAGIR HHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCEE VNAVFPGPIATPMLDQATQTRLAAAASFGRIGQPREVADAVAFLVSAEASFITGAELIVD EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHCCCCEEEEC GGQCLQIR CCCEEEEC >Mature Secondary Structure TGGSAQPPRVALVTGAAGGQGRAIAERLRGNGYAVAACDRRIDELAATVAASGDDRLIA CCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEE VELDVTSEQQWRSAVERVVDRFGALSALVNCAGVLHRTPLPQETADAFENAWRVNCFGAF EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCEEHHHHHHH LGMRAALERLRGTPGASIVNICSTGAIHPFPQHCAYGSSKWALRGLTQTAAAELAPAGIR HHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCEE VNAVFPGPIATPMLDQATQTRLAAAASFGRIGQPREVADAVAFLVSAEASFITGAELIVD EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHCCCCEEEEC GGQCLQIR CCCEEEEC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11173520 [H]